Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calpain 1, (mu/I) large subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | calpain A | calpain 1, (mu/I) large subunit | 714 aa | 753 aa | 31.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0089 | 0.0842 | 0.1485 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0359 | 0.4259 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0089 | 0.0842 | 0.1485 |
Schistosoma mansoni | lipoxygenase | 0.0162 | 0.2355 | 0.3756 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0842 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0089 | 0.0842 | 0.0803 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0532 | 1 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0532 | 1 | 0.5 |
Echinococcus multilocularis | RUN | 0.0089 | 0.0842 | 0.1485 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0089 | 0.0842 | 0.5 |
Schistosoma mansoni | rab6-interacting | 0.0089 | 0.0842 | 0.091 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0089 | 0.0842 | 0.5 |
Onchocerca volvulus | 0.0089 | 0.0842 | 0.5 | |
Onchocerca volvulus | 0.0089 | 0.0842 | 0.5 | |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0089 | 0.0842 | 0.1485 |
Brugia malayi | hypothetical protein | 0.0089 | 0.0842 | 1 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0089 | 0.0842 | 0.0803 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0066 | 0.0359 | 0.4259 |
Echinococcus multilocularis | calpain A | 0.0069 | 0.042 | 0.0741 |
Schistosoma mansoni | loxhd1 | 0.0089 | 0.0842 | 0.091 |
Brugia malayi | Doublecortin family protein | 0.0089 | 0.0842 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0323 | 0.5673 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0205 | 0.2428 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0842 | 1 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0069 | 0.042 | 0.0741 |
Loa Loa (eye worm) | doublecortin family protein | 0.0089 | 0.0842 | 1 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0532 | 1 | 0.5 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0069 | 0.042 | 0.0116 |
Brugia malayi | hypothetical protein | 0.0089 | 0.0842 | 1 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0069 | 0.042 | 0.0116 |
Schistosoma mansoni | lipoxygenase | 0.0323 | 0.5673 | 1 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0532 | 1 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0323 | 0.5673 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0089 | 0.0842 | 0.091 |
Schistosoma mansoni | rab6-interacting | 0.0089 | 0.0842 | 0.091 |
Schistosoma mansoni | polycystin 1-related | 0.0089 | 0.0842 | 0.091 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0532 | 1 | 0.5 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0089 | 0.0842 | 0.0803 |
Echinococcus granulosus | RUN | 0.0089 | 0.0842 | 0.0803 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.