Detailed information for compound 115692

Basic information

Technical information
  • TDR Targets ID: 115692
  • Name: 3-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyri din-3-yl)methyl]phenyl]-N-methylsulfonyl-3-ph enylpropanamide
  • MW: 490.617 | Formula: C27H30N4O3S
  • H donors: 1 H acceptors: 5 LogP: 4.43 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1nc2c(n1Cc1ccc(cc1)C(c1ccccc1)CC(=O)NS(=O)(=O)C)nc(cc2C)C
  • InChi: 1S/C27H30N4O3S/c1-5-24-29-26-18(2)15-19(3)28-27(26)31(24)17-20-11-13-22(14-12-20)23(21-9-7-6-8-10-21)16-25(32)30-35(4,33)34/h6-15,23H,5,16-17H2,1-4H3,(H,30,32)
  • InChiKey: IETLIFYTCVLLRL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[4-[(2-ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-N-methylsulfonyl-3-phenyl-propanamide
  • 3-[4-[(2-ethyl-5,7-dimethyl-3-imidazo[4,5-b]pyridinyl)methyl]phenyl]-N-methylsulfonyl-3-phenylpropanamide
  • 3-[4-[(2-ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-N-mesyl-3-phenyl-propionamide
  • 3-[4-[(2-ethyl-5,7-dimethylimidazo[5,4-b]pyridin-3-yl)methyl]phenyl]-N-methylsulfonyl-3-phenylpropanamide
  • 3-[4-[(2-ethyl-5,7-dimethyl-imidazo[5,4-b]pyridin-3-yl)methyl]phenyl]-N-methylsulfonyl-3-phenyl-propanamide
  • 3-[4-[(2-ethyl-5,7-dimethyl-3-imidazo[5,4-b]pyridinyl)methyl]phenyl]-N-methylsulfonyl-3-phenylpropanamide
  • 3-[4-[(2-ethyl-5,7-dimethyl-imidazo[5,4-b]pyridin-3-yl)methyl]phenyl]-N-mesyl-3-phenyl-propionamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Angiotensin II receptor (AT-1) type-1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Angiotensin II receptor (AT-1) type-1   359 aa 325 aa 20.9 %
Loa Loa (eye worm) hypothetical protein Angiotensin II receptor (AT-1) type-1   359 aa 308 aa 27.6 %
Echinococcus granulosus thyrotropin releasing hormone receptor Angiotensin II receptor (AT-1) type-1   359 aa 363 aa 23.7 %
Loa Loa (eye worm) neuropeptide F receptor Angiotensin II receptor (AT-1) type-1   359 aa 344 aa 23.5 %
Echinococcus granulosus allatostatin A receptor Angiotensin II receptor (AT-1) type-1   359 aa 342 aa 27.2 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 314 aa 25.2 %
Echinococcus multilocularis G-protein coupled receptor, putative Angiotensin II receptor (AT-1) type-1   359 aa 307 aa 22.1 %
Echinococcus multilocularis allatostatin A receptor Angiotensin II receptor (AT-1) type-1   359 aa 342 aa 26.6 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Angiotensin II receptor (AT-1) type-1   359 aa 346 aa 18.2 %
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Angiotensin II receptor (AT-1) type-1   359 aa 300 aa 21.0 %
Echinococcus granulosus neuropeptide receptor Angiotensin II receptor (AT-1) type-1   359 aa 317 aa 24.6 %
Echinococcus multilocularis neuropeptide receptor Angiotensin II receptor (AT-1) type-1   359 aa 317 aa 24.9 %
Echinococcus granulosus growth hormone secretagogue receptor type 1 Angiotensin II receptor (AT-1) type-1   359 aa 343 aa 23.0 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 386 aa 24.4 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Angiotensin II receptor (AT-1) type-1   359 aa 350 aa 23.1 %
Brugia malayi putative neuropeptide receptor NPR1 Angiotensin II receptor (AT-1) type-1   359 aa 295 aa 27.1 %
Loa Loa (eye worm) hypothetical protein Angiotensin II receptor (AT-1) type-1   359 aa 329 aa 24.0 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 305 aa 24.9 %
Schistosoma mansoni peptide (allatostatin)-like receptor Angiotensin II receptor (AT-1) type-1   359 aa 323 aa 25.7 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 292 aa 24.7 %
Brugia malayi ORL1-like opioid receptor Angiotensin II receptor (AT-1) type-1   359 aa 314 aa 20.4 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Angiotensin II receptor (AT-1) type-1   359 aa 307 aa 24.1 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 350 aa 24.0 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor Angiotensin II receptor (AT-1) type-1   359 aa 366 aa 19.7 %
Brugia malayi GnHR receptor homolog Angiotensin II receptor (AT-1) type-1   359 aa 357 aa 20.4 %
Schistosoma mansoni opsin-like receptor Angiotensin II receptor (AT-1) type-1   359 aa 299 aa 25.8 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Angiotensin II receptor (AT-1) type-1   359 aa 354 aa 20.6 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 355 aa 23.9 %
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Angiotensin II receptor (AT-1) type-1   359 aa 365 aa 20.0 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Angiotensin II receptor (AT-1) type-1   359 aa 363 aa 23.4 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 309 aa 18.8 %
Echinococcus granulosus tm gpcr rhodopsin Angiotensin II receptor (AT-1) type-1   359 aa 300 aa 21.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide receptor 0.0052 0.0132 0.0448
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0132 0.0448
Onchocerca volvulus 0.0052 0.0132 0.0335
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0052 0.0132 0.0448
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0132 0.0162
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Brugia malayi GnHR receptor homolog 0.0052 0.0132 0.0132
Echinococcus granulosus G protein coupled receptor 139 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Brugia malayi Dopamine receptor 0.0052 0.0132 0.0132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0097 0.2659 0.536
Brugia malayi hypothetical protein 0.0052 0.0132 0.0132
Brugia malayi Serotonin receptor 0.0052 0.0132 0.0132
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2947 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Brugia malayi Dopamine receptor protein 1 0.0052 0.0132 0.0132
Brugia malayi hypothetical protein 0.0052 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Schistosoma mansoni alpha-1 adrenergic receptor 0.0052 0.0132 0.0162
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Mycobacterium leprae PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) 0.0228 1 0.5
Echinococcus granulosus General substrate transporter 0.0088 0.2142 0.727
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0132 0.0448
Schistosoma mansoni neuropeptide receptor 0.0052 0.0132 0.0162
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0132 0.0448
Schistosoma mansoni amine GPCR 0.0052 0.0132 0.0162
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0052 0.0132 0.0266
Mycobacterium ulcerans acetolactate synthase 1 catalytic subunit 0.0228 1 1
Onchocerca volvulus 0.012 0.3939 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Echinococcus multilocularis neuropeptide s receptor 0.0052 0.0132 0.0448
Brugia malayi sulfakinin receptor protein 0.0052 0.0132 0.0132
Echinococcus granulosus tachykinin peptides receptor 99D 0.0052 0.0132 0.0448
Onchocerca volvulus 0.0052 0.0132 0.0335
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0132 0.0448
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0132 0.0448
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0132 0.0448
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0132 0.0448
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0052 0.0132 0.0266
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0052 0.0132 0.0448
Brugia malayi hypothetical protein 0.0052 0.0132 0.0132
Onchocerca volvulus 0.0052 0.0132 0.0335
Echinococcus granulosus g protein coupled receptor 0.0052 0.0132 0.0448
Onchocerca volvulus 0.0052 0.0132 0.0335
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0132 0.0448
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0052 0.0132 0.0448
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0132 0.0448
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0132 0.0162
Echinococcus granulosus allatostatin A receptor 0.0052 0.0132 0.0448
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0132 0.0448
Schistosoma mansoni neuropeptide f receptor 76f 0.0052 0.0132 0.0162
Mycobacterium ulcerans pyruvate or indole-3-pyruvate decarboxylase Pdc 0.0131 0.4535 0.368
Schistosoma mansoni growth hormone secretagogue receptor 0.0052 0.0132 0.0162
Brugia malayi hypothetical protein 0.0052 0.0132 0.0132
Schistosoma mansoni opsin-like receptor 0.0052 0.0132 0.0162
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0132 0.0448
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0132 0.0448
Onchocerca volvulus 0.0052 0.0132 0.0335
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0132 0.0448
Brugia malayi putative neuropeptide receptor 0.0052 0.0132 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0132 0.0162
Schistosoma mansoni amine GPCR 0.0052 0.0132 0.0162
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0052 0.0132 0.0448
Echinococcus granulosus sex peptide receptor 0.0052 0.0132 0.0448
Echinococcus multilocularis General substrate transporter 0.0088 0.2142 0.727
Schistosoma mansoni neuropeptide receptor 0.0052 0.0132 0.0162
Schistosoma mansoni hypothetical protein 0.0052 0.0132 0.0162
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2947 1
Brugia malayi neuropeptide F receptor 0.0052 0.0132 0.0132
Plasmodium falciparum acyl-CoA synthetase 0.0131 0.4535 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Brugia malayi neuropeptide F receptor 0.0052 0.0132 0.0132
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.012 0.3939 0.4838
Echinococcus granulosus hypothetical protein 0.0052 0.0132 0.0448
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0132 0.0448
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0132 0.0266
Echinococcus granulosus alpha 1A adrenergic receptor 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2947 1
Schistosoma mansoni glucose transport protein 0.0102 0.2947 0.362
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Schistosoma mansoni amine GPCR 0.0052 0.0132 0.0162
Leishmania major putative pyruvate/indole-pyruvate carboxylase, putative 0.0131 0.4535 1
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0132 0.0266
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Schistosoma mansoni opsin-like receptor 0.0052 0.0132 0.0162
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0052 0.0132 0.0132
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0132 0.0448
Schistosoma mansoni hypothetical protein 0.0052 0.0132 0.0162
Brugia malayi ORL1-like opioid receptor 0.0052 0.0132 0.0132
Schistosoma mansoni adenoreceptor 0.0052 0.0132 0.0162
Echinococcus multilocularis serotonin receptor 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Mycobacterium leprae Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) 0.0228 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0052 0.0132 0.0132
Echinococcus granulosus serotonin receptor 0.0052 0.0132 0.0448
Echinococcus multilocularis G-protein coupled receptor, putative 0.0052 0.0132 0.0448
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0132 0.0162
Schistosoma mansoni biogenic amine receptor 0.0052 0.0132 0.0162
Trypanosoma brucei phosphonopyruvate decarboxylase-like protein, putative 0.0074 0.1354 0.5
Schistosoma mansoni amine GPCR 0.0052 0.0132 0.0162
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0052 0.0132 0.0162
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0052 0.0132 0.0448
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Onchocerca volvulus Neuropeptide F receptor homolog 0.0052 0.0132 0.0335
Echinococcus granulosus g protein coupled receptor 0.0052 0.0132 0.0448
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0132 0.0162
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0132 0.0448
Echinococcus multilocularis g-protein coupled receptor 0.0052 0.0132 0.0448
Brugia malayi AKH receptor 0.0052 0.0132 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0132 0.0162
Schistosoma mansoni hypothetical protein 0.0102 0.2947 0.362
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Echinococcus multilocularis orexin receptor type 2 0.0052 0.0132 0.0448
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0052 0.0132 0.0162
Brugia malayi G-protein coupled receptor 0.0052 0.0132 0.0132
Mycobacterium ulcerans acetolactate synthase 0.0131 0.4535 0.368
Brugia malayi putative neuropeptide receptor NPR1 0.0052 0.0132 0.0132
Onchocerca volvulus 0.0052 0.0132 0.0335
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2947 1
Echinococcus granulosus neuropeptide receptor 0.0052 0.0132 0.0448
Echinococcus granulosus peptide allatostatin:somatostatin 0.0052 0.0132 0.0448
Echinococcus granulosus orexin receptor type 2 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Brugia malayi Dopamine receptor protein 2 0.0052 0.0132 0.0132
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0052 0.0132 0.0162
Echinococcus multilocularis serotonin receptor 0.0052 0.0132 0.0448
Schistosoma mansoni glucose transport protein 0.0102 0.2947 0.362
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0052 0.0132 0.0132
Echinococcus granulosus neuropeptide FF receptor 2 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0132 0.0266
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0052 0.0132 0.0266
Schistosoma mansoni biogenic amine receptor 0.0052 0.0132 0.0162
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2947 1
Brugia malayi Cation transporter family protein 0.012 0.3939 0.3939
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Onchocerca volvulus 0.0052 0.0132 0.0335
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0052 0.0132 0.0448
Trypanosoma cruzi phosphonopyruvate decarboxylase, putative 0.0074 0.1354 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Loa Loa (eye worm) ILVBL protein 0.0138 0.496 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0132 0.0448
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0132 0.0266
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0052 0.0132 0.0162
Mycobacterium ulcerans putative oxalyl-CoA decarboxylase 0.0228 1 1
Brugia malayi Melatonin receptor type 1A 0.0052 0.0132 0.0132
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0132 0.0448
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0132 0.0162
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0052 0.0132 0.0448
Schistosoma mansoni glucose transport protein 0.0102 0.2947 0.362
Mycobacterium ulcerans hypothetical protein 0.0228 1 1
Schistosoma mansoni opsin-like receptor 0.0052 0.0132 0.0162
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0132 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2947 0.5
Brugia malayi G-protein coupled receptor 0.0052 0.0132 0.0132
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0132 0.0448
Brugia malayi hypothetical protein 0.0052 0.0132 0.0132
Brugia malayi hypothetical protein 0.0052 0.0132 0.0132
Schistosoma mansoni hypothetical protein 0.0052 0.0132 0.0162
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0052 0.0132 0.0162
Onchocerca volvulus 0.0052 0.0132 0.0335
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0052 0.0132 0.0132
Echinococcus multilocularis G protein coupled receptor 139 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Schistosoma mansoni myosin xvIII 0.0052 0.0132 0.0162
Trypanosoma cruzi phosphonopyruvate decarboxylase, putative 0.0074 0.1354 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0132 0.0448
Plasmodium vivax acyl-CoA synthetase, putative 0.0131 0.4535 1
Onchocerca volvulus 0.012 0.3939 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2947 0.5
Echinococcus granulosus g protein coupled receptor 0.0052 0.0132 0.0448
Echinococcus multilocularis neuropeptide FF receptor 2 0.0052 0.0132 0.0448
Schistosoma mansoni histamine h1 receptor 0.0052 0.0132 0.0162
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.012 0.3939 0.794
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Onchocerca volvulus 0.0052 0.0132 0.0335
Mycobacterium tuberculosis Probable oxalyl-CoA decarboxylase OxcA 0.0228 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0132 0.0448
Onchocerca volvulus 0.0052 0.0132 0.0335
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0052 0.0132 0.0162
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0052 0.0132 0.0266
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0132 0.0448
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0132 0.0448
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0132 0.0162
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Onchocerca volvulus 0.0052 0.0132 0.0335
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0052 0.0132 0.0448
Brugia malayi Tachykinin-like peptides receptor 99D 0.0052 0.0132 0.0132
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0052 0.0132 0.0448
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0052 0.0132 0.0132
Echinococcus granulosus neuropeptide receptor A26 0.0052 0.0132 0.0448
Trypanosoma brucei phosphonopyruvate decarboxylase-like protein, putative 0.0074 0.1354 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0132 0.0162
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Onchocerca volvulus 0.0052 0.0132 0.0335
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0132 0.0162
Brugia malayi G protein-coupled receptor 0.0052 0.0132 0.0132
Onchocerca volvulus 0.012 0.3939 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0052 0.0132 0.0448
Onchocerca volvulus 0.0052 0.0132 0.0335
Echinococcus granulosus dro:myosuppressin receptor 0.0052 0.0132 0.0448
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0132 0.0162
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0052 0.0132 0.0335
Schistosoma mansoni acetolactate synthase 0.0195 0.8142 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Echinococcus multilocularis sex peptide receptor 0.0052 0.0132 0.0448
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0132 0.0448
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0132 0.0448
Loa Loa (eye worm) thiamine pyrophosphate enzyme 0.0131 0.4548 0.9168
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Loa Loa (eye worm) melatonin receptor type 1A 0.0052 0.0132 0.0266
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0132 0.0448
Schistosoma mansoni acetolactate synthase 0.0195 0.8142 1
Onchocerca volvulus 0.0052 0.0132 0.0335
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0132 0.0162
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0132 0.0448
Onchocerca volvulus 0.0052 0.0132 0.0335
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2947 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0052 0.0132 0.0448
Brugia malayi G protein-coupled receptor F59B2.13 0.0052 0.0132 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0132 0.0162
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Onchocerca volvulus 0.0052 0.0132 0.0335
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0052 0.0132 0.0162
Mycobacterium ulcerans acetolactate synthase large subunit IlvB 0.0131 0.4535 0.368
Brugia malayi hypothetical protein 0.0052 0.0132 0.0132
Loa Loa (eye worm) TYRA-2 protein 0.0052 0.0132 0.0266
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2947 1
Echinococcus granulosus fmrfamide receptor 0.0052 0.0132 0.0448
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.012 0.3939 0.4838
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0132 0.0162
Mycobacterium tuberculosis Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) 0.0228 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0132 0.0162
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0132 0.0162
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Schistosoma mansoni biogenic amine receptor 0.0052 0.0132 0.0162
Echinococcus granulosus g-protein coupled receptor 0.0052 0.0132 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Schistosoma mansoni neuropeptide receptor 0.0052 0.0132 0.0162
Brugia malayi follicle stimulating hormone receptor 0.0052 0.0132 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0132 0.0162
Echinococcus granulosus 7TM GPCR rhodopsin 0.0052 0.0132 0.0448
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0052 0.0132 0.0448
Brugia malayi hypothetical protein 0.0052 0.0132 0.0132
Schistosoma mansoni amine GPCR 0.0052 0.0132 0.0162
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0132 0.0448
Brugia malayi Serotonin receptor 0.0052 0.0132 0.0132
Echinococcus granulosus neuropeptide s receptor 0.0052 0.0132 0.0448
Brugia malayi RE15519p 0.0052 0.0132 0.0132
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0132 0.0162
Echinococcus multilocularis somatostatin receptor 0.0052 0.0132 0.0448
Loa Loa (eye worm) sugar transporter 0.0102 0.2947 0.5941
Echinococcus multilocularis allatostatin A receptor 0.0052 0.0132 0.0448
Onchocerca volvulus 0.0052 0.0132 0.0335
Schistosoma mansoni hypothetical protein 0.0052 0.0132 0.0162
Echinococcus multilocularis neuropeptide receptor A26 0.0052 0.0132 0.0448
Schistosoma mansoni neuropeptide receptor 0.0052 0.0132 0.0162
Loa Loa (eye worm) hypothetical protein 0.012 0.3939 0.794
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2947 1
Brugia malayi Sugar transporter family protein 0.0102 0.2947 0.2947
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0052 0.0132 0.0162
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0052 0.0132 0.0266
Brugia malayi hypothetical protein 0.0052 0.0132 0.0132
Echinococcus granulosus somatostatin receptor 0.0052 0.0132 0.0448
Brugia malayi larval opioid receptor 0.0052 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0266
Brugia malayi hypothetical protein 0.0052 0.0132 0.0132
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0132 0.0448
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0132 0.0448
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0132 0.0448

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.094 uM Inhibitory concentration was evaluated by measuring displacement of [3H]-AII from rat liver Angiotensin II receptor, type 1 ChEMBL. 8667363
IC50 (binding) = 0.094 uM Inhibitory concentration was evaluated by measuring displacement of [3H]-AII from rat liver Angiotensin II receptor, type 1 ChEMBL. 8667363
Inhibition (functional) = 72.7 % In vivo inhibitory percentage of pressor response induced by exogenous submaxilmal dose of angiotensin-II (3 ug/kg) administered iv to pithed rats ChEMBL. 8667363
Inhibition (functional) = 72.7 % In vivo inhibitory percentage of pressor response induced by exogenous submaxilmal dose of angiotensin-II (3 ug/kg) administered iv to pithed rats ChEMBL. 8667363

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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