TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 397.532 | Formula: C27H29N2O+
H donors: 0 H acceptors: 1 LogP: 6.82 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc2c(c1)cccc2)C[n+]1ccn(c1)c1c(cccc1C(C)C)C(C)C
InChi: 1S/C27H29N2O/c1-19(2)24-10-7-11-25(20(3)4)27(24)29-15-14-28(18-29)17-26(30)23-13-12-21-8-5-6-9-22(21)16-23/h5-16,18-20H,17H2,1-4H3/q+1
InChiKey: MJOFTOXWTXWMQL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0178	0.0867	0.1797
Entamoeba histolytica	cysteine protease, putative	0.0767	0.4611	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0767	0.4611	1
Leishmania major	cathepsin L-like protease	0.0767	0.4611	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0767	0.4611	1
Echinococcus granulosus	cathepsin l1	0.0528	0.3093	0.3093
Echinococcus multilocularis	cathepsin L	0.0417	0.2385	0.2385
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0767	0.4611	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0767	0.4611	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0178	0.0867	0.1797
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0867	0.0824
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1255	0.1214
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0767	0.4611	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0178	0.0867	0.0824
Entamoeba histolytica	cysteine protease, putative	0.0417	0.2385	0.5171
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0178	0.0867	0.0867
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0767	0.4611	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0178	0.0867	0.1797
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0178	0.0867	0.0867
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0767	0.4611	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0767	0.4611	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0528	0.3093	0.3093
Brugia malayi	Papain family cysteine protease containing protein	0.0417	0.2385	0.2385
Trypanosoma cruzi	cysteine peptidase, putative	0.0417	0.2385	0.2349
Onchocerca volvulus		0.0767	0.4611	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0178	0.0867	0.1797
Toxoplasma gondii	cathepsin CPL	0.0767	0.4611	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0767	0.4611	1
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0867	0.0824
Echinococcus granulosus	cathepsin b	0.1616	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0767	0.4611	0.4611
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0178	0.0867	0.0867
Echinococcus granulosus	cysteine protease	0.0417	0.2385	0.2385
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0178	0.0867	0.0824
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0417	0.2385	0.2385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0767	0.4611	1
Plasmodium falciparum	serine repeat antigen 7	0.0178	0.0867	0.1797
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0417	0.2385	0.2385
Entamoeba histolytica	cysteine protease, putative	0.0417	0.2385	0.5171
Entamoeba histolytica	cysteine protease, putative	0.0417	0.2385	0.5171
Brugia malayi	Cathepsin L-like precursor	0.0528	0.3093	0.3093
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0178	0.0867	0.1797
Onchocerca volvulus		0.0767	0.4611	1
Brugia malayi	Cathepsin L-like precursor	0.0767	0.4611	0.4611
Leishmania major	cathepsin L-like protease	0.0767	0.4611	1
Onchocerca volvulus		0.0767	0.4611	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0071	0.0071
Plasmodium vivax	unspecified product	0.0417	0.2385	0.5122
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0767	0.4611	1
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1255	0.1214
Brugia malayi	Cathepsin L-like precursor	0.0767	0.4611	0.4611
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0767	0.4611	1
Toxoplasma gondii	cathepsin CPC1	0.0178	0.0867	0.1797
Entamoeba histolytica	cysteine protease, putative	0.0417	0.2385	0.5171
Trypanosoma cruzi	cysteine peptidase, putative	0.0767	0.4611	0.4586
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0867	0.0824
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0124	0.0522	1
Plasmodium falciparum	serine repeat antigen 1	0.0178	0.0867	0.1797
Echinococcus multilocularis	cathepsin L cysteine protease	0.0767	0.4611	0.4611
Entamoeba histolytica	cysteine protease, putative	0.0417	0.2385	0.5171
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0767	0.4611	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0239	0.1255	0.1214
Entamoeba histolytica	cysteine protease, putative	0.0417	0.2385	0.5171
Loa Loa (eye worm)	ctsf protein	0.0767	0.4611	0.4586
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0767	0.4611	0.4611
Brugia malayi	Cathepsin L-like precursor	0.0767	0.4611	0.4611
Plasmodium falciparum	serine repeat antigen 4	0.0178	0.0867	0.1797
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0767	0.4611	0.4611
Giardia lamblia	Cathepsin B precursor	0.0623	0.3691	1
Loa Loa (eye worm)	hypothetical protein	0.1616	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0071	0.0071
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0124	0.0522	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0767	0.4611	1
Plasmodium falciparum	serine repeat antigen 3	0.0178	0.0867	0.1797
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0178	0.0867	0.0867
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0178	0.0867	0.1879
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0867	0.0824
Onchocerca volvulus	Cathepsin F homolog	0.0767	0.4611	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0417	0.2385	0.2385
Brugia malayi	Papain family cysteine protease containing protein	0.0178	0.0867	0.0867
Schistosoma mansoni	cathepsin S (C01 family)	0.0178	0.0867	0.0867
Trypanosoma cruzi	major cysteine proteinase, putative	0.0178	0.0867	0.0824
Brugia malayi	Cathepsin L-like precursor	0.0239	0.1255	0.1255
Plasmodium falciparum	serine repeat antigen 8	0.0178	0.0867	0.1797
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1616	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0528	0.3093	0.3093
Brugia malayi	cathepsin F-like cysteine proteinase	0.0178	0.0867	0.0867
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0767	0.4611	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0417	0.2385	0.5171
Entamoeba histolytica	cysteine protease, putative	0.0178	0.0867	0.1879
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0178	0.0867	0.1797
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0767	0.4611	1
Entamoeba histolytica	cysteine protease, putative	0.0178	0.0867	0.1879
Onchocerca volvulus		0.0767	0.4611	1
Plasmodium vivax	vivapain-3	0.0417	0.2385	0.5122
Leishmania major	cathepsin L-like protease	0.0767	0.4611	1
Brugia malayi	Cathepsin L-like precursor	0.0767	0.4611	0.4611
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0767	0.4611	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0767	0.4611	1
Loa Loa (eye worm)	hypothetical protein	0.0528	0.3093	0.3061
Schistosoma mansoni	cathepsin B (C01 family)	0.0178	0.0867	0.0867
Trypanosoma cruzi	cysteine proteinase, putative	0.0417	0.2385	0.2349
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0767	0.4611	0.4611
Giardia lamblia	Cathepsin B precursor	0.0623	0.3691	1
Plasmodium vivax	unspecified product	0.0239	0.1255	0.2647
Leishmania major	cathepsin L-like protease	0.0767	0.4611	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0623	0.3691	0.7985
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0417	0.2385	0.5122
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0417	0.2385	0.2385
Onchocerca volvulus		0.0767	0.4611	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0767	0.4611	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0767	0.4611	1
Brugia malayi	Thioredoxin reductase	0.0049	0.0046	0.0046
Trypanosoma cruzi	cysteine peptidase, putative	0.0767	0.4611	0.4586
Onchocerca volvulus		0.0767	0.4611	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0528	0.3093	0.3061
Plasmodium falciparum	serine repeat antigen 5	0.0178	0.0867	0.1797
Mycobacterium tuberculosis	Probable reductase	0.0111	0.0443	0.8342
Giardia lamblia	Cathepsin B precursor	0.0623	0.3691	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0767	0.4611	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0178	0.0867	0.0824
Loa Loa (eye worm)	cysteine protease	0.0767	0.4611	0.4586
Entamoeba histolytica	cysteine protease, putative	0.0417	0.2385	0.5171
Entamoeba histolytica	cysteine protease, putative	0.0178	0.0867	0.1879
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0417	0.2385	0.5122
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0767	0.4611	1
Entamoeba histolytica	cysteine protease, putative	0.0417	0.2385	0.5171
Brugia malayi	cathepsin L-like cysteine proteinase	0.0178	0.0867	0.0867
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0767	0.4611	0.4586
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0867	0.0824
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0623	0.3691	0.3662
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0239	0.1255	0.1255
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0767	0.4611	1
Brugia malayi	Cathepsin L-like precursor	0.0528	0.3093	0.3093
Entamoeba histolytica	cysteine proteinase 2	0.0417	0.2385	0.5171
Schistosoma mansoni	cathepsin s	0.0239	0.1255	0.1255
Entamoeba histolytica	cysteine proteinase, putative	0.0417	0.2385	0.5171
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0767	0.4611	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0178	0.0867	0.0824
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0071	0.0071
Plasmodium falciparum	serine repeat antigen 6	0.0178	0.0867	0.1797
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0178	0.0867	0.0867
Leishmania major	cathepsin L-like protease	0.0767	0.4611	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0767	0.4611	1
Entamoeba histolytica	cysteine protease, putative	0.0178	0.0867	0.1879
Plasmodium vivax	unspecified product	0.0178	0.0867	0.1797
Echinococcus granulosus	cathepsin l1	0.0767	0.4611	0.4611
Plasmodium vivax	serine-repeat antigen (SERA)	0.0178	0.0867	0.1797
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0178	0.0867	0.0867
Brugia malayi	Papain family cysteine protease containing protein	0.0178	0.0867	0.0867
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0071	0.0071
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0178	0.0867	0.1797
Plasmodium falciparum	serine repeat antigen 2	0.0178	0.0867	0.1797
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1255	0.1214
Toxoplasma gondii	cathepsin CPC2	0.0178	0.0867	0.1797
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0178	0.0867	0.0867
Entamoeba histolytica	cysteine protease, putative	0.0417	0.2385	0.5171
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0111	0.0443	0.8342
Trypanosoma cruzi	cysteine peptidase, putative	0.0239	0.1255	0.1214
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0111	0.0443	0.8342
Plasmodium vivax	serine-repeat antigen (SERA)	0.0178	0.0867	0.1797
Trypanosoma cruzi	cruzipain precursor, putative	0.0767	0.4611	0.4586
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0071	0.0071
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0178	0.0867	0.0867
Echinococcus multilocularis	cathepsin b	0.1616	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0767	0.4611	1
Onchocerca volvulus		0.0528	0.3093	0.5946
Echinococcus granulosus	thioredoxin glutathione reductase	0.0049	0.0046	0.0046
Loa Loa (eye worm)	fibroinase	0.0767	0.4611	0.4586
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0417	0.2385	0.5122
Onchocerca volvulus	Cathepsin L homolog	0.0767	0.4611	1
Entamoeba histolytica	cysteine proteinase, putative	0.0767	0.4611	1
Entamoeba histolytica	cysteine protease, putative	0.0178	0.0867	0.1879
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0767	0.4611	1
Entamoeba histolytica	cysteine proteinase, putative	0.0767	0.4611	1
Echinococcus multilocularis	cathepsin L	0.0178	0.0867	0.0867
Echinococcus multilocularis	cathepsin b	0.1616	1	1
Brugia malayi	cathepsin L precursor	0.0178	0.0867	0.0867
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0049	0.0046	0.0046
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0111	0.0443	0.8342
Plasmodium vivax	vivapain-2	0.0767	0.4611	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0111	0.0443	0.8342
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1616	1	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0178	0.0867	0.1797
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0767	0.4611	1
Entamoeba histolytica	cysteine protease, putative	0.0178	0.0867	0.1879
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0767	0.4611	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0767	0.4611	0.4611
Entamoeba histolytica	cysteine proteinase, putative	0.0417	0.2385	0.5171
Echinococcus multilocularis	cysteine protease	0.0767	0.4611	0.4611
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0623	0.3691	0.7985
Echinococcus granulosus	cathepsin b	0.1616	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0767	0.4611	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0767	0.4611	1
Leishmania major	cysteine peptidase A (CPA)	0.0767	0.4611	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0071	0.0025
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0178	0.0867	0.1797
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0767	0.4611	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0417	0.2385	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0767	0.4611	0.4586
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0767	0.4611	0.4611
Entamoeba histolytica	cysteine protease, putative	0.0417	0.2385	0.5171
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0178	0.0867	0.1879
Echinococcus multilocularis	cathepsin L cysteine protease	0.0767	0.4611	0.4611
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0417	0.2385	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0767	0.4611	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1616	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0767	0.4611	1
Brugia malayi	Papain family cysteine protease containing protein	0.0178	0.0867	0.0867
Brugia malayi	glutathione reductase	0.0049	0.0046	0.0046
Brugia malayi	cathepsin L-like precursor	0.0528	0.3093	0.3093
Toxoplasma gondii	cathepsin B	0.0623	0.3691	0.7985
Echinococcus multilocularis	cysteine protease	0.0767	0.4611	0.4611
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0767	0.4611	1
Schistosoma mansoni	cathepsin C	0.0178	0.0867	0.0867
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0071	0.0071
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0178	0.0867	0.1797
Entamoeba histolytica	cysteine proteinase, putative	0.0417	0.2385	0.5171
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0071	0.0071
Entamoeba histolytica	cysteine protease, putative	0.0417	0.2385	0.5171
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0767	0.4611	0.4586
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0178	0.0867	0.1797
Plasmodium falciparum	serine repeat antigen 9	0.0178	0.0867	0.1797
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0767	0.4611	1
Leishmania major	cathepsin L-like protease	0.0767	0.4611	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0178	0.0867	0.0867
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0767	0.4611	1
Entamoeba histolytica	cysteine protease, putative	0.0417	0.2385	0.5171
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1616	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0178	0.0867	0.0867
Mycobacterium tuberculosis	Probable dehydrogenase	0.0111	0.0443	0.8342
Loa Loa (eye worm)	cathepsin B	0.0623	0.3691	0.3662
Brugia malayi	Cathepsin L-like precursor	0.0767	0.4611	0.4611
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0178	0.0867	0.1797
Entamoeba histolytica	cysteine proteinase, putative	0.0528	0.3093	0.6708
Entamoeba histolytica	cysteine protease, putative	0.0417	0.2385	0.5171
Brugia malayi	Papain family cysteine protease containing protein	0.0417	0.2385	0.2385
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0767	0.4611	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0767	0.4611	1
Leishmania major	cathepsin L-like protease	0.0767	0.4611	1
Trypanosoma cruzi	cysteine protease, putative	0.0417	0.2385	0.2349
Brugia malayi	Papain family cysteine protease containing protein	0.0767	0.4611	0.4611
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0178	0.0867	0.0867
Trypanosoma cruzi	cysteine peptidase, putative	0.0767	0.4611	0.4586
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0178	0.0867	0.0867
Brugia malayi	cathepsin F-like cysteine proteinase	0.0239	0.1255	0.1255
Brugia malayi	Cathepsin L-like precursor	0.0767	0.4611	0.4611
Onchocerca volvulus	Cathepsin L homolog	0.0767	0.4611	1
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0867	0.0824
Plasmodium vivax	vivapain-2	0.0767	0.4611	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0178	0.0867	0.1797
Mycobacterium tuberculosis	Probable oxidoreductase	0.0124	0.0522	1
Onchocerca volvulus		0.0767	0.4611	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0417	0.2385	0.2349
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1616	1	1
Brugia malayi	fibroinase precursor	0.0178	0.0867	0.0867
Plasmodium vivax	vivapain-1	0.0417	0.2385	0.5122
Loa Loa (eye worm)	hypothetical protein	0.0528	0.3093	0.3061
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0417	0.2385	0.2349
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0178	0.0867	0.1797
Trypanosoma cruzi	cruzipain precursor, putative	0.0239	0.1255	0.1214
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0623	0.3691	0.7543
Entamoeba histolytica	hypothetical protein	0.0178	0.0867	0.1879
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0528	0.3093	0.5946
Leishmania major	cathepsin L-like protease	0.0767	0.4611	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0623	0.3691	0.3691
Echinococcus granulosus	cathepsin L	0.0417	0.2385	0.2385
Entamoeba histolytica	cysteine proteinase, putative	0.0417	0.2385	0.5171
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0124	0.0522	1
Echinococcus granulosus	cathepsin L	0.0178	0.0867	0.0867
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0528	0.3093	0.5946
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0071	0.0071
Trypanosoma cruzi	cysteine peptidase, putative	0.0767	0.4611	0.4586
Loa Loa (eye worm)	hypothetical protein	0.0528	0.3093	0.3061

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1187803

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1143549