TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 813.945 | Formula: C41H55N11O7
H donors: 9 H acceptors: 7 LogP: 0.32 Rotable bonds: 10
Rule of 5 violations (Lipinski): 3
SMILES: NC(=N)NCCC[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C(=O)CCC(=O)NCCCC[C@H](NC(=O)[C@@H](NC1=O)Cc1c[nH]c2c1cccc2)C(=O)N
InChi: 1S/C41H55N11O7/c42-36(55)29-14-6-7-19-45-34(53)17-18-35(54)52-21-9-16-33(52)40(59)51-31(22-25-10-2-1-3-11-25)38(57)49-30(15-8-20-46-41(43)44)37(56)50-32(39(58)48-29)23-26-24-47-28-13-5-4-12-27(26)28/h1-5,10-13,24,29-33,47H,6-9,14-23H2,(H2,42,55)(H,45,53)(H,48,58)(H,49,57)(H,50,56)(H,51,59)(H4,43,44,46)/t29-,30+,31-,32-,33+/m0/s1
InChiKey: RSZGGZUMSYSTES-HJCKZFGESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	melanocortin 4 receptor	Starlite/ChEMBL	References
Homo sapiens	melanocortin 3 receptor	Starlite/ChEMBL	References
Homo sapiens	melanocortin 5 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	hypothetical protein	melanocortin 5 receptor	325 aa	311 aa	20.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	glutathione reductase	0.0221	0.2009	0.2009
Trypanosoma brucei	DNA polymerase kappa, putative	0.0033	0.0147	0.0233
Brugia malayi	glutathione reductase	0.0221	0.2009	0.2009
Giardia lamblia	Hypothetical protein	0.0108	0.0896	0.2367
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0862	0.0862
Echinococcus granulosus	serine:threonine protein kinase	0.0238	0.218	0.218
Entamoeba histolytica	hypothetical protein	0.0108	0.0896	0.1995
Brugia malayi	polk-prov protein	0.0041	0.0226	0.0226
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.0776	0.0776
Loa Loa (eye worm)	animal heme peroxidase	0.0105	0.0862	0.0862
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0108	0.0896	0.0896
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0005	0.0005
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0109	0.0905	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0577	0.0577
Echinococcus granulosus	neuropeptide FF receptor 2	0.0018	0.0005	0.0005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0462	0.4399	0.7624
Giardia lamblia	Phosphoglycerate kinase	0.0094	0.0749	0.1969
Echinococcus multilocularis	dro:myosuppressin receptor	0.0018	0.0005	0.0005
Brugia malayi	Papain family cysteine protease containing protein	0.0462	0.4399	0.4399
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0018	0.0005	0.0005
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0018	0.0005	0.0005
Echinococcus multilocularis	neuropeptide s receptor	0.0018	0.0005	0.0005
Schistosoma mansoni	neuropeptide F-like receptor	0.0018	0.0005	0.0005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0108	0.0896	0.1521
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0462	0.4399	0.7624
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0027	0.0091	0.0119
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0776	0.0776
Brugia malayi	ImpB/MucB/SamB family protein	0.0065	0.0467	0.0467
Trichomonas vaginalis	conserved hypothetical protein	0.0108	0.0896	0.1521
Echinococcus granulosus	neuropeptide receptor A26	0.0018	0.0005	0.0005
Trypanosoma brucei	DNA polymerase kappa, putative	0.0066	0.0479	0.0855
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0027	0.0004
Echinococcus granulosus	pyruvate kinase	0.0109	0.0905	0.0905
Loa Loa (eye worm)	neuropeptide F receptor	0.0018	0.0005	0.0005
Trypanosoma brucei	antigen, putative	0.0021	0.0027	0.0008
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0294	0.2737	0.2737
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.007	0.0512	0.0915
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0462	0.4399	0.4399
Mycobacterium ulcerans	DNA polymerase IV	0.0066	0.0479	0.0796
Trypanosoma cruzi	cysteine protease, putative	0.0252	0.2316	0.2299
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Echinococcus multilocularis	cathepsin L	0.0108	0.0896	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1667	0.1667
Loa Loa (eye worm)	hypothetical protein	0.0462	0.4399	0.4399
Leishmania major	phosphopantetheinyl transferase-like protein	0.0052	0.034	0.0595
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0108	0.0896	0.0896
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0005	0.0005
Leishmania major	cathepsin L-like protease	0.0462	0.4399	0.819
Brugia malayi	Thioredoxin reductase	0.0221	0.2009	0.2009
Schistosoma mansoni	opsin-like receptor	0.0018	0.0005	0.0005
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0005	0.0005
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0077	0.058	0.097
Schistosoma mansoni	sulfide quinone reductase	0.002	0.0023	0.0023
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0018	0.0005	0.0005
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0018	0.0005	0.0005
Toxoplasma gondii	cathepsin CPC2	0.0108	0.0896	0.2023
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0252	0.2316	0.3995
Brugia malayi	Cathepsin L-like precursor	0.0462	0.4399	0.4399
Echinococcus multilocularis	glutamate synthase	0.002	0.0023	0.0023
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0462	0.4399	0.4399
Toxoplasma gondii	Dullard family phosphatase domain-containing protein	0.0027	0.0091	0.019
Loa Loa (eye worm)	pyruvate kinase	0.0109	0.0905	0.0905
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0462	0.4399	0.7624
Loa Loa (eye worm)	fibroinase	0.0462	0.4399	0.4399
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0088	0.0114
Trypanosoma cruzi	major cysteine proteinase, putative	0.0206	0.1863	0.1845
Echinococcus granulosus	proteasome prosome macropain	0.007	0.0512	0.0512
Echinococcus multilocularis	geminin	0.0537	0.5143	0.5143
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0058	0.0391	0.0391
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0026	0.008	0.008
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0044	0.0261	0.0447
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0264	0.042
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0136	0.1169	0.1998
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0462	0.4399	0.7624
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0018	0.0005	0.0005
Mycobacterium tuberculosis	Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase)	0.0027	0.0088	0.0122
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0319	0.2979	0.2979
Echinococcus granulosus	neuropeptide Y receptor	0.0018	0.0005	0.0005
Onchocerca volvulus		0.0108	0.0896	0.1756
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Toxoplasma gondii	phosphoglycerate kinase PGKII	0.0094	0.0749	0.1689
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Brugia malayi	Cathepsin L-like precursor	0.0319	0.2979	0.2979
Plasmodium falciparum	serine repeat antigen 1	0.0108	0.0896	0.1995
Onchocerca volvulus	Cathepsin F homolog	0.0462	0.4399	0.8658
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0037	0.019	0.019
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.056	0.5366	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.0018	0.0005	0.0005
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0284	0.0284
Echinococcus granulosus	somatostatin receptor	0.0018	0.0005	0.0005
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0018	0.0005	0.0005
Echinococcus granulosus	SAM and MBT domain containing protein	0.0052	0.0341	0.0341
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.056	0.5366	1
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0193	0.1735	0.1735
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0057	0.0382	0.036
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0034	0.0162	0.014
Trichomonas vaginalis	chromobox protein, putative	0.0048	0.0297	0.0478
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0018	0.0005	0.0005
Brugia malayi	Proteasome A-type and B-type family protein	0.007	0.0512	0.0512
Echinococcus multilocularis	microtubule associated protein 2	0.0716	0.6917	0.6917
Mycobacterium tuberculosis	Probable phosphoglycerate kinase Pgk	0.0094	0.0749	0.1359
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0862	0.0862
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0037	0.019	0.019
Entamoeba histolytica	cysteine protease, putative	0.0252	0.2316	0.524
Echinococcus granulosus	neuropeptide receptor	0.0018	0.0005	0.0005
Echinococcus granulosus	allatostatin A receptor	0.0018	0.0005	0.0005
Onchocerca volvulus	Dual oxidase homolog	0.0105	0.0862	0.1689
Plasmodium vivax	vivapain-2	0.0462	0.4399	1
Entamoeba histolytica	cysteine proteinase, putative	0.0252	0.2316	0.524
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0862	0.0862
Loa Loa (eye worm)	neuropeptide F receptor	0.0018	0.0005	0.0005
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0108	0.0896	0.0896
Schistosoma mansoni	cathepsin S (C01 family)	0.0108	0.0896	0.0896
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0018	0.0005	0.0005
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0067	0.0484	0.0484
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0026	0.008	0.008
Loa Loa (eye worm)	glutaminase	0.06	0.5763	0.5763
Onchocerca volvulus		0.0105	0.0862	0.1689
Echinococcus multilocularis	traf and tnf receptor associated protein	0.0193	0.1735	0.1735
Loa Loa (eye worm)	transcription factor SMAD2	0.0383	0.3619	0.3619
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0108	0.0896	0.1995
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0143	0.1242	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Schistosoma mansoni	ap endonuclease	0.0023	0.0053	0.0053
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0018	0.0005	0.0005
Onchocerca volvulus	Peroxidasin homolog	0.0108	0.0891	0.1746
Toxoplasma gondii	hypothetical protein	0.0053	0.0349	0.0778
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0862	0.0862
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0462	0.4399	0.7624
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.0053	0.0053
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0462	0.4399	0.7624
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0156	0.137	0.2521
Echinococcus granulosus	apoptosis inducing factor 1 mitochondrial	0.002	0.0023	0.0023
Plasmodium falciparum	serine repeat antigen 7	0.0108	0.0896	0.1995
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0018	0.0005	0.0005
Giardia lamblia	Cathepsin B precursor	0.0108	0.0896	0.2367
Leishmania major	pyruvate kinase	0.0109	0.0905	0.1651
Leishmania major	hypothetical protein, conserved	0.0234	0.2135	0.3953
Brugia malayi	Cathepsin L-like precursor	0.0462	0.4399	0.4399
Trypanosoma cruzi	cruzipain precursor, putative	0.0143	0.1242	0.1222
Entamoeba histolytica	cysteine proteinase 2	0.0252	0.2316	0.524
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0005	0.0005
Echinococcus multilocularis	somatostatin receptor	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0005	0.0005
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0052	0.034	0.0758
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0027	0.0088	0.0114
Loa Loa (eye worm)	hypothetical protein	0.1027	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0005	0.0005
Echinococcus granulosus	L aminoadipate semialdehyde	0.0186	0.1667	0.1667
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0214	0.1939	0.1939
Leishmania major	cathepsin L-like protease	0.056	0.5366	1
Trypanosoma brucei	hypothetical protein, conserved	0.0234	0.2135	0.3953
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0454	0.0454
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.002	0.0023	0.0034
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0094	0.0749	0.1266
Trypanosoma brucei	calpain-like protein, putative	0.0021	0.0027	0.0008
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Onchocerca volvulus		0.0319	0.2979	0.586
Giardia lamblia	Cysteine protease	0.0108	0.0896	0.2367
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0018	0.0005	0.0005
Brugia malayi	Serotonin receptor	0.0018	0.0005	0.0005
Echinococcus granulosus	serotonin receptor	0.0018	0.0005	0.0005
Leishmania major	cathepsin L-like protease	0.0462	0.4399	0.819
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0108	0.0896	0.1995
Echinococcus multilocularis	G protein coupled receptor 139	0.0018	0.0005	0.0005
Brugia malayi	pyruvate kinase, muscle isozyme	0.0023	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0862	0.0862
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.002	0.0023	0.0023
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0077	0.058	0.1042
Brugia malayi	G-protein coupled receptor	0.0018	0.0005	0.0005
Brugia malayi	TAR-binding protein	0.0064	0.0454	0.0454
Trypanosoma brucei	unspecified product	0.0059	0.0408	0.072
Echinococcus granulosus	orexin receptor type 2	0.0018	0.0005	0.0005
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0021	0.0027	0.0004
Brugia malayi	hypothetical protein	0.0018	0.0005	0.0005
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0027	0.0004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0108	0.0896	0.1521
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0896	0.0896
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0462	0.4399	0.7624
Brugia malayi	Serotonin receptor	0.0018	0.0005	0.0005
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0108	0.0896	0.1995
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0462	0.4399	0.7624
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0136	0.1169	0.2146
Trichomonas vaginalis	chromobox protein, putative	0.0048	0.0297	0.0478
Trypanosoma cruzi	cysteine peptidase, putative	0.0143	0.1242	0.1222
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0052	0.034	0.0726
Giardia lamblia	Cathepsin L precursor	0.0108	0.0896	0.2367
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0005	0.0005
Giardia lamblia	Pyruvate kinase	0.0109	0.0905	0.2392
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0896	0.0896
Brugia malayi	ImpB/MucB/SamB family protein	0.0037	0.019	0.019
Onchocerca volvulus		0.0462	0.4399	0.8658
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0018	0.0005	0.0005
Brugia malayi	Blistered cuticle protein 3	0.0105	0.0862	0.0862
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.004	0.0213	0.0469
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.0776	0.0776
Brugia malayi	Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1	0.0027	0.0091	0.0091
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0026	0.008	0.008
Echinococcus multilocularis	sex peptide receptor	0.0018	0.0005	0.0005
Schistosoma mansoni	phosphoglycerate kinase	0.0094	0.0749	0.0749
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0862	0.0862
Leishmania major	proteasome beta 5 subunit, putative	0.007	0.0512	0.0915
Entamoeba histolytica	cysteine protease, putative	0.0252	0.2316	0.524
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0018	0.0005	0.0005
Echinococcus granulosus	peroxidasin	0.0108	0.0891	0.0891
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0077	0.058	0.151
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0077	0.058	0.1042
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1242	0.1242
Echinococcus multilocularis	transcription factor Dp 1	0.017	0.1509	0.1509
Entamoeba histolytica	cysteine protease, putative	0.0108	0.0896	0.1995
Entamoeba histolytica	cysteine proteinase, putative	0.0252	0.2316	0.524
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0005	0.0005
Brugia malayi	larval opioid receptor	0.0018	0.0005	0.0005
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0037	0.019	0.0381
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0027	0.0008
Echinococcus granulosus	biogenic amine 5HT receptor	0.0018	0.0005	0.0005
Brugia malayi	fibroinase precursor	0.0108	0.0896	0.0896
Trypanosoma brucei	DNA polymerase kappa, putative	0.0066	0.0479	0.0855
Schistosoma mansoni	peroxidasin	0.0105	0.0862	0.0862
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0052	0.034	0.4376
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0005	0.0005
Plasmodium falciparum	thioredoxin reductase	0.0221	0.2009	0.4539
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0027	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0005	0.0005
Echinococcus granulosus	transcription factor Dp 1	0.017	0.1509	0.1509
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0896	0.0896
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1027	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0462	0.4399	0.4399
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0226	0.0226
Echinococcus multilocularis	chromobox protein 1	0.008	0.061	0.061
Brugia malayi	calpain family protein 1	0.0055	0.0366	0.0366
Giardia lamblia	Cathepsin B precursor	0.0393	0.3711	1
Onchocerca volvulus	Huntingtin homolog	0.0275	0.2541	0.4998
Echinococcus multilocularis	hypothetical protein	0.0021	0.0027	0.0027
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0005	0.0005
Toxoplasma gondii	cathepsin CPL	0.0462	0.4399	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0077	0.058	0.7666
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0027	0.0088	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0108	0.0896	0.0896
Plasmodium vivax	serine-repeat antigen (SERA)	0.0108	0.0896	0.1995
Brugia malayi	calpain 7	0.0021	0.0027	0.0027
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0005	0.0005
Mycobacterium ulcerans	proteasome PrcB	0.007	0.0512	0.0852
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0896	0.0896
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0135	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Echinococcus granulosus	pyridine nucleotide disulfide oxidoreductase	0.002	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0052	0.034	0.3603
Schistosoma mansoni	sex comb on midleg homolog	0.0052	0.0341	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0462	0.4399	0.7624
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.056	0.5366	1
Leishmania major	DNA polymerase eta, putative	0.0065	0.0467	0.0832
Leishmania major	trypanothione reductase	0.0221	0.2009	0.3718
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0108	0.0896	0.0896
Echinococcus multilocularis	phosphoglycerate kinase 1	0.0094	0.0749	0.0749
Schistosoma mansoni	cathepsin s	0.0143	0.1242	0.1242
Giardia lamblia	Cysteine protease	0.0108	0.0896	0.2367
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0108	0.0896	0.2367
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0077	0.058	0.1272
Echinococcus granulosus	cathepsin b	0.1027	1	1
Brugia malayi	Heterochromatin protein 1	0.008	0.061	0.061
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.002	0.0023	0.0023
Brugia malayi	cathepsin F-like cysteine proteinase	0.0143	0.1242	0.1242
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0183	0.1639	0.3715
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0108	0.0896	0.1995
Brugia malayi	Peroxidasin	0.0108	0.0891	0.0891
Entamoeba histolytica	cysteine protease, putative	0.0252	0.2316	0.524
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0862	0.0862
Plasmodium falciparum	serine repeat antigen 2	0.0108	0.0896	0.1995
Onchocerca volvulus		0.0105	0.0862	0.1689
Trypanosoma cruzi	trypanothione reductase, putative	0.0221	0.2009	0.1991
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0018	0.0005	0.0005
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0018	0.0005	0.0005
Trichomonas vaginalis	pyruvate kinase, putative	0.0109	0.0905	0.1537
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0018	0.0005	0.0005
Echinococcus granulosus	pyruvate kinase	0.0109	0.0905	0.0905
Trypanosoma brucei	trypanothione reductase	0.0221	0.2009	0.3718
Trypanosoma brucei	pyruvate kinase 1	0.0109	0.0905	0.1651
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0018	0.0005	0.0005
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0021	0.0027	0.0027
Brugia malayi	cathepsin L-like precursor	0.0319	0.2979	0.2979
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0462	0.4399	0.4399
Echinococcus multilocularis	calpain A	0.0058	0.0391	0.0391
Schistosoma mansoni	hypothetical protein	0.0537	0.5143	0.5143
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.056	0.5366	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0108	0.0896	0.0896
Brugia malayi	hypothetical protein	0.0018	0.0005	0.0005
Trypanosoma cruzi	cysteine peptidase, putative	0.0252	0.2316	0.2299
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.007	0.0512	0.0915
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0454	0.0454
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0018	0.0005	0.0005
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0143	0.1242	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0386	0.0386
Echinococcus multilocularis	calpain 7 (C02 family)	0.0021	0.0027	0.0027
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0027	0.0088	0.0122
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0053	0.0053
Trypanosoma cruzi	hypothetical protein, conserved	0.0234	0.2135	0.2117
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0027	0.0004
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0454	0.0454
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0053	0.042
Echinococcus multilocularis	orexin receptor type 2	0.0018	0.0005	0.0005
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0077	0.058	0.1042
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.007	0.0512	0.1118
Brugia malayi	hypothetical protein	0.0018	0.0005	0.0005
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.0776	0.0776
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0018	0.0005	0.0005
Loa Loa (eye worm)	pyruvate kinase	0.0109	0.0905	0.0905
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0294	0.2737	0.272
Brugia malayi	neuropeptide F receptor	0.0018	0.0005	0.0005
Toxoplasma gondii	exonuclease III APE	0.0023	0.0053	0.0104
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.0027	0.0088	0.0088
Mycobacterium ulcerans	glutaminase	0.06	0.5763	1
Loa Loa (eye worm)	calpain family protein 1	0.0041	0.0223	0.0223
Loa Loa (eye worm)	G-protein coupled receptor	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Echinococcus multilocularis	peroxidasin	0.0108	0.0891	0.0891
Schistosoma mansoni	neuropeptide f receptor 76f	0.0018	0.0005	0.0005
Plasmodium vivax	calpain, putative	0.0021	0.0027	0.001
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.033	0.3093	0.5746
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Plasmodium vivax	proteasome subunit beta type-5, putative	0.007	0.0512	0.1118
Echinococcus granulosus	7TM GPCR rhodopsin	0.0018	0.0005	0.0005
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0091	0.0069
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0027	0.0088	0.0088
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0088	0.0114
Brugia malayi	Cathepsin L-like precursor	0.0462	0.4399	0.4399
Trypanosoma cruzi	cruzipain precursor, putative	0.056	0.5366	0.5356
Leishmania major	phosphoglycerate kinase B, cytosolic	0.0094	0.0749	0.136
Loa Loa (eye worm)	ctsf protein	0.0462	0.4399	0.4399
Brugia malayi	Dopamine receptor	0.0018	0.0005	0.0005
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0005	0.0005
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0077	0.058	0.1272
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0281	0.0259
Trypanosoma brucei	DNA polymerase IV, putative	0.0059	0.0408	0.072
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0108	0.0896	0.1521
Brugia malayi	cathepsin F-like cysteine proteinase	0.0108	0.0896	0.0896
Echinococcus granulosus	pyruvate kinase	0.0056	0.0378	0.0378
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0462	0.4399	0.7624
Giardia lamblia	Cathepsin B precursor	0.0108	0.0896	0.2367
Brugia malayi	Animal haem peroxidase family protein	0.0105	0.0862	0.0862
Brugia malayi	Phosphoglycerate kinase	0.0094	0.0749	0.0749
Schistosoma mansoni	cathepsin C	0.0108	0.0896	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0294	0.2737	0.5079
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0108	0.0896	0.0896
Entamoeba histolytica	cysteine protease, putative	0.0252	0.2316	0.524
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.056	0.5366	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0005	0.0005
Echinococcus granulosus	calpain A	0.0021	0.0027	0.0027
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0454	0.0454
Loa Loa (eye worm)	calpain	0.0021	0.0027	0.0027
Plasmodium vivax	pyruvate kinase 2, putative	0.0056	0.0378	0.0811
Giardia lamblia	Nuclear LIM interactor-interacting factor 1	0.0027	0.0091	0.0186
Schistosoma mansoni	hypothetical protein	0.0018	0.0005	0.0005
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0252	0.2316	0.2316
Entamoeba histolytica	cysteine protease, putative	0.0252	0.2316	0.524
Trichomonas vaginalis	glutaminase, putative	0.06	0.5763	1
Giardia lamblia	Cathepsin B precursor	0.0108	0.0896	0.2367
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0053	0.0053
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0252	0.2316	0.524
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0018	0.0005	0.0005
Echinococcus multilocularis	myosin light chain kinase, smooth muscle	0.0238	0.218	0.218
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0109	0.0905	0.0905
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0005	0.0005
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.056	0.5369	1
Schistosoma mansoni	smad1 5 8 and	0.0026	0.008	0.008
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0077	0.058	0.0558
Giardia lamblia	Cathepsin L precursor	0.0108	0.0896	0.2367
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0281	0.0259
Schistosoma mansoni	hypothetical protein	0.0018	0.0005	0.0005
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.056	0.5369	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0005	0.0005
Echinococcus granulosus	cathepsin L cysteine protease	0.0252	0.2316	0.2316
Trypanosoma cruzi	3-phosphoglycerate kinase, glycosomal	0.0034	0.0162	0.014
Brugia malayi	Papain family cysteine protease containing protein	0.0108	0.0896	0.0896
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0108	0.0896	0.1521
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0005	0.0005
Giardia lamblia	Cathepsin L precursor	0.0108	0.0896	0.2367
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0862	0.0862
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0393	0.3711	0.6903
Schistosoma mansoni	calpain-7 (C02 family)	0.0021	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.002	0.0023	0.0023
Entamoeba histolytica	cysteine protease, putative	0.0252	0.2316	0.524
Onchocerca volvulus		0.0462	0.4399	0.8658
Echinococcus multilocularis	calpain 5	0.0021	0.0027	0.0027
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0454	0.0454
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.0776	0.0776
Brugia malayi	hypothetical protein	0.0105	0.0862	0.0862
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0108	0.0896	0.1995
Schistosoma mansoni	aldehyde dehydrogenase	0.0136	0.1169	0.1169
Schistosoma mansoni	amine GPCR	0.0018	0.0005	0.0005
Toxoplasma gondii	NADPH-glutathione reductase	0.0077	0.058	0.1302
Brugia malayi	Animal haem peroxidase family protein	0.0105	0.0862	0.0862
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.033	0.3093	0.3077
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0077	0.058	0.058
Schistosoma mansoni	amine GPCR	0.0018	0.0005	0.0005
Plasmodium vivax	vivapain-3	0.0252	0.2316	0.524
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0094	0.0749	0.0728
Brugia malayi	MH2 domain containing protein	0.0026	0.008	0.008
Brugia malayi	glutaminase DH11.1	0.06	0.5763	0.5763
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0091	0.0091
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0046	0.0281	0.0484
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0108	0.0896	0.0896
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0005	0.0005
Plasmodium falciparum	serine repeat antigen 3	0.0108	0.0896	0.1995
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	0.0027	0.0091	0.0156
Echinococcus granulosus	biogenic amine 5HT receptor	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Brugia malayi	Dopamine receptor protein 1	0.0018	0.0005	0.0005
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0077	0.058	0.1272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0462	0.4399	0.7624
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0862	0.0862
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0776	0.0776
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.006	0.0413	0.0413
Trichomonas vaginalis	set domain proteins, putative	0.0531	0.508	0.881
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0222	0.2025	0.2025
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0454	0.0454
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1027	1	1
Echinococcus multilocularis	g-protein coupled receptor	0.0018	0.0005	0.0005
Trypanosoma brucei	pyruvate kinase 1, putative	0.0109	0.0905	0.1651
Echinococcus multilocularis	cathepsin L	0.0252	0.2316	0.2316
Echinococcus granulosus	calpain	0.0021	0.0027	0.0027
Loa Loa (eye worm)	pyruvate kinase-PB	0.0076	0.0577	0.0577
Echinococcus granulosus	polycomb protein SCMH1	0.0052	0.0341	0.0341
Onchocerca volvulus		0.0052	0.0341	0.0664
Trichomonas vaginalis	chromobox protein, putative	0.008	0.061	0.1024
Onchocerca volvulus		0.0462	0.4399	0.8658
Schistosoma mansoni	hypothetical protein	0.0537	0.5143	0.5143
Echinococcus multilocularis	pyruvate kinase	0.0086	0.0677	0.0677
Brugia malayi	Animal haem peroxidase family protein	0.0105	0.0862	0.0862
Brugia malayi	Phosphoglycerate kinase	0.0034	0.0162	0.0162
Loa Loa (eye worm)	cysteine protease	0.0462	0.4399	0.4399
Echinococcus granulosus	calpain A	0.0058	0.0391	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2541	0.2541
Onchocerca volvulus		0.0105	0.0862	0.1689
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0462	0.4399	0.4399
Echinococcus multilocularis	smad	0.0026	0.008	0.008
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Entamoeba histolytica	phosphoglycerate kinase, putative	0.0094	0.0749	0.166
Toxoplasma gondii	thioredoxin reductase	0.0221	0.2009	0.4558
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0027	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0005	0.0005
Giardia lamblia	Cathepsin L precursor	0.0108	0.0896	0.2367
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.0896	0.1521
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.002	0.0023	0.0023
Echinococcus granulosus	sulfide:quinone oxidoreductase	0.002	0.0023	0.0023
Onchocerca volvulus		0.008	0.0613	0.1199
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0058	0.0391	0.0391
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0096	0.0776	0.0776
Giardia lamblia	Cathepsin L precursor	0.0108	0.0896	0.2367
Onchocerca volvulus		0.0034	0.0161	0.0308
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.0896	0.1521
Plasmodium vivax	glutathione reductase, putative	0.0221	0.2009	0.4539
Brugia malayi	Cathepsin L-like precursor	0.0462	0.4399	0.4399
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0005	0.0005
Schistosoma mansoni	peroxidasin	0.0105	0.0862	0.0862
Toxoplasma gondii	NADH dehydrogenase (NDH2-II)	0.002	0.0023	0.0034
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.007	0.0512	0.1326
Echinococcus granulosus	smad	0.0026	0.008	0.008
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0005	0.0005
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0108	0.0896	0.1995
Entamoeba histolytica	cysteine protease, putative	0.0252	0.2316	0.524
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0504	0.4812	0.8958
Brugia malayi	Cathepsin L-like precursor	0.0319	0.2979	0.2979
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0207	0.0207
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0261	0.0447
Plasmodium falciparum	proteasome subunit beta type-5	0.007	0.0512	0.1118
Echinococcus granulosus	neuropeptides capa receptor	0.0018	0.0005	0.0005
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0026	0.008	0.008
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0027	0.0004
Echinococcus multilocularis	pyruvate kinase	0.0056	0.0378	0.0378
Echinococcus multilocularis		0.0027	0.0091	0.0091
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Entamoeba histolytica	NLI interacting factor-like phosphatase domain-containing protein	0.0027	0.0091	0.0156
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0454	0.0454
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.006	0.0413	0.0413
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0034	0.0162	0.014
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0108	0.0896	0.0896
Echinococcus granulosus	dna polymerase eta	0.0065	0.0467	0.0467
Echinococcus granulosus	traf and tnf receptor associated protein	0.0193	0.1735	0.1735
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0058	0.0391	0.0391
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0207	0.0207
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.007	0.0512	0.0852
Loa Loa (eye worm)	calpain family protein 1	0.0055	0.0366	0.0366
Onchocerca volvulus		0.0186	0.1667	0.3276
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0462	0.4399	0.7624
Brugia malayi	hypothetical protein	0.0275	0.2541	0.2541
Trypanosoma brucei	DNA polymerase kappa, putative	0.0066	0.0479	0.0855
Brugia malayi	Pre-SET motif family protein	0.0067	0.0484	0.0484
Entamoeba histolytica	cysteine protease, putative	0.0252	0.2316	0.524
Echinococcus multilocularis	neuropeptides capa receptor	0.0018	0.0005	0.0005
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0077	0.058	0.0558
Echinococcus multilocularis	cysteine protease	0.0462	0.4399	0.4399
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0108	0.0896	0.1995
Onchocerca volvulus	Pyruvate kinase homolog	0.0109	0.0905	0.1774
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0053	0.0031
Trypanosoma brucei	unspecified product	0.0026	0.0075	0.0099
Brugia malayi	hypothetical protein	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0467	0.0467
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0052	0.0341	0.0341
Echinococcus granulosus	neuropeptide receptor	0.0018	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0229	0.2089	0.2089
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.008	0.0613	0.0613
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0037	0.019	0.019
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0027	0.0091	0.0119
Loa Loa (eye worm)	MBCTL1	0.006	0.0413	0.0413
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0077	0.058	0.0558
Trypanosoma brucei	DNA polymerase kappa, putative	0.0066	0.0479	0.0855
Plasmodium falciparum	serine repeat antigen 6	0.0108	0.0896	0.1995
Trichomonas vaginalis	dullard protein, putative	0.0027	0.0091	0.0119
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0252	0.2316	0.3995
Loa Loa (eye worm)	blistered cuticle protein 3	0.0105	0.0862	0.0862
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0077	0.058	0.058
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.056	0.5366	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0018	0.0005	0.0005
Schistosoma mansoni	calpain-7 (C02 family)	0.0021	0.0027	0.0027
Brugia malayi	cathepsin L precursor	0.0108	0.0896	0.0896
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.007	0.0512	0.0915
Echinococcus granulosus	NADPH:adrenodoxin oxidoreductase	0.002	0.0023	0.0023
Schistosoma mansoni	smad1 5 8 and	0.0026	0.008	0.008
Echinococcus granulosus	histone lysine methyltransferase setb	0.0067	0.0484	0.0484
Toxoplasma gondii	pyruvate kinase PyK1	0.0109	0.0905	0.2043
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0862	0.0862
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0109	0.0905	0.165
Plasmodium falciparum	thioredoxin reductase	0.0077	0.058	0.1272
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0156	0.137	0.2521
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Trypanosoma cruzi	cysteine peptidase, putative	0.056	0.5366	0.5356
Trypanosoma brucei	unspecified product	0.0026	0.0075	0.0099
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0027	0.0008
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0136	0.1169	0.1998
Brugia malayi	Pre-SET motif family protein	0.0466	0.4442	0.4442
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.002	0.0023	0.0034
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.0386	0.0386
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0136	0.1169	0.1169
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0056	0.0378	0.0378
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0462	0.4399	1
Plasmodium falciparum	pyruvate kinase 2	0.0056	0.0378	0.0811
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0252	0.2316	0.4292
Brugia malayi	mbt repeat family protein	0.0052	0.0341	0.0341
Trichomonas vaginalis	pyruvate kinase, putative	0.0109	0.0905	0.1537
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0005	0.0005
Echinococcus granulosus	hypothetical protein	0.0018	0.0005	0.0005
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0386	0.0386
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0294	0.2737	0.6202
Echinococcus multilocularis	neuropeptide Y receptor	0.0018	0.0005	0.0005
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1027	1	1
Loa Loa (eye worm)	animal heme peroxidase	0.0105	0.0862	0.0862
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0108	0.0896	0.0896
Onchocerca volvulus		0.0462	0.4399	0.8658
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0077	0.058	0.0558
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0108	0.0896	0.1995
Brugia malayi	NADPH:adrenodoxin oxidoreductase, mitochondrial precursor	0.002	0.0023	0.0023
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0053	0.007
Echinococcus multilocularis	neuropeptides capa receptor	0.0018	0.0005	0.0005
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.002	0.0023	0.0023
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0416	0.3946	0.3932
Echinococcus multilocularis	Carboxy terminal domain RNA polymerase II	0.0027	0.0091	0.0091
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0214	0.1939	0.1939
Wolbachia endosymbiont of Brugia malayi	phosphoglycerate kinase	0.0094	0.0749	1
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0454	0.0454
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0108	0.0896	0.1521
Schistosoma mansoni	amine GPCR	0.0018	0.0005	0.0005
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0077	0.058	0.058
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0108	0.0896	0.2367
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0108	0.0896	0.1521
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0005	0.0005
Brugia malayi	mbt repeat family protein	0.0052	0.0341	0.0341
Mycobacterium ulcerans	citrate lyase beta subunit, CitE_2	0.0027	0.0088	0.0114
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.006	0.0413	0.0413
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0252	0.2316	0.2299
Loa Loa (eye worm)	hypothetical protein	0.0229	0.2089	0.2089
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0027	0.0088	0.0065
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0252	0.2316	0.2316
Echinococcus multilocularis	histone acetyltransferase MYST2	0.006	0.0413	0.0413
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0018	0.0005	0.0005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0462	0.4399	0.7624
Brugia malayi	hypothetical protein	0.0018	0.0005	0.0005
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.007	0.0512	0.0512
Trypanosoma cruzi	trypanothione reductase, putative	0.0077	0.058	0.0558
Schistosoma mansoni	hypothetical protein	0.0047	0.0284	0.0284
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0018	0.0005	0.0005
Trichomonas vaginalis	chromobox protein, putative	0.008	0.061	0.1024
Brugia malayi	Cathepsin L-like precursor	0.0462	0.4399	0.4399
Onchocerca volvulus	Pyruvate kinase homolog	0.0109	0.0905	0.1774
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0108	0.0896	0.1521
Schistosoma mansoni	chromobox protein	0.008	0.061	0.061
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0018	0.0005	0.0005
Toxoplasma gondii	cathepsin B	0.0393	0.3711	0.8434
Entamoeba histolytica	cysteine protease, putative	0.0108	0.0896	0.1995
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0484	0.0484
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0294	0.2737	0.2737
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.002	0.0023	0.0023
Schistosoma mansoni	sulfide quinone reductase	0.002	0.0023	0.0023
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0005	0.0005
Echinococcus granulosus	citrate lyase subunit beta protein	0.0027	0.0088	0.0088
Toxoplasma gondii	phosphoglycerate kinase PGKI	0.0094	0.0749	0.1689
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0067	0.0484	0.0484
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0108	0.0896	0.0896
Entamoeba histolytica	cysteine proteinase, putative	0.0462	0.4399	1
Schistosoma mansoni	myelin transcription factor 1 myt1	0.006	0.0413	0.0413
Trypanosoma cruzi	DNA polymerase eta, putative	0.0065	0.0467	0.0446
Brugia malayi	putative neuropeptide receptor	0.0018	0.0005	0.0005
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0037	0.019	0.019
Giardia lamblia	Hypothetical protein	0.0108	0.0896	0.2367
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.056	0.5366	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0462	0.4399	0.7624
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0052	0.034	0.4376
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Echinococcus granulosus	neuropeptides capa receptor	0.0018	0.0005	0.0005
Leishmania major	cathepsin L-like protease	0.0462	0.4399	0.819
Brugia malayi	Smad1	0.0026	0.008	0.008
Giardia lamblia	Cysteine protease	0.0108	0.0896	0.2367
Brugia malayi	hypothetical protein	0.0018	0.0005	0.0005
Plasmodium falciparum	pyruvate kinase	0.0109	0.0905	0.2016
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0005	0.0005
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0504	0.4812	0.8958
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0018	0.0005	0.0005
Trichomonas vaginalis	mercuric reductase, putative	0.0077	0.058	0.097
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0005	0.0005
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0034	0.0162	0.014
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0862	0.0862
Schistosoma mansoni	glutamate synthase	0.002	0.0023	0.0023
Echinococcus granulosus	neuropeptide s receptor	0.0018	0.0005	0.0005
Brugia malayi	G protein-coupled receptor F59B2.13	0.0018	0.0005	0.0005
Loa Loa (eye worm)	heterochromatin protein 1	0.008	0.061	0.061
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0052	0.0341	0.0341
Trypanosoma brucei	DNA polymerase kappa, putative	0.0033	0.0147	0.0233
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0018	0.0005	0.0005
Giardia lamblia	Cathepsin B precursor	0.0108	0.0896	0.2367
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0264	0.042
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.056	0.5369	1
Onchocerca volvulus	Cathepsin L homolog	0.0462	0.4399	0.8658
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0027	0.0088	0.0065
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0294	0.2737	0.272
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Trypanosoma brucei	phosphoglycerate kinase	0.0094	0.0749	0.136
Loa Loa (eye worm)	melatonin receptor type 1A	0.0018	0.0005	0.0005
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0462	0.4399	0.7624
Echinococcus multilocularis	allatostatin A receptor	0.0018	0.0005	0.0005
Schistosoma mansoni	glutamate synthase	0.002	0.0023	0.0023
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0454	0.0454
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0018	0.0005	0.0005
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0005	0.0005
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0077	0.058	0.1042
Giardia lamblia	Cathepsin B precursor	0.0108	0.0896	0.2367
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.0033	0.0149	0.0149
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0294	0.2737	0.2737
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Entamoeba histolytica	cysteine protease, putative	0.0108	0.0896	0.1995
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Brugia malayi	ORL1-like opioid receptor	0.0018	0.0005	0.0005
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0284	0.0284
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0005	0.0005
Echinococcus multilocularis	pyruvate kinase	0.0056	0.0378	0.0378
Echinococcus multilocularis	neuropeptide receptor A26	0.0018	0.0005	0.0005
Loa Loa (eye worm)	glutaminase 2	0.06	0.5763	0.5763
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0393	0.3711	0.3711
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0462	0.4399	0.7624
Echinococcus granulosus	cathepsin L	0.0252	0.2316	0.2316
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0052	0.034	0.0554
Brugia malayi	Papain family cysteine protease containing protein	0.0252	0.2316	0.2316
Onchocerca volvulus	Chorion peroxidase homolog	0.0105	0.0862	0.1689
Plasmodium vivax	serine-repeat antigen (SERA)	0.0108	0.0896	0.1995
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0018	0.0005	0.0005
Chlamydia trachomatis	phosphoglycerate kinase	0.0094	0.0749	0.8234
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0462	0.4399	1
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0294	0.2737	0.2737
Toxoplasma gondii	pyruvate kinase PyKII	0.0056	0.0378	0.0842
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0462	0.4399	1
Plasmodium vivax	vivapain-1	0.0252	0.2316	0.524
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0018	0.0005	0.0005
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0067	0.0484	0.0484
Plasmodium falciparum	serine repeat antigen 9	0.0108	0.0896	0.1995
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0504	0.4812	0.8958
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0136	0.1169	0.2145
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0077	0.058	0.1042
Echinococcus multilocularis	fmrfamide receptor	0.0018	0.0005	0.0005
Echinococcus granulosus	glutamate synthase	0.002	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Echinococcus granulosus	dna polymerase kappa	0.0066	0.0479	0.0479
Giardia lamblia	Cathepsin B precursor	0.0393	0.3711	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0108	0.0896	0.1521
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0226	0.038
Loa Loa (eye worm)	mbt repeat family protein	0.0052	0.0341	0.0341
Loa Loa (eye worm)	MH2 domain-containing protein	0.0383	0.3619	0.3619
Trypanosoma brucei	DNA polymerase kappa, putative	0.0066	0.0479	0.0855
Echinococcus granulosus	pyruvate kinase	0.0056	0.0378	0.0378
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0466	0.4442	0.4442
Brugia malayi	GnHR receptor homolog	0.0018	0.0005	0.0005
Leishmania major	cathepsin L-like protease	0.056	0.5366	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0067	0.0484	0.0484
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0393	0.3711	0.3697
Schistosoma mansoni	sex comb on midleg homolog	0.0052	0.0341	0.0341
Schistosoma mansoni	pyruvate kinase	0.0056	0.0378	0.0378
Brugia malayi	sulfakinin receptor protein	0.0018	0.0005	0.0005
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0018	0.0005	0.0005
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.007	0.0512	0.049
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0294	0.2737	0.5079
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Mycobacterium ulcerans	DNA polymerase IV	0.0066	0.0479	0.0796
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0066	0.0479	0.0458
Echinococcus granulosus	histone acetyltransferase MYST2	0.006	0.0413	0.0413
Brugia malayi	chromobox protein homolog 3	0.0045	0.0264	0.0264
Brugia malayi	putative neuropeptide receptor NPR1	0.0018	0.0005	0.0005
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0108	0.0896	0.0896
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0056	0.0378	0.0378
Onchocerca volvulus		0.002	0.0023	0.0035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0462	0.4399	0.7624
Trypanosoma brucei	phosphoglycerate kinase	0.0094	0.0749	0.136
Entamoeba histolytica	cysteine protease, putative	0.0252	0.2316	0.524
Echinococcus granulosus	microtubule associated protein 2	0.0716	0.6917	0.6917
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0027	0.0004
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0053	0.0053
Loa Loa (eye worm)	cathepsin B	0.0393	0.3711	0.3711
Trypanosoma cruzi	cysteine proteinase, putative	0.0252	0.2316	0.2299
Echinococcus multilocularis	sulfide:quinone oxidoreductase	0.002	0.0023	0.0023
Schistosoma mansoni	growth hormone secretagogue receptor	0.0018	0.0005	0.0005
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	0.0027	0.0091	0.0156
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0052	0.034	0.0595
Leishmania major	DNA polymerase kappa, putative	0.0044	0.0261	0.0447
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0066	0.0479	0.0796
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0366	0.0366
Loa Loa (eye worm)	pyruvate kinase	0.0109	0.0905	0.0905
Brugia malayi	MH2 domain containing protein	0.0026	0.008	0.008
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0077	0.058	0.0558
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0462	0.4399	0.7624
Onchocerca volvulus	Peroxidase homolog	0.0105	0.0862	0.1689
Brugia malayi	AKH receptor	0.0018	0.0005	0.0005
Echinococcus multilocularis	NADPH:adrenodoxin oxidoreductase	0.002	0.0023	0.0023
Trypanosoma cruzi	cysteine peptidase, putative	0.056	0.5366	0.5356
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0108	0.0896	0.1995
Echinococcus multilocularis	Smad4	0.0026	0.008	0.008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.0896	0.1521
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0077	0.058	0.6312
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0053	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Entamoeba histolytica	cysteine proteinase, putative	0.0462	0.4399	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Mycobacterium tuberculosis	Probable dehydrogenase	0.0504	0.4812	0.8958
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.056	0.5366	1
Loa Loa (eye worm)	pyruvate kinase	0.0023	0.005	0.005
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0108	0.0896	0.0896
Echinococcus multilocularis	cathepsin b	0.1027	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0252	0.2316	0.524
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0052	0.034	0.0758
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0096	0.0776	0.0776
Echinococcus granulosus	cathepsin l1	0.0319	0.2979	0.2979
Onchocerca volvulus		0.0462	0.4399	0.8658
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0749	0.0749
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0018	0.0005	0.0005
Schistosoma mansoni	calpain C (C02 family)	0.0021	0.0027	0.0027
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0066	0.0479	0.0458
Brugia malayi	RE15519p	0.0018	0.0005	0.0005
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0294	0.2737	0.2737
Echinococcus granulosus	pyruvate kinase	0.0056	0.0378	0.0378
Echinococcus multilocularis	serine:threonine protein kinase	0.0238	0.218	0.218
Onchocerca volvulus	Cathepsin L homolog	0.0462	0.4399	0.8658
Echinococcus granulosus	calpain 7 C02 family	0.0021	0.0027	0.0027
Chlamydia trachomatis	pyruvate kinase	0.0109	0.0905	1
Brugia malayi	calpain family protein 1	0.0055	0.0366	0.0366
Giardia lamblia	Cysteine protease	0.0108	0.0896	0.2367
Echinococcus multilocularis	dna polymerase eta	0.0065	0.0467	0.0467
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0077	0.058	0.1042
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.006	0.0413	0.0413
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0386	0.0386
Schistosoma mansoni	aldehyde dehydrogenase	0.0136	0.1169	0.1169
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0252	0.2316	0.2316
Mycobacterium ulcerans	hypothetical protein	0.0174	0.1545	0.2652
Brugia malayi	Papain family cysteine protease containing protein	0.0252	0.2316	0.2316
Treponema pallidum	NADH oxidase	0.0077	0.058	0.7666
Entamoeba histolytica	cysteine protease, putative	0.0252	0.2316	0.524
Schistosoma mansoni	hypothetical protein	0.0018	0.0005	0.0005
Echinococcus granulosus	mothers against decapentaplegic 5	0.0026	0.008	0.008
Toxoplasma gondii	proteasome subunit beta type, putative	0.007	0.0512	0.1148
Plasmodium vivax	unspecified product	0.0108	0.0896	0.1995
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0027	0.0008
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0053	0.0083
Trypanosoma brucei	DNA polymerase kappa, putative	0.0066	0.0479	0.0855
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0226	0.038
Plasmodium vivax	thioredoxin reductase, putative	0.0221	0.2009	0.4539
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0005	0.0005
Plasmodium falciparum	NLI interacting factor-like phosphatase, putative	0.0027	0.0091	0.0156
Entamoeba histolytica	cysteine protease, putative	0.0252	0.2316	0.524
Schistosoma mansoni	Smad4	0.0026	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.002	0.0023	0.0023
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0135	0.0195
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0067	0.0484	0.1085
Loa Loa (eye worm)	animal heme peroxidase	0.0105	0.0862	0.0862
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0027	0.0091	0.0091
Plasmodium falciparum	phosphoglycerate kinase	0.0094	0.0749	0.166
Echinococcus granulosus	cathepsin L	0.0108	0.0896	0.0896
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0005	0.0005
Schistosoma mansoni	amine GPCR	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0319	0.2979	0.2979
Entamoeba histolytica	hypothetical protein	0.0052	0.034	0.0726
Mycobacterium tuberculosis	Probable reductase	0.0504	0.4812	0.8958
Brugia malayi	Papain family cysteine protease containing protein	0.0108	0.0896	0.0896
Schistosoma mansoni	glutamate synthase	0.002	0.0023	0.0023
Trypanosoma cruzi	cysteine peptidase, putative	0.056	0.5366	0.5356
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0108	0.0896	0.1995
Schistosoma mansoni	phosphoglycerate kinase	0.0094	0.0749	0.0749
Schistosoma mansoni	microtubule-associated protein tau	0.0716	0.6917	0.6917
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0108	0.0896	0.1995
Entamoeba histolytica	cysteine protease, putative	0.0252	0.2316	0.524
Schistosoma mansoni	opsin-like receptor	0.0018	0.0005	0.0005
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0094	0.0749	0.0728
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0005	0.0005
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0077	0.058	0.1042
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.056	0.5366	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0053	0.007
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0005	0.0005
Giardia lamblia	Encystation-specific protease	0.0108	0.0896	0.2367
Echinococcus multilocularis	cathepsin b	0.1027	1	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0341	0.0341
Trypanosoma brucei	DNA polymerase kappa, putative	0.0033	0.0147	0.0233
Echinococcus granulosus	Smad4	0.0026	0.008	0.008
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0108	0.0896	0.2023
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0108	0.0896	0.1521
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0077	0.058	0.7666
Entamoeba histolytica	cysteine protease, putative	0.0462	0.4399	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0229	0.2089	0.2089
Echinococcus multilocularis	fmrfamide receptor	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1242	0.1242
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0136	0.1169	0.1998
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0108	0.0896	0.1995
Toxoplasma gondii	cathepsin CPC1	0.0108	0.0896	0.2023
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0064	0.046	0.046
Toxoplasma gondii	selenide, water dikinase	0.002	0.0023	0.0034
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0027	0.0004
Mycobacterium leprae	Probable phosphoglycerate kinase Pgk	0.0094	0.0749	0.1359
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0037	0.019	0.019
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.056	0.5366	1
Schistosoma mansoni	histamine h1 receptor	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0896	0.0896
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0027	0.0091	0.0119
Trypanosoma brucei	Mitochondrial import inner membrane translocase subunit TIM50	0.0027	0.0091	0.0128
Trichomonas vaginalis	DNA polymerase eta, putative	0.0066	0.0479	0.0796
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.0896	0.1521
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1027	1	1
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0027	0.0091	0.0119
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.019	0.1707	0.1707
Trypanosoma cruzi	cysteine peptidase, putative	0.0462	0.4399	0.4386
Echinococcus granulosus	myosin light chain kinase smooth muscle	0.0238	0.218	0.218
Schistosoma mansoni	smad1 5 8 and	0.0026	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0905	0.0905
Onchocerca volvulus		0.0035	0.0168	0.0322
Onchocerca volvulus		0.0531	0.508	1
Brugia malayi	Cathepsin L-like precursor	0.0143	0.1242	0.1242
Onchocerca volvulus		0.0047	0.0284	0.055
Trypanosoma brucei	DNA polymerase kappa, putative	0.0066	0.0479	0.0855
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0504	0.4812	0.8958
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0053	0.0057
Schistosoma mansoni	chromobox protein	0.008	0.061	0.061
Onchocerca volvulus		0.0462	0.4399	0.8658
Onchocerca volvulus	Cathepsin L homolog	0.0108	0.0896	0.1756
Echinococcus granulosus	thioredoxin glutathione reductase	0.0222	0.2025	0.2025
Plasmodium vivax	vivapain-2	0.0462	0.4399	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0027	0.0004
Schistosoma mansoni	hypothetical protein	0.0039	0.0207	0.0207
Echinococcus granulosus	cysteine protease	0.0252	0.2316	0.2316
Brugia malayi	Animal haem peroxidase family protein	0.0105	0.0862	0.0862
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0462	0.4399	0.7624
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Brugia malayi	Cathepsin L-like precursor	0.0462	0.4399	0.4399
Trypanosoma brucei	DNA polymerase kappa, putative	0.0066	0.0479	0.0855
Schistosoma mansoni	pyruvate kinase	0.0109	0.0905	0.0905
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0462	0.4399	0.4399
Echinococcus granulosus	G protein coupled receptor 139	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2541	0.2541
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0018	0.0005	0.0005
Entamoeba histolytica	cysteine protease, putative	0.0108	0.0896	0.1995
Loa Loa (eye worm)	programmed cell death 8	0.002	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0319	0.2979	0.2979
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.007	0.0512	0.0512
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0045	0.0264	0.051
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Schistosoma mansoni	cathepsin B (C01 family)	0.0108	0.0896	0.0896
Echinococcus multilocularis	pyruvate kinase	0.0109	0.0905	0.0905
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0005	0.0005
Trypanosoma cruzi	major cysteine proteinase, putative	0.0108	0.0896	0.0875
Giardia lamblia	Cathepsin L-like protease	0.0108	0.0896	0.2367
Echinococcus granulosus	phosphoglycerate kinase 1	0.0094	0.0749	0.0749
Schistosoma mansoni	neuropeptide F-like receptor	0.0018	0.0005	0.0005
Trypanosoma cruzi	hypothetical protein, conserved	0.0234	0.2135	0.2117
Trypanosoma brucei	DNA polymerase IV, putative	0.0066	0.0479	0.0855
Brugia malayi	G-protein coupled receptor	0.0018	0.0005	0.0005
Plasmodium vivax	unspecified product	0.0252	0.2316	0.524
Schistosoma mansoni	adenoreceptor	0.0018	0.0005	0.0005
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0053	0.042
Trichomonas vaginalis	dullard protein, putative	0.0027	0.0091	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.002	0.0023	0.0023
Echinococcus multilocularis	dna polymerase kappa	0.0066	0.0479	0.0479
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1027	1	1
Schistosoma mansoni	DNA polymerase eta	0.0065	0.0467	0.0467
Echinococcus multilocularis	serotonin receptor	0.0018	0.0005	0.0005
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0108	0.0896	0.2367
Echinococcus multilocularis	pyruvate kinase	0.0109	0.0905	0.0905
Brugia malayi	MH1 domain containing protein	0.0026	0.008	0.008
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0462	0.4399	0.7624
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Echinococcus multilocularis	neuropeptide Y receptor	0.0018	0.0005	0.0005
Leishmania major	cathepsin L-like protease	0.0462	0.4399	0.819
Brugia malayi	Animal haem peroxidase family protein	0.0108	0.0891	0.0891
Leishmania major	DNA polymerase eta, putative	0.004	0.0213	0.0357
Trypanosoma brucei	DNA polymerase eta, putative	0.0065	0.0467	0.0832
Loa Loa (eye worm)	G-protein coupled receptor	0.0018	0.0005	0.0005
Entamoeba histolytica	cysteine protease, putative	0.0252	0.2316	0.524
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0053	0.0057
Giardia lamblia	Pyruvate kinase	0.0056	0.0378	0.0962
Echinococcus multilocularis	neuropeptide receptor	0.0018	0.0005	0.0005
Trypanosoma brucei	hypothetical protein, conserved	0.0052	0.034	0.0595
Schistosoma mansoni	disulfide oxidoreductase	0.002	0.0023	0.0023
Plasmodium falciparum	serine repeat antigen 5	0.0108	0.0896	0.1995
Brugia malayi	Dopamine receptor protein 2	0.0018	0.0005	0.0005
Brugia malayi	Melatonin receptor type 1A	0.0018	0.0005	0.0005
Treponema pallidum	phosphoglycerate kinase	0.0094	0.0749	1
Echinococcus granulosus	Carboxy terminal domain RNA polymerase II	0.0027	0.0091	0.0091
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0393	0.3711	0.6903
Entamoeba histolytica	cysteine proteinase, putative	0.0252	0.2316	0.524
Trypanosoma cruzi	DNA polymerase eta, putative	0.004	0.0213	0.0191
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0108	0.0896	0.1521
Schistosoma mansoni	smad	0.0026	0.008	0.008
Entamoeba histolytica	cysteine protease, putative	0.0108	0.0896	0.1995
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0018	0.0005	0.0005
Echinococcus multilocularis	pyridine nucleotide disulfide oxidoreductase	0.002	0.0023	0.0023
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0018	0.0005	0.0005
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0066	0.0479	0.0458
Brugia malayi	hypothetical protein	0.0018	0.0005	0.0005
Loa Loa (eye worm)	MH1 domain-containing protein	0.0026	0.008	0.008
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0896	0.0896
Loa Loa (eye worm)	MH2 domain-containing protein	0.0026	0.008	0.008
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0393	0.3711	0.6426
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0018	0.0005	0.0005
Schistosoma mansoni	cathepsin F (C01 family)	0.0319	0.2979	0.2979
Echinococcus multilocularis	neuropeptide receptor	0.0018	0.0005	0.0005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0319	0.2979	0.515
Trypanosoma brucei	calpain-like protein, putative	0.0021	0.0027	0.0008
Onchocerca volvulus		0.0462	0.4399	0.8658
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0077	0.058	0.097
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0077	0.058	0.0558
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0021	0.0027	0.0008
Echinococcus granulosus	g-protein coupled receptor	0.0018	0.0005	0.0005
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0504	0.4812	0.8958
Echinococcus multilocularis	calpain family protein 1, d	0.0041	0.0223	0.0223
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0027	0.0008
Brugia malayi	hypothetical protein	0.0018	0.0005	0.0005
Entamoeba histolytica	cysteine proteinase, putative	0.0319	0.2979	0.6755
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0046	0.0281	0.0259
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0077	0.058	0.1302
Schistosoma mansoni	cathepsin F (C01 family)	0.0462	0.4399	0.4399
Echinococcus multilocularis	apoptosis inducing factor 1 mitochondrial	0.002	0.0023	0.0023
Onchocerca volvulus	Pyruvate kinase homolog	0.0109	0.0905	0.1774
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0044	0.0261	0.0447
Schistosoma mansoni	hypothetical protein	0.0326	0.3051	0.3051
Leishmania major	cathepsin L-like protease	0.0462	0.4399	0.819
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0462	0.4399	0.7624
Schistosoma mansoni	myosin xvIII	0.0018	0.0005	0.0005
Entamoeba histolytica	cysteine proteinase, putative	0.0252	0.2316	0.524
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0454	0.0454
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.002	0.0023	0.0023
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0058	0.0391	0.0391
Echinococcus granulosus	sex peptide receptor	0.0018	0.0005	0.0005
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0066	0.0479	0.0458
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0108	0.0896	0.0896
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0077	0.058	0.0558
Plasmodium vivax	phosphoglycerate kinase, putative	0.0094	0.0749	0.166
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0462	0.4399	0.7624
Echinococcus multilocularis	cathepsin L cysteine protease	0.0462	0.4399	0.4399
Giardia lamblia	DINP protein human, muc B family	0.0044	0.0261	0.0648
Toxoplasma gondii	non-proton pumping type-II NADH dehydrogenase I	0.002	0.0023	0.0034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0319	0.2979	0.515
Mycobacterium tuberculosis	Probable oxidoreductase	0.056	0.5369	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0168	0.0168
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0005	0.0005
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0462	0.4399	0.4399
Entamoeba histolytica	pyruvate kinase, putative	0.0076	0.0577	0.1267
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0052	0.0341	0.0664
Trypanosoma brucei	phosphoglycerate kinase, putative	0.0034	0.0162	0.0261
Loa Loa (eye worm)	TYRA-2 protein	0.0018	0.0005	0.0005
Toxoplasma gondii	aldehyde dehydrogenase	0.0136	0.1169	0.2646
Onchocerca volvulus	Peroxidasin homolog	0.0108	0.0891	0.1746
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0052	0.034	0.0726
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.0896	0.1521
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0034	0.0162	0.0261
Loa Loa (eye worm)	animal heme peroxidase	0.0108	0.0891	0.0891
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0462	0.4399	0.7624
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0055	0.0366	0.0366
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0005	0.0005
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.0027	0.0088	0.0114
Trypanosoma brucei	DNA polymerase kappa, putative	0.0066	0.0479	0.0855
Plasmodium vivax	unspecified product	0.0143	0.1242	0.2785
Plasmodium falciparum	glutathione reductase	0.0077	0.058	0.1272
Mycobacterium leprae	conserved hypothetical protein	0.0052	0.034	0.0595
Trypanosoma brucei	calpain-like protein, putative	0.0021	0.0027	0.0008
Mycobacterium tuberculosis	Conserved protein	0.0027	0.0088	0.0122
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0156	0.137	0.135
Brugia malayi	follicle stimulating hormone receptor	0.0018	0.0005	0.0005
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0077	0.058	0.1272
Echinococcus granulosus	survival motor neuron protein 1	0.0229	0.2089	0.2089
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0034	0.0162	0.014
Entamoeba histolytica	cysteine protease, putative	0.0108	0.0896	0.1995
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0005	0.0005
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0109	0.0905	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0319	0.2979	0.2979
Echinococcus granulosus	CTD small phosphatase protein like	0.0027	0.0091	0.0091
Plasmodium vivax	SET domain protein, putative	0.0067	0.0484	0.1054
Giardia lamblia	Cathepsin B precursor	0.0393	0.3711	1
Echinococcus granulosus	chromobox protein 1	0.008	0.061	0.061
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0186	0.1667	0.1667
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0862	0.0862
Schistosoma mansoni	ap endonuclease	0.0023	0.0053	0.0053
Echinococcus multilocularis	cathepsin L cysteine protease	0.0462	0.4399	0.4399
Brugia malayi	MH1 domain containing protein	0.0026	0.008	0.008
Giardia lamblia	Cathepsin L precursor	0.0108	0.0896	0.2367
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.007	0.0512	0.049
Onchocerca volvulus	Peroxidase homolog	0.0105	0.0862	0.1689
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0005	0.0005
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0109	0.0905	0.165
Echinococcus multilocularis	chromobox protein 1	0.008	0.061	0.061
Mycobacterium ulcerans	pyruvate kinase	0.0109	0.0905	0.1537
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.033	0.3093	0.3077
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0018	0.0005	0.0005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.0896	0.1521
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Loa Loa (eye worm)	thioredoxin reductase	0.0221	0.2009	0.2009
Onchocerca volvulus	Huntingtin homolog	0.0275	0.2541	0.4998
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0108	0.0896	0.2367
Brugia malayi	Papain family cysteine protease containing protein	0.0108	0.0896	0.0896
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0108	0.0896	0.0896
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0005	0.0005
Brugia malayi	G protein-coupled receptor	0.0018	0.0005	0.0005
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0186	0.1667	0.1667
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0305	0.0305
Brugia malayi	glutamate synthase	0.002	0.0023	0.0023
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1242	0.1242
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0108	0.0896	0.1995
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0108	0.0896	0.1995
Trypanosoma brucei	calpain-like protein, putative	0.0021	0.0027	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0862	0.0862
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0053	0.007
Mycobacterium ulcerans	phosphoglycerate kinase	0.0094	0.0749	0.1266
Echinococcus multilocularis	calpain	0.0021	0.0027	0.0027
Trypanosoma cruzi	cysteine proteinase, putative	0.0252	0.2316	0.2299
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Giardia lamblia	Cathepsin L-like protease	0.0108	0.0896	0.2367
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0891	0.0891
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0027	0.0091	0.0091
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0053	0.0057
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0048	0.0297	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0161	0.0161
Echinococcus granulosus	chromobox protein 1	0.008	0.061	0.061
Brugia malayi	neuropeptide F receptor	0.0018	0.0005	0.0005
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0037	0.019	0.0312
Trichomonas vaginalis	conserved hypothetical protein	0.0108	0.0896	0.1521
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0108	0.0896	0.1995
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0174	0.1545	0.2847
Schistosoma mansoni	amine GPCR	0.0018	0.0005	0.0005
Echinococcus granulosus	fmrfamide receptor	0.0018	0.0005	0.0005
Echinococcus multilocularis	cysteine protease	0.0462	0.4399	0.4399
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0077	0.058	0.1042
Leishmania major	mitochondrial DNA polymerase beta	0.033	0.3093	0.5746
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0018	0.0005	0.0005
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0077	0.058	0.1042
Schistosoma mansoni	glutaminase	0.06	0.5763	0.5763
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0108	0.0896	0.1521
Brugia malayi	hypothetical protein	0.0018	0.0005	0.0005
Plasmodium falciparum	serine repeat antigen 4	0.0108	0.0896	0.1995
Echinococcus multilocularis	pyruvate kinase	0.0056	0.0378	0.0378
Schistosoma mansoni	calpain (C02 family)	0.0021	0.0027	0.0027
Echinococcus granulosus	cathepsin l1	0.0462	0.4399	0.4399
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0052	0.034	0.0554
Echinococcus granulosus	7tm_1 domain containing protein	0.0018	0.0005	0.0005
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0077	0.058	0.058
Brugia malayi	hypothetical protein	0.0018	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0223	0.0223
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0067	0.0484	0.0484
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0018	0.0005	0.0005
Leishmania major	cathepsin L-like protease	0.056	0.5366	1
Schistosoma mansoni	opsin-like receptor	0.0018	0.0005	0.0005
Loa Loa (eye worm)	Smad1	0.0026	0.008	0.008
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0252	0.2316	0.4292
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.056	0.5366	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0066	0.0479	0.0855
Schistosoma mansoni	pyruvate kinase	0.0109	0.0905	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0094	0.0749	0.1266
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0005	0.0005
Plasmodium falciparum	glutathione reductase	0.0221	0.2009	0.4539
Leishmania major	cysteine peptidase A (CPA)	0.0462	0.4399	0.819
Echinococcus granulosus	calpain 5	0.0021	0.0027	0.0027
Trypanosoma brucei	phosphoglycerate kinase	0.0034	0.0162	0.0261
Echinococcus multilocularis	serotonin receptor	0.0018	0.0005	0.0005
Plasmodium vivax	pyruvate kinase, putative	0.0109	0.0905	0.2016
Brugia malayi	MH2 domain containing protein	0.0383	0.3619	0.3619
Echinococcus granulosus	geminin	0.0537	0.5143	0.5143
Leishmania major	phosphoglycerate kinase C, glycosomal	0.0094	0.0749	0.136
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0462	0.4399	0.7624
Echinococcus multilocularis	polycomb protein SCMH1	0.0052	0.0341	0.0341
Echinococcus granulosus	neuropeptide Y receptor	0.0018	0.0005	0.0005
Echinococcus granulosus	cathepsin b	0.1027	1	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0018	0.0005	0.0005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0462	0.4399	0.7624
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0776	0.0776
Trichomonas vaginalis	dullard protein, putative	0.0027	0.0091	0.0119
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0108	0.0896	0.0896
Plasmodium falciparum	serine repeat antigen 8	0.0108	0.0896	0.1995
Brugia malayi	pyruvate kinase	0.0023	0.005	0.005
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0109	0.0905	0.0905
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0136	0.1169	0.1169
Leishmania major	pyruvate kinase	0.0109	0.0905	0.1651
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0005
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0454	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0088	0.0088
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0221	0.2009	0.3716
Leishmania major	hypothetical protein, conserved	0.0027	0.0091	0.0128
Trichomonas vaginalis	glutathione reductase, putative	0.0077	0.058	0.097
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0077	0.058	0.097
Brugia malayi	RNA binding protein	0.0064	0.0454	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0264	0.0264
Echinococcus multilocularis	proteasome (prosome, macropain)	0.007	0.0512	0.0512
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0186	0.1667	0.1667
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0077	0.058	0.0558
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.002	0.0023	0.0034

Activities

Activity type	Activity value	Assay description	Source	Reference
ACT (functional)	= 21 %	Stimulation of intracellular cAMP levels in CHO cells expressing human Melanocortin-3 receptor	ChEMBL.	12036373
ACT (functional)	= 60.5 %	Stimulation of intracellular cAMP levels in CHO cells expressing human Melanocortin-4 receptor	ChEMBL.	12036373
ACT (functional)	= 100 %	Stimulation of intracellular cAMP levels in CHO cells expressing human melanocortin 5 receptor	ChEMBL.	12036373
EC50 (binding)	= 790 nM	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL.	12036373
EC50 (binding)	= 1300 nM	Effective concentration against human melanocortin 5 receptor (hMC5R) in HEK293 cells	ChEMBL.	12036373
EC50 (binding)	= 2300 nM	Inhibition of binding to human Melanocortin-4 receptor (hMC4R)	ChEMBL.	12036373
Ki (binding)	= 190 nM	Binding affinity for human Melanocortin-4 receptor (hMC4R)	ChEMBL.	12036373
Ki (binding)	= 390 nM	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL.	12036373
Ki (binding)	= 990 nM	Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells	ChEMBL.	12036373

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL606990

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1133417