TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 257.288 | Formula: C14H15N3O2
H donors: 1 H acceptors: 2 LogP: 1.56 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: CN1Cc2cc(ccc2NC1=O)c1c(C)noc1C
InChi: 1S/C14H15N3O2/c1-8-13(9(2)19-16-8)10-4-5-12-11(6-10)7-17(3)14(18)15-12/h4-6H,7H2,1-3H3,(H,15,18)
InChiKey: DRKGLYHLBGWKHL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	bromodomain containing 2	Starlite/ChEMBL	References
Homo sapiens	CREB binding protein	Starlite/ChEMBL	References
Homo sapiens	bromodomain containing 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Echinococcus granulosus	CREB binding protein	Get druggable targets OG5_129174	All targets in OG5_129174
Echinococcus granulosus	CREB binding protein	Get druggable targets OG5_129174	All targets in OG5_129174
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Entamoeba histolytica	bromodomain-containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Brugia malayi	hypothetical protein	Get druggable targets OG5_126719	All targets in OG5_126719
Giardia lamblia	Kinase, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Echinococcus multilocularis	CREB binding protein	Get druggable targets OG5_129174	All targets in OG5_129174
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Echinococcus multilocularis	CREB binding protein	Get druggable targets OG5_129174	All targets in OG5_129174
Candida albicans	two potential bromodomain protein similar to S. cerevisiae transcription regulator BDF1	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126719	All targets in OG5_126719
Loa Loa (eye worm)	CBP-B	Get druggable targets OG5_129174	All targets in OG5_129174
Trichomonas vaginalis	bromodomain-containing protein 4, brd4, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Neospora caninum	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Entamoeba histolytica	bromodomain-containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Echinococcus multilocularis	CREB binding protein	Get druggable targets OG5_129174	All targets in OG5_129174
Echinococcus multilocularis	CREB binding protein	Get druggable targets OG5_129174	All targets in OG5_129174
Loa Loa (eye worm)	bromodomain containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Schistosoma japonicum	ko:K04498 E1A/CREB-binding protein, putative	Get druggable targets OG5_129174	All targets in OG5_129174
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Schistosoma mansoni	CREB-binding protein 1 (SmCBP1)	Get druggable targets OG5_129174	All targets in OG5_129174
Toxoplasma gondii	bromodomain-containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Schistosoma japonicum	ko:K08871 bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129174	All targets in OG5_129174
Echinococcus granulosus	bromodomain containing 2	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Schistosoma mansoni	CREB-binding protein 2	Get druggable targets OG5_129174	All targets in OG5_129174
Echinococcus multilocularis	Bromodomain containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Echinococcus multilocularis	bromodomain containing 2	Get druggable targets OG5_126719	All targets in OG5_126719
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Schistosoma mansoni	bromodomain-containing protein 3 brd3	Get druggable targets OG5_126719	All targets in OG5_126719
Echinococcus granulosus	CREB binding protein	Get druggable targets OG5_129174	All targets in OG5_129174
Schistosoma japonicum	Protein cbp-1, putative	Get druggable targets OG5_129174	All targets in OG5_129174
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129174	All targets in OG5_129174
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Brugia malayi	TAZ zinc finger family protein	Get druggable targets OG5_129174	All targets in OG5_129174
Schistosoma japonicum	IPR011071,Polysaccharide lyase family 8-like, C-terminal,domain-containing	Get druggable targets OG5_129174	All targets in OG5_129174
Schistosoma japonicum	CREB-binding protein, putative	Get druggable targets OG5_129174	All targets in OG5_129174
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Candida albicans	two potential bromodomain protein similar to S. cerevisiae transcription regulator BDF1	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Onchocerca volvulus		Get druggable targets OG5_126719	All targets in OG5_126719
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Echinococcus granulosus	CREB binding protein	Get druggable targets OG5_129174	All targets in OG5_129174
Entamoeba histolytica	bromodomain-containing protein	Get druggable targets OG5_126719	All targets in OG5_126719

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	CXXC zinc finger family protein	0.0063	0.0407	0.0937
Brugia malayi	jmjC domain containing protein	0.0302	0.2893	0.6666
Echinococcus granulosus	phd:f box containing protein	0.003	0.0059	0.004
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Echinococcus multilocularis	jumonji domain containing 1A	0.003	0.0059	0.004
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0061	0.0382	0.0363
Schistosoma mansoni	inositol monophosphatase	0.004	0.0163	0.0158
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0103	0.0676
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0153	0.0119
Plasmodium falciparum	phd finger protein, putative	0.0092	0.0709	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0317	0.3046	0.7018
Echinococcus multilocularis	neuropeptide s receptor	0.0985	1	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0081	0.0596	0.0578
Trichomonas vaginalis	bromodomain containing protein, putative	0.0081	0.0594	0.0732
Brugia malayi	hypothetical protein	0.0039	0.0152	0.0351
Brugia malayi	jmjC domain containing protein	0.003	0.0059	0.0136
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0111	0.0907	0.1253
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Echinococcus granulosus	survival motor neuron protein 1	0.0246	0.2306	0.2291
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0282	0.342
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0618	0.6177	1
Echinococcus multilocularis	Bromodomain containing protein	0.0081	0.0594	0.0576
Echinococcus granulosus	neuropeptide receptor A26	0.0985	1	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0217	0.2003	0.4615
Onchocerca volvulus		0.0064	0.042	0.0555
Echinococcus granulosus	geminin	0.036	0.35	0.3487
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0282	0.0649
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.003	0.0063	0.1212
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0074	0.0521	0.0612
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0189	0.1712	0.5924
Loa Loa (eye worm)	hypothetical protein	0.003	0.0059	0.0136
Onchocerca volvulus		0.0502	0.4973	1
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0074	0.0521	1
Echinococcus granulosus	hormone sensitive lipase	0.0381	0.3717	0.3705
Schistosoma mansoni	CREB-binding protein 1 (SmCBP1)	0.0136	0.1166	0.1262
Brugia malayi	Bromodomain containing protein	0.0177	0.1586	0.3654
Brugia malayi	TAZ zinc finger family protein	0.0136	0.1166	0.2687
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Echinococcus granulosus	jumonji domain containing protein	0.0128	0.1085	0.1068
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0092	0.0709	0.0692
Loa Loa (eye worm)	jmjC domain-containing protein	0.003	0.0059	0.0136
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0618	0.6177	1
Echinococcus multilocularis	short transient receptor potential channel 6	0.0072	0.05	0.0481
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0302	0.2889	1
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0153	0.0119
Plasmodium vivax	hypothetical protein, conserved	0.0092	0.0709	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0064	0.042	0.0402
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.025	0.0231
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.025	0.0231
Schistosoma mansoni	bromodomain-containing protein 3 brd3	0.0177	0.1586	0.1723
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.003	0.0059	0.1137
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.0282	0.1346
Entamoeba histolytica	bromodomain-containing protein	0.0081	0.0594	0.0732
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0163	0.0017
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Schistosoma mansoni	transient receptor potential channel 4	0.0109	0.0884	0.0951
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.003	0.0063	0.0024
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.025	0.0254
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0081	0.0596	0.0578
Echinococcus multilocularis	muscleblind protein 1	0.0148	0.1289	0.1272
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0368	0.0847
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Brugia malayi	latrophilin 2 splice variant baaae	0.0217	0.2003	0.4615
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3046	0.7018
Toxoplasma gondii	PHD-finger domain-containing protein	0.0092	0.0709	0.3935
Brugia malayi	Latrophilin receptor protein 2	0.01	0.0792	0.1826
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0145	0.0333
Brugia malayi	PHD-finger family protein	0.0036	0.012	0.0277
Loa Loa (eye worm)	latrophilin receptor protein 2	0.01	0.0792	0.1826
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1289	0.2969
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0082	0.0606	0.0646
Schistosoma mansoni	zinc finger protein	0.0037	0.013	0.0122
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0177	0.1586	0.238
Echinococcus multilocularis	dnaJ subfamily B	0.09	0.9111	0.9109
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0153	0.0352
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0153	0.0528
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0064	0.042	0.0441
Echinococcus granulosus	inositol monophosphatase 1	0.004	0.0163	0.0144
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.025	0.0254
Echinococcus granulosus	bromodomain containing 2	0.0177	0.1586	0.157
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.003	0.0059	0.0044
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0064	0.042	0.2185
Echinococcus granulosus	short transient receptor potential channel 6	0.0072	0.05	0.0481
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0074	0.0521	0.12
Loa Loa (eye worm)	hypothetical protein	0.0246	0.2306	0.5312
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Entamoeba histolytica	bromodomain-containing protein	0.0081	0.0594	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0606	0.1396
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0153	0.0528
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.004	0.0163	0.5
Schistosoma mansoni	hypothetical protein	0.036	0.35	0.3828
Brugia malayi	Muscleblind-like protein	0.0148	0.1289	0.2969
Schistosoma mansoni	phd/f-box containing protein	0.003	0.0059	0.0044
Brugia malayi	beta-lactamase family protein	0.0039	0.0153	0.0352
Schistosoma mansoni	inositol monophosphatase	0.004	0.0163	0.0158
Echinococcus multilocularis	transient receptor potential gamma protein	0.0109	0.0884	0.0866
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0317	0.3046	0.7018
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0076	0.0543	0.0525
Echinococcus multilocularis	muscleblind protein	0.0148	0.1289	0.1272
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0189	0.1712	0.5924
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.004	0.0163	0.0018
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.025	0.0254
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0063	0.0407	0.0937
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.003	0.0063	0.1212
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0618	0.6177	1
Echinococcus multilocularis	zinc finger protein	0.0037	0.013	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0158	0.1395	0.3214
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.025	0.0231
Trichomonas vaginalis	bromodomain containing protein, putative	0.0111	0.0907	0.1253
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0317	0.3046	0.7018
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0171	0.0394
Brugia malayi	hypothetical protein	0.0065	0.0428	0.0986
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0153	0.0119
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0076	0.0543	0.0525
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0035	0.0116	0.0097
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0618	0.6177	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0153	0.0147
Echinococcus multilocularis	inositol monophosphatase 1	0.004	0.0163	0.0144
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.0907	0.1253
Brugia malayi	hypothetical protein	0.0051	0.0282	0.0649
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0441	0.434	1
Brugia malayi	jmjC domain containing protein	0.003	0.0059	0.0136
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0081	0.0596	0.0634
Onchocerca volvulus		0.0081	0.0594	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0153	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0462	0.1064
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0594	0.0732
Echinococcus multilocularis	survival motor neuron protein 1	0.0246	0.2306	0.2291
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0153	0.0119
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.0282	0.342
Brugia malayi	hypothetical protein	0.0033	0.0093	0.0214
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0153	0.0528
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.004	0.0163	0.0564
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0153	0.0119
Echinococcus granulosus	PHD finger protein rhinoceros	0.0092	0.0709	0.0692
Brugia malayi	PHD-finger family protein	0.0042	0.0185	0.0426
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Echinococcus multilocularis	jumonji domain containing protein	0.0128	0.1085	0.1068
Loa Loa (eye worm)	hypothetical protein	0.0036	0.012	0.0277
Echinococcus multilocularis	phd:f box containing protein	0.003	0.0059	0.004
Echinococcus multilocularis	peregrin	0.0108	0.0875	0.0857
Onchocerca volvulus	Alhambra homolog	0.0092	0.0709	0.1155
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.004	0.0163	0.0628
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0153	0.2931
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0271	0.0624
Schistosoma mansoni	protein phosphatase 2C	0.003	0.0059	0.0044
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Echinococcus granulosus	jumonji domain containing 1A	0.003	0.0059	0.004
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0153	0.0352
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0618	0.6177	1
Echinococcus granulosus	short transient receptor potential channel 6	0.0072	0.05	0.0481
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.025	0.0575
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0153	0.0147
Loa Loa (eye worm)	hypothetical protein	0.01	0.0792	0.1826
Brugia malayi	PHD-finger family protein	0.0092	0.0709	0.1634
Brugia malayi	Bromodomain containing protein	0.0091	0.0701	0.1615
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Echinococcus granulosus	TRP transient receptor potential channel	0.0041	0.0171	0.0152
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0189	0.1712	0.5924
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0153	0.0119
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0347	0.08
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.01	0.0792	0.0775
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.012	0.0101
Schistosoma mansoni	hypothetical protein	0.09	0.9111	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0111	0.0907	0.1253
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0248	0.2326	0.7966
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0234	0.2189	0.5042
Schistosoma mansoni	transient receptor potential channel	0.0072	0.05	0.0528
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0074	0.0521	0.0503
Brugia malayi	beta-lactamase family protein	0.0039	0.0153	0.0352
Echinococcus multilocularis	hormone sensitive lipase	0.0381	0.3717	0.3705
Echinococcus granulosus	lysine specific demethylase 5A	0.0117	0.0968	0.0951
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0081	0.0594	0.0732
Echinococcus granulosus	L aminoadipate semialdehyde	0.0082	0.0606	0.0588
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0153	0.0528
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0189	0.1712	0.1696
Echinococcus multilocularis	neuropeptide receptor A26	0.0985	1	1
Onchocerca volvulus		0.0063	0.0407	0.0527
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0163	0.3131
Brugia malayi	F/Y-rich N-terminus family protein	0.0054	0.0308	0.0709
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0138	0.1184	0.681
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0041	0.0171	0.0152
Echinococcus multilocularis	lysine specific demethylase 6a	0.003	0.0059	0.004
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.012	0.0101
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0302	0.2889	1
Schistosoma mansoni	hypothetical protein	0.01	0.0792	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0153	0.0352
Schistosoma mansoni	aldehyde dehydrogenase	0.0189	0.1712	0.1861
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.003	0.0059	0.1137
Plasmodium vivax	SET domain protein, putative	0.0064	0.042	0.5552
Loa Loa (eye worm)	cytochrome P450 family protein	0.0055	0.0322	0.0741
Loa Loa (eye worm)	hypothetical protein	0.007	0.0478	0.1101
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0302	0.2893	0.288
Schistosoma mansoni	bromodomain containing protein	0.008	0.058	0.0617
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0035	0.0116	0.0097
Schistosoma mansoni	hypothetical protein	0.003	0.0063	0.0048
Trichomonas vaginalis	inositol monophosphatase, putative	0.004	0.0163	0.0017
Loa Loa (eye worm)	inositol-1	0.004	0.0163	0.0376
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.01	0.0792	0.0775
Loa Loa (eye worm)	jmjC domain-containing protein	0.0191	0.1731	0.3989
Echinococcus granulosus	transcription factor Dp 1	0.0043	0.0196	0.0177
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.01	0.0792	0.1826
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0092	0.0709	0.0759
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0189	0.1712	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0054	0.031	0.0715
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0074	0.0521	0.12
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.003	0.0059	0.1137
Schistosoma mansoni	transient receptor potential channel	0.0109	0.0884	0.0951
Onchocerca volvulus		0.005	0.0271	0.0245
Echinococcus granulosus	cpg binding protein	0.0069	0.0464	0.0446
Toxoplasma gondii	ABC1 family protein	0.0039	0.0153	0.0565
Echinococcus granulosus	CREB binding protein	0.0089	0.0678	0.066
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0381	0.3717	0.4067
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0163	0.3131
Brugia malayi	jmjC domain containing protein	0.0117	0.0968	0.2231
Echinococcus granulosus	lysine specific demethylase 6a	0.003	0.0059	0.004
Schistosoma mansoni	hypothetical protein	0.036	0.35	0.3828
Schistosoma mansoni	CREB-binding protein 2	0.0136	0.1166	0.1262
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.042	0.0441
Echinococcus granulosus	zinc finger protein	0.0037	0.013	0.0111
Echinococcus multilocularis	JmjC domain containing protein 4	0.003	0.0059	0.004
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0282	0.5406
Schistosoma mansoni	survival motor neuron protein	0.005	0.0271	0.0277
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0082	0.0606	0.1396
Schistosoma mansoni	hypothetical protein	0.01	0.0792	0.0851
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0302	0.2889	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0074	0.0521	1
Brugia malayi	Bromodomain containing protein	0.0108	0.0875	0.2016
Treponema pallidum	fructose-bisphosphate aldolase	0.0618	0.6177	0.5
Loa Loa (eye worm)	bromodomain containing protein	0.0031	0.0073	0.0167
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0153	0.0119
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0163	0.0017
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0153	0.0119
Brugia malayi	Pre-SET motif family protein	0.0064	0.042	0.0968
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Schistosoma mansoni	cpg binding protein	0.0069	0.0464	0.0489
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0074	0.0521	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0081	0.0596	0.0634
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0153	0.2931
Loa Loa (eye worm)	jmjC domain-containing protein	0.003	0.0059	0.0136
Giardia lamblia	PHD finger protein 15	0.0092	0.0709	0.0207
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0063	0.0024
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0153	0.0134
Schistosoma mansoni	hypothetical protein	0.0217	0.2003	0.2182
Schistosoma mansoni	transient receptor potential channel	0.0072	0.05	0.0528
Brugia malayi	AF-10 protein	0.003	0.0063	0.0145
Schistosoma mansoni	phosphatidylserine receptor	0.003	0.0059	0.0044
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0117	0.0968	0.1044
Loa Loa (eye worm)	hypothetical protein	0.003	0.0059	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0153	0.0352
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0074	0.0521	0.3043
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0153	0.0119
Schistosoma mansoni	cpg binding protein	0.0069	0.0464	0.0489
Brugia malayi	jmjC domain containing protein	0.003	0.0059	0.0136
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.0282	0.5406
Brugia malayi	Bromodomain containing protein	0.0177	0.1586	0.3654
Echinococcus multilocularis	geminin	0.036	0.35	0.3487
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0153	0.2931
Trichomonas vaginalis	set domain proteins, putative	0.0502	0.4973	0.8002
Entamoeba histolytica	bromodomain-containing protein	0.0081	0.0594	0.0732
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0618	0.6177	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0153	0.0352
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0111	0.0907	0.1253
Brugia malayi	beta-lactamase	0.0039	0.0153	0.0352
Loa Loa (eye worm)	jmjC domain-containing protein	0.003	0.0059	0.0136
Loa Loa (eye worm)	CBP-B	0.0099	0.0777	0.179
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0034	0.0103	0.0676
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0074	0.0521	0.0552
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0153	0.0119
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0153	0.0352
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0153	0.1437
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0618	0.6177	1
Leishmania major	hypothetical protein, conserved	0.003	0.0059	0.0346
Echinococcus multilocularis	CREB binding protein	0.0098	0.0766	0.0748
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0117	0.0968	0.1044
Brugia malayi	follicle stimulating hormone receptor	0.0234	0.2189	0.5042
Echinococcus multilocularis	transient receptor potential ion channel A	0.0105	0.0846	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1289	0.2969
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0302	0.2893	0.288
Echinococcus multilocularis	cpg binding protein	0.0069	0.0464	0.0446
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0153	0.0352
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0163	0.0953
Toxoplasma gondii	aldehyde dehydrogenase	0.0189	0.1712	1
Echinococcus granulosus	transient receptor potential ion channel A	0.0105	0.0846	0.0828
Echinococcus granulosus	GPCR family 2	0.01	0.0792	0.0775
Echinococcus granulosus	JmjC domain containing protein 4	0.003	0.0059	0.004
Trichomonas vaginalis	bromodomain-containing protein 4, brd4, putative	0.0081	0.0594	0.0732
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0618	0.6177	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0189	0.1712	0.5748
Schistosoma mansoni	jumonji domain containing protein	0.003	0.0059	0.0044
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0081	0.0594	0.0732
Schistosoma mansoni	hypothetical protein	0.005	0.0271	0.0277
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.01	0.0792	0.0775
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0618	0.6177	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0177	0.1586	0.238
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0189	0.1712	1
Echinococcus granulosus	transient receptor potential gamma protein	0.0109	0.0884	0.0866
Toxoplasma gondii	PHD-finger domain-containing protein	0.0092	0.0709	0.3935
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.025	0.0231
Schistosoma mansoni	hypothetical protein	0.0092	0.0709	0.0759
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0152	0.0133
Giardia lamblia	Fructose-bisphosphate aldolase	0.0618	0.6177	1
Toxoplasma gondii	bromodomain-containing protein	0.0081	0.0594	0.3234
Loa Loa (eye worm)	bromodomain containing protein	0.0081	0.0594	0.1368
Echinococcus multilocularis	bromodomain containing 2	0.0177	0.1586	0.157
Echinococcus multilocularis	GPCR, family 2	0.01	0.0792	0.0775
Loa Loa (eye worm)	jmjC domain-containing protein	0.0117	0.0968	0.2231
Brugia malayi	Inositol-1	0.004	0.0163	0.0376
Mycobacterium ulcerans	lipase LipD	0.0039	0.0153	0.0528
Schistosoma mansoni	jumonji domain containing protein	0.024	0.2247	0.2451
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0152	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1586	0.3654
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.0742	0.0978
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0381	0.3717	0.4067
Brugia malayi	Cytochrome P450 family protein	0.0055	0.0322	0.0741
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0153	0.0119
Schistosoma mansoni	hypothetical protein	0.01	0.0792	0.0851
Schistosoma mansoni	aldehyde dehydrogenase	0.0189	0.1712	0.1861
Brugia malayi	Bromodomain containing protein	0.0052	0.0285	0.0657
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.01	0.0792	0.0775
Loa Loa (eye worm)	PHD-finger family protein	0.0092	0.0709	0.1634
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0282	0.5406
Echinococcus multilocularis	transcription factor Dp 1	0.0043	0.0196	0.0177
Echinococcus granulosus	dnaJ subfamily B	0.09	0.9111	0.9109
Schistosoma mansoni	hypothetical protein	0.01	0.0792	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0884	0.2036
Leishmania major	hypothetical protein, conserved	0.0039	0.0153	0.0892
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0136	0.1168	0.1263
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0074	0.0521	0.0503
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.025	0.0575
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0163	0.3131
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0596	0.1373
Brugia malayi	Transient-receptor-potential like protein	0.0041	0.0171	0.0394
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0082	0.0606	0.0588
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0618	0.6177	1
Echinococcus granulosus	muscleblind protein	0.0148	0.1289	0.1272
Echinococcus multilocularis	short transient receptor potential channel 6	0.0072	0.05	0.0481
Brugia malayi	hypothetical protein	0.0246	0.2306	0.5312
Echinococcus granulosus	peregrin	0.0108	0.0875	0.0857
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0153	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0381	0.3717	0.8563
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0381	0.3717	0.4067
Echinococcus multilocularis	lysine specific demethylase 5A	0.0112	0.0911	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0133	0.0307
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0152	0.0133
Echinococcus granulosus	CREB binding protein	0.0136	0.1166	0.1149
Brugia malayi	Pre-SET motif family protein	0.0441	0.434	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0048	0.0251	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0153	0.0352
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0282	0.342
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0153	0.0134
Leishmania major	hypothetical protein, conserved	0.0051	0.0282	0.1645
Brugia malayi	jmjC domain containing protein	0.003	0.0059	0.0136
Onchocerca volvulus		0.0082	0.0606	0.0941
Schistosoma mansoni	hypothetical protein	0.0039	0.0152	0.0147
Schistosoma mansoni	cpg binding protein	0.0063	0.0407	0.0426
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0709	0.1634

Activities

Activity type	Activity value	Assay description	Source	Reference
Delta Tm (binding)	= -0.1 degrees C	Binding affinity to PCAF assessed as change in melting temperature at 100 uM by differential scanning fluorimetry	ChEMBL.	21851057
Delta Tm (binding)	= 0.4 degrees C	Binding affinity to BAZ2B assessed as change in melting temperature at 100 uM by differential scanning fluorimetry	ChEMBL.	21851057
Delta Tm (binding)	= 0.7 degrees C	Binding affinity to PB1 assessed as change in melting temperature at 100 uM by differential scanning fluorimetry	ChEMBL.	21851057
Delta Tm (binding)	= 3.2 degrees C	Binding affinity to BRDT assessed as change in melting temperature at 100 uM by differential scanning fluorimetry	ChEMBL.	21851057
Delta Tm (binding)	= 3.8 degrees C	Binding affinity to CREBBP assessed as change in melting temperature at 100 uM by differential scanning fluorimetry	ChEMBL.	21851057
Delta Tm (binding)	= 5.3 degrees C	Binding affinity to second bromodomain of BRD4 assessed as change in melting temperature at 100 uM by differential scanning fluorimetry	ChEMBL.	21851057
Delta Tm (binding)	= 5.4 degrees C	Binding affinity to first bromodomain of BRD2 assessed as change in melting temperature at 100 uM by differential scanning fluorimetry	ChEMBL.	21851057
Delta Tm (binding)	= 6.2 degrees C	Binding affinity to second bromodomain of BRD2 assessed as change in melting temperature at 100 uM by differential scanning fluorimetry	ChEMBL.	21851057
Delta Tm (binding)	= 6.8 degrees C	Binding affinity to second bromodomain of BRD3 assessed as change in melting temperature at 100 uM by differential scanning fluorimetry	ChEMBL.	21851057
Delta Tm (binding)	= 7.2 degrees C	Binding affinity to first bromodomain of BRD3 assessed as change in melting temperature at 100 uM by differential scanning fluorimetry	ChEMBL.	21851057
Delta Tm (binding)	= 8 degrees C	Binding affinity to first bromodomain of BRD4 assessed as change in melting temperature at 100 uM by differential scanning fluorimetry	ChEMBL.	21851057
IC50 (binding)	= 3 uM	Inhibition of first bromodomain of BRD2	ChEMBL.	21851057
IC50 (binding)	= 3.4 uM	Displacement of H3K56Ac from human CREBBP by peptide displacement assay	ChEMBL.	21851057
IC50 (binding)	= 4.8 uM	Displacement of H4Ac4 peptide from first bromodomain of human BRD4 by peptide displacement assay	ChEMBL.	21851057
IC50 (binding)	= 7 uM	Inhibition of first bromodomain of BRD4	ChEMBL.	21851057

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1828978

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1111095