TDR Targets

Basic information

Technical information

TDR Targets ID: 1154107
Name: E565-0117
MW: 479.531 | Formula: C22H17N5O4S2
H donors: 1 H acceptors: 5 LogP: 4.01 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)S(=O)(=O)c1nnn2c1nc(NCc1ccc3c(c1)OCO3)c1c2ccs1
InChi: 1S/C22H17N5O4S2/c1-13-2-5-15(6-3-13)33(28,29)22-21-24-20(19-16(8-9-32-19)27(21)26-25-22)23-11-14-4-7-17-18(10-14)31-12-30-17/h2-10H,11-12H2,1H3,(H,23,24)
InChiKey: VXOIIEGRKCFRHF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

NCGC00122740-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	Starlite/ChEMBL	References
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Bacillus subtilis (strain 168)	ATP-dependent Clp protease proteolytic subunit	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma mansoni	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Get druggable targets OG5_145685	All targets in OG5_145685
Echinococcus multilocularis	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	tm gpcr rhodopsin	Get druggable targets OG5_145685	All targets in OG5_145685
Schistosoma japonicum	ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium yoelii	ATP-dependent Clp protease, proteolytic subunit ClpP, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Babesia bovis	ATP-dependent Clp protease proteolytic subunit 1, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Brugia malayi	Probable ClpP-like protease	Get druggable targets OG5_127187	All targets in OG5_127187
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus granulosus	peptidase Clp S14 family	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	ko:K06275 parvin, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Neospora caninum	ATP-dependent Clp protease proteolytic subunit, related	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium yoelii	Clp protease	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.6 %
Chlamydia trachomatis	hypothetical protein	ATP-dependent Clp protease proteolytic subunit	197 aa	171 aa	22.8 %
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	186 aa	40.3 %
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	ATP-dependent Clp protease proteolytic subunit	197 aa	172 aa	57.0 %
Schistosoma mansoni	neuropeptide receptor	ATP-dependent Clp protease proteolytic subunit	197 aa	174 aa	20.1 %
Onchocerca volvulus	Putative V-type proton ATPase subunit F	ATP-dependent Clp protease proteolytic subunit	197 aa	194 aa	54.1 %
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	36.0 %
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.1 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	35.5 %
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	180 aa	36.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0171	0.0394
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0094	0.0814	0.0785
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0033	0.0188	0.2004
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.0814	1
Echinococcus granulosus	lamin	0.0026	0.0122	0.0092
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0066	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0814	0.1881
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0066	0.0448
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.8286	1
Loa Loa (eye worm)	hypothetical protein	0.0442	0.4327	1
Loa Loa (eye worm)	hypothetical protein	0.0333	0.3229	0.7463
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0066	0.0035
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0066	0.1081
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0112	0.0992	0.8837
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0066	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0339	0.0309
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0124	0.1182
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0066	0.1081
Trypanosoma brucei	trypanothione reductase	0.0049	0.0355	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0062	0.0485	0.4175
Plasmodium falciparum	thioredoxin reductase	0.0049	0.0355	0.4145
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0125	0.1118	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0112	0.0992	0.8837
Brugia malayi	hypothetical protein	0.0078	0.0648	0.2008
Schistosoma mansoni	ap endonuclease	0.002	0.0066	0.0042
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0171	0.014
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.0814	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0066	0.1081
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0066	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0049	0.0355	0.2985
Mycobacterium tuberculosis	Probable reductase	0.0112	0.0992	0.8837
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0339	0.0373
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0112	0.0992	0.8837
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0066	0.0448
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0842	0.8375	0.837
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0097	0.0844	0.2614
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0062	0.0485	0.0455
Echinococcus multilocularis	lamin dm0	0.0026	0.0122	0.0092
Echinococcus granulosus	peptidase Clp S14 family	0.0062	0.0485	0.0455
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.8286	0.828
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0066	0.0323
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0066	0.0153
Echinococcus multilocularis	geminin	0.0354	0.3434	0.3414
Toxoplasma gondii	exonuclease III APE	0.002	0.0066	0.0448
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0814	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0844	0.1951
Plasmodium falciparum	glutathione reductase	0.0049	0.0355	0.4145
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0094	0.0814	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0171	0.014
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0171	0.014
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0814	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0112	0.0992	0.8837
Brugia malayi	glutathione reductase	0.0049	0.0355	0.1101
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0339	0.0373
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0124	0.2853
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0171	0.014
Loa Loa (eye worm)	thioredoxin reductase	0.0049	0.0355	0.0821
Schistosoma mansoni	hypothetical protein	0.0354	0.3434	0.4122
Entamoeba histolytica	hypothetical protein	0.0078	0.0648	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.0532	0.1648
Plasmodium vivax	thioredoxin reductase, putative	0.0049	0.0355	0.4145
Schistosoma mansoni	peptidase Clp (S14 family)	0.0094	0.0814	0.0948
Brugia malayi	intermediate filament protein	0.0026	0.0122	0.0379
Brugia malayi	Probable ClpP-like protease	0.0094	0.0814	0.252
Echinococcus granulosus	geminin	0.0354	0.3434	0.3414
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0062	0.0485	0.3192
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0339	0.0309
Brugia malayi	Thioredoxin reductase	0.0049	0.0355	0.1101
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0125	0.1118	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0112	0.0992	0.8837
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0049	0.0355	0.0326
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0066	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0171	0.0394
Schistosoma mansoni	hypothetical protein	0.0031	0.0171	0.0169
Trypanosoma cruzi	trypanothione reductase, putative	0.0049	0.0355	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0033	0.0188	0.2004
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0124	0.1182
Brugia malayi	hypothetical protein	0.0026	0.0124	0.0383
Schistosoma mansoni	transcription factor LCR-F1	0.0078	0.0648	0.0748
Echinococcus multilocularis	hormone sensitive lipase	0.0442	0.4327	0.4309
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0097	0.0844	0.2614
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0124	0.0285
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0171	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0122	0.0283
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0339	0.0373
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0171	0.014
Echinococcus granulosus	thioredoxin glutathione reductase	0.0049	0.0355	0.0326
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0339	0.0784
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0122	0.0283
Echinococcus granulosus	hormone sensitive lipase	0.0442	0.4327	0.4309
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0122	0.0283
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0814	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0124	0.2853
Onchocerca volvulus		0.0333	0.3229	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0115	0.1025	0.2369
Schistosoma mansoni	lamin	0.0026	0.0122	0.0111
Loa Loa (eye worm)	glutathione reductase	0.0049	0.0355	0.0821
Schistosoma mansoni	hypothetical protein	0.0354	0.3434	0.4122
Echinococcus granulosus	GPCR family 2	0.0031	0.0171	0.014
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0097	0.0844	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0532	0.123
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0442	0.4327	0.5204
Mycobacterium tuberculosis	Probable oxidoreductase	0.0125	0.1118	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0033	0.0188	0.2004
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0031	0.0096
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0124	0.2853
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0442	0.4327	0.5204
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0124	0.2853
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0814	1
Entamoeba histolytica	hypothetical protein	0.0078	0.0648	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0066	0.0448
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0062	0.0485	0.4175
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0112	0.0992	0.8641
Brugia malayi	MH2 domain containing protein	0.0115	0.1025	0.3175
Echinococcus granulosus	lamin dm0	0.0026	0.0122	0.0092
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0814	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0171	0.0169
Leishmania major	trypanothione reductase	0.0049	0.0355	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0814	1
Plasmodium vivax	glutathione reductase, putative	0.0049	0.0355	0.4145
Brugia malayi	hypothetical protein	0.0333	0.3229	1
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0066	1
Toxoplasma gondii	thioredoxin reductase	0.0049	0.0355	0.4145
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0125	0.1118	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0094	0.0814	0.673
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0339	0.0309
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0078	0.0648	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0117	0.0272
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0066	0.0448
Schistosoma mansoni	hypothetical protein	0.0078	0.0648	0.0748
Echinococcus granulosus	intermediate filament protein	0.0026	0.0122	0.0092
Echinococcus multilocularis	lamin	0.0026	0.0122	0.0092
Schistosoma mansoni	hypothetical protein	0.0031	0.0171	0.0169
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0078	0.0648	0.0619
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0066	0.0204
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0124	0.1182
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0122	0.0111
Schistosoma mansoni	hypothetical protein	0.0067	0.0532	0.0607
Echinococcus multilocularis	musashi	0.0026	0.0122	0.0092
Schistosoma mansoni	lamin	0.0026	0.0122	0.0111
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0066	0.0035
Entamoeba histolytica	hypothetical protein	0.0078	0.0648	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0122	0.0379
Schistosoma mansoni	hypothetical protein	0.0031	0.0171	0.0169
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0339	0.105
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0171	0.0528
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0814	1
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0442	0.4327	0.5204
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0124	0.1182
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0094	0.0814	0.0785
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.8286	0.828
Toxoplasma gondii	hypothetical protein	0.0033	0.0188	0.2004
Entamoeba histolytica	hypothetical protein	0.0078	0.0648	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1003	1	1
Schistosoma mansoni	ap endonuclease	0.002	0.0066	0.0042
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0339	0.0309
Brugia malayi	hypothetical protein	0.0017	0.003	0.0092
Loa Loa (eye worm)	transcription factor SMAD2	0.0115	0.1025	0.2369

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 1.25 uM	Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production	ChEMBL.	20541425
Potency (functional)	0.5012 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.9811 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.9811 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1169898

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1154107