Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0064 | 0.0029 |
Onchocerca volvulus | 0.0651 | 1 | 1 | |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0036 | 0.0219 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0064 | 0.009 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.1598 | 0.1568 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0053 | 0.031 | 0.0275 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0232 | 0.3204 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0651 | 1 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0121 | 0.1409 | 0.8658 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0134 | 0.1627 | 0.5113 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0651 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0132 | 0.1598 | 0.1568 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.3204 | 0.318 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0554 | 1 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0232 | 0.3204 | 0.318 |
Plasmodium vivax | hypothetical protein, conserved | 0.0651 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0087 | 0.0052 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0554 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.109 | 0.1058 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0332 | 0.0298 |
Leishmania major | hypothetical protein, conserved | 0.0232 | 0.3204 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0053 | 0.031 | 0.0275 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0053 | 0.031 | 0.0275 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0064 | 0.0029 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0068 | 0.0554 | 0.1742 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0232 | 0.3204 | 0.318 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0101 | 0.109 | 0.1058 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0232 | 0.3204 | 1 |
Brugia malayi | glutathione reductase | 0.0053 | 0.031 | 0.0275 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0327 | 0.0293 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0232 | 0.3204 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0101 | 0.109 | 0.1058 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0068 | 0.0554 | 0.052 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0054 | 0.0327 | 0.0293 |
Echinococcus granulosus | geminin | 0.0185 | 0.2445 | 0.2418 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0651 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0232 | 0.3204 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.1598 | 0.1568 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0232 | 0.3204 | 0.318 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0036 | 0.0112 |
Mycobacterium tuberculosis | Probable reductase | 0.0121 | 0.1409 | 0.4427 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0232 | 0.3204 | 0.318 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.109 | 0.1058 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.3746 | 0.3723 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0265 | 0.3746 | 0.3723 |
Trypanosoma brucei | trypanothione reductase | 0.0053 | 0.031 | 0.0865 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0651 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0232 | 0.3204 | 1 |
Schistosoma mansoni | RNA binding protein | 0.0232 | 0.3204 | 0.318 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.2445 | 0.2418 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.3204 | 0.318 |
Onchocerca volvulus | 0.0232 | 0.3204 | 0.318 | |
Leishmania major | hypothetical protein, conserved | 0.0232 | 0.3204 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0087 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0036 | 0.0112 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0036 | 0.0112 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0651 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0101 | 0.109 | 0.1058 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0232 | 0.3204 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0036 | 0.0112 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0068 | 0.0554 | 0.052 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0064 | 0.009 |
Loa Loa (eye worm) | RNA binding protein | 0.0132 | 0.1598 | 0.1568 |
Schistosoma mansoni | brg-1 associated factor | 0.0651 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0651 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0651 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.3204 | 0.318 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0036 | 0.0112 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0121 | 0.1409 | 0.4427 |
Brugia malayi | brahma associated protein 60 kDa | 0.0651 | 1 | 1 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0651 | 1 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0064 | 0.009 |
Plasmodium falciparum | zinc finger Ran-binding domain-containing protein 2, putative | 0.0232 | 0.3204 | 0.2987 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0054 | 0.0018 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 0.0554 | 0.052 |
Onchocerca volvulus | 0.0232 | 0.3204 | 0.318 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0332 | 0.0298 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0064 | 0.0029 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.0064 | 0.0029 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0134 | 0.1627 | 0.5113 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0121 | 0.1409 | 0.4427 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0232 | 0.3204 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0101 | 0.109 | 0.1058 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.1598 | 0.1568 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0332 | 0.0298 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0651 | 1 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0036 | 0.0112 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0068 | 0.0554 | 0.1637 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0121 | 0.1409 | 0.4427 |
Leishmania major | trypanothione reductase | 0.0053 | 0.031 | 0.0865 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0054 | 0.0018 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.0064 | 0.0029 |
Echinococcus multilocularis | tar DNA binding protein | 0.0132 | 0.1598 | 0.1568 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0101 | 0.109 | 0.1058 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0232 | 0.3204 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0232 | 0.3204 | 0.318 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0232 | 0.3204 | 1 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0651 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0054 | 0.0018 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0064 | 0.0029 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.0064 | 0.0029 |
Onchocerca volvulus | 0.0054 | 0.0327 | 0.0293 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.109 | 0.1058 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.0064 | 0.0029 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0651 | 1 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0232 | 0.3204 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.0064 | 0.0551 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0087 | 0.0052 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0121 | 0.1409 | 0.4427 |
Onchocerca volvulus | 0.0232 | 0.3204 | 0.318 | |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0232 | 0.3204 | 0.318 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0232 | 0.3204 | 0.318 |
Loa Loa (eye worm) | TAR-binding protein | 0.0132 | 0.1598 | 0.1568 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0036 | 0.0112 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0651 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0232 | 0.3204 | 0.318 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0232 | 0.3204 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0332 | 0.0298 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0651 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0232 | 0.3204 | 1 |
Brugia malayi | RNA binding protein | 0.0132 | 0.1598 | 0.1568 |
Onchocerca volvulus | 0.0232 | 0.3204 | 0.318 | |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0036 | 0.0112 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0232 | 0.3204 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0232 | 0.3204 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.023 | 0.3183 | 1 |
Toxoplasma gondii | ran binding protein | 0.0232 | 0.3204 | 0.318 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0232 | 0.3204 | 0.318 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.0554 | 0.052 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0132 | 0.1598 | 0.1568 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0232 | 0.3204 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.3204 | 0.318 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.3204 | 0.318 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0132 | 0.1598 | 0.1568 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0101 | 0.109 | 0.1058 |
Brugia malayi | Thioredoxin reductase | 0.0053 | 0.031 | 0.0275 |
Brugia malayi | Inositol-1 | 0.0038 | 0.0064 | 0.0029 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0651 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0036 | 0.0219 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0232 | 0.3204 | 0.318 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0087 | 0.0052 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0232 | 0.3204 | 0.318 |
Loa Loa (eye worm) | glutathione reductase | 0.0053 | 0.031 | 0.0275 |
Loa Loa (eye worm) | brahma associated protein | 0.0651 | 1 | 1 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0232 | 0.3204 | 0.318 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.0554 | 0.052 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0036 | 0.0112 |
Chlamydia trachomatis | SWIB complex protein | 0.0651 | 1 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0053 | 0.031 | 0.0275 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0232 | 0.3204 | 0.318 |
Echinococcus multilocularis | geminin | 0.0185 | 0.2445 | 0.2418 |
Plasmodium vivax | glutathione reductase, putative | 0.0053 | 0.031 | 0.0275 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0265 | 0.3746 | 0.3723 |
Echinococcus granulosus | tar DNA binding protein | 0.0132 | 0.1598 | 0.1568 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0232 | 0.3204 | 0.318 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0053 | 0.031 | 0.0275 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.1598 | 0.1568 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0087 | 1 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0232 | 0.3204 | 0.318 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0087 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0054 | 0.0327 | 0.0293 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0134 | 0.1627 | 0.5113 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0053 | 0.031 | 0.0973 |
Leishmania major | hypothetical protein, conserved | 0.0232 | 0.3204 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0651 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0265 | 0.3746 | 0.3723 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0134 | 0.1627 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0036 | 0.0112 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.2445 | 0.2418 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0232 | 0.3204 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0232 | 0.3204 | 0.318 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0087 | 0.0052 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0087 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0651 | 1 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.0064 | 0.0029 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0087 | 0.0052 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0232 | 0.3204 | 0.318 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0651 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0651 | 1 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0064 | 0.009 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.1598 | 0.1568 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.0064 | 0.5 |
Schistosoma mansoni | fusion | 0.0232 | 0.3204 | 0.318 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0121 | 0.1409 | 0.4427 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0554 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0053 | 0.031 | 0.0865 |
Schistosoma mansoni | zinc finger protein | 0.0232 | 0.3204 | 0.318 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.