TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 340.434 | Formula: C21H25FN2O
H donors: 0 H acceptors: 0 LogP: 4.46 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)N1CCN(CC1)CCOc1ccc2c(c1)CCC2
InChi: 1S/C21H25FN2O/c22-19-5-7-20(8-6-19)24-12-10-23(11-13-24)14-15-25-21-9-4-17-2-1-3-18(17)16-21/h4-9,16H,1-3,10-15H2
InChiKey: COSYVRVEUXGRHY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0276	0.0294
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0968	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1856	0.1979
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.3067	0.301
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0108	0.3067	0.3212
Plasmodium vivax	vivapain-1	0.0059	0.1291	0.4054
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0145	0.4433	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0026	0.0081	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0081	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1856	0.1979
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0968	0.1032
Leishmania major	cathepsin L-like protease	0.0108	0.3067	0.8528
Brugia malayi	Steroid receptor seven-up type 2	0.0032	0.0276	0.0294
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0297	1	1
Echinococcus granulosus	cathepsin l1	0.0075	0.1856	0.191
Schistosoma mansoni	aldehyde dehydrogenase	0.0122	0.3596	0.3782
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0081	0.0223
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0108	0.3067	0.327
Brugia malayi	Papain family cysteine protease containing protein	0.0059	0.1291	0.1377
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0032	0.0276	0.0294
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0032	0.0276	0.021
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0108	0.3067	0.3212
Schistosoma mansoni	nuclear hormone receptor	0.0032	0.0276	0.021
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.0276	0.021
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0276	0.0294
Entamoeba histolytica	cysteine protease, putative	0.0059	0.1291	0.1291
Brugia malayi	Cathepsin L-like precursor	0.0108	0.3067	0.327
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0032	0.0276	0.021
Toxoplasma gondii	cathepsin B	0.0105	0.2956	0.8178
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.3067	0.301
Leishmania major	cathepsin L-like protease	0.0108	0.3067	0.8528
Brugia malayi	nuclear receptor NHR-88	0.0032	0.0276	0.0294
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0081	0.0081
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0108	0.3067	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0032	0.0276	0.021
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1291	0.122
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0108	0.3067	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0382	0.0408
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1291	0.122
Giardia lamblia	Cathepsin B precursor	0.0105	0.2956	0.2899
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.3067	0.301
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0276	0.0294
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0108	0.3067	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0435	0.0382
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0297	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0032	0.0276	0.0294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0108	0.3067	0.301
Toxoplasma gondii	aldehyde dehydrogenase	0.0122	0.3596	1
Brugia malayi	Cathepsin L-like precursor	0.0108	0.3067	0.327
Schistosoma mansoni	retinoic acid receptor RXR	0.0032	0.0276	0.021
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0968	0.1032
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.028	0.9377	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.0276	0.0294
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0108	0.3067	1
Plasmodium vivax	unspecified product	0.0033	0.0328	0.0828
Toxoplasma gondii	cathepsin CPL	0.0108	0.3067	0.8494
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0122	0.3596	0.8112
Echinococcus granulosus	cathepsin l1	0.0108	0.3067	0.3212
Entamoeba histolytica	cysteine protease, putative	0.0059	0.1291	0.1291
Echinococcus granulosus	ecdysone induced protein 78C	0.0032	0.0276	0.021
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0108	0.3067	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.3067	0.301
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.1291	0.1302
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0435	0.0382
Trypanosoma cruzi	cysteine peptidase, putative	0.0108	0.3067	0.3212
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0081	0.0086
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0122	0.3596	0.3782
Leishmania major	cathepsin L-like protease	0.0108	0.3067	0.8528
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0105	0.2956	0.9375
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0032	0.0276	0.021
Onchocerca volvulus		0.0032	0.0276	0.0765
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	0.1856	0.179
Onchocerca volvulus		0.0108	0.3067	0.8505
Echinococcus granulosus	cathepsin b	0.028	0.9377	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.3067	0.301
Echinococcus granulosus	cathepsin L cysteine protease	0.0059	0.1291	0.1302
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.3067	0.301
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0059	0.1291	0.1302
Onchocerca volvulus	Cathepsin F homolog	0.0108	0.3067	0.8505
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0075	0.1856	0.1979
Entamoeba histolytica	hypothetical protein	0.0036	0.0435	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0276	0.0294
Echinococcus multilocularis	cysteine protease	0.0108	0.3067	0.3212
Entamoeba histolytica	cysteine proteinase, putative	0.0075	0.1856	0.1856
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0297	1	1
Loa Loa (eye worm)	cathepsin B	0.0105	0.2956	0.3152
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0986	0.0974
Brugia malayi	cathepsin B-like cysteine proteinase	0.028	0.9377	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0032	0.0276	0.0294
Giardia lamblia	Fructose-bisphosphate aldolase	0.0297	1	1
Plasmodium vivax	vivapain-3	0.0059	0.1291	0.4054
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0435	0.0382
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0297	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0986	0.0974
Brugia malayi	nuclear hormone receptor	0.0032	0.0276	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0276	0.0294
Onchocerca volvulus	Protein ultraspiracle homolog	0.0032	0.0276	0.0765
Onchocerca volvulus	Huntingtin homolog	0.0122	0.3606	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0026	0.0081	0.0081
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0032	0.0276	0.021
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0032	0.0276	0.021
Brugia malayi	Cathepsin L-like precursor	0.0075	0.1856	0.1979
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0108	0.3067	0.3212
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0032	0.0276	0.0294
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0032	0.0276	0.0294
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0033	0.0328	0.035
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0297	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0108	0.3067	0.3212
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0108	0.3067	0.301
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0081	0.0086
Schistosoma mansoni	aldehyde dehydrogenase	0.0122	0.3596	0.3782
Brugia malayi	steroid hormone receptor	0.0032	0.0276	0.0294
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0297	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0108	0.3067	0.3212
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0081	0.0086
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0108	0.3067	0.327
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0122	0.3606	0.3845
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0032	0.0276	0.0294
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0032	0.0276	0.0294
Echinococcus multilocularis	cathepsin b	0.028	0.9377	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0122	0.3596	0.3782
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0108	0.3067	0.301
Schistosoma mansoni	cathepsin s	0.0033	0.0328	0.0266
Schistosoma mansoni	thyroid hormone receptor	0.0032	0.0276	0.021
Brugia malayi	cathepsin F-like cysteine proteinase	0.0033	0.0328	0.035
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0276	0.0294
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.028	0.9377	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0032	0.0276	0.021
Giardia lamblia	Cathepsin B precursor	0.0105	0.2956	0.2899
Entamoeba histolytica	cysteine protease, putative	0.0108	0.3067	0.3067
Loa Loa (eye worm)	hypothetical protein	0.0236	0.7781	0.8298
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0382	0.0408
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0986	0.0974
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0884	0.0865
Onchocerca volvulus		0.0048	0.0884	0.2452
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0276	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0081	0.0086
Brugia malayi	hypothetical protein	0.0122	0.3606	0.3845
Loa Loa (eye worm)	hypothetical protein	0.028	0.9377	1
Leishmania major	cathepsin L-like protease	0.0108	0.3067	0.8528
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0032	0.0276	0.021
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0105	0.2956	0.8219
Giardia lamblia	Cathepsin B precursor	0.0105	0.2956	0.2899
Brugia malayi	cathepsin L precursor	0.0026	0.0081	0.0086
Entamoeba histolytica	cysteine protease, putative	0.0059	0.1291	0.1291
Echinococcus multilocularis	cathepsin L cysteine protease	0.0108	0.3067	0.3212
Onchocerca volvulus	Cathepsin L homolog	0.0108	0.3067	0.8505
Brugia malayi	Papain family cysteine protease containing protein	0.0059	0.1291	0.1377
Entamoeba histolytica	cysteine protease, putative	0.0059	0.1291	0.1291
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0032	0.0276	0.0294
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0081	0.0086
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0986	0.1052
Schistosoma mansoni	thyroid hormone receptor	0.0032	0.0276	0.021
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0026	0.0081	0.0081
Onchocerca volvulus		0.0108	0.3067	0.8505
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0297	1	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0968	0.1032
Leishmania major	cathepsin L-like protease	0.0108	0.3067	0.8528
Onchocerca volvulus	Bile acid receptor homolog	0.0032	0.0276	0.0765
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0059	0.1291	0.1302
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0328	0.035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0108	0.3067	0.301
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0032	0.0276	0.021
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0032	0.0276	0.0294
Entamoeba histolytica	cysteine proteinase 1, putative	0.0059	0.1291	0.1291
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0884	0.0943
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0032	0.0276	0.0294
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.0276	0.021
Leishmania major	cysteine peptidase A (CPA)	0.0108	0.3067	0.8528
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.0276	0.021
Entamoeba histolytica	hypothetical protein	0.0036	0.0435	0.0435
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.1291	0.1291
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	0.1856	0.179
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.0276	0.021
Brugia malayi	Cathepsin L-like precursor	0.0108	0.3067	0.327
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.3067	0.301
Onchocerca volvulus		0.0075	0.1856	0.5148
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0108	0.3067	0.301
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0145	0.4433	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0105	0.2956	0.3093
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0032	0.0276	0.0294
Brugia malayi	Cathepsin L-like precursor	0.0108	0.3067	0.327
Plasmodium vivax	vivapain-2	0.0108	0.3067	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0032	0.0276	0.021
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0108	0.3067	0.301
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.0276	0.0294
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0108	0.3067	1
Onchocerca volvulus		0.0108	0.3067	0.8505
Entamoeba histolytica	cysteine protease, putative	0.0059	0.1291	0.1291
Onchocerca volvulus		0.0108	0.3067	0.8505
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0108	0.3067	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0033	0.0328	0.0266
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.0276	0.0294
Onchocerca volvulus		0.0108	0.3067	0.8505
Entamoeba histolytica	cysteine protease, putative	0.0059	0.1291	0.1291
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0108	0.3067	0.3212
Brugia malayi	cathepsin F-like cysteine proteinase	0.0026	0.0081	0.0086
Leishmania major	cathepsin L-like protease	0.0108	0.3067	0.8528
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0059	0.1291	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.1291	0.1291
Brugia malayi	Papain family cysteine protease containing protein	0.0108	0.3067	0.327
Echinococcus multilocularis	cathepsin L cysteine protease	0.0108	0.3067	0.3212
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.028	0.9377	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0108	0.3067	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0884	0.0865
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.3067	0.301
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0108	0.3067	0.301
Echinococcus granulosus	cathepsin L	0.0059	0.1291	0.1302
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0108	0.3067	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.0276	0.0294
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0081	0.0081
Echinococcus multilocularis	FTZ F1 alpha	0.0032	0.0276	0.021
Entamoeba histolytica	cysteine proteinase, putative	0.0108	0.3067	0.3067
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0032	0.0276	0.021
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0108	0.3067	1
Brugia malayi	hypothetical protein	0.0036	0.0435	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0328	0.035
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.1291	0.1291
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0032	0.0276	0.021
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0032	0.0276	0.0294
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0297	1	1
Loa Loa (eye worm)	fibroinase	0.0108	0.3067	0.327
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.3067	0.301
Schistosoma mansoni	hypothetical protein	0.0035	0.0382	0.0325
Trypanosoma cruzi	cysteine protease, putative	0.0059	0.1291	0.1302
Schistosoma mansoni	RAR-like nuclear receptor	0.0032	0.0276	0.021
Loa Loa (eye worm)	steroid hormone receptor	0.0032	0.0276	0.0294
Echinococcus granulosus	cysteine protease	0.0059	0.1291	0.1302
Echinococcus granulosus	survival motor neuron protein 1	0.0236	0.7781	0.8283
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0122	0.3596	1
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0081	0.0081
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0108	0.3067	1
Entamoeba histolytica	cysteine protease, putative	0.0059	0.1291	0.1291
Brugia malayi	hypothetical protein	0.0236	0.7781	0.8298
Echinococcus multilocularis	cysteine protease	0.0108	0.3067	0.3212
Schistosoma mansoni	coup transcription factor	0.0032	0.0276	0.021
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.0276	0.0294
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0032	0.0276	0.021
Brugia malayi	ecdysteroid receptor	0.0032	0.0276	0.0294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0108	0.3067	0.301
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0328	0.035
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0276	0.0294
Onchocerca volvulus	Cathepsin L homolog	0.0108	0.3067	0.8505
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0075	0.1856	0.191
Trypanosoma cruzi	cysteine proteinase, putative	0.0059	0.1291	0.1302
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0297	1	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0033	0.0328	0.035
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0081	0.0086
Echinococcus multilocularis	ecdysone induced protein 78C	0.0032	0.0276	0.021
Trypanosoma cruzi	cruzipain precursor, putative	0.0033	0.0328	0.0266
Brugia malayi	photoreceptor-specific nuclear receptor	0.0032	0.0276	0.0294
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0328	0.035
Brugia malayi	Cathepsin L-like precursor	0.0108	0.3067	0.327
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0032	0.0276	0.021
Entamoeba histolytica	hypothetical protein	0.0036	0.0435	0.0435
Leishmania major	cathepsin L-like protease	0.0108	0.3067	0.8528
Loa Loa (eye worm)	hypothetical protein	0.0108	0.3067	0.327
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.0081	0.0086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.3067	0.301
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0032	0.0276	0.021
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0108	0.3067	0.301
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.0081	0.0086
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0026	0.0081	0.0086
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0032	0.0276	0.0294
Brugia malayi	fibroinase precursor	0.0026	0.0081	0.0086
Brugia malayi	Cathepsin L-like precursor	0.0075	0.1856	0.1979
Echinococcus granulosus	FTZ F1 alpha	0.0032	0.0276	0.021
Onchocerca volvulus		0.0108	0.3067	0.8505
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0032	0.0276	0.021
Plasmodium vivax	unspecified product	0.0059	0.1291	0.4054
Brugia malayi	cathepsin L-like precursor	0.0075	0.1856	0.1979
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.3067	0.301
Trypanosoma cruzi	cruzipain precursor, putative	0.0108	0.3067	0.3212
Trypanosoma cruzi	cysteine peptidase, putative	0.0108	0.3067	0.3212
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.1291	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1856	0.1979
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0026	0.0081	0.0086
Entamoeba histolytica	cysteine proteinase, putative	0.0108	0.3067	0.3067
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0108	0.3067	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0986	0.0974
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.3067	0.301
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0105	0.2956	0.3093
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0122	0.3596	0.8112
Echinococcus multilocularis	cathepsin L	0.0059	0.1291	0.1302
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0032	0.0276	0.0765
Brugia malayi	Nuclear hormone receptor-like 1	0.0032	0.0276	0.0294
Schistosoma mansoni	cathepsin F (C01 family)	0.0108	0.3067	0.3212
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0122	0.3596	0.8112
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0105	0.2956	0.2899
Entamoeba histolytica	cysteine protease, putative	0.0059	0.1291	0.1291
Entamoeba histolytica	cysteine protease, putative	0.0059	0.1291	0.1291
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0108	0.3067	0.301
Entamoeba histolytica	cysteine protease, putative	0.0059	0.1291	0.1291
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0032	0.0276	0.021
Trypanosoma cruzi	cysteine peptidase, putative	0.0108	0.3067	0.3212
Entamoeba histolytica	hypothetical protein	0.0036	0.0435	0.0435
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.028	0.9377	1
Echinococcus multilocularis	cathepsin b	0.028	0.9377	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0059	0.1291	0.1302
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0081	0.0086
Entamoeba histolytica	cysteine proteinase 2	0.0059	0.1291	0.1291
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0108	0.3067	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0986	0.0974
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.028	0.9377	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0986	0.1052
Entamoeba histolytica	cysteine protease, putative	0.0059	0.1291	0.1291
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0059	0.1291	0.1302
Onchocerca volvulus		0.0108	0.3067	0.8505
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0108	0.3067	1
Onchocerca volvulus	Huntingtin homolog	0.0122	0.3606	1
Echinococcus granulosus	cathepsin b	0.028	0.9377	1
Loa Loa (eye worm)	cysteine protease	0.0108	0.3067	0.327
Entamoeba histolytica	cysteine protease, putative	0.0059	0.1291	0.1291
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0986	0.0974
Echinococcus multilocularis	survival motor neuron protein 1	0.0236	0.7781	0.8283
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0026	0.0081	0.0086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.3067	0.301
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0986	0.0974
Plasmodium vivax	vivapain-2	0.0108	0.3067	1
Entamoeba histolytica	hypothetical protein	0.0026	0.0081	0.0081
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0059	0.1291	0.1302
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0032	0.0276	0.0294
Entamoeba histolytica	cysteine protease, putative	0.0059	0.1291	0.1291
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0081	0.0081
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0145	0.4433	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0297	1	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.0075	0.1856	0.191
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.0276	0.0294
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0026	0.0081	0.0086
Loa Loa (eye worm)	ctsf protein	0.0108	0.3067	0.327
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0122	0.3596	0.8112
Onchocerca volvulus		0.0026	0.0081	0.0223
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0081	0.0086
Leishmania major	cathepsin L-like protease	0.0108	0.3067	0.8528
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0081	0.0081
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.3067	0.301
Loa Loa (eye worm)	hypothetical protein	0.0122	0.3606	0.3845
Brugia malayi	Cathepsin L-like precursor	0.0108	0.3067	0.327
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0108	0.3067	0.301
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0435	0.0382

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1192978

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1151705