Detailed information for compound 1120333

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 418.554 | Formula: C24H26N4OS
  • H donors: 2 H acceptors: 2 LogP: 6.03 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1CNc1nc(NCc2ccc(cc2)C(C)C)c2c(n1)ccs2
  • InChi: 1S/C24H26N4OS/c1-16(2)18-10-8-17(9-11-18)14-25-23-22-20(12-13-30-22)27-24(28-23)26-15-19-6-4-5-7-21(19)29-3/h4-13,16H,14-15H2,1-3H3,(H2,25,26,27,28)
  • InChiKey: YXGBAYGREBAMMP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, putative 0.0091 0.1023 0.1357
Loa Loa (eye worm) hypothetical protein 0.006 0.0632 0.0835
Brugia malayi RNA binding protein 0.0062 0.0661 0.0878
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0216 0.2612 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0125 0.0456
Onchocerca volvulus 0.0091 0.1023 0.349
Loa Loa (eye worm) hypothetical protein 0.0047 0.047 0.0618
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0044 0.0423 0.4137
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0602 0.75 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0634 0.241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0091 0.1023 0.3903
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0602 0.75 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0423 0.112
Giardia lamblia Cathepsin L-like protease 0.0044 0.0423 0.112
Brugia malayi cathepsin L-like cysteine proteinase 0.0044 0.0423 0.0562
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0116 0.0146
Entamoeba histolytica cysteine proteinase, putative 0.0091 0.1023 0.2907
Mycobacterium tuberculosis Probable reductase 0.0191 0.2295 0.8942
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.042 0.1608
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0213 0.2566 1
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0097 0.0653
Loa Loa (eye worm) RNA binding protein 0.0062 0.0661 0.0873
Brugia malayi cathepsin B-like cysteine proteinase 0.0602 0.75 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0634 0.0838
Onchocerca volvulus Cathepsin L homolog 0.0044 0.0423 0.1327
Brugia malayi Cathepsin L-like precursor 0.0044 0.0423 0.0562
Entamoeba histolytica cysteine protease, putative 0.0091 0.1023 0.2907
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1023 0.2841
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0459 0.1224
Loa Loa (eye worm) hypothetical protein 0.0047 0.047 0.0618
Echinococcus multilocularis peregrin 0.0032 0.028 0.0273
Onchocerca volvulus Neurogenic locus notch homolog 0.0034 0.0304 0.0894
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.3521 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0176 0.1026
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.051 0.0504
Brugia malayi Cathepsin L-like cysteine proteinase 0.0044 0.0423 0.0562
Onchocerca volvulus Cathepsin L homolog 0.0091 0.1023 0.349
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0044 0.0423 0.112
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.031 0.0405
Brugia malayi EGF-like domain containing protein 0.0034 0.0304 0.0402
Onchocerca volvulus Peroxidasin homolog 0.0144 0.1696 0.5914
Entamoeba histolytica cysteine protease, putative 0.0044 0.0423 0.1203
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0097 0.095
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0174 0.1018
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0238 0.2326
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0085 0.0305
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0162 0.1303
Loa Loa (eye worm) hypothetical protein 0.0029 0.0234 0.0303
Trypanosoma cruzi cruzipain precursor, putative 0.0091 0.1023 0.1357
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0174 0.0655
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0319 0.0417
Plasmodium falciparum serine repeat antigen 5 0.0044 0.0423 0.3944
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1023 0.2841
Mycobacterium ulcerans hypothetical protein 0.0024 0.0176 0.1026
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0331 0.0433
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.051 0.1952
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0057 0.0588 0.2232
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0634 0.3813
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0125 0.0164
Schistosoma mansoni polycystin 1-related 0.0019 0.0116 0.0151
Loa Loa (eye worm) hypothetical protein 0.002 0.0125 0.0159
Echinococcus multilocularis neurogenic locus protein delta 0.0034 0.0304 0.0297
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1023 0.2841
Entamoeba histolytica cysteine protease, putative 0.0091 0.1023 0.2907
Entamoeba histolytica cysteine protease, putative 0.0091 0.1023 0.2907
Schistosoma mansoni hypothetical protein 0.0041 0.0391 0.0518
Leishmania major cathepsin L-like protease 0.0091 0.1023 0.3903
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.1741 0.2319
Onchocerca volvulus Ribonuclease H1 homolog 0.0022 0.0142 0.0313
Loa Loa (eye worm) hypothetical protein 0.0044 0.0423 0.0556
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0162 0.0595
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0304 0.0402
Brugia malayi Cathepsin L-like precursor 0.0091 0.1023 0.1362
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1055 0.2932
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0091 0.1023 0.1017
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0116 0.0841
Schistosoma mansoni rab6-interacting 0.0019 0.0116 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1023 0.2841
Entamoeba histolytica cysteine proteinase, putative 0.0091 0.1023 0.2907
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0044 0.0423 0.0562
Loa Loa (eye worm) hypothetical protein 0.0602 0.75 1
Brugia malayi Peroxidasin 0.0144 0.1696 0.2258
Plasmodium falciparum serine repeat antigen 3 0.0044 0.0423 0.3944
Plasmodium falciparum phd finger protein, putative 0.0029 0.0234 0.2031
Echinococcus granulosus slit 2 protein 0.0034 0.0304 0.0396
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0908 0.1208
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0694 0.0918
Schistosoma mansoni hypothetical protein 0.0034 0.0304 0.0402
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.046 0.0611
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0304 0.0402
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0044 0.0423 0.4137
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0044 0.0423 0.112
Echinococcus granulosus protein jagged 1 0.0034 0.0304 0.0396
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0013 0.0033 0.0035
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0091 0.1023 0.1357
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0034 0.0304 0.0402
Onchocerca volvulus 0.0091 0.1023 0.349
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0125 0.0266
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.1492 0.9019
Echinococcus granulosus GPCR family 2 0.0019 0.0111 0.0139
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0044 0.0423 0.112
Entamoeba histolytica cysteine proteinase 1, putative 0.0091 0.1023 0.2907
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0013 0.0033 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1023 0.2841
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.051 0.1369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1023 0.2841
Echinococcus multilocularis GPCR, family 2 0.0019 0.0111 0.0104
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0013 0.0033 0.0035
Loa Loa (eye worm) notch protein 0.0034 0.0304 0.0396
Giardia lamblia PHD finger protein 15 0.0029 0.0234 0.0577
Echinococcus multilocularis cathepsin b 0.0602 0.75 0.7499
Loa Loa (eye worm) pip kinase 1 0.0013 0.0033 0.0035
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0391 0.0518
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.051 0.0672
Leishmania major cathepsin L-like protease 0.0091 0.1023 0.3903
Schistosoma mansoni cathepsin S (C01 family) 0.0044 0.0423 0.0562
Brugia malayi Delta serrate ligand family protein 0.0034 0.0304 0.0402
Toxoplasma gondii cathepsin CPL 0.0091 0.1023 0.3918
Toxoplasma gondii aldehyde dehydrogenase 0.0128 0.1492 0.571
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0044 0.0423 0.112
Onchocerca volvulus 0.016 0.19 0.6652
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0044 0.0423 0.3944
Loa Loa (eye worm) hypothetical protein 0.0044 0.0423 0.0556
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0331 0.1245
Loa Loa (eye worm) cathepsin B 0.0216 0.2612 0.3477
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0125 0.0266
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1023 0.2841
Brugia malayi Papain family cysteine protease containing protein 0.0044 0.0423 0.0562
Trichomonas vaginalis ribonuclease H1, putative 0.0022 0.0142 0.0314
Echinococcus granulosus jumonji domain containing protein 0.004 0.0376 0.0493
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.046 0.0605
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.014 0.0184
Brugia malayi Blistered cuticle protein 3 0.0144 0.1696 0.2258
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0125 0.048
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0013 0.0033 0.0035
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0007 0.0025
Toxoplasma gondii cathepsin B 0.0216 0.2612 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0661 0.0655
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0234 0.0303
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0044 0.0423 0.4137
Schistosoma mansoni cathepsin B (C01 family) 0.0044 0.0423 0.0562
Brugia malayi RNase H family protein 0.0022 0.0142 0.0187
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0176 0.1026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1023 0.2841
Giardia lamblia High cysteine protein 0.0034 0.0304 0.0777
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.051 0.1369
Loa Loa (eye worm) hypothetical protein 0.0144 0.1696 0.2254
Entamoeba histolytica hypothetical protein 0.0044 0.0423 0.1203
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0082 0.0904 0.1198
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.1492 0.1986
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0238 0.0589
Echinococcus granulosus cathepsin L 0.0044 0.0423 0.0556
Loa Loa (eye worm) hypothetical protein 0.0144 0.1696 0.2254
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0238 0.0309
Entamoeba histolytica cysteine protease, putative 0.0091 0.1023 0.2907
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0034 0.0304 0.0402
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0082 0.0904 0.1198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0423 0.112
Entamoeba histolytica hypothetical protein 0.0023 0.0162 0.0459
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0238 0.0309
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0033 0.0318
Loa Loa (eye worm) hypothetical protein 0.0047 0.047 0.0618
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0116 0.0146
Mycobacterium ulcerans hypothetical protein 0.0024 0.0174 0.1018
Onchocerca volvulus Peroxidase homolog 0.0144 0.1696 0.5914
Echinococcus granulosus cathepsin l1 0.0044 0.0423 0.0556
Brugia malayi EGF-like domain containing protein 0.0034 0.0304 0.0402
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.051 0.0672
Echinococcus multilocularis bloom syndrome protein 0.002 0.0125 0.0119
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1055 0.2932
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1023 0.2841
Schistosoma mansoni hypothetical protein 0.0019 0.0116 0.0151
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0013 0.0033 0.0125
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0033 0.0092
Echinococcus multilocularis protein jagged 2 0.0034 0.0304 0.0297
Echinococcus granulosus notch 0.0034 0.0304 0.0396
Giardia lamblia Cathepsin L precursor 0.0044 0.0423 0.112
Onchocerca volvulus 0.0144 0.1696 0.5914
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0125 0.0266
Onchocerca volvulus 0.0091 0.1023 0.349
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.3521 1
Schistosoma mansoni hypothetical protein 0.0034 0.0304 0.0402
Giardia lamblia Cathepsin B precursor 0.0044 0.0423 0.112
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0242 0.032
Schistosoma mansoni hypothetical protein 0.0034 0.0304 0.0402
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0044 0.0423 0.4137
Schistosoma mansoni DNA helicase recq5 0.002 0.0125 0.0164
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0013 0.0033 0.0099
Giardia lamblia Cysteine protease 0.0044 0.0423 0.112
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0013 0.0033 0.0125
Brugia malayi Inositol-1 0.0036 0.0331 0.0438
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0091 0.1023 0.1357
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0153 0.1802 0.24
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.046 0.0454
Brugia malayi Papain family cysteine protease containing protein 0.0091 0.1023 0.1362
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.016 0.19 0.2527
Brugia malayi Cytochrome P450 family protein 0.0011 0.0007 0.0006
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0216 0.2612 0.3477
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.051 0.0672
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1055 0.2932
Entamoeba histolytica hypothetical protein 0.0035 0.0319 0.0906
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0283 0.1078
Schistosoma mansoni hypothetical protein 0.0034 0.0304 0.0402
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0033 0.0035
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0146
Brugia malayi Papain family cysteine protease containing protein 0.0044 0.0423 0.0562
Brugia malayi hypothetical protein 0.0019 0.0116 0.0151
Schistosoma mansoni notch 0.0034 0.0304 0.0402
Plasmodium falciparum serine repeat antigen 6 0.0044 0.0423 0.3944
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0238 0.2074
Echinococcus granulosus cathepsin L cysteine protease 0.0091 0.1023 0.1357
Trypanosoma cruzi cysteine peptidase, putative 0.0091 0.1023 0.1357
Giardia lamblia Cathepsin B precursor 0.0216 0.2612 0.7395
Brugia malayi Pre-SET motif family protein 0.0029 0.0242 0.032
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0091 0.1023 1
Onchocerca volvulus 0.0034 0.0304 0.0894
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1055 0.1399
Echinococcus granulosus neural cadherin 0.0034 0.0304 0.0396
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1062 0.1056
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0162 0.0942
Echinococcus granulosus cathepsin b 0.0602 0.75 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0091 0.1023 1
Loa Loa (eye worm) acetyltransferase 0.0148 0.1741 0.2315
Entamoeba histolytica cysteine protease, putative 0.0091 0.1023 0.2907
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0091 0.1023 0.3903
Schistosoma mansoni hypothetical protein 0.0081 0.0892 0.1187
Entamoeba histolytica cysteine proteinase, putative 0.0091 0.1023 0.2907
Giardia lamblia Cathepsin L precursor 0.0044 0.0423 0.112
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.051 0.0672
Loa Loa (eye worm) glutathione reductase 0.0084 0.0933 0.1236
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0085 0.0305
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0694 0.0918
Trypanosoma cruzi cysteine peptidase, putative 0.0091 0.1023 0.1357
Mycobacterium tuberculosis Probable dehydrogenase 0.0191 0.2295 0.8942
Schistosoma mansoni peroxidasin 0.0144 0.1696 0.2258
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0085 0.0305
Brugia malayi notch-like transmembrane receptor 0.0034 0.0304 0.0402
Giardia lamblia Cathepsin B precursor 0.0044 0.0423 0.112
Brugia malayi Animal haem peroxidase family protein 0.0144 0.1696 0.2258
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0319 0.0313
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0125 0.0266
Loa Loa (eye worm) pip kinase 2 0.016 0.19 0.2527
Entamoeba histolytica cysteine protease, putative 0.0091 0.1023 0.2907
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0044 0.0423 0.112
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0634 0.2453
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0423 0.112
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.016 0.19 0.2531
Echinococcus multilocularis cathepsin L cysteine protease 0.0091 0.1023 0.1017
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0091 0.1023 0.1362
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0125 0.0159
Schistosoma mansoni cell polarity protein 0.0034 0.0304 0.0402
Echinococcus multilocularis cathepsin L 0.0091 0.1023 0.1017
Echinococcus granulosus cathepsin l1 0.0091 0.1023 0.1357
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.1055 0.1399
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0044 0.0423 0.4137
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0634 0.0628
Trypanosoma brucei unspecified product 0.0023 0.0165 0.0609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3521 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3521 1
Giardia lamblia Hypothetical protein 0.0044 0.0423 0.112
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.1055 0.1399
Loa Loa (eye worm) hypothetical protein 0.0144 0.1696 0.2254
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0091 0.1023 0.3903
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0238 0.0309
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0013 0.0033 0.0125
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0238 0.0309
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0559 0.0553
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0632 0.084
Entamoeba histolytica hypothetical protein 0.0035 0.0319 0.0906
Echinococcus granulosus fibropellin Ia 0.0034 0.0304 0.0396
Entamoeba histolytica cysteine protease, putative 0.0044 0.0423 0.1203
Brugia malayi Animal haem peroxidase family protein 0.0144 0.1696 0.2258
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.051 0.1369
Loa Loa (eye worm) hypothetical protein 0.0044 0.0423 0.0556
Entamoeba histolytica cysteine proteinase, putative 0.0091 0.1023 0.2907
Plasmodium falciparum glutathione reductase 0.0029 0.0238 0.2074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0091 0.1023 0.3903
Brugia malayi Cytochrome P450 family protein 0.005 0.0499 0.0663
Giardia lamblia Cysteine protease 0.0044 0.0423 0.112
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0229 0.0296
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0091 0.1023 0.3903
Giardia lamblia Hypothetical protein 0.0044 0.0423 0.112
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0044 0.0423 0.0556
Loa Loa (eye worm) animal heme peroxidase 0.0144 0.1696 0.2254
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0097 0.055
Onchocerca volvulus 0.0034 0.0304 0.0894
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0213 0.2566 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.3521 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0331 0.0438
Loa Loa (eye worm) hypothetical protein 0.0049 0.0494 0.065
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0234 0.0309
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.1492 0.9019
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0176 0.066
Plasmodium vivax vivapain-2 0.0091 0.1023 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0423 0.0556
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0044 0.0423 0.112
Giardia lamblia Cathepsin B precursor 0.0216 0.2612 0.7395
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0238 0.1405
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0234 0.0303
Brugia malayi Cathepsin L-like precursor 0.0091 0.1023 0.1362
Echinococcus granulosus neurogenic locus notch protein 4 0.0034 0.0304 0.0396
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0174 0.0229
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0234 0.0895
Plasmodium vivax SET domain protein, putative 0.0029 0.0242 0.2369
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0374 0.1063
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0238 0.0314
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0044 0.0423 0.112
Loa Loa (eye worm) hypothetical protein 0.0018 0.0097 0.0121
Entamoeba histolytica phosphoinositide kinase, putative 0.0013 0.0033 0.0092
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0033 0.0035
Echinococcus granulosus peregrin 0.0032 0.028 0.0364
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.144 0.1913
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0191 0.2295 0.8942
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0238 0.0589
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0216 0.2612 0.3481
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0162 0.0595
Giardia lamblia Cysteine protease 0.0044 0.0423 0.112
Schistosoma mansoni cathepsin s 0.0047 0.047 0.0623
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0033 0.0099
Plasmodium vivax glutathione reductase, putative 0.0084 0.0933 0.9115
Schistosoma mansoni cathepsin F (C01 family) 0.0091 0.1023 0.1362
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0694 0.0918
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.051 0.1369
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.1055 0.3605
Giardia lamblia Cathepsin B precursor 0.0216 0.2612 0.7395
Onchocerca volvulus 0.0144 0.1696 0.5914
Brugia malayi Bromodomain containing protein 0.0032 0.028 0.037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0423 0.112
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0153 0.1802 0.2396
Echinococcus multilocularis fibropellin Ia 0.0034 0.0304 0.0297
Entamoeba histolytica cysteine protease, putative 0.0091 0.1023 0.2907
Onchocerca volvulus Peroxidasin homolog 0.0144 0.1696 0.5914
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0013 0.0033 0.004
Plasmodium falciparum thioredoxin reductase 0.0029 0.0238 0.2074
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0174 0.0495
Schistosoma mansoni hypothetical protein 0.0034 0.0304 0.0402
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0622 0.0821
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.031 0.0304
Schistosoma mansoni phosphoglucomutase 0.0022 0.0142 0.0187
Loa Loa (eye worm) animal heme peroxidase 0.0144 0.1696 0.2254
Brugia malayi PHD-finger family protein 0.0029 0.0234 0.0309
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0238 0.5075
Onchocerca volvulus 0.0034 0.0304 0.0894
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0176 0.1026
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0174 0.1018
Schistosoma mansoni apoptosis regulator bax 0.0082 0.0904 0.1203
Loa Loa (eye worm) hypothetical protein 0.0144 0.1696 0.2254
Loa Loa (eye worm) hypothetical protein 0.0144 0.1696 0.2254
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0176 0.0648
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0331 0.0856
Entamoeba histolytica cysteine protease, putative 0.0091 0.1023 0.2907
Brugia malayi cathepsin Z-like cysteine proteinase 0.0044 0.0423 0.0562
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.247 0.3287
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.1055 0.1049
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0661 0.0873
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.051 0.1932
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0091 0.1023 0.3903
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0153 0.1802 0.2396
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0033 0.0318
Loa Loa (eye worm) ctsf protein 0.0091 0.1023 0.1357
Brugia malayi hypothetical protein 0.0035 0.0319 0.0422
Loa Loa (eye worm) hypothetical protein 0.0144 0.1696 0.2254
Loa Loa (eye worm) hypothetical protein 0.0018 0.0097 0.0121
Onchocerca volvulus 0.0019 0.0116 0.0218
Loa Loa (eye worm) hypothetical protein 0.0044 0.0423 0.0556
Giardia lamblia Cathepsin L precursor 0.0044 0.0423 0.112
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0153 0.1802 0.2396
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0238 0.1405
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0347 0.0454
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0908 0.1208
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0097 0.0354
Plasmodium falciparum serine repeat antigen 4 0.0044 0.0423 0.3944
Loa Loa (eye worm) hypothetical protein 0.0044 0.0423 0.0556
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1023 0.2841
Brugia malayi cathepsin L-like precursor 0.0044 0.0423 0.0562
Loa Loa (eye worm) hypothetical protein 0.0144 0.1696 0.2254
Brugia malayi EGF-like domain containing protein 0.0034 0.0304 0.0402
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.031 0.0411
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0661 0.0878
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1023 0.2841
Leishmania major 0.0153 0.1802 0.6891
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.031 0.0411
Schistosoma mansoni peroxidasin 0.0144 0.1696 0.2258
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0128 0.1492 0.5699
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1023 0.2841
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0013 0.0033 0.0099
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.0933 0.3619
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0091 0.1023 0.3903
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0111 0.0104
Brugia malayi EGF-like domain containing protein 0.0034 0.0304 0.0402
Echinococcus multilocularis cathepsin L cysteine protease 0.0091 0.1023 0.1017
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0044 0.0423 0.4137
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Brugia malayi EGF-like domain containing protein 0.0034 0.0304 0.0402
Brugia malayi Cathepsin L-like precursor 0.0047 0.047 0.0623
Echinococcus multilocularis protein jagged 1 0.0034 0.0304 0.0297
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0165 0.0609
Loa Loa (eye worm) cysteine protease 0.0091 0.1023 0.1357
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0091 0.1023 0.3903
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0174 0.0495
Schistosoma mansoni hypothetical protein 0.0019 0.0111 0.0145
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Brugia malayi cathepsin F-like cysteine proteinase 0.0044 0.0423 0.0562
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.042 0.4104
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.046 0.0454
Loa Loa (eye worm) animal heme peroxidase 0.0144 0.1696 0.2254
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0044 0.0423 0.0562
Onchocerca volvulus 0.0024 0.0174 0.0428
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0006
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0044 0.0423 0.0556
Echinococcus multilocularis neurogenic locus protein delta 0.0034 0.0304 0.0297
Brugia malayi Cathepsin L-like precursor 0.0044 0.0423 0.0562
Echinococcus multilocularis thioredoxin glutathione reductase 0.0084 0.0939 0.0933
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0162 0.1031
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0331 1
Entamoeba histolytica cysteine proteinase 2 0.0091 0.1023 0.2907
Loa Loa (eye worm) hypothetical protein 0.0144 0.1696 0.2254
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0423 0.112
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.1741 0.1736
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1023 0.2841
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0128 0.1492 0.5803
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0661 0.0878
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.051 0.1932
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0111 0.0145
Toxoplasma gondii preprocathepsin c precursor, putative 0.0044 0.0423 0.1621
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0634 0.0843
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0242 0.0236
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0044 0.0423 0.0562
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0423 0.112
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0125 0.0159
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0632 0.084
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0033 0.0035
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1055 0.2932
Trypanosoma cruzi cysteine peptidase, putative 0.0091 0.1023 0.1357
Echinococcus granulosus protein jagged 2 0.0034 0.0304 0.0396
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0174 0.0655
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1023 0.2841
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0091 0.1023 0.3903
Trypanosoma cruzi major cysteine proteinase, putative 0.0044 0.0423 0.0556
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0602 0.75 1
Entamoeba histolytica cysteine protease, putative 0.0044 0.0423 0.1203
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.051 0.0504
Brugia malayi EGF-like domain containing protein 0.0034 0.0304 0.0402
Loa Loa (eye worm) hypothetical protein 0.0082 0.0904 0.1198
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0319 0.0422
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0091 0.1023 0.1357
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0044 0.0423 0.0562
Schistosoma mansoni rab6-interacting 0.0019 0.0116 0.0151
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0376 0.037
Schistosoma mansoni notch 0.0034 0.0304 0.0402
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0347 0.034
Echinococcus multilocularis slit 2 protein 0.0034 0.0304 0.0297
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1023 0.2841
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0238 0.0314
Schistosoma mansoni notch 0.0034 0.0304 0.0402
Entamoeba histolytica cysteine protease, putative 0.0091 0.1023 0.2907
Mycobacterium tuberculosis Conserved protein 0.0024 0.0176 0.066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1023 0.2841
Schistosoma mansoni laminin gamma-3 chain 0.0034 0.0304 0.0402
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0174 0.1018
Loa Loa (eye worm) hypothetical protein 0.016 0.19 0.2527
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.0933 0.9115
Entamoeba histolytica recQ family helicase, putative 0.002 0.0125 0.0356
Brugia malayi Cathepsin L-like precursor 0.0091 0.1023 0.1362
Echinococcus granulosus thioredoxin glutathione reductase 0.0084 0.0939 0.1244
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.016 0.19 0.1895
Echinococcus multilocularis neurogenic locus notch protein 0.0034 0.0304 0.0297
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0116 0.0109
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0374 0.0979
Entamoeba histolytica cysteine protease, putative 0.0091 0.1023 0.2907
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0538 0.0709
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0174 0.0643
Onchocerca volvulus Peroxidase homolog 0.0144 0.1696 0.5914
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0044 0.0423 0.4137
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0213 0.2566 1
Trypanosoma brucei ribonuclease H1 0.0022 0.0142 0.052
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0125 0.0164
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0459 0.1224
Plasmodium falciparum glutathione reductase 0.0084 0.0933 0.9085
Brugia malayi Pre-SET motif family protein 0.0205 0.247 0.3291
Brugia malayi TAR-binding protein 0.0062 0.0661 0.0878
Toxoplasma gondii cathepsin CPC2 0.0044 0.0423 0.1621
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0331 0.0433
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0085 0.0305
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0162 0.0606
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.031 0.0405
Brugia malayi Thioredoxin reductase 0.0084 0.0933 0.1241
Loa Loa (eye worm) hypothetical protein 0.0144 0.1696 0.2254
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0238 0.1405
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0044 0.0423 0.1203
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0602 0.75 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0082 0.0904 0.0898
Toxoplasma gondii fructose-bisphospatase II 0.0153 0.1802 0.6898
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0238 0.0309
Trypanosoma brucei cysteine peptidase C (CPC) 0.0216 0.2612 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0116 0.0109
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.0933 0.1236
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.1055 0.2997
Loa Loa (eye worm) hypothetical protein 0.0044 0.0423 0.0556
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3521 1
Brugia malayi glutathione reductase 0.0084 0.0933 0.1241
Onchocerca volvulus 0.0034 0.0304 0.0894
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1023 0.2841
Brugia malayi cathepsin Z-like cysteine proteinase 0.0044 0.0423 0.0562
Brugia malayi Muscle positioning protein 4 0.0034 0.0304 0.0402
Loa Loa (eye worm) hypothetical protein 0.0044 0.0423 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0216 0.2612 0.7395
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Trypanosoma brucei RNA helicase, putative 0.0081 0.0892 0.3398
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0142 0.0181
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0174 0.0643
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0125 0.0456
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0423 0.112
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0091 0.1023 0.2841
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1023 0.2841
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0242 0.032
Brugia malayi cathepsin L precursor 0.0044 0.0423 0.0562
Onchocerca volvulus Cathepsin F homolog 0.0091 0.1023 0.349
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0331 0.1245
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0013 0.0033 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0242 0.032
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0224
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0238 0.0888
Entamoeba histolytica hypothetical protein 0.0035 0.0319 0.0906
Brugia malayi cytochrome P450 0.0011 0.0007 0.0006
Echinococcus multilocularis protein jagged 1 0.0034 0.0304 0.0297
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0694 0.0688
Schistosoma mansoni notch 0.0034 0.0304 0.0402
Schistosoma mansoni lipoxygenase 0.0019 0.0116 0.0151
Echinococcus granulosus protein jagged 2 0.0034 0.0304 0.0396
Loa Loa (eye worm) hypothetical protein 0.0144 0.1696 0.2254
Brugia malayi Papain family cysteine protease containing protein 0.0044 0.0423 0.0562
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0634 0.0843
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.1653 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.1055 0.4025
Loa Loa (eye worm) apoptosis regulator protein 0.0082 0.0904 0.1198
Leishmania major ribonuclease H1, putative 0.0022 0.0142 0.052
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0044 0.0423 0.112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3521 1
Brugia malayi RNase H family protein 0.0022 0.0142 0.0187
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0044 0.0423 0.0562
Brugia malayi Cadherin domain containing protein 0.0034 0.0304 0.0402
Echinococcus granulosus cathepsin l cysteine peptidase 0.0091 0.1023 0.1357
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1023 0.2841
Loa Loa (eye worm) hypothetical protein 0.0144 0.1696 0.2254
Brugia malayi Cathepsin L-like precursor 0.0091 0.1023 0.1362
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Schistosoma mansoni hypothetical protein 0.0035 0.0319 0.0422
Leishmania major cysteine peptidase A (CPA) 0.0091 0.1023 0.3903
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.1492 0.1986
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0044 0.0423 0.0562
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0238 0.0888
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0238 0.0911
Plasmodium falciparum serine repeat antigen 2 0.0044 0.0423 0.3944
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0013 0.0033 0.0099
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0238 0.2074
Plasmodium falciparum serine repeat antigen 7 0.0044 0.0423 0.3944
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0661 0.0878
Loa Loa (eye worm) inositol-1 0.0036 0.0331 0.0433
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0174 0.1018
Toxoplasma gondii ribonuclease HI protein 0.0022 0.0142 0.0544
Echinococcus multilocularis neural cadherin 0.0034 0.0304 0.0297
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0559 0.0737
Echinococcus granulosus delta-like protein 1 0.0034 0.0304 0.0396
Trypanosoma cruzi cysteine protease, putative 0.0091 0.1023 0.1357
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0238 0.0888
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0044 0.0423 0.4137
Plasmodium vivax serine-repeat antigen (SERA) 0.0044 0.0423 0.4137
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0139
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0176 0.1026
Schistosoma mansoni phosphoglucomutase 0.0022 0.0142 0.0187
Echinococcus multilocularis fat cadherin tumor suppressor 0.0034 0.0304 0.0297
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0091 0.1023 0.1362
Plasmodium vivax unspecified product 0.0047 0.047 0.4589
Schistosoma mansoni hypothetical protein 0.0034 0.0304 0.0402
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0238 0.0309
Giardia lamblia Cathepsin L precursor 0.0044 0.0423 0.112
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0331 0.0325
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0238 0.0309
Entamoeba histolytica cysteine protease, putative 0.0091 0.1023 0.2907
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0162 0.0619
Schistosoma mansoni loxhd1 0.0019 0.0116 0.0151
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.051 0.1369
Schistosoma mansoni septate junction protein 0.0034 0.0304 0.0402
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0632 0.0835
Trypanosoma brucei ingi protein (ORF1) 0.0023 0.0165 0.0609
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0116 0.1132
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0331 0.0856
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0142 0.0181
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0661 0.0878
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0908 0.0902
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0057 0.0588 0.0776
Leishmania major cathepsin L-like protease 0.0091 0.1023 0.3903
Brugia malayi Cytochrome P450 family protein 0.0011 0.0007 0.0006
Trypanosoma cruzi cysteine peptidase, putative 0.0091 0.1023 0.1357
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0111 0.0139
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0238 0.0232
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0191 0.2295 0.8942
Treponema pallidum NADH oxidase 0.0029 0.0238 0.0284
Brugia malayi jmjC domain containing protein 0.0094 0.1062 0.1414
Entamoeba histolytica cysteine protease, putative 0.0091 0.1023 0.2907
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.1741 0.2319
Brugia malayi Papain family cysteine protease containing protein 0.0091 0.1023 0.1362
Entamoeba histolytica cysteine protease, putative 0.0044 0.0423 0.1203
Plasmodium vivax unspecified product 0.0091 0.1023 1
Schistosoma mansoni kinase 0.0048 0.0475 0.063
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0111 0.0139
Entamoeba histolytica cysteine proteinase, putative 0.0044 0.0423 0.1203
Echinococcus granulosus neurogenic locus notch protein 0.0034 0.0304 0.0396
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0044 0.0423 0.0562
Schistosoma mansoni hypothetical protein 0.0082 0.0904 0.1203
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.051 0.0677
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0238 1
Trypanosoma brucei polo-like protein kinase 0.0094 0.1055 0.4025
Trypanosoma cruzi cruzipain precursor, putative 0.0047 0.047 0.0618
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.046 0.0605
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.1653 0.6434
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0162 0.4578
Schistosoma mansoni inositol monophosphatase 0.0036 0.0331 0.0438
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.046 0.0611
Giardia lamblia Cathepsin L precursor 0.0044 0.0423 0.112
Giardia lamblia Cathepsin B precursor 0.0044 0.0423 0.112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.046 0.0611
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0082 0.0904 0.0898
Loa Loa (eye worm) hypothetical protein 0.0018 0.0097 0.0121
Echinococcus multilocularis cathepsin L 0.0044 0.0423 0.0417
Loa Loa (eye worm) hypothetical protein 0.0018 0.0097 0.0121
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0174 0.1018
Entamoeba histolytica hypothetical protein 0.0035 0.0319 0.0906
Plasmodium vivax vivapain-3 0.0091 0.1023 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1062 0.1409
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0044 0.0423 0.112
Echinococcus granulosus cathepsin L cysteine proteinase 0.0091 0.1023 0.1357
Onchocerca volvulus 0.0044 0.0423 0.1327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1023 0.2841
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0044 0.0423 0.112
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0125 0.0119
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0116 0.0109
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.1653 0.6434
Schistosoma mansoni phosphoglucomutase 0.0022 0.0142 0.0187
Brugia malayi MAP kinase sur-1 0.0051 0.051 0.0677
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.0933 0.1236
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0013 0.0033 0.004
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0044 0.0423 0.4137
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0238 0.0888
Echinococcus granulosus neurogenic locus protein delta 0.0034 0.0304 0.0396
Plasmodium vivax vivapain-1 0.0091 0.1023 1
Onchocerca volvulus 0.0029 0.0242 0.0674
Onchocerca volvulus 0.0091 0.1023 0.349
Onchocerca volvulus Dual oxidase homolog 0.0144 0.1696 0.5914
Giardia lamblia Cysteine protease 0.0044 0.0423 0.112
Loa Loa (eye worm) hypothetical protein 0.0041 0.0391 0.0513
Entamoeba histolytica cysteine proteinase, putative 0.0091 0.1023 0.2907
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0283 0.1078
Schistosoma mansoni hypothetical protein 0.0029 0.0234 0.0309
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0331 0.0433
Giardia lamblia Cathepsin B precursor 0.0044 0.0423 0.112
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.1492 0.9019
Echinococcus granulosus neurogenic locus notch protein 0.0034 0.0304 0.0396
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0174 0.0655
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0125 0.0938
Trypanosoma cruzi hypothetical protein, conserved 0.021 0.2527 0.3364
Toxoplasma gondii cathepsin CPC1 0.0044 0.0423 0.1621
Entamoeba histolytica cysteine protease, putative 0.0091 0.1023 0.2907
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0044 0.0423 0.112
Echinococcus granulosus cathepsin b 0.0602 0.75 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0242 0.0236
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0044 0.0423 0.112
Echinococcus multilocularis peroxidasin 0.0144 0.1696 0.169
Schistosoma mansoni hypothetical protein 0.0082 0.0904 0.1203
Toxoplasma gondii EGF family domain-containing protein 0.0034 0.0304 0.1162
Schistosoma mansoni hypothetical protein 0.0019 0.0111 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1023 0.2841
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0174 0.0643
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0047 0.047 0.0623
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Entamoeba histolytica cysteine proteinase, putative 0.0091 0.1023 0.2907
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0044 0.0423 0.1203
Brugia malayi EGF-like domain containing protein 0.0034 0.0304 0.0402
Onchocerca volvulus Cathepsin L homolog 0.0091 0.1023 0.349
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0191 0.2295 0.8942
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0176 0.0225
Brugia malayi Papain family cysteine protease containing protein 0.0091 0.1023 0.1362
Loa Loa (eye worm) animal heme peroxidase 0.0144 0.1696 0.2254
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3521 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0242 0.0315
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0044 0.0423 0.0562
Schistosoma mansoni cytochrome P450 0.0011 0.0007 0.0006
Brugia malayi Animal haem peroxidase family protein 0.0144 0.1696 0.2258
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0331 0.197
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0044 0.0423 0.3944
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0238 0.0309
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0242 0.032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0423 0.112
Toxoplasma gondii fructose-bisphospatase I 0.0057 0.0588 0.2252
Onchocerca volvulus Putative cubilin 0.0034 0.0304 0.0894
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0057 0.0588 0.2252
Giardia lamblia Cathepsin L-like protease 0.0044 0.0423 0.112
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0044 0.0423 0.0556
Onchocerca volvulus Chorion peroxidase homolog 0.0144 0.1696 0.5914
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0694 0.2639
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0128 0.1492 0.1486
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0234 0.2284
Brugia malayi Doublecortin family protein 0.0019 0.0116 0.0151
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Leishmania major cathepsin L-like protease 0.0091 0.1023 0.3903
Loa Loa (eye worm) FYVE zinc finger family protein 0.0013 0.0033 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3521 1
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0304 0.0402
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0176 0.0169
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0242 0.0928
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1055 0.1399
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1055 0.1404
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.042 0.1608
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0162 0.158
Brugia malayi fructose-1,6-bisphosphatase 0.0153 0.1802 0.24
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0423 0.112
Leishmania major cathepsin L-like protease 0.0091 0.1023 0.3903
Loa Loa (eye worm) hypothetical protein 0.0144 0.1696 0.2254
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0091 0.1023 0.1362
Entamoeba histolytica cysteine protease, putative 0.0091 0.1023 0.2907
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0238 0.2326
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.1689 0.2245
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.042 0.1111
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.042 0.0552
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0013 0.0033 0.0099
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0238 0.0309
Trypanosoma cruzi major cysteine proteinase, putative 0.0044 0.0423 0.0556
Onchocerca volvulus 0.0082 0.0908 0.3075
Plasmodium falciparum serine repeat antigen 8 0.0044 0.0423 0.3944
Plasmodium vivax serine-repeat antigen (SERA) 0.0044 0.0423 0.4137
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0238 0.0888
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0013 0.0033 0.0099
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0125 0.0159
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0694 0.0923
Giardia lamblia Encystation-specific protease 0.0044 0.0423 0.112
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0125 0.0938
Onchocerca volvulus 0.0019 0.0116 0.0218
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0013 0.0033 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0091 0.1023 0.2841
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.016 0.19 0.2531
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0128 0.1492 0.1982
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0111 0.0104
Echinococcus multilocularis notch 0.0034 0.0304 0.0297
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0238 0.0888
Onchocerca volvulus 0.0091 0.1023 0.349
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0694 0.2639
Brugia malayi Cathepsin L-like precursor 0.0091 0.1023 0.1362
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0125 0.0119
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0091 0.1023 0.1017
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0423 0.112
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.144 0.1913
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.046 0.0611
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0044 0.0423 0.4137
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1055 0.2932
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0374 0.3447
Plasmodium vivax unspecified product 0.0044 0.0423 0.4137
Giardia lamblia Cathepsin B precursor 0.0044 0.0423 0.112
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0238 0.5075
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.051 0.1932
Leishmania major hypothetical protein, conserved 0.021 0.2527 0.9674
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1055 0.2932
Echinococcus multilocularis ribonuclease H1 0.0022 0.0142 0.0136
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Trypanosoma brucei hypothetical protein, conserved 0.021 0.2527 0.9674
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0033 0.0099
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0162 0.0619
Brugia malayi RNase H family protein 0.0022 0.0142 0.0187
Schistosoma mansoni cathepsin F (C01 family) 0.0091 0.1023 0.1362
Plasmodium falciparum cysteine proteinase falcipain 1 0.0091 0.1023 1
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0013 0.0033 0.0035
Plasmodium falciparum thioredoxin reductase 0.0084 0.0933 0.9085
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0013 0.0033 0.004
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0238 0.0888
Giardia lamblia Cathepsin L precursor 0.0044 0.0423 0.112
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0499 0.0658
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0162 0.0058
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.051 0.0672
Schistosoma mansoni DNA helicase recq1 0.002 0.0125 0.0164
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0013 0.0033 0.0035
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0044 0.0423 0.0562
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0174 0.0229
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1023 0.2841
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.1055 0.1404
Leishmania major cathepsin L-like protease 0.0091 0.1023 0.3903
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.3521 1
Onchocerca volvulus 0.0091 0.1023 0.349
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0116 0.0146
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0817 0.1087
Loa Loa (eye worm) hypothetical protein 0.0018 0.0097 0.0121
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0111 0.0145
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Schistosoma mansoni notch 0.0034 0.0304 0.0402
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0176 0.0225
Brugia malayi Pip kinase protein 2 0.016 0.19 0.2531
Onchocerca volvulus Alhambra homolog 0.0029 0.0234 0.0643
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0661 0.0878
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Schistosoma mansoni slit 0.0034 0.0304 0.0402
Echinococcus granulosus ribonuclease H1 0.0022 0.0142 0.0181
Leishmania major cathepsin L-like protease 0.0091 0.1023 0.3903
Brugia malayi Cadherin domain containing protein 0.0034 0.0304 0.0402
Leishmania major cathepsin L-like protease 0.0091 0.1023 0.3903
Trypanosoma brucei protein kinase, putative 0.0051 0.051 0.1932
Schistosoma mansoni hypothetical protein 0.0082 0.0904 0.1203
Onchocerca volvulus 0.0234 0.2829 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0162 0.0942
Loa Loa (eye worm) hypothetical protein 0.0144 0.1696 0.2254
Echinococcus granulosus RUN 0.0019 0.0116 0.0146
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0057 0.0588 0.0776
Loa Loa (eye worm) Notch2 0.0034 0.0304 0.0396
Echinococcus multilocularis cathepsin b 0.0602 0.75 0.7499
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Plasmodium vivax vivapain-2 0.0091 0.1023 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0661 0.0878
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0091 0.1023 0.3903
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0044 0.0423 0.0556
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.014 0.0184
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0174 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0423 0.112
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0044 0.0423 0.0562
Loa Loa (eye worm) hypothetical protein 0.0029 0.0242 0.0315
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0091 0.1023 1
Brugia malayi GCC2 and GCC3 family protein 0.0034 0.0304 0.0402
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0047 0.047 0.0618
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0694 0.0918
Onchocerca volvulus 0.0034 0.0304 0.0894
Schistosoma mansoni hypothetical protein 0.0034 0.0304 0.0402
Brugia malayi cathepsin F-like cysteine proteinase 0.0047 0.047 0.0623
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0013 0.0033 0.0099
Brugia malayi hypothetical protein 0.0144 0.1696 0.2258
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0153 0.1802 0.2396
Mycobacterium tuberculosis Probable oxidoreductase 0.0213 0.2566 1
Schistosoma mansoni cathepsin C 0.0044 0.0423 0.0562
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0694 0.1972
Schistosoma mansoni lipoxygenase 0.0054 0.0559 0.0743
Loa Loa (eye worm) hypothetical protein 0.0082 0.0908 0.1203
Echinococcus granulosus peroxidasin 0.0144 0.1696 0.2254
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.047 0.0618
Brugia malayi Cytochrome P450 family protein 0.0011 0.0007 0.0006
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.042 0.1111
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0174 0.1018
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0023 0.0165 0.0609
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0238 0.0911
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0174 0.0655
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0331 0.1267
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.051 0.0672
Brugia malayi Pip kinase protein 1 0.0013 0.0033 0.004
Loa Loa (eye worm) hypothetical protein 0.0091 0.1023 0.1357
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0331 0.0856
Loa Loa (eye worm) blistered cuticle protein 3 0.0144 0.1696 0.2254
Echinococcus granulosus cysteine protease 0.0091 0.1023 0.1357
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0013 0.0033 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0423 0.112
Onchocerca volvulus 0.0144 0.1696 0.5914
Entamoeba histolytica cysteine protease, putative 0.0044 0.0423 0.1203
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0153 0.1802 0.1797
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0116 0.0146
Giardia lamblia Kinase, PLK 0.0094 0.1055 0.2932
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0034 0.0304 0.0894
Leishmania major trypanothione reductase 0.0084 0.0933 0.3555
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0013 0.0033 0.0026
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0125 0.0159
Schistosoma mansoni hypothetical protein 0.0019 0.0111 0.0145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0091 0.1023 0.3903
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0238 0.0309
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3521 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0224
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0238 0.0904
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0044 0.0423 0.3944
Brugia malayi MH2 domain containing protein 0.0124 0.144 0.1918
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0082 0.0904 0.1203
Loa Loa (eye worm) hypothetical protein 0.0044 0.0423 0.0556
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0091 0.1023 0.3903
Echinococcus multilocularis cysteine protease 0.0091 0.1023 0.1017
Brugia malayi Animal haem peroxidase family protein 0.0144 0.1696 0.2258
Giardia lamblia Ribonuclease H 0.0022 0.0142 0.0314
Plasmodium falciparum serine repeat antigen 1 0.0044 0.0423 0.3944
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0331 0.094
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0013 0.0033 0.0035
Trypanosoma cruzi cysteine proteinase, putative 0.0091 0.1023 0.1357
Echinococcus multilocularis RUN 0.0019 0.0116 0.0109
Echinococcus multilocularis neurogenic locus notch protein 0.0034 0.0304 0.0297
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0234 0.0227
Echinococcus multilocularis neurogenic locus notch protein 4 0.0034 0.0304 0.0297
Echinococcus granulosus bloom syndrome protein 0.002 0.0125 0.0159
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0191 0.2295 0.8942
Brugia malayi fibroinase precursor 0.0044 0.0423 0.0562
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0908 0.1203
Brugia malayi hypothetical protein 0.0019 0.0116 0.0151
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0238 0.0888
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0191 0.2295 0.8942
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0224
Loa Loa (eye worm) RecQ helicase 0.002 0.0125 0.0159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1023 0.2841
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0602 0.75 1
Onchocerca volvulus 0.0044 0.0423 0.1327
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0176 0.041
Echinococcus multilocularis cysteine protease 0.0091 0.1023 0.1017
Trypanosoma cruzi cysteine proteinase, putative 0.0091 0.1023 0.1357
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0153 0.1802 0.6891
Trypanosoma brucei ingi protein (ORF1) 0.0023 0.0165 0.0609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1023 0.2841
Schistosoma mansoni notch 0.0034 0.0304 0.0402
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0423 0.112
Loa Loa (eye worm) fibroinase 0.0091 0.1023 0.1357
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2829 0.8016
Brugia malayi jmjC domain containing protein 0.0035 0.031 0.0411
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0176 0.0225
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0174 0.0495
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0396
Trypanosoma cruzi hypothetical protein, conserved 0.021 0.2527 0.3364
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3521 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0661 0.0873
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0238 0.0589
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0013 0.0033 0.004
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0634 0.3813
Echinococcus granulosus tar DNA binding protein 0.0062 0.0661 0.0873
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1055 0.2932
Schistosoma mansoni hypothetical protein 0.0019 0.0111 0.0145
Onchocerca volvulus Slit protein homolog 0.0034 0.0304 0.0894
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0125 0.048
Loa Loa (eye worm) hypothetical protein 0.0144 0.1696 0.2254
Echinococcus granulosus protein jagged 1 0.0034 0.0304 0.0396
Plasmodium falciparum serine repeat antigen 9 0.0044 0.0423 0.3944
Toxoplasma gondii thioredoxin reductase 0.0084 0.0933 0.3571
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0091 0.1023 0.3903
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0111 0.0139
Echinococcus granulosus cathepsin L 0.0091 0.1023 0.1357
Brugia malayi Cathepsin L-like precursor 0.0091 0.1023 0.1362
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.046 0.0605
Schistosoma mansoni cathepsin F (C01 family) 0.0044 0.0423 0.0562
Brugia malayi Animal haem peroxidase family protein 0.0144 0.1696 0.2258
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0082 0.0904 0.1203
Trypanosoma brucei trypanothione reductase 0.0084 0.0933 0.3555
Onchocerca volvulus 0.0091 0.1023 0.349
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0694 0.0923
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0125 0.0164
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0174 0.1018
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0234 0.0895
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0162 0.0606
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.051 0.0672
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1023 0.2841
Entamoeba histolytica cysteine protease, putative 0.0044 0.0423 0.1203

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Inhibitors of PI5P4K: Confirmation in Primary Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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