Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 ratio (binding) | = 30 | Binding affinity to microtubules, activity expressed as ID50 of compound/ID50 of paclitaxel | ChEMBL. | No reference |
Log 1/ratio (binding) | = -1.4771 | Binding affinity to microtubules, activity expressed as log 1/ID50 of compound/ID50 of paclitaxel | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.