Detailed information for compound 1149010

Basic information

Technical information
  • TDR Targets ID: 1149010
  • Name: 1-methyl-3-(2-piperidin-4-ylethyl)indole
  • MW: 242.359 | Formula: C16H22N2
  • H donors: 1 H acceptors: 0 LogP: 3.12 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1cc(c2c1cccc2)CCC1CCNCC1
  • InChi: 1S/C16H22N2/c1-18-12-14(15-4-2-3-5-16(15)18)7-6-13-8-10-17-11-9-13/h2-5,12-13,17H,6-11H2,1H3
  • InChiKey: SPDNEIRGFSAONU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-methyl-3-[2-(4-piperidyl)ethyl]indole
  • 1-methyl-3-[2-(4-piperidinyl)ethyl]indole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus glutamate NMDA receptor subunit 0.0024 0.0173 0.0173
Loa Loa (eye worm) aminopeptidase N 0.0036 0.061 0.061
Echinococcus multilocularis cathepsin b 0.0278 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.4398 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0517 0.0517
Onchocerca volvulus 0.0121 0.3914 0.4147
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.1269 0.1269
Plasmodium vivax calpain, putative 0.0037 0.0681 0.5367
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0274 0.0274
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0104 0.3249 0.3249
Schistosoma mansoni calpain (C02 family) 0.0037 0.0681 0.0681
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.3879 0.8796
Echinococcus granulosus L aminoadipate semialdehyde 0.0092 0.2814 0.2814
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0038 0.0709 0.1849
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0352 0.0352
Echinococcus multilocularis survival motor neuron protein 1 0.0263 0.9422 0.9422
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0037 0.0681 0.0597
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0517 0.0517
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0517 0.1095
Loa Loa (eye worm) hypothetical protein 0.0073 0.2061 0.2061
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0036 0.061 0.1931
Trypanosoma cruzi Aminopeptidase M1, putative 0.0036 0.061 0.0525
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0517 0.0517
Plasmodium falciparum thioredoxin reductase 0.0053 0.1269 1
Plasmodium vivax SET domain protein, putative 0.0033 0.0517 0.4079
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0092 0.2814 0.2814
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.1269 0.1269
Trichomonas vaginalis set domain proteins, putative 0.0263 0.9439 1
Schistosoma mansoni lipoxygenase 0.0119 0.3831 0.3831
Brugia malayi Augmenter of liver regeneration 0.0038 0.0709 0.0709
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.061 0.061
Echinococcus multilocularis nmda type glutamate receptor 0.0032 0.0473 0.0473
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.4398 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0092 0.2785 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.061 0.061
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.3831 0.3831
Echinococcus multilocularis hypothetical protein 0.0037 0.0681 0.0681
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0037 0.0681 0.0597
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0036 0.061 0.1457
Brugia malayi Glutamate receptor 1 precursor 0.0024 0.0173 0.0173
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.3831 0.3831
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.1269 0.2738
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0517 0.0517
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0036 0.061 0.061
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0231 0.82 0.82
Brugia malayi Pre-SET motif family protein 0.0231 0.82 0.82
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0274 0.0274
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0037 0.0681 0.0597
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0681 0.2195
Onchocerca volvulus 0.0062 0.1625 0.1721
Brugia malayi calpain family protein 1 0.0099 0.3075 0.3075
Brugia malayi Thioredoxin reductase 0.0053 0.1269 0.1269
Loa Loa (eye worm) hypothetical protein 0.0023 0.0125 0.0125
Leishmania major hypothetical protein, conserved 0.0038 0.0709 0.2301
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0032 0.0473 0.0473
Loa Loa (eye worm) hypothetical protein 0.0099 0.3075 0.3075
Schistosoma mansoni survival motor neuron protein 0.0054 0.131 0.131
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0092 0.2785 0.2785
Loa Loa (eye worm) calpain 0.0037 0.0681 0.0681
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.061 0.061
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0037 0.0681 0.0597
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0681 0.0597
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0517 0.0517
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0681 0.2195
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.1379 0.1379
Schistosoma mansoni Mername-AA248 (C02 family) 0.0037 0.0681 0.0681
Loa Loa (eye worm) hypothetical protein 0.0085 0.2536 0.2536
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0239 1
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0027 0.0274 0.0274
Trypanosoma brucei trypanothione reductase 0.0053 0.1269 0.4046
Echinococcus multilocularis calpain 5 0.0037 0.0681 0.0681
Leishmania major kinesin, putative 0.0026 0.0245 0.0579
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0038 0.0709 0.0709
Toxoplasma gondii t-complex protein beta subunit 0.0027 0.0274 0.0139
Schistosoma mansoni hypothetical protein 0.0054 0.131 0.131
Brugia malayi Peptidase family M1 containing protein 0.0036 0.061 0.061
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0278 1 1
Trypanosoma cruzi kinesin, putative 0.0026 0.0245 0.0157
Entamoeba histolytica protein kinase, putative 0.0026 0.0245 0.0169
Trypanosoma cruzi kinesin, putative 0.0026 0.0245 0.0157
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0104 0.3249 0.3249
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0036 0.061 0.061
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0274 0.0274
Onchocerca volvulus 0.0033 0.0517 0.0548
Loa Loa (eye worm) T-complex protein 1 0.0027 0.0274 0.0274
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0027 0.0274 0.0187
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.061 0.061
Echinococcus granulosus cathepsin b 0.0278 1 1
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0023 0.0125 0.0685
Loa Loa (eye worm) glutamate receptor 2 0.0024 0.0173 0.0173
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0092 0.2814 0.2814
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1202 0.1202
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.061 0.061
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.4398 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.343 0.343
Echinococcus granulosus allatostatin A receptor 0.0149 0.5015 0.5015
Loa Loa (eye worm) cathepsin B 0.0092 0.2785 0.2785
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0036 0.061 0.061
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0038 0.0709 0.5591
Brugia malayi Pre-SET motif family protein 0.0033 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.0149 0.5015 0.5015
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0037 0.0681 0.0597
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0352 0.0352
Plasmodium falciparum T-complex protein 1 subunit beta 0.0027 0.0274 0.2161
Entamoeba histolytica aminopeptidase, putative 0.0036 0.061 1
Echinococcus multilocularis calpain family protein 1, d 0.0073 0.2061 0.2061
Giardia lamblia Cathepsin B precursor 0.0092 0.2785 1
Echinococcus granulosus calpain 0.0037 0.0681 0.0681
Giardia lamblia Cathepsin B precursor 0.0092 0.2785 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0239 0.5
Schistosoma mansoni glutamate receptor kainate 0.0024 0.0173 0.0173
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0038 0.0709 0.0709
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.1269 0.119
Brugia malayi calpain family protein 1 0.0099 0.3075 0.3075
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.07 0.07
Onchocerca volvulus 0.0036 0.061 0.0646
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0023 0.0125 0.2383
Onchocerca volvulus 0.0092 0.2814 0.2981
Schistosoma mansoni calpain C (C02 family) 0.0037 0.0681 0.0681
Echinococcus granulosus aminopeptidase N 0.0121 0.3914 0.3914
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.1269 1
Echinococcus granulosus calpain A 0.0037 0.0681 0.0681
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1202 0.1202
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0036 0.061 0.0366
Loa Loa (eye worm) hypothetical protein 0.0055 0.1379 0.1379
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.1202 0.1202
Toxoplasma gondii Erv1 / Alr family protein 0.0038 0.0709 0.1849
Brugia malayi calpain 7 0.0037 0.0681 0.0681
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0239 0.2876
Echinococcus multilocularis calpain A 0.0104 0.3249 0.3249
Plasmodium vivax glutathione reductase, putative 0.0053 0.1269 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0092 0.2785 0.272
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1202 0.1202
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0278 1 1
Schistosoma mansoni glutamate receptor NMDA 0.0029 0.0352 0.0352
Loa Loa (eye worm) hypothetical protein 0.0062 0.1625 0.1625
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0038 0.0709 0.0626
Echinococcus multilocularis glutamate receptor 2 0.0024 0.0173 0.0173
Onchocerca volvulus 0.0054 0.131 0.1387
Trypanosoma brucei kinesin, putative 0.0026 0.0245 0.0025
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.061 0.061
Schistosoma mansoni ATP-binding cassette transporter 0.0024 0.0173 0.0173
Schistosoma mansoni glutamate receptor AMPA 0.0024 0.0173 0.0173
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0027 0.0274 0.2161
Schistosoma mansoni glutamate receptor NMDA 0.0024 0.0173 0.0173
Trypanosoma brucei calpain-like protein, putative 0.0037 0.0681 0.1737
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0036 0.061 0.0525
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.061 0.061
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0352 0.0352
Echinococcus granulosus glutamate receptor 2 0.002 0.0003 0.0003
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0023 0.0125 0.0083
Echinococcus granulosus nmda type glutamate receptor 0.0032 0.0473 0.0473
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0352 0.0352
Echinococcus granulosus glutamate receptor 2 0.0029 0.0352 0.0352
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0239 0.2876
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.012 0.3879 0.8753
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0027 0.0274 0.0139
Loa Loa (eye worm) calpain family protein 1 0.0073 0.2061 0.2061
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.1379 0.1379
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0036 0.061 0.1931
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0352 0.0352
Trypanosoma brucei Aminopeptidase M1, putative 0.0036 0.061 0.1457
Schistosoma mansoni glutamate receptor kainate 0.0024 0.0173 0.0173
Onchocerca volvulus 0.0263 0.9439 1
Toxoplasma gondii Erv1 / Alr family protein 0.0038 0.0709 0.1849
Brugia malayi hypothetical protein 0.0036 0.061 0.061
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0681 0.1737
Trypanosoma brucei antigen, putative 0.0037 0.0681 0.1737
Onchocerca volvulus 0.0149 0.5015 0.5313
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0239 0.0555
Toxoplasma gondii thioredoxin reductase 0.0053 0.1269 0.4046
Loa Loa (eye worm) hypothetical protein 0.0023 0.0125 0.0125
Mycobacterium tuberculosis Probable reductase 0.012 0.3879 0.8796
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1202 0.1202
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0278 1 1
Brugia malayi glutathione reductase 0.0053 0.1269 0.1269
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0104 0.3249 0.3249
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0037 0.0681 0.0597
Giardia lamblia Cathepsin B precursor 0.0092 0.2785 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.4398 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0239 0.1882
Echinococcus multilocularis allatostatin A receptor 0.0149 0.5015 0.5015
Echinococcus granulosus cathepsin b 0.0278 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.047 0.047
Schistosoma mansoni glutamate receptor kainate 0.0024 0.0173 0.0173
Echinococcus multilocularis aminopeptidase N 0.0121 0.3914 0.3914
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0024 0.0173 0.0173
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0023 0.0125 0.0125
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0517 0.0517
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0278 1 1
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0274 0.0274
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0239 0.0347
Brugia malayi hypothetical protein 0.0263 0.9422 0.9422
Echinococcus multilocularis L aminoadipate semialdehyde 0.0092 0.2814 0.2814
Loa Loa (eye worm) calpain family protein 1 0.0099 0.3075 0.3075
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.3879 0.8796
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0022 0.0089 0.0702
Loa Loa (eye worm) hypothetical protein 0.0092 0.2814 0.2814
Trypanosoma brucei calpain-like protein, putative 0.0037 0.0681 0.1737
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0681 0.0597
Plasmodium falciparum glutathione reductase 0.0053 0.1269 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0149 0.5015 0.5015
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.1379 0.1379
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.3879 0.8796
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.1202 0.1202
Leishmania major T-complex protein 1, beta subunit, putative 0.0027 0.0274 0.0687
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0038 0.0709 0.0626
Echinococcus granulosus calpain 7 C02 family 0.0037 0.0681 0.0681
Entamoeba histolytica calpain large subunit domain III containing protein 0.0026 0.0245 0.0169
Schistosoma mansoni glutamate receptor AMPA 0.0024 0.0173 0.0173
Echinococcus granulosus calpain 5 0.0037 0.0681 0.0681
Echinococcus multilocularis cathepsin b 0.0278 1 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0029 0.0352 0.0352
Echinococcus granulosus survival motor neuron protein 1 0.0263 0.9422 0.9422
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0517 0.0517
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0092 0.2785 0.2739
Trypanosoma brucei Aminopeptidase M1, putative 0.0036 0.061 0.1457
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1202 0.1202
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0274 0.0274
Schistosoma mansoni calpain-7 (C02 family) 0.0037 0.0681 0.0681
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0023 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0088 0.2639 0.2639
Echinococcus multilocularis calpain 0.0037 0.0681 0.0681
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1202 0.1202
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0104 0.3249 0.3249
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0029 0.0352 0.0352
Loa Loa (eye worm) hypothetical protein 0.0263 0.9422 0.9422
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0023 0.0125 0.2383
Echinococcus multilocularis glutamate receptor 2 0.002 0.0003 0.0003
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0038 0.0709 0.0626
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0027 0.0274 0.0274
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0278 1 1
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.1269 0.1269
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0092 0.2785 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0036 0.061 0.0366
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0239 0.1882
Echinococcus granulosus calpain A 0.0104 0.3249 0.3249
Mycobacterium ulcerans aminopeptidase N PepN 0.0036 0.061 1
Toxoplasma gondii cathepsin B 0.0092 0.2785 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.3879 0.8796
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0681 0.0597
Leishmania major trypanothione reductase 0.0053 0.1269 0.4376
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0681 0.0597
Schistosoma mansoni hypothetical protein 0.0038 0.07 0.07
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0023 0.0125 0.0036
Brugia malayi Glutamate receptor 2 precursor 0.0024 0.0173 0.0173
Loa Loa (eye worm) calpain 5 0.0026 0.0245 0.0245
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1202 0.1202
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0037 0.0681 0.1737
Trypanosoma brucei calpain-like protein, putative 0.0037 0.0681 0.1737
Loa Loa (eye worm) glutathione reductase 0.0053 0.1269 0.1269
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0038 0.0709 0.5591
Trypanosoma cruzi aminopeptidase, putative 0.0036 0.061 0.0525
Loa Loa (eye worm) hypothetical protein 0.0038 0.07 0.07
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0027 0.0274 0.0956
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.061 0.061
Echinococcus multilocularis calpain 7 (C02 family) 0.0037 0.0681 0.0681
Echinococcus multilocularis glutamate receptor 2 0.0029 0.0352 0.0352
Schistosoma mansoni calpain-7 (C02 family) 0.0037 0.0681 0.0681
Loa Loa (eye worm) hepatopoietin HPO2 0.0038 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0278 1 1
Loa Loa (eye worm) glutamate receptor 1 0.0024 0.0173 0.0173
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0352 0.0352
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0099 0.3075 0.3075
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0681 0.2195
Loa Loa (eye worm) peptidase family M1 containing protein 0.0098 0.302 0.302
Brugia malayi Peptidase family M1 containing protein 0.0121 0.3914 0.3914
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0517 0.0517
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.061 0.061
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.131 0.131
Brugia malayi calpain 5 0.0026 0.0245 0.0245
Schistosoma mansoni lipoxygenase 0.0083 0.2447 0.2447
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0239 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.3879 0.8796
Trypanosoma brucei calpain-like protein, putative 0.0037 0.0681 0.1737

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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