Detailed information for compound 1134717

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 623.775 | Formula: C11H29ClN9O13P3
  • H donors: 11 H acceptors: 12 LogP: -13.88 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 4
  • SMILES: CNc1nc(Cl)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O.N.N.N.N
  • InChi: 1S/C11H17ClN5O13P3.4H3N/c1-13-8-5-9(16-11(12)15-8)17(3-14-5)10-7(19)6(18)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22;;;;/h3-4,6-7,10,18-19H,2H2,1H3,(H,23,24)(H,25,26)(H,13,15,16)(H2,20,21,22);4*1H3/t4-,6-,7-,10-;;;;/m1..../s1
  • InChiKey: WUAFZHKHKNPRCP-KWIZKVQNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens G protein-coupled receptor 17 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus peptide allatostatin:somatostatin G protein-coupled receptor 17 367 aa 306 aa 21.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans hypothetical protein 0.0125 0.2921 0.2898
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0129 0.0153
Brugia malayi ecdysteroid receptor 0.0024 0.0181 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0181 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0181 0.0052
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0129 0.0124
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0181 0.0296
Echinococcus multilocularis protein patched 0.0048 0.083 0.1358
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0181 0.0052
Loa Loa (eye worm) hypothetical protein 0.0024 0.0199 0.0326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0181 0.0296
Mycobacterium ulcerans pyruvate or indole-3-pyruvate decarboxylase Pdc 0.0221 0.5526 0.5511
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0181 0.0296
Echinococcus multilocularis Niemann Pick C1 protein 0.0158 0.3835 0.6275
Echinococcus granulosus nuclear factor of activated T cells 5 0.0086 0.1875 0.3068
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0181 0.0052
Schistosoma mansoni hypothetical protein 0.0049 0.0881 0.1039
Mycobacterium leprae PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SH 0.0069 0.14 0.1225
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0181 0.0214
Loa Loa (eye worm) hypothetical protein 0.0048 0.083 0.1358
Schistosoma mansoni hypothetical protein 0.0046 0.0783 0.0924
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0199 0.0289
Trypanosoma brucei trypanothione reductase 0.0043 0.0695 0.2026
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.2447 0.4004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0181 0.0296
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0181 0.0296
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0181 0.0296
Echinococcus granulosus GPCR family 2 0.0034 0.046 0.0753
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0111 0.2545 1
Mycobacterium ulcerans acetolactate synthase 1 catalytic subunit 0.0385 1 1
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0181 0.0214
Echinococcus multilocularis expressed conserved protein 0.0104 0.2363 0.3867
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0181 0.0296
Mycobacterium ulcerans acetolactate synthase large subunit IlvB 0.0221 0.5526 0.5511
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.6111 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0199 0.0194
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0881 0.0761
Schistosoma mansoni hypothetical protein 0.0147 0.3531 0.4164
Schistosoma mansoni DNA polymerase eta 0.0022 0.0129 0.0153
Trypanosoma brucei phosphonopyruvate decarboxylase-like protein, putative 0.0125 0.2921 1
Echinococcus granulosus Protein patched homolog 1 0.0048 0.083 0.1358
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0181 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0053
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0181 0.0296
Mycobacterium ulcerans hypothetical protein 0.0385 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0181 0.0296
Leishmania major phosphonopyruvate decarboxylase-like protein 0.0125 0.2921 0.5173
Brugia malayi Thioredoxin reductase 0.0043 0.0695 0.0573
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0199 0.0129
Echinococcus multilocularis dna polymerase eta 0.0022 0.0129 0.0212
Echinococcus granulosus Niemann Pick C1 protein 0.0111 0.2545 0.4165
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0181 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0181 0.0052
Trypanosoma cruzi phosphonopyruvate decarboxylase, putative 0.0125 0.2921 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0181 0.0052
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0112 0.2592 0.3057
Echinococcus multilocularis protein dispatched 1 0.0054 0.1012 0.1656
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0147 0.3531 0.5778
Schistosoma mansoni patched 1 0.0048 0.083 0.0979
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0056 0.1062 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0181 0.0296
Loa Loa (eye worm) hypothetical protein 0.0034 0.046 0.0753
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0695 0.2026
Loa Loa (eye worm) hypothetical protein 0.0107 0.2447 0.4004
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0129 0.0212
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.071 0.1163
Giardia lamblia Pyruvate-flavodoxin oxidoreductase 0.0056 0.1062 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0239 0.6018 1
Schistosoma mansoni hypothetical protein 0.0073 0.1527 0.1801
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0056 0.1062 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0181 0.0214
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0086 0.1875 0.3068
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0129 0.0124
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0199 0.0071
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0056 0.1062 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.112 0.1833
Mycobacterium leprae Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) 0.0385 1 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0199 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0181 0.0052
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0129 0.0212
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.6111 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0181 0.0296
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0181 0.0052
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0108 0.2468 0.2315
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0181 0.0296
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0181 0.0296
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0199 0.0129
Leishmania major putative pyruvate/indole-pyruvate carboxylase, putative 0.0221 0.5526 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0181 0.0296
Treponema pallidum pyruvate oxidoreductase 0.0056 0.1062 0.5
Loa Loa (eye worm) glutathione reductase 0.0043 0.0695 0.1137
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0181 0.0296
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0181 0.0214
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0147 0.3531 0.5778
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0053
Mycobacterium tuberculosis Probable oxidoreductase (beta subunit) 0.0056 0.1062 0.1057
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0181 0.0296
Schistosoma mansoni hypothetical protein 0.0046 0.0783 0.0924
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0056 0.1062 1
Brugia malayi Latrophilin receptor protein 2 0.0034 0.046 0.0335
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0199 0.0289
Trypanosoma brucei phosphonopyruvate decarboxylase-like protein, putative 0.0125 0.2921 1
Mycobacterium tuberculosis Probable reductase 0.0097 0.2174 0.217
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0181 0.0296
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0199 0.0071
Mycobacterium leprae PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) 0.0385 1 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0129 0.0212
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.046 0.0753
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0199 0.0194
Loa Loa (eye worm) hypothetical protein 0.0024 0.0181 0.0296
Loa Loa (eye worm) hypothetical protein 0.0111 0.2545 0.4165
Echinococcus granulosus expressed conserved protein 0.0104 0.2363 0.3867
Loa Loa (eye worm) hypothetical protein 0.0024 0.0181 0.0296
Plasmodium falciparum acyl-CoA synthetase 0.0239 0.6018 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0181 0.0296
Echinococcus granulosus dna polymerase eta 0.0022 0.0129 0.0212
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0053
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0199 0.0071
Mycobacterium ulcerans 2-oxoglutarate ferredoxin oxidoreductase subunit beta 0.0056 0.1062 0.1033
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0181 0.0214
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.083 0.1358
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.2447 0.2348
Loa Loa (eye worm) hypothetical protein 0.0024 0.0199 0.0326
Loa Loa (eye worm) hypothetical protein 0.0024 0.0181 0.0296
Schistosoma mansoni thyroid hormone receptor 0.0171 0.4172 0.492
Mycobacterium ulcerans acetolactate synthase 0.0221 0.5526 0.5511
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0129 0.0097
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0199 0.0289
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0181 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0199 0.0167
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0056 0.1062 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0695 0.069
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0181 0.0052
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0181 0.0052
Mycobacterium ulcerans hypothetical protein 0.0024 0.0199 0.0167
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0181 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.083 0.7512
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.083 0.1358
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.046 0.0753
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.071 0.1163
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0056 0.1062 1
Schistosoma mansoni acetolactate synthase 0.0329 0.8479 1
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0181 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0181 0.0052
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0181 0.0214
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0181 0.0214
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0181 0.0214
Loa Loa (eye worm) hypothetical protein 0.0024 0.0181 0.0296
Loa Loa (eye worm) hypothetical protein 0.0242 0.6111 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.046 0.0753
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0108 0.2468 0.2464
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0199 0.0129
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0097 0.2174 0.217
Mycobacterium ulcerans 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase 0.0069 0.14 0.1371
Brugia malayi hypothetical protein 0.0242 0.6111 0.606
Loa Loa (eye worm) hypothetical protein 0.0024 0.0199 0.0326
Trypanosoma cruzi phosphonopyruvate decarboxylase, putative 0.0125 0.2921 1
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0695 0.1137
Schistosoma mansoni coup transcription factor 0.0024 0.0181 0.0214
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0181 0.0296
Loa Loa (eye worm) hypothetical protein 0.0073 0.1527 0.2499
Brugia malayi nuclear hormone receptor 0.0024 0.0181 0.0052
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.046 0.0753
Schistosoma mansoni acetolactate synthase 0.0329 0.8479 1
Schistosoma mansoni thyroid hormone receptor 0.0171 0.4172 0.492
Schistosoma mansoni hypothetical protein 0.0046 0.0783 0.0924
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0053
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0033 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0181 0.0052
Mycobacterium tuberculosis Probable dehydrogenase 0.0097 0.2174 0.217
Onchocerca volvulus 0.0024 0.0199 0.0258
Echinococcus granulosus dna polymerase kappa 0.0022 0.0129 0.0212
Loa Loa (eye worm) hypothetical protein 0.0024 0.0181 0.0296
Schistosoma mansoni hypothetical protein 0.0034 0.046 0.0543
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0181 0.0052
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0097 0.2174 0.2015
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.046 0.0753
Leishmania major trypanothione reductase 0.0043 0.0695 0.1048
Mycobacterium tuberculosis Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) 0.0165 0.4015 0.4011
Echinococcus granulosus Niemann Pick C1 protein 0.0158 0.3835 0.6275
Echinococcus multilocularis GPCR, family 2 0.0034 0.046 0.0753
Echinococcus multilocularis Niemann Pick C1 protein 0.0111 0.2545 0.4165
Loa Loa (eye worm) ILVBL protein 0.0233 0.5874 0.9612
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0033 0.0027
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0199 0.0167
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0108 0.2468 0.2464
Onchocerca volvulus 0.0049 0.0881 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0181 0.0052
Entamoeba histolytica pyruvate:ferredoxin oxidoreductase 0.0056 0.1062 0.386
Loa Loa (eye worm) thiamine pyrophosphate enzyme 0.0221 0.5536 0.9059
Schistosoma mansoni survival motor neuron protein 0.0049 0.0881 0.1039
Schistosoma mansoni hypothetical protein 0.0046 0.0783 0.0924
Loa Loa (eye worm) hypothetical protein 0.0022 0.0129 0.0212
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0129 0.0153
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0097 0.2174 0.217
Brugia malayi Niemann-Pick C1 protein precursor 0.0111 0.2545 0.2448
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0181 0.0214
Brugia malayi steroid hormone receptor 0.0024 0.0181 0.0052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0181 0.0296
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.083 0.1358
Brugia malayi glutathione reductase 0.0043 0.0695 0.0573
Mycobacterium tuberculosis Probable oxidoreductase 0.0108 0.2468 0.2464
Toxoplasma gondii thioredoxin reductase 0.0043 0.0695 0.5
Mycobacterium ulcerans putative oxalyl-CoA decarboxylase 0.0385 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0181 0.0296
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.2447 0.2348
Mycobacterium tuberculosis Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) 0.0385 1 1
Schistosoma mansoni hypothetical protein 0.0034 0.046 0.0543
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0181 0.0296
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0129 0.0212
Brugia malayi CHE-14 protein 0.0048 0.083 0.071
Brugia malayi nuclear receptor NHR-88 0.0024 0.0181 0.0052
Echinococcus multilocularis thyroid hormone receptor alpha 0.0171 0.4172 0.6827
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0181 0.0296
Mycobacterium tuberculosis Probable oxalyl-CoA decarboxylase OxcA 0.0385 1 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0097 0.2174 0.217
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0199 0.0167
Loa Loa (eye worm) hypothetical protein 0.0024 0.0181 0.0296
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0199 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0181 0.0296
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0181 0.0296
Schistosoma mansoni hypothetical protein 0.0034 0.046 0.0543
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.1527 0.1416
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0129 0.0097
Schistosoma mansoni hypothetical protein 0.0034 0.046 0.0543
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0199 0.0167
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.046 0.0335
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0053
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0097 0.2174 0.217
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0199 0.0167

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 11 nM Agonist activity at human GPR17 expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration assay ChEMBL. 20394377

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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