Detailed information for compound 1141689

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 221.105 | Formula: C6H8NO6P
  • H donors: 5 H acceptors: 6 LogP: -2.01 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1[nH]cc(c1)C(P(=O)(O)O)O
  • InChi: 1S/C6H8NO6P/c8-5(9)4-1-3(2-7-4)6(10)14(11,12)13/h1-2,6-7,10H,(H,8,9)(H2,11,12,13)
  • InChiKey: FUIBIIXRDPUFOF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli 5-enolpyruvylshikimate-3-phosphate synthetase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum 3-dehydroquinate synthase (EC 4.2.3.4), related Get druggable targets OG5_127183 All targets in OG5_127183
Schistosoma mansoni 3-dehydroquinate synthase Get druggable targets OG5_127183 All targets in OG5_127183
Mycobacterium leprae 3-dehydroquinate synthase AroB Get druggable targets OG5_127183 All targets in OG5_127183
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase Get druggable targets OG5_127183 All targets in OG5_127183
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS Get druggable targets OG5_127183 All targets in OG5_127183
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein Get druggable targets OG5_127183 All targets in OG5_127183
Candida albicans similar to S. cerevisiae ARO1 pentafunctional aromatic amino acid family biosynthesis protein Get druggable targets OG5_127183 All targets in OG5_127183
Chlamydia trachomatis dehyroquinate synthase Get druggable targets OG5_127183 All targets in OG5_127183
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase Get druggable targets OG5_127183 All targets in OG5_127183
Candida albicans similar to S. cerevisiae ARO1 pentafunctional aromatic amino acid family biosynthesis protein Get druggable targets OG5_127183 All targets in OG5_127183
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) Get druggable targets OG5_127183 All targets in OG5_127183
Mycobacterium ulcerans 3-dehydroquinate synthase Get druggable targets OG5_127183 All targets in OG5_127183
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB Get druggable targets OG5_127183 All targets in OG5_127183
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus roundabout 2 0.0015 0.016 0.0157
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.143 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0498 0.0577
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0033 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0263 0.1136
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0276 0.002
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0015 0.016 0.0137
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.4678 0.4676
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0015 0.016 0.0157
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0774 0.0585
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0033 0.0128
Mycobacterium ulcerans glutaminase 0.0264 0.6611 0.7263
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0276 0.0254
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0098 0.2299 0.2297
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0173 0.0149
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0276 0.0273
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0173 0.0166
Brugia malayi glutaminase DH11.1 0.0264 0.6611 0.7689
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0276 0.0822
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.001 0.0037 0.0034
Echinococcus granulosus contactin 0.0015 0.016 0.0157
Echinococcus multilocularis roundabout 2 0.0015 0.016 0.0157
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0276 0.0321
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0276 0.1718
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Echinococcus granulosus GPCR family 2 0.0035 0.0673 0.067
Echinococcus multilocularis roundabout 2 0.0046 0.0976 0.0974
Trypanosoma brucei unspecified product 0.0019 0.0263 0.1136
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0774 0.0805
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0173 0.017
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0673 0.0779
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0015 0.016 0.0157
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0173 0.0149
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0173 0.0998
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0263 0.0303
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0263 0.026
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0276 0.0281
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0973 0.0951
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.4678 0.4676
Brugia malayi jmjC domain containing protein 0.0058 0.1291 0.1502
Schistosoma mansoni hypothetical protein 0.0396 1 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0032 0.0597 0.0594
Loa Loa (eye worm) hypothetical protein 0.0015 0.016 0.0183
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0276 0.1235
Brugia malayi jmjC domain containing protein 0.0015 0.0173 0.0201
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.143 0.1661
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0357 0.9002 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0774 0.5305
Leishmania major DNA polymerase kappa, putative 0.0019 0.0263 0.0718
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.143 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Schistosoma mansoni hypothetical protein 0.0035 0.0673 0.065
Schistosoma mansoni tyrosine kinase 0.0017 0.0208 0.0185
Onchocerca volvulus 0.0028 0.0498 0.0441
Schistosoma mansoni jumonji domain containing protein 0.0057 0.125 0.123
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0173 0.017
Brugia malayi Fibronectin type III domain containing protein 0.0032 0.0597 0.0694
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0263 0.024
Loa Loa (eye worm) hypothetical protein 0.0032 0.0597 0.0691
Schistosoma mansoni cell adhesion molecule 0.0015 0.016 0.0137
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0735 0.0733
Brugia malayi Peroxidasin 0.0015 0.016 0.0186
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.1291 0.1499
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0263 0.1645
Echinococcus granulosus roundabout 2 0.0015 0.016 0.0157
Echinococcus multilocularis Immunoglobulin 0.0032 0.0597 0.0594
Loa Loa (eye worm) hypothetical protein 0.0035 0.0673 0.0779
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0173 0.017
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.1291 0.1271
Toxoplasma gondii exonuclease III APE 0.0038 0.0774 0.0836
Echinococcus multilocularis roundabout 2 0.0015 0.016 0.0157
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0276 0.002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.1291 0.1271
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0098 0.2299 0.2297
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0173 0.0166
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0263 0.0718
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0035
Schistosoma mansoni ap endonuclease 0.0038 0.0774 0.0752
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.143 0.1428
Schistosoma mansoni septate junction protein 0.0015 0.016 0.0137
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0973 0.1128
Echinococcus multilocularis neuroglian 0.0015 0.016 0.0157
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0032 0.0597 0.0575
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0263 0.1645
Echinococcus multilocularis dnaJ subfamily B 0.0396 1 1
Schistosoma mansoni tyrosine kinase 0.0098 0.2299 0.2281
Echinococcus granulosus defective proboscis extension response 0.0032 0.0597 0.0594
Loa Loa (eye worm) hypothetical protein 0.0015 0.016 0.0183
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0173 0.0149
Echinococcus granulosus dna polymerase eta 0.0019 0.0263 0.026
Brugia malayi CXXC zinc finger family protein 0.0028 0.0498 0.058
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0276 0.0273
Loa Loa (eye worm) hypothetical protein 0.0075 0.1707 0.1983
Loa Loa (eye worm) hypothetical protein 0.0046 0.0976 0.1133
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0673 0.067
Schistosoma mansoni cpg binding protein 0.0029 0.0539 0.0517
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0218 0.5413 0.3627
Echinococcus multilocularis dna polymerase eta 0.0019 0.0263 0.026
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0139 0.337 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.125 0.1248
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.1138 0.1117
Brugia malayi mbt repeat family protein 0.0046 0.0973 0.1131
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0973 0.097
Schistosoma mansoni roundabout 0.0015 0.016 0.0137
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0276 0.0273
Loa Loa (eye worm) hypothetical protein 0.0109 0.2599 0.3021
Schistosoma mansoni cpg binding protein 0.0029 0.0539 0.0517
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Loa Loa (eye worm) RecQ helicase 0.0019 0.0276 0.0318
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0357 0.9002 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1303 0.1282
Loa Loa (eye worm) hypothetical protein 0.0032 0.0597 0.0691
Onchocerca volvulus 0.0301 0.7562 0.9666
Schistosoma mansoni cell adhesion molecule 0.0038 0.0768 0.0746
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.143 1
Schistosoma mansoni cell adhesion molecule 0.0015 0.016 0.0137
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0276 0.1738
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0263 0.0306
Loa Loa (eye worm) hypothetical protein 0.0038 0.0768 0.089
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0973 0.0951
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.1291 0.1289
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0263 0.1136
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0276 0.0321
Loa Loa (eye worm) TK protein kinase 0.0106 0.2507 0.2914
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0214 0.0211
Schistosoma mansoni ap endonuclease 0.0038 0.0774 0.0752
Loa Loa (eye worm) hypothetical protein 0.0032 0.0597 0.0691
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0276 0.0281
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0973 0.097
Echinococcus granulosus cpg binding protein 0.0029 0.0539 0.0537
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0774 0.1377
Schistosoma mansoni titin 0.0015 0.016 0.0137
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0263 0.0306
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0015 0.016 0.0157
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0173 0.017
Echinococcus granulosus phd:f box containing protein 0.0015 0.0173 0.017
Loa Loa (eye worm) MBCTL1 0.0053 0.1138 0.132
Echinococcus granulosus tyrosine protein kinase otk 0.0015 0.016 0.0157
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0673 0.0782
Echinococcus granulosus peroxidasin 0.0015 0.016 0.0157
Schistosoma mansoni hypothetical protein 0.0075 0.1707 0.1688
Schistosoma mansoni glutaminase 0.0264 0.6611 0.6603
Leishmania major DNA polymerase eta, putative 0.0019 0.0263 0.0718
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0276 0.1794
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0173 0.017
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0263 0.024
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0774 1
Echinococcus granulosus roundabout 2 0.0046 0.0976 0.0974
Schistosoma mansoni septate junction protein 0.0015 0.016 0.0137
Loa Loa (eye worm) glutaminase 0.0264 0.6611 0.7689
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0973 0.0951
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.125 0.1248
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0098 0.2299 0.2297
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0973 0.097
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.2599 0.3023
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0015 0.016 0.0157
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0774 0.0772
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0173 0.0451
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0033 0.001
Schistosoma mansoni vesicular amine transporter 0.0032 0.0597 0.0575
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0276 0.0321
Brugia malayi Prion-like- 0.0015 0.016 0.0186
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.143 0.141
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0276 0.0273
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0263 0.1136
Schistosoma mansoni cpg binding protein 0.0028 0.0498 0.0476
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0173 0.017
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0263 0.1702
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.1138 0.1135
Loa Loa (eye worm) hypothetical protein 0.0053 0.1138 0.132
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0357 0.9002 1
Brugia malayi hypothetical protein 0.0032 0.0597 0.0694
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0015 0.016 0.0183
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0198
Echinococcus granulosus dna polymerase kappa 0.0019 0.0263 0.026
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0198
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.125 0.1248
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.1138 0.1135
Schistosoma mansoni hypothetical protein 0.0288 0.7226 0.7219
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0774 0.1645
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0173 0.0998
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0276 0.0318
Brugia malayi jmjC domain containing protein 0.0057 0.125 0.1454
Loa Loa (eye worm) hypothetical protein 0.0019 0.0263 0.0303
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0673 0.067
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0341 0.8597 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0038 0.0768 0.0765
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0139 0.337 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0214 0.0211
Loa Loa (eye worm) hypothetical protein 0.0015 0.016 0.0183
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0173 0.0198
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0673 0.0782
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.1138 0.1135
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.016 0.0183
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.143 1
Echinococcus multilocularis peroxidasin 0.0015 0.016 0.0157
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0263 0.1645
Echinococcus granulosus twitchin 0.004 0.0805 0.0803
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0774 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0973 0.097
Onchocerca volvulus Tyrosine kinase homolog 0.0311 0.7818 1
Schistosoma mansoni hypothetical protein 0.0035 0.0673 0.065
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0263 0.026
Echinococcus multilocularis hemicentin 1 0.0015 0.016 0.0157
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0774 0.5305
Loa Loa (eye worm) hypothetical protein 0.0032 0.0597 0.0691
Loa Loa (eye worm) hypothetical protein 0.0015 0.016 0.0183
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0263 0.026
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0173 0.0198
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0015 0.016 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Loa Loa (eye worm) hypothetical protein 0.0015 0.016 0.0183
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0973 0.1061
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0774 0.5337
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0015 0.016 0.0157
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0735 0.0733
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0357 0.9002 1
Echinococcus multilocularis lachesin 0.0015 0.016 0.0157
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0774 0.0772
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0173 0.0149
Loa Loa (eye worm) hypothetical protein 0.0032 0.0597 0.0691
Schistosoma mansoni hypothetical protein 0.0035 0.0673 0.065
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.1138 0.1323
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.001 0.0037 0.0034
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0597 0.0694
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0673 0.067
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0276 0.002
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0173 0.017
Schistosoma mansoni nephrin 0.0015 0.016 0.0137
Schistosoma mansoni neuroglian 0.0015 0.016 0.0137
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0218 0.5413 1
Onchocerca volvulus 0.0046 0.0973 0.1061
Plasmodium vivax JmjC domain containing protein 0.0015 0.0173 0.1986
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0774 0.0805
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0015 0.016 0.0137
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0774 1
Schistosoma mansoni 3-dehydroquinate synthase 0.0139 0.337 0.3355
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0139 0.337 0.3556
Loa Loa (eye worm) hypothetical protein 0.0015 0.016 0.0183
Loa Loa (eye worm) glutaminase 2 0.0264 0.6611 0.7689
Echinococcus multilocularis Immunoglobulin 0.0032 0.0597 0.0594
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.143 0.1663
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0263 0.1645
Loa Loa (eye worm) hypothetical protein 0.0046 0.0976 0.1133
Echinococcus multilocularis hemicentin 1 0.0015 0.016 0.0157
Echinococcus granulosus hemicentin 1 0.0015 0.016 0.0157
Schistosoma mansoni DNA helicase recq5 0.0019 0.0276 0.0253
Loa Loa (eye worm) hypothetical protein 0.0046 0.0973 0.1128
Loa Loa (eye worm) hypothetical protein 0.0015 0.016 0.0183
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.2599 0.3021
Brugia malayi Immunoglobulin I-set domain containing protein 0.0106 0.2507 0.2916
Echinococcus granulosus neuroglian 0.004 0.0805 0.0803
Brugia malayi jmjC domain containing protein 0.0015 0.0173 0.0201
Echinococcus granulosus Immunoglobulin 0.0032 0.0597 0.0594
Echinococcus multilocularis tyrosine protein kinase otk 0.0015 0.016 0.0157
Schistosoma mansoni DNA polymerase eta 0.0019 0.0263 0.024
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0774 0.5019
Loa Loa (eye worm) hypothetical protein 0.0032 0.0597 0.0691
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0276 0.0273
Echinococcus granulosus bloom syndrome protein 0.0019 0.0276 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Echinococcus granulosus neuroglian 0.0015 0.016 0.0157
Echinococcus multilocularis cpg binding protein 0.0029 0.0539 0.0537
Schistosoma mansoni cell adhesion molecule 0.0015 0.016 0.0137
Schistosoma mansoni DNA helicase recq1 0.0019 0.0276 0.0253
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.016 0.0183
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0218 0.5413 0.5893
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0276 0.1718
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0774 0.0901
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0032 0.0597 0.0575
Echinococcus multilocularis GPCR, family 2 0.0035 0.0673 0.067
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.1707 0.1986
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.016 0.0183
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0774 0.4784
Loa Loa (eye worm) hypothetical protein 0.0019 0.0276 0.0318
Brugia malayi Immunoglobulin I-set domain containing protein 0.0341 0.8597 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.016 0.0183
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0218 0.5413 1
Brugia malayi jmjC domain containing protein 0.0015 0.0173 0.0201
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.2599 0.3023
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.1138 0.1135
Echinococcus granulosus lachesin 0.0015 0.016 0.0157
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0173 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.016 0.0186
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0263 0.1136
Schistosoma mansoni nephrin 0.004 0.0805 0.0783
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0263 0.1645
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.143 0.1428
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0198
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.114 0.1244
Brugia malayi jmjC domain containing protein 0.0015 0.0173 0.0201
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0173 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Brugia malayi mbt repeat family protein 0.0046 0.0973 0.1131
Echinococcus granulosus fibroblast growth factor receptor 4 0.0098 0.2299 0.2297
Echinococcus multilocularis neuroglian 0.004 0.0805 0.0803
Schistosoma mansoni hypothetical protein 0.0035 0.0673 0.065
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0774 0.0898
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.143 1
Trichomonas vaginalis glutaminase, putative 0.0264 0.6611 1
Loa Loa (eye worm) TK/ROR protein kinase 0.001 0.0037 0.004
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0035
Entamoeba histolytica recQ family DNA helicase 0.001 0.0033 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0263 0.1136
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0673 0.067

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 14.5 nM Compound was tested for inhibitory activity against EPSP(5-enolpyruvylshikimate 3-phosphate) synthase in E. coli. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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