Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ceramide glucosyltransferase | 0.023 | 0.2577 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0002 | 0.0002 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0503 | 1 | 1 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.023 | 0.2577 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0503 | 1 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.023 | 0.2577 | 0.2577 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0348 | 0.5775 | 0.1027 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.033 | 0.5291 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0348 | 0.5775 | 0.1027 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.023 | 0.2577 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0503 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0503 | 1 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.023 | 0.2577 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0503 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0503 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0503 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 44.9 nM | Inhibition of VLA-4 binding to radiolabeled vascular cell adhesion molecule-1(VCAM-1) Ig fusion protein in human Jurkat cells | ChEMBL. | 12127523 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.