TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 748.834 | Formula: C40H47F3N6O5
H donors: 5 H acceptors: 4 LogP: 7.57 Rotable bonds: 18
Rule of 5 violations (Lipinski): 2
SMILES: NC(=N)Nc1ccc(cc1)CC(C(=O)C(F)(F)F)NC(=O)[C@H](c1ccc2c(c1)cccc2)NC(=O)[C@@H](C(C)(C)C)NC(=O)OC12CC3CC(C2)CC(C1)C3
InChi: 1S/C40H47F3N6O5/c1-38(2,3)32(49-37(53)54-39-19-23-14-24(20-39)16-25(15-23)21-39)35(52)48-31(28-11-10-26-6-4-5-7-27(26)18-28)34(51)47-30(33(50)40(41,42)43)17-22-8-12-29(13-9-22)46-36(44)45/h4-13,18,23-25,30-32H,14-17,19-21H2,1-3H3,(H,47,51)(H,48,52)(H,49,53)(H4,44,45,46)/t23?,24?,25?,30?,31-,32-,39?/m0/s1
InChiKey: FSQMPBMPAVBLCK-RQEWZCSHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	kallikrein B, plasma (Fletcher factor) 1	Starlite/ChEMBL	References
Rattus norvegicus	Plasminogen	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	hypothetical protein	Get druggable targets OG5_134971	All targets in OG5_134971
Neospora caninum	hypothetical protein	Get druggable targets OG5_134971	All targets in OG5_134971
Toxoplasma gondii	PAN domain-containing protein	Get druggable targets OG5_134971	All targets in OG5_134971
Toxoplasma gondii	PAN domain-containing protein	Get druggable targets OG5_134971	All targets in OG5_134971
Neospora caninum	hypothetical protein	Get druggable targets OG5_134971	All targets in OG5_134971

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Niemann Pick C1 protein	0.0102	0.0621	0.0608
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0249	1
Echinococcus granulosus	ring finger protein 113a	0.0022	0.0066	0.0053
Toxoplasma gondii	hypothetical protein	0.0021	0.0064	0.0062
Schistosoma mansoni	hypothetical protein	0.0042	0.0207	0.0194
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0121	0.0108
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Schistosoma mansoni	hypothetical protein	0.0042	0.0207	0.0194
Leishmania major	hypothetical protein, conserved	0.0422	0.2829	1
Echinococcus granulosus	muscleblind protein	0.0465	0.3126	0.3117
Loa Loa (eye worm)	hypothetical protein	0.0422	0.2829	0.3479
Echinococcus multilocularis	sterol regulatory element binding protein	0.0044	0.0218	0.0205
Toxoplasma gondii	microneme protein MIC17B	0.004	0.0193	0.0221
Leishmania major	hypothetical protein, conserved	0.0021	0.0064	0.0179
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0173	0.016
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.0266	0.0898
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0249	0.0291
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Schistosoma mansoni	hypothetical protein	0.0042	0.0207	0.0194
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.0266	0.0898
Onchocerca volvulus		0.0021	0.0064	0.0062
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0422	0.2829	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0422	0.2829	0.3479
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0261	0.0306
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0064	0.0179
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0021	0.0064	0.0179
Echinococcus multilocularis	E3 ubiquitin protein ligase MYLIP	0.0021	0.0064	0.0051
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.1187	0.8104	1
Onchocerca volvulus		0.004	0.0193	0.0221
Brugia malayi	PAN domain containing protein	0.004	0.0193	0.0221
Leishmania major	hypothetical protein, conserved	0.0021	0.0064	0.0179
Echinococcus granulosus	E3 ubiquitin protein ligase Bre1	0.0021	0.0064	0.0051
Schistosoma mansoni	mind bomb	0.0021	0.0064	0.0051
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Plasmodium vivax	SET domain protein, putative	0.003	0.0121	0.0133
Schistosoma mansoni	hypothetical protein	0.0422	0.2829	0.2819
Brugia malayi	Pre-SET motif family protein	0.003	0.0121	0.0133
Trypanosoma brucei	ring finger containing protein	0.0021	0.0064	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0187
Leishmania major	hypothetical protein, conserved	0.0422	0.2829	1
Loa Loa (eye worm)	hypothetical protein	0.0465	0.3126	0.3847
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0099	0.0305
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0.0064	0.0832
Echinococcus multilocularis	Niemann Pick C1 protein	0.0102	0.0621	0.0608
Brugia malayi	Zinc finger, C2H2 type family protein	0.0021	0.0064	0.0062
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Brugia malayi	Protein kinase domain containing protein	0.0027	0.0099	0.0106
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0422	0.2829	1
Toxoplasma gondii	SWI2/SNF2-containing protein RAD5	0.0021	0.0064	0.0062
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Loa Loa (eye worm)	hypothetical protein	0.004	0.0193	0.0221
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0422	0.2829	0.3479
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Loa Loa (eye worm)	hypothetical protein	0.0422	0.2829	0.3479
Toxoplasma gondii	hypothetical protein	0.0021	0.0064	0.0062
Brugia malayi	PAN domain containing protein	0.004	0.0193	0.0221
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0121	0.0108
Echinococcus multilocularis	ring finger protein 113a	0.0022	0.0066	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0621	0.075
Schistosoma mansoni	TRABID protein (C64 family)	0.0422	0.2829	0.2819
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0121	0.0133
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Schistosoma mansoni	hypothetical protein	0.1187	0.8104	0.8102
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0021	0.0064	0.0062
Leishmania major	hypothetical protein, conserved	0.0021	0.0064	0.0179
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0014	0.0014	0.0546
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0064	0.0179
Loa Loa (eye worm)	brahma associated protein	0.1187	0.8104	1
Onchocerca volvulus		0.0422	0.2829	0.3479
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0048	0.0249	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0193	0.0221
Schistosoma mansoni	hypothetical protein	0.0022	0.0066	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Brugia malayi	hypothetical protein	0.0021	0.0064	0.0062
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0121	0.0108
Echinococcus multilocularis	E3 ubiquitin protein ligase Bre1	0.0021	0.0064	0.0051
Brugia malayi	PAN domain containing protein	0.004	0.0193	0.0221
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0.0064	0.0832
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0422	0.2829	0.2819
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Toxoplasma gondii	ran binding protein	0.0422	0.2829	0.3479
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Onchocerca volvulus		0.004	0.0193	0.0221
Brugia malayi	PAN domain containing protein	0.004	0.0193	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0249	0.0291
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0249	0.3872
Toxoplasma gondii	hypothetical protein	0.004	0.0193	0.0221
Schistosoma mansoni	inhibitor of apoptosis 1 diap1	0.0021	0.0064	0.0051
Schistosoma mansoni	peter pan-related	0.0021	0.0064	0.0051
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Giardia lamblia	Kinase, NEK	0.0022	0.0067	0.0157
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Entamoeba histolytica	hypothetical protein	0.0037	0.0173	0.2633
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0021	0.0064	0.0062
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0249	1
Leishmania major	hypothetical protein, unknown function	0.0021	0.0064	0.0179
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0.0064	0.0832
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Trichomonas vaginalis	ankyrin, putative	0.0021	0.0064	0.0062
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0422	0.2829	0.3479
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0048	0.0249	1
Echinococcus multilocularis	microtubule associated protein 2	0.1462	1	1
Toxoplasma gondii	microneme protein MIC17A	0.004	0.0193	0.0221
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Plasmodium vivax	trophozoite exported protein 1, putative	0.0021	0.0064	0.0062
Loa Loa (eye worm)	PAN domain-containing protein	0.004	0.0193	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0422	0.2829	0.3479
Onchocerca volvulus	RING finger protein 141 homolog	0.0021	0.0064	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0249	0.0291
Echinococcus multilocularis		0.0021	0.0064	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Schistosoma mansoni	zinc finger protein	0.0021	0.0064	0.0051
Trichomonas vaginalis	ion channel nompc, putative	0.0021	0.0064	0.0062
Trichomonas vaginalis	ankyrin, putative	0.0021	0.0064	0.0062
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Onchocerca volvulus		0.0021	0.0064	0.0062
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0151	0.6071
Leishmania major	hypothetical protein, conserved	0.0021	0.0064	0.0179
Echinococcus multilocularis	muscleblind protein	0.0465	0.3126	0.3117
Loa Loa (eye worm)	PAN domain-containing protein	0.004	0.0193	0.0221
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0048	0.0249	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0193	0.0221
Echinococcus granulosus	SWI:SNF matrix associated	0.1187	0.8104	0.8102
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1187	0.8104	1
Onchocerca volvulus		0.004	0.0193	0.0221
Onchocerca volvulus	Protein neuralized homolog	0.0021	0.0064	0.0062
Brugia malayi	YY1-associated factor 2	0.0422	0.2829	0.3479
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0422	0.2829	0.2819
Trypanosoma brucei	hypothetical protein, conserved	0.0422	0.2829	1
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Schistosoma mansoni	zinc finger protein	0.0422	0.2829	0.2819
Toxoplasma gondii	PAN domain-containing protein	0.0373	0.2492	0.3064
Onchocerca volvulus		0.005	0.0261	0.0306
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0014	0.0546
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0249	0.0835
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0.0064	0.0832
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Echinococcus granulosus	Niemann Pick C1 protein	0.0146	0.0923	0.0911
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0422	0.2829	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0151	0.6071
Schistosoma mansoni	patched 1	0.0044	0.0218	0.0205
Schistosoma mansoni	hypothetical protein	0.1187	0.8104	0.8102
Schistosoma mansoni	hypothetical protein	0.0042	0.0207	0.0194
Brugia malayi	SWIB/MDM2 domain containing protein	0.1187	0.8104	1
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0014	0.0014	0.0546
Trypanosoma cruzi	hypothetical protein, conserved	0.0422	0.2829	1
Mycobacterium ulcerans	hypothetical protein	0.0048	0.0249	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0422	0.2829	1
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.1187	0.8104	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0104	0.0632	0.0619
Onchocerca volvulus		0.004	0.0193	0.0221
Trypanosoma cruzi	hypothetical protein, conserved	0.0422	0.2829	1
Loa Loa (eye worm)	RING finger protein 20	0.0021	0.0064	0.0062
Loa Loa (eye worm)	hypothetical protein	0.004	0.0193	0.0221
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0014	0.0546
Echinococcus multilocularis	protein patched	0.0044	0.0218	0.0205
Brugia malayi	hypothetical protein	0.0245	0.1609	0.1972
Chlamydia trachomatis	DNA topoisomerase I	0.1187	0.8104	1
Schistosoma mansoni	microtubule-associated protein tau	0.1462	1	1
Trypanosoma cruzi	WLM domain containing protein, putative	0.0422	0.2829	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0249	0.0835
Toxoplasma gondii	hypothetical protein	0.0021	0.0064	0.0062
Leishmania major	hypothetical protein, conserved	0.0021	0.0064	0.0179
Trichomonas vaginalis	cell cycle control protein cwf24, putative	0.0022	0.0066	0.0065
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0173	0.016
Brugia malayi	RING zinc finger protein	0.0021	0.0064	0.0062
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0021	0.0064	0.0051
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0266	0.0312
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0021	0.0064	0.0062
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0048	0.0249	1
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0218	0.0253
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0249	1
Schistosoma mansoni	RNA binding protein	0.0422	0.2829	0.2819
Onchocerca volvulus		0.0027	0.0099	0.0106
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Plasmodium falciparum	trophozoite exported protein 1	0.0021	0.0064	0.0062
Entamoeba histolytica	hypothetical protein	0.0037	0.0173	0.2633
Trypanosoma brucei	protein kinase, putative	0.0051	0.0266	0.0898
Entamoeba histolytica	acyl-coA synthetase, putative	0.0048	0.0249	0.3872
Brugia malayi	Kringle domain containing protein	0.0027	0.0099	0.0106
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0021	0.0064	0.0062
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0014	0.0546
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0266	0.0898
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0249	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0114	0.01
Schistosoma mansoni	fusion	0.0422	0.2829	0.2819
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0021	0.0064	0.0062
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0266	0.0312
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0173	0.016
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0422	0.2829	1
Plasmodium vivax	RING zinc finger protein, putative	0.0021	0.0064	0.0062
Echinococcus multilocularis	RING finger and transmembrane domain containing protein	0.0021	0.0064	0.0051
Onchocerca volvulus		0.004	0.0193	0.0221
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Brugia malayi	hypothetical protein	0.0037	0.0173	0.0198
Toxoplasma gondii	kringle domain-containing protein	0.0027	0.0099	0.0106
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0422	0.2829	0.3479
Leishmania major	hypothetical protein, conserved	0.0021	0.0064	0.0179
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Brugia malayi	hypothetical protein	0.0021	0.0064	0.0062
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0266	0.0312
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0422	0.2829	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0173	0.2633
Leishmania major	hypothetical protein, conserved	0.0021	0.0064	0.0179
Brugia malayi	PAN domain containing protein	0.004	0.0193	0.0221
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0422	0.2829	0.3479
Leishmania major	hypothetical protein, conserved	0.0021	0.0064	0.0179
Echinococcus granulosus	tissue type plasminogen activator	0.0027	0.0099	0.0086
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0422	0.2829	1
Onchocerca volvulus		0.004	0.0193	0.0221
Onchocerca volvulus	Putative RING finger protein 207	0.0021	0.0064	0.0062
Loa Loa (eye worm)	hypothetical protein	0.004	0.0193	0.0221
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Schistosoma mansoni	hypothetical protein	0.0021	0.0064	0.0051
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0021	0.0064	0.0062
Plasmodium vivax	zinc finger protein, putative	0.0021	0.0064	0.0062
Onchocerca volvulus		0.004	0.0193	0.0221
Toxoplasma gondii	PAN domain-containing protein	0.004	0.0193	0.0221
Trypanosoma cruzi	hypothetical protein	0.0021	0.0064	0.0179
Toxoplasma gondii	PAN/Apple domain-containing protein	0.004	0.0193	0.0221
Onchocerca volvulus		0.0048	0.0249	0.0291
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0064	0.0179
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0422	0.2829	0.3479
Echinococcus granulosus	cell growth regulator with ring finger domain	0.0021	0.0064	0.0051
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Toxoplasma gondii	microneme protein, putative	0.004	0.0193	0.0221
Loa Loa (eye worm)	TK/ROR protein kinase	0.0027	0.0099	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0465	0.3126	0.3847
Loa Loa (eye worm)	PAN domain-containing protein	0.004	0.0193	0.0221
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0064	0.0179
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Trypanosoma brucei	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0021	0.0064	0.0062
Toxoplasma gondii	RING zinc finger protein	0.0021	0.0064	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Schistosoma mansoni	hypothetical protein	0.1187	0.8104	0.8102
Schistosoma mansoni	hypothetical protein	0.0027	0.0099	0.0086
Chlamydia trachomatis	SWIB complex protein	0.1187	0.8104	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0036	0.0165	0.6617
Echinococcus multilocularis	Niemann Pick C1 protein	0.0146	0.0923	0.0911
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Echinococcus multilocularis	ring finger protein 170	0.0021	0.0064	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Echinococcus multilocularis	protein dispatched 1	0.005	0.0261	0.0248
Giardia lamblia	Kinase, NEK	0.0022	0.0067	0.0157
Schistosoma mansoni	hypothetical protein	0.0021	0.0064	0.0051
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0064	0.0179
Entamoeba histolytica	hypothetical protein	0.0021	0.0064	0.0832
Plasmodium falciparum	zinc finger protein, putative	0.0021	0.0064	0.0062
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0121	0.0108
Toxoplasma gondii	microneme protein MIC17C	0.004	0.0193	0.0221
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Echinococcus granulosus	sterol regulatory element binding protein	0.0044	0.0218	0.0205
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.1187	0.8104	0.8102
Onchocerca volvulus		0.004	0.0193	0.0221
Onchocerca volvulus		0.0021	0.0064	0.0062
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0121	0.0108
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0.0064	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0187
Toxoplasma gondii	microneme protein MIC4	0.004	0.0193	0.0221
Leishmania major	hypothetical protein, conserved	0.0027	0.0099	0.0305
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0064	0.0179
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Leishmania major	hypothetical protein, conserved	0.0021	0.0064	0.0179
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0021	0.0064	0.0062
Echinococcus multilocularis	tissue type plasminogen activator	0.0027	0.0099	0.0086
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.0266	0.0898
Leishmania major	DNA repair protein-like protein	0.0021	0.0064	0.0179
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0253
Echinococcus granulosus	survival motor neuron protein 1	0.0245	0.1609	0.1597
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Schistosoma mansoni	rnf5	0.0021	0.0064	0.0051
Echinococcus multilocularis	expressed conserved protein	0.0096	0.0578	0.0565
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0021	0.0064	0.0062
Echinococcus multilocularis	muscleblind protein 1	0.0465	0.3126	0.3117
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0422	0.2829	0.2819
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0187
Trichomonas vaginalis	conserved hypothetical protein	0.1187	0.8104	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0064	0.0062
Onchocerca volvulus		0.1187	0.8104	1
Toxoplasma gondii	subtilisin SUB12	0.004	0.0193	0.0221
Echinococcus multilocularis	E3 ubiquitin protein ligase LRSAM1	0.0021	0.0064	0.0051
Brugia malayi	hypothetical protein	0.0021	0.0064	0.0062
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0.0064	0.0832
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0208	0.1348	0.1649
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0422	0.2829	1
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Trypanosoma brucei	SNF2 family N-terminal domain/Ring finger domain containing protein, putative	0.0021	0.0064	0.0179
Echinococcus granulosus	RING finger protein 185	0.0021	0.0064	0.0051
Plasmodium vivax	DNA repair protein RAD5, putative	0.0021	0.0064	0.0062
Onchocerca volvulus		0.004	0.0193	0.0221
Brugia malayi	RING finger protein 20	0.0021	0.0064	0.0062
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Loa Loa (eye worm)	hypothetical protein	0.004	0.0193	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0064	0.0062
Echinococcus multilocularis	survival motor neuron protein 1	0.0245	0.1609	0.1597
Echinococcus multilocularis	RING finger protein 185	0.0021	0.0064	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0064	0.0062
Onchocerca volvulus		0.0021	0.0064	0.0062
Toxoplasma gondii	hypothetical protein	0.004	0.0193	0.0221
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0021	0.0064	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0245	0.1609	0.1972
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.0266	0.0253
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.0266	0.0253
Onchocerca volvulus		0.0422	0.2829	0.3479
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0014	0.0014	0.0546
Brugia malayi	PAN domain containing protein	0.004	0.0193	0.0221
Echinococcus granulosus	zinc finger protein Ran binding	0.0422	0.2829	0.2819
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0422	0.2829	0.3479
Trichomonas vaginalis	ankyrin, putative	0.0021	0.0064	0.0062
Giardia lamblia	Kinase	0.0022	0.0067	0.0157
Trypanosoma brucei	hypothetical protein, conserved	0.0422	0.2829	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0064	0.0062
Entamoeba histolytica	SPRY domain protein	0.0021	0.0064	0.0832
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.0266	0.0253
Plasmodium falciparum	E3 ubiquitin-protein ligase RNF5, putative	0.0021	0.0064	0.0062
Onchocerca volvulus		0.0021	0.0064	0.0062
Trichomonas vaginalis	hypothetical protein	0.0021	0.0064	0.0062
Plasmodium falciparum	RING zinc finger protein, putative	0.0021	0.0064	0.0062
Brugia malayi	PAN domain containing protein	0.004	0.0193	0.0221
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Brugia malayi	B-box zinc finger family protein	0.0021	0.0064	0.0062
Brugia malayi	hypothetical protein	0.0021	0.0064	0.0062
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Trypanosoma brucei	DNA repair protein, putative	0.0021	0.0064	0.0179
Brugia malayi	brahma associated protein 60 kDa	0.1187	0.8104	1
Loa Loa (eye worm)	RiNg Finger protein family member	0.0022	0.0066	0.0065
Leishmania major	hypothetical protein, conserved	0.0021	0.0064	0.0179
Plasmodium vivax	E3 ubiquitin-protein ligase, putative	0.0021	0.0064	0.0062
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0842	0.5721	0.5715
Brugia malayi	Muscleblind-like protein	0.0465	0.3126	0.3847
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Trypanosoma brucei	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Onchocerca volvulus		0.0236	0.1545	0.1893
Schistosoma mansoni	ring finger protein 151	0.0021	0.0064	0.0051
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0014	0.0014	0.0546
Leishmania major	hypothetical protein, conserved	0.0422	0.2829	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0064	0.0062
Brugia malayi	PAN domain containing protein	0.004	0.0193	0.0221
Plasmodium vivax	acyl-CoA synthetase, putative	0.0036	0.0165	0.0187
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0151	0.6071
Echinococcus granulosus	E3 ubiquitin protein ligase LRSAM1	0.0021	0.0064	0.0051
Brugia malayi	Niemann-Pick C1 protein precursor	0.0102	0.0621	0.075
Loa Loa (eye worm)	hypothetical protein	0.003	0.0121	0.0133
Brugia malayi	PAN domain containing protein	0.004	0.0193	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0064	0.0062
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0249	0.3872
Trypanosoma cruzi	hypothetical protein	0.0021	0.0064	0.0179
Toxoplasma gondii	PAN domain-containing protein	0.004	0.0193	0.0221
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0067	0.0054
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0048	0.0249	1
Onchocerca volvulus		0.004	0.0193	0.0221
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Loa Loa (eye worm)	PAN domain-containing protein	0.004	0.0193	0.0221
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Entamoeba histolytica	hypothetical protein	0.0021	0.0064	0.0832
Loa Loa (eye worm)	hypothetical protein	0.004	0.0193	0.0221
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0249	0.0291
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0021	0.0064	0.0051
Schistosoma mansoni	peter pan-related	0.0021	0.0064	0.0051
Brugia malayi	MAP kinase sur-1	0.0051	0.0266	0.0312
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0249	1
Echinococcus multilocularis	zinc finger protein Ran binding	0.0422	0.2829	0.2819
Toxoplasma gondii	PAN domain-containing protein	0.004	0.0193	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0286	0.0337
Loa Loa (eye worm)	PAN domain-containing protein	0.004	0.0193	0.0221
Plasmodium falciparum	E3 ubiquitin-protein ligase, putative	0.0021	0.0064	0.0062
Echinococcus multilocularis	SWI:SNF matrix associated	0.1187	0.8104	0.8102
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Plasmodium falciparum	cysteine repeat modular protein 1	0.0027	0.0099	0.0106
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0014	0.0014	0.0546
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.0266	0.0253
Schistosoma mansoni	brg-1 associated factor	0.1187	0.8104	0.8102
Echinococcus granulosus	ring finger protein 170	0.0021	0.0064	0.0051
Toxoplasma gondii	PAN domain-containing protein	0.0373	0.2492	0.3064
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0064	0.0062
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0102	0.0621	1
Echinococcus granulosus	RING finger and transmembrane domain containing protein	0.0021	0.0064	0.0051
Brugia malayi	PAN domain containing protein	0.004	0.0193	0.0221
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Brugia malayi	Zinc finger protein 183 homolog	0.0022	0.0066	0.0065
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0044	0.0218	0.0253
Onchocerca volvulus		0.003	0.0121	0.0133
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0014	0.0546
Plasmodium vivax	E3 ubiquitin-protein ligase RNF5, putative	0.0021	0.0064	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0099	0.0106
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.0266	0.0898
Echinococcus multilocularis	ring and YY1 binding protein	0.0422	0.2829	0.2819
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.0266	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0187
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0249	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0165	0.0187
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0.0064	0.0832
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0021	0.0064	0.0062
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0014	0.0014	0.0546
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Leishmania major	hypothetical protein, conserved	0.0021	0.0064	0.0179
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0064	0.0062
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0036	0.0165	0.6421
Brugia malayi	Hypothetical RING finger protein C16C10.7 in chromosome III	0.0021	0.0064	0.0062
Plasmodium falciparum	acyl-CoA synthetase	0.0036	0.0165	0.0187
Leishmania major	hypothetical protein, conserved	0.0021	0.0064	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0249	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0064	0.0062
Trypanosoma brucei	predicted zinc finger protein	0.0021	0.0064	0.0179
Schistosoma mansoni	survival motor neuron protein	0.005	0.0261	0.0248
Schistosoma mansoni	hypothetical protein	0.0037	0.0173	0.016
Echinococcus multilocularis	SWI:SNF matrix associated	0.1187	0.8104	0.8102
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0249	0.0835
Leishmania major	hypothetical protein, conserved	0.0422	0.2829	1
Onchocerca volvulus		0.004	0.0193	0.0221
Leishmania major	hypothetical protein, conserved	0.0422	0.2829	1
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.0266	0.0898
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.1187	0.8104	0.8102
Brugia malayi	brahma associated protein 60 kDa	0.1187	0.8104	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0064	0.0179
Brugia malayi	Pre-SET motif family protein	0.0208	0.1348	0.1649
Toxoplasma gondii	Bardet-Biedl syndrome 5, putative	0.0021	0.0064	0.0062
Leishmania major	hypothetical protein	0.0021	0.0064	0.0179
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0014	0.0014	0.0546
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0021	0.0064	0.0179
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1187	0.8104	1
Onchocerca volvulus		0.0422	0.2829	0.3479
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Brugia malayi	hypothetical protein	0.0021	0.0064	0.0062
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0121	0.0108
Giardia lamblia	Ser/Thr protein kinase	0.0021	0.0064	0.00000042516
Giardia lamblia	Kinase, CMGC MAPK	0.0051	0.0266	1
Plasmodium vivax	hypothetical protein, conserved	0.1187	0.8104	1
Loa Loa (eye worm)	hypothetical protein	0.0422	0.2829	0.3479
Onchocerca volvulus		0.0422	0.2829	0.3479
Echinococcus granulosus	E3 ubiquitin protein ligase RNF146	0.0021	0.0064	0.0051
Leishmania major	hypothetical protein, conserved	0.0021	0.0064	0.0179
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Toxoplasma gondii	helicase, putative	0.0021	0.0064	0.0062
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0266	0.0312
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Echinococcus granulosus	Protein patched homolog 1	0.0044	0.0218	0.0205
Onchocerca volvulus		0.0021	0.0064	0.0062
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.0266	0.0312
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0.0064	0.0832
Echinococcus multilocularis	SWI:SNF matrix associated	0.1187	0.8104	0.8102
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0151	0.6071
Toxoplasma gondii	1,3(4)-beta-glucanase	0.004	0.0193	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0422	0.2829	0.3479
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0064	0.0062
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0027	0.0099	0.0106
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0064	0.0179
Trypanosoma cruzi	WLM domain containing protein, putative	0.0422	0.2829	1
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger) containing protein, putative	0.0021	0.0064	0.0179
Brugia malayi	hypothetical protein	0.0021	0.0064	0.0062
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.0266	0.0312
Echinococcus granulosus	ring and YY1 binding protein	0.0422	0.2829	0.2819
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.1187	0.8104	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0173	0.2633
Brugia malayi	Neuralized family protein	0.0021	0.0064	0.0062
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Echinococcus granulosus	expressed conserved protein	0.0096	0.0578	0.0565
Toxoplasma gondii	hypothetical protein	0.0021	0.0064	0.0062
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0048	0.0249	1
Echinococcus granulosus	E3 ubiquitin protein ligase MYLIP	0.0021	0.0064	0.0051
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0121	0.0108
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.1187	0.8104	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0064	0.0062
Schistosoma mansoni	hypothetical protein	0.005	0.0261	0.0248
Toxoplasma gondii	PAN domain-containing protein	0.004	0.0193	0.0221
Brugia malayi	CHE-14 protein	0.0044	0.0218	0.0253
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0266	0.0898
Giardia lamblia	Protein 21.1	0.0021	0.0064	0.00000042516
Trichomonas vaginalis	set domain proteins, putative	0.0236	0.1545	0.1893
Echinococcus granulosus	Zinc finger RanBP2 type	0.0422	0.2829	0.2819

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.5 uM	Inhibitory activity of compound against human plasma Kallikrein (PK)	ChEMBL.	10091673
Ki (binding)	= 0.5 uM	Inhibitory activity of compound against Plasmin (HP)	ChEMBL.	10091673
Ki (binding)	> 50 uM	Inhibitory activity of compound against Tissue Kallikrein (TK)	ChEMBL.	10091673

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1160805

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1137366