Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0359 | 0.3481 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.017 | 0.1648 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0208 | 0.0208 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0092 | 0.1031 | 0.2445 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.042 | 0.6561 | 0.6561 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0208 | 0.0494 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0222 | 0.3231 | 0.3231 |
Toxoplasma gondii | thioredoxin reductase | 0.0088 | 0.0965 | 1 |
Leishmania major | trypanothione reductase | 0.0088 | 0.0965 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0641 | 0.5476 |
Mycobacterium tuberculosis | Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase) | 0.0624 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0359 | 0.0851 |
Brugia malayi | Cytochrome P450 family protein | 0.0057 | 0.0443 | 0.43 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0088 | 0.0965 | 0.0965 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0222 | 0.3231 | 0.3231 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0043 | 0.0208 | 0.0208 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0092 | 0.1031 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Trypanosoma brucei | trypanothione reductase | 0.0088 | 0.0965 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0043 | 0.0208 | 0.0208 |
Mycobacterium leprae | PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) | 0.042 | 0.6561 | 0.6488 |
Brugia malayi | hypothetical protein | 0.0048 | 0.0295 | 0.2861 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0208 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0043 | 0.0208 | 0.0208 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0064 | 0.0569 | 0.5521 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.02 | 0.2856 | 0.2704 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0273 | 0.4088 | 0.4088 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0222 | 0.3231 | 0.3087 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0208 | 0.0208 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0208 | 1 |
Echinococcus granulosus | caspase 2 | 0.0068 | 0.0641 | 0.6221 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.003 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0208 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0088 | 0.0965 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0092 | 0.1031 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.02 | 0.2856 | 0.2856 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0208 | 0.0208 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0359 | 0.3481 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0092 | 0.1031 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.02 | 0.2856 | 0.2856 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0043 | 0.0208 | 0.0208 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0048 | 0.0295 | 0.2861 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0359 | 0.0851 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0208 | 0.216 |
Plasmodium vivax | glutathione reductase, putative | 0.0088 | 0.0965 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0068 | 0.0641 | 0.6221 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.003 | 0 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0208 | 0.216 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0359 | 0.2195 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0208 | 0.0208 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0048 | 0.0295 | 0.2861 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.003 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.02 | 0.2856 | 0.2856 |
Brugia malayi | glutathione reductase | 0.0088 | 0.0965 | 0.9357 |
Schistosoma mansoni | lipoxygenase | 0.0064 | 0.0569 | 0.135 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0359 | 0.0851 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0208 | 0.2021 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0208 | 0.2021 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0208 | 0.216 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0048 | 0.0292 | 0.0292 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0092 | 0.1031 | 1 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.042 | 0.6561 | 0.6561 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0043 | 0.0208 | 0.0208 |
Plasmodium falciparum | glutathione reductase | 0.0088 | 0.0965 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.0485 | 0.3663 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Mycobacterium ulcerans | naphthoate synthase | 0.0624 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0057 | 0.0443 | 0.3176 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0208 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.02 | 0.2856 | 0.2856 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0043 | 0.0208 | 0.0208 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0208 | 0.2021 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.042 | 0.6561 | 0.6561 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0208 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0088 | 0.0965 | 0.9357 |
Onchocerca volvulus | 0.0048 | 0.0295 | 0.2 | |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.017 | 0.0403 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0064 | 0.0569 | 0.5521 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.042 | 0.6561 | 0.6561 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0089 | 0.0984 | 0.9548 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0208 | 0.2021 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0222 | 0.3231 | 0.3231 |
Mycobacterium leprae | Isocitrate lyase | 0.0197 | 0.2804 | 0.265 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.0485 | 0.4707 |
Echinococcus multilocularis | caspase 2 | 0.0068 | 0.0641 | 0.6221 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0208 | 0.216 |
Loa Loa (eye worm) | glutathione reductase | 0.0088 | 0.0965 | 0.923 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0208 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0208 | 0.0494 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0295 | 0.07 |
Plasmodium falciparum | thioredoxin reductase | 0.0088 | 0.0965 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0092 | 0.1031 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0092 | 0.1031 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0359 | 0.3481 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.02 | 0.2856 | 0.2856 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.042 | 0.6561 | 0.6561 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0208 | 0.2021 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0068 | 0.0641 | 0.1521 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0208 | 0.0208 |
Treponema pallidum | NADH oxidase | 0.003 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.0485 | 0.4707 |
Mycobacterium tuberculosis | Probable reductase | 0.02 | 0.2856 | 0.2856 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0295 | 0.1453 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0208 | 0.0447 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0208 | 0.0208 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0359 | 0.3481 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0485 | 0.3663 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0208 | 0.0447 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0359 | 0.3481 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0088 | 0.0965 | 0.923 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0208 | 0.2021 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0088 | 0.0965 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0043 | 0.0208 | 0.0208 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0089 | 0.0984 | 0.9548 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0208 | 0.216 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0068 | 0.0641 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0208 | 0.216 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.