Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.2352 | 0.2315 |
Loa Loa (eye worm) | glutaminase | 0.0296 | 0.1549 | 0.1509 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0112 | 0.0113 |
Echinococcus granulosus | pyruvate kinase | 0.0312 | 0.1646 | 0.1585 |
Loa Loa (eye worm) | pyruvate kinase | 0.0607 | 0.351 | 0.3479 |
Plasmodium vivax | pyruvate kinase, putative | 0.0607 | 0.351 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0099 | 0.0308 | 0.0308 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0128 | 0.0487 | 0.0417 |
Echinococcus multilocularis | pyruvate kinase | 0.0312 | 0.1646 | 0.1585 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0128 | 0.0487 | 0.0417 |
Loa Loa (eye worm) | hypothetical protein | 0.1636 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0206 | 0.0983 | 0.0917 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0607 | 0.351 | 1 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.0184 | 0.084 | 0.223 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.0312 | 0.1646 | 0.4516 |
Schistosoma mansoni | pyruvate kinase | 0.0607 | 0.351 | 0.351 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0607 | 0.351 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0296 | 0.1549 | 0.4294 |
Loa Loa (eye worm) | carboxylesterase | 0.0206 | 0.0983 | 0.0941 |
Brugia malayi | pyruvate kinase | 0.0128 | 0.0488 | 0.1207 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0206 | 0.0983 | 0.0983 |
Giardia lamblia | Pyruvate kinase | 0.0607 | 0.351 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0557 | 0.0513 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0206 | 0.0983 | 0.0941 |
Echinococcus multilocularis | pyruvate kinase | 0.0312 | 0.1646 | 0.1585 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0068 | 0.0112 | 0.0113 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0607 | 0.351 | 1 |
Brugia malayi | pyruvate kinase, muscle isozyme | 0.0128 | 0.0488 | 0.1207 |
Schistosoma mansoni | lipoxygenase | 0.0128 | 0.0487 | 0.0487 |
Echinococcus multilocularis | pyruvate kinase | 0.0479 | 0.2703 | 0.2649 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0607 | 0.351 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.0983 | 0.0941 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0206 | 0.0983 | 0.0917 |
Echinococcus granulosus | carboxylesterase 5A | 0.0206 | 0.0983 | 0.0917 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0607 | 0.351 | 1 |
Schistosoma mansoni | glutaminase | 0.0296 | 0.1549 | 0.1549 |
Echinococcus granulosus | pyruvate kinase | 0.0312 | 0.1646 | 0.1585 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1636 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.0983 | 0.0941 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0607 | 0.351 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0607 | 0.351 | 0.351 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0607 | 0.351 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0068 | 0.0112 | 0.0113 |
Mycobacterium ulcerans | glutaminase | 0.0296 | 0.1549 | 0.4294 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0112 | 0.0113 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0557 | 0.0513 |
Loa Loa (eye worm) | glutaminase 2 | 0.0296 | 0.1549 | 0.1509 |
Brugia malayi | hypothetical protein | 0.0139 | 0.0557 | 0.1409 |
Mycobacterium ulcerans | pyruvate kinase | 0.0607 | 0.351 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0607 | 0.351 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0062 | 0.0073 | 0.0073 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1636 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0312 | 0.1646 | 0.1585 |
Loa Loa (eye worm) | pyruvate kinase | 0.0128 | 0.0488 | 0.0443 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0099 | 0.0308 | 0.0263 |
Loa Loa (eye worm) | hypothetical protein | 0.0607 | 0.351 | 0.3479 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0607 | 0.351 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.0607 | 0.351 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0607 | 0.351 | 0.3462 |
Onchocerca volvulus | Huntingtin homolog | 0.0139 | 0.0557 | 0.0778 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.0112 | 0.0112 |
Trichomonas vaginalis | glutaminase, putative | 0.0296 | 0.1549 | 0.3875 |
Schistosoma mansoni | lipoxygenase | 0.0089 | 0.0245 | 0.0245 |
Echinococcus multilocularis | hormone sensitive lipase | 0.1636 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0423 | 0.2352 | 0.2315 |
Giardia lamblia | Pyruvate kinase | 0.0312 | 0.1646 | 0.418 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0068 | 0.0112 | 0.0039 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0099 | 0.0308 | 0.0237 |
Onchocerca volvulus | Huntingtin homolog | 0.0139 | 0.0557 | 0.0778 |
Brugia malayi | Carboxylesterase family protein | 0.0206 | 0.0983 | 0.2648 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0099 | 0.0308 | 0.0684 |
Echinococcus multilocularis | acetylcholinesterase | 0.0206 | 0.0983 | 0.0917 |
Loa Loa (eye worm) | pyruvate kinase | 0.0607 | 0.351 | 0.3479 |
Leishmania major | pyruvate kinase | 0.0607 | 0.351 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0607 | 0.351 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0607 | 0.351 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0099 | 0.0308 | 0.0237 |
Schistosoma mansoni | pyruvate kinase | 0.0312 | 0.1646 | 0.1646 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0607 | 0.351 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0112 | 0.0113 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0607 | 0.351 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0607 | 0.351 | 0.3462 |
Brugia malayi | Carboxylesterase family protein | 0.0206 | 0.0983 | 0.2648 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0423 | 0.2352 | 1 |
Leishmania major | pyruvate kinase | 0.0607 | 0.351 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0607 | 0.351 | 0.3479 |
Plasmodium falciparum | pyruvate kinase | 0.0607 | 0.351 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0206 | 0.0983 | 0.0917 |
Echinococcus multilocularis | acetylcholinesterase | 0.0206 | 0.0983 | 0.0917 |
Echinococcus multilocularis | pyruvate kinase | 0.0312 | 0.1646 | 0.1585 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1636 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 0.0112 | 0.0039 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0607 | 0.351 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0607 | 0.351 | 0.3462 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0099 | 0.0308 | 0.0684 |
Echinococcus granulosus | pyruvate kinase | 0.0607 | 0.351 | 0.3462 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.