Detailed information for compound 1159542

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 370.227 | Formula: C17H17Cl2NO4
  • H donors: 2 H acceptors: 2 LogP: 3.92 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)Cc1ccc(c(c1Cl)Cl)Oc1ccc(c(c1)CN)O
  • InChi: 1S/C17H17Cl2NO4/c1-2-23-15(22)8-10-3-6-14(17(19)16(10)18)24-12-4-5-13(21)11(7-12)9-20/h3-7,21H,2,8-9,20H2,1H3
  • InChiKey: SSJCTHNPNPTJOB-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum serine repeat antigen 4 0.032 0.1122 0.2158
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0057 0.0133 0.1528
Mycobacterium ulcerans hypothetical protein 0.0039 0.0065 0.307
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.1401 0.5189 0.5189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1448 0.5366 1
Echinococcus multilocularis transcription factor btf3 0.0031 0.0035 0.0033
Entamoeba histolytica cysteine proteinase, putative 0.0762 0.2787 0.5368
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.032 0.1122 0.2158
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0065 0.307
Loa Loa (eye worm) hypothetical protein 0.0039 0.0065 0.0065
Brugia malayi Cathepsin L-like precursor 0.0958 0.3524 0.3524
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2679 1 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.004 0.0509
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0087 0.0244 0.2825
Schistosoma mansoni alpha-glucosidase 0.0149 0.0478 0.0478
Echinococcus multilocularis cathepsin L cysteine protease 0.1401 0.5189 0.5188
Loa Loa (eye worm) hypothetical protein 0.0039 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0049 0.0102 0.0102
Echinococcus granulosus cathepsin L cysteine proteinase 0.1401 0.5189 0.5188
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.0202 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0035 0.0064
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.0857 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0031 0.0055
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0054 0.01
Giardia lamblia Cathepsin B precursor 0.105 0.3867 1
Loa Loa (eye worm) hypothetical protein 0.032 0.1122 0.1122
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0065 0.0065
Echinococcus multilocularis cathepsin L cysteine protease 0.1401 0.5189 0.5188
Onchocerca volvulus 0.0958 0.3524 0.679
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0057 0.0133 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.1122 0.2158
Loa Loa (eye worm) papain family cysteine protease containing protein 0.032 0.1122 0.1122
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0206 0.0379
Loa Loa (eye worm) hypothetical protein 0.0442 0.1583 0.1583
Entamoeba histolytica cysteine protease, putative 0.0762 0.2787 0.5368
Plasmodium falciparum glutathione reductase 0.0087 0.0244 0.0466
Onchocerca volvulus 0.1401 0.5189 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0133 0.0133
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0077 0.0206 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.0144
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0062 0.0115
Plasmodium vivax acyl-CoA synthetase, putative 0.0057 0.0133 0.0252
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0065 0.0731
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.105 0.3867 0.3866
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1448 0.5366 1
Giardia lamblia Cysteine protease 0.032 0.1122 0.2843
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0002 0.0002
Leishmania major cathepsin L-like protease 0.1401 0.5189 0.967
Schistosoma mansoni hypothetical protein 0.0087 0.0247 0.0247
Entamoeba histolytica cysteine proteinase 1, putative 0.0762 0.2787 0.5368
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1401 0.5189 1
Plasmodium falciparum glutathione reductase 0.003 0.0031 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2787 0.5368
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0008 0.0005
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0031 0.0055
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0077 0.0206 1
Brugia malayi Cathepsin L-like precursor 0.1401 0.5189 0.5189
Entamoeba histolytica cysteine protease, putative 0.0762 0.2787 0.5368
Brugia malayi beta-NAC-like protein 0.0031 0.0035 0.0035
Entamoeba histolytica papain family cysteine protease domain containing protein 0.032 0.1122 0.2158
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1401 0.5189 0.5188
Plasmodium vivax unspecified product 0.0762 0.2787 0.5368
Echinococcus granulosus chromobox protein 1 0.0076 0.0202 0.02
Plasmodium vivax serine-repeat antigen (SERA), putative 0.032 0.1122 0.2158
Toxoplasma gondii cathepsin CPC1 0.032 0.1122 0.2158
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0031 0.0055
Loa Loa (eye worm) hypothetical protein 0.0039 0.0065 0.0065
Giardia lamblia Encystation-specific protease 0.032 0.1122 0.2843
Plasmodium falciparum serine repeat antigen 7 0.032 0.1122 0.2158
Loa Loa (eye worm) hypothetical protein 0.032 0.1122 0.1122
Onchocerca volvulus Cathepsin L homolog 0.1401 0.5189 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0031 0.0053
Loa Loa (eye worm) hypothetical protein 0.2679 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0762 0.2787 0.2786
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0065 0.012
Loa Loa (eye worm) hypothetical protein 0.032 0.1122 0.1122
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0054 0.01
Trypanosoma brucei glucosidase, putative 0.0038 0.0062 0.0112
Echinococcus granulosus cathepsin b 0.2679 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0287 0.0285
Giardia lamblia Cathepsin L precursor 0.032 0.1122 0.2843
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.032 0.1122 0.2158
Loa Loa (eye worm) hypothetical protein 0.0077 0.0206 0.0206
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2679 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0065 0.0065
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0287 0.0285
Echinococcus multilocularis cathepsin L 0.032 0.1122 0.112
Plasmodium vivax vivapain-2 0.1401 0.5189 1
Schistosoma mansoni transcription factor LCR-F1 0.0152 0.0488 0.0488
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0206 0.0205
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.0206 0.238
Brugia malayi cathepsin F-like cysteine proteinase 0.032 0.1122 0.1121
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0062 0.0115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2787 0.5191
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0065 0.0065
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1741 0.647 0.647
Echinococcus multilocularis protein dispatched 1 0.0104 0.0307 0.0305
Brugia malayi Cathepsin L-like precursor 0.1401 0.5189 0.5189
Entamoeba histolytica hypothetical protein 0.0152 0.0488 0.0937
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1401 0.5189 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0044 0.0043
Loa Loa (eye worm) hypothetical protein 0.0043 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1401 0.5189 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0031 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0121 0.1391
Mycobacterium tuberculosis Conserved protein 0.0039 0.0065 0.0731
Plasmodium vivax thioredoxin reductase, putative 0.0087 0.0244 0.0466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1448 0.5366 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0002 0.0002
Entamoeba histolytica papain family cysteine protease domain containing protein 0.032 0.1122 0.2158
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0008 0.0008
Toxoplasma gondii thioredoxin reductase 0.0087 0.0244 0.0466
Loa Loa (eye worm) hypothetical protein 0.0091 0.0259 0.0259
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0031 0.0028
Onchocerca volvulus 0.01 0.0294 0.0563
Loa Loa (eye worm) hypothetical protein 0.0057 0.0133 0.0133
Giardia lamblia Cathepsin L-like protease 0.032 0.1122 0.2843
Giardia lamblia Cathepsin L precursor 0.032 0.1122 0.2843
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0031 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.032 0.1122 0.2158
Entamoeba histolytica cysteine protease, putative 0.0762 0.2787 0.5368
Trypanosoma cruzi cysteine peptidase, putative 0.0442 0.1583 0.1581
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0054 0.01
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1401 0.5189 1
Giardia lamblia Cathepsin L-like protease 0.032 0.1122 0.2843
Echinococcus multilocularis geminin 0.0356 0.1256 0.1254
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.032 0.1122 0.2158
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.032 0.1122 0.2158
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.004 0.0442
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0089 0.0168
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0002 0.0002
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0062 0.006
Onchocerca volvulus 0.0077 0.0206 0.0392
Brugia malayi Glycosyl hydrolases family 31 protein 0.0173 0.0569 0.0568
Brugia malayi hypothetical protein 0.0251 0.0862 0.0862
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0031 0.0053
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0062 0.0061
Onchocerca volvulus 0.1401 0.5189 1
Echinococcus multilocularis cathepsin b 0.2679 1 1
Plasmodium falciparum serine repeat antigen 2 0.032 0.1122 0.2158
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.032 0.1122 0.2158
Loa Loa (eye worm) hypothetical protein 0.0057 0.0133 0.0133
Onchocerca volvulus Cathepsin L homolog 0.032 0.1122 0.2158
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.032 0.1122 0.1122
Brugia malayi Inositol-1 0.0036 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.032 0.1122 0.2158
Schistosoma mansoni hypothetical protein 0.0087 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0958 0.3524 0.3524
Plasmodium falciparum serine repeat antigen 6 0.032 0.1122 0.2158
Loa Loa (eye worm) hypothetical protein 0.0442 0.1583 0.1583
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.032 0.1122 0.1122
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.105 0.3867 0.7452
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0121 0.1391
Loa Loa (eye worm) fibroinase 0.1401 0.5189 0.5189
Echinococcus granulosus cathepsin L cysteine protease 0.0762 0.2787 0.2785
Brugia malayi Bromodomain containing protein 0.008 0.0217 0.0217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1401 0.5189 1
Leishmania major cathepsin L-like protease 0.1448 0.5366 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0065 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.003 0.003 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.032 0.1122 0.2158
Giardia lamblia Cathepsin B precursor 0.105 0.3867 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1401 0.5189 1
Leishmania major cysteine peptidase A (CPA) 0.1401 0.5189 0.967
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.0862 0.0861
Entamoeba histolytica cysteine protease, putative 0.1401 0.5189 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0031 0.0053
Echinococcus granulosus Protein patched homolog 1 0.0091 0.0259 0.0257
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0062 0.0115
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0156 0.0154
Onchocerca volvulus 0.1401 0.5189 1
Schistosoma mansoni alpha glucosidase 0.0038 0.0062 0.0062
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0054 0.0097
Brugia malayi Niemann-Pick C1 protein precursor 0.0211 0.0713 0.0713
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0035 0.0064
Entamoeba histolytica cysteine protease, putative 0.0762 0.2787 0.5368
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0031 0.1397
Trypanosoma brucei cysteine peptidase C (CPC) 0.105 0.3867 0.7206
Onchocerca volvulus Cathepsin L homolog 0.1401 0.5189 1
Entamoeba histolytica hypothetical protein 0.0152 0.0488 0.0937
Entamoeba histolytica cysteine proteinase, putative 0.0762 0.2787 0.5368
Plasmodium falciparum thioredoxin reductase 0.0087 0.0244 0.0466
Entamoeba histolytica hypothetical protein 0.032 0.1122 0.2158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1401 0.5189 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0367 0.1298 0.1297
Schistosoma mansoni cathepsin F (C01 family) 0.0958 0.3524 0.3524
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0008 0.0005
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0031 0.0055
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.0569 0.0567
Giardia lamblia Dipeptidyl-peptidase I precursor 0.032 0.1122 0.2843
Brugia malayi Cathepsin L-like precursor 0.1401 0.5189 0.5189
Trichomonas vaginalis conserved hypothetical protein 0.003 0.003 0.0055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0121 0.1391
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.032 0.1122 0.2158
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.105 0.3867 0.7206
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0442 0.1583 0.1583
Entamoeba histolytica cysteine protease, putative 0.032 0.1122 0.2158
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0031 0.0028
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0002 0.0002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0065 0.0731
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0077 0.0206 1
Entamoeba histolytica cysteine protease, putative 0.0762 0.2787 0.5368
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.032 0.1122 0.2158
Giardia lamblia Cysteine protease 0.032 0.1122 0.2843
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0156 0.0154
Loa Loa (eye worm) cathepsin B 0.105 0.3867 0.3867
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0206 0.0392
Schistosoma mansoni bromodomain containing protein 0.0067 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0034 0.0044 0.0044
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0065 0.012
Onchocerca volvulus 0.1401 0.5189 1
Trypanosoma brucei transcription factor BTF3, putative 0.0031 0.0035 0.0062
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.032 0.1122 0.2158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1401 0.5189 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.032 0.1122 0.2158
Loa Loa (eye worm) hypothetical protein 0.0075 0.02 0.02
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0065 0.012
Schistosoma mansoni microtubule-associated protein tau 0.0747 0.2727 0.2727
Trypanosoma brucei trypanothione reductase 0.0087 0.0244 0.045
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Echinococcus multilocularis cathepsin b 0.2679 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0077 0.0077
Plasmodium vivax serine-repeat antigen (SERA), putative 0.032 0.1122 0.2158
Plasmodium falciparum serine repeat antigen 5 0.032 0.1122 0.2158
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0287 0.0285
Entamoeba histolytica cysteine proteinase 2 0.0762 0.2787 0.5368
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0054 0.0052
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0287 0.0286
Brugia malayi Thioredoxin reductase 0.0087 0.0244 0.0243
Entamoeba histolytica hypothetical protein 0.0152 0.0488 0.0937
Loa Loa (eye worm) hypothetical protein 0.0958 0.3524 0.3524
Giardia lamblia Cysteine protease 0.032 0.1122 0.2843
Onchocerca volvulus 0.0039 0.0065 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0065 0.0062
Brugia malayi Cathepsin L-like precursor 0.1401 0.5189 0.5189
Echinococcus multilocularis cysteine protease 0.1401 0.5189 0.5188
Brugia malayi Papain family cysteine protease containing protein 0.032 0.1122 0.1121
Mycobacterium tuberculosis Probable dehydrogenase 0.0198 0.0662 0.7713
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.032 0.1122 0.1122
Loa Loa (eye worm) thioredoxin reductase 0.0087 0.0244 0.0244
Brugia malayi Papain family cysteine protease containing protein 0.032 0.1122 0.1121
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0211 0.0713 0.1371
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0062 0.0115
Schistosoma mansoni hypothetical protein 0.0356 0.1256 0.1256
Toxoplasma gondii cathepsin CPL 0.1401 0.5189 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.011 0.011
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0065 0.0062
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0031 0.0055
Echinococcus granulosus cathepsin l cysteine peptidase 0.1401 0.5189 0.5188
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0287 0.0285
Echinococcus granulosus cysteine protease 0.0762 0.2787 0.2785
Onchocerca volvulus 0.0039 0.0065 0.012
Echinococcus granulosus geminin 0.0356 0.1256 0.1254
Loa Loa (eye worm) papain family cysteine protease containing protein 0.032 0.1122 0.1122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1401 0.5189 1
Brugia malayi cathepsin L precursor 0.032 0.1122 0.1121
Echinococcus multilocularis microtubule associated protein 2 0.0747 0.2727 0.2726
Loa Loa (eye worm) hypothetical protein 0.0111 0.0336 0.0336
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0065 0.0062
Echinococcus multilocularis protein patched 0.0091 0.0259 0.0257
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0287 0.0287
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0031 0.0053
Plasmodium falciparum serine repeat antigen 9 0.032 0.1122 0.2158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1401 0.5189 1
Entamoeba histolytica cysteine protease, putative 0.0762 0.2787 0.5368
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0065 0.307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1448 0.5366 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1448 0.5366 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0206 0.0379
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0054 0.01
Echinococcus granulosus microtubule associated protein 2 0.0747 0.2727 0.2726
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.032 0.1122 0.1122
Schistosoma mansoni hypothetical protein 0.0087 0.0247 0.0247
Plasmodium vivax unspecified product 0.032 0.1122 0.2158
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.0144
Onchocerca volvulus 0.1401 0.5189 1
Brugia malayi beta-lactamase 0.0039 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0958 0.3524 0.3524
Leishmania major cathepsin L-like protease 0.1401 0.5189 0.967
Leishmania major cathepsin L-like protease 0.1448 0.5366 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0077 0.0206 1
Entamoeba histolytica hypothetical protein 0.0031 0.0035 0.0064
Entamoeba histolytica cysteine protease, putative 0.0762 0.2787 0.5368
Mycobacterium ulcerans lipase LipD 0.0039 0.0065 0.307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1401 0.5189 1
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0065 0.0116
Mycobacterium tuberculosis Conserved protein 0.0039 0.0065 0.0731
Echinococcus granulosus transcription factor btf3 0.0031 0.0035 0.0033
Brugia malayi Bromodomain containing protein 0.0041 0.0071 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.1122 0.2158
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0061 0.0059
Trypanosoma cruzi cruzipain precursor, putative 0.1448 0.5366 0.5365
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0762 0.2787 0.2785
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.032 0.1122 0.1122
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0198 0.0662 0.8882
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0065 0.012
Mycobacterium ulcerans hypothetical protein 0.0077 0.0206 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1401 0.5189 1
Trypanosoma cruzi cysteine peptidase, putative 0.0762 0.2787 0.2785
Brugia malayi Cathepsin L-like precursor 0.1401 0.5189 0.5189
Trypanosoma cruzi major cysteine proteinase, putative 0.032 0.1122 0.112
Trypanosoma cruzi cysteine proteinase, putative 0.0762 0.2787 0.2785
Brugia malayi Cathepsin L-like precursor 0.1401 0.5189 0.5189
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0031 0.0333
Toxoplasma gondii preprocathepsin c precursor, putative 0.032 0.1122 0.2158
Echinococcus granulosus sterol regulatory element binding protein 0.0091 0.0259 0.0257
Echinococcus multilocularis Niemann Pick C1 protein 0.0211 0.0713 0.0711
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0173 0.0569 0.0569
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.032 0.1122 0.1122
Plasmodium vivax basic transcription factor 3b, putative 0.0031 0.0035 0.0064
Trypanosoma cruzi trypanothione reductase, putative 0.0087 0.0244 0.0242
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0206 0.0205
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0202 0.0386
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0206 0.0379
Plasmodium vivax vivapain-1 0.0762 0.2787 0.5368
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.022 0.0745 1
Onchocerca volvulus 0.0039 0.0065 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0062 0.006
Loa Loa (eye worm) hypothetical protein 0.0442 0.1583 0.1583
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0206 1
Giardia lamblia Hypothetical protein 0.032 0.1122 0.2843
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0089 0.0168
Toxoplasma gondii cathepsin CPC2 0.032 0.1122 0.2158
Onchocerca volvulus 0.1401 0.5189 1
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0065 0.012
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.032 0.1122 0.2158
Brugia malayi chromobox protein homolog 3 0.0042 0.0077 0.0076
Giardia lamblia Cathepsin B precursor 0.032 0.1122 0.2843
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0031 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2787 0.5191
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0062 0.0112
Entamoeba histolytica cysteine protease, putative 0.0762 0.2787 0.5368
Entamoeba histolytica acyl-coA synthetase, putative 0.0077 0.0206 0.0392
Mycobacterium ulcerans beta-lactamase 0.0039 0.0065 0.307
Echinococcus granulosus chromobox protein 1 0.0076 0.0202 0.02
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0215 0.0725 0.0725
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0062 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0958 0.3524 0.679
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0206 1
Leishmania major basic transcription factor 3a, putative 0.0031 0.0035 0.0062
Brugia malayi beta-lactamase family protein 0.0039 0.0065 0.0064
Giardia lamblia Cathepsin B precursor 0.032 0.1122 0.2843
Plasmodium vivax unspecified product 0.0442 0.1583 0.3047
Toxoplasma gondii cathepsin B 0.105 0.3867 0.7452
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0062 0.0062
Echinococcus granulosus thioredoxin glutathione reductase 0.0087 0.0246 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.1122 0.2158
Entamoeba histolytica cysteine proteinase, putative 0.0958 0.3524 0.679
Giardia lamblia Cathepsin B precursor 0.032 0.1122 0.2843
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0031 0.1397
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0133 0.6421
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2679 1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0302 0.1055 0.1053
Schistosoma mansoni cathepsin F (C01 family) 0.1401 0.5189 0.5189
Brugia malayi Papain family cysteine protease containing protein 0.1401 0.5189 0.5189
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0062 0.0115
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0089 0.0168
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.032 0.1122 0.1122
Trypanosoma cruzi transcription factor btf3, putative 0.0031 0.0035 0.0033
Brugia malayi fibroinase precursor 0.032 0.1122 0.1121
Loa Loa (eye worm) hypothetical protein 0.0033 0.0043 0.0043
Echinococcus granulosus cathepsin l1 0.0958 0.3524 0.3523
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0062 0.006
Schistosoma mansoni survival motor neuron protein 0.0051 0.011 0.011
Loa Loa (eye worm) ctsf protein 0.1401 0.5189 0.5189
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.032 0.1122 0.2843
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.032 0.1122 0.2158
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0202 0.0386
Mycobacterium tuberculosis Probable reductase 0.0198 0.0662 0.7713
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0958 0.3524 0.679
Giardia lamblia Cathepsin B precursor 0.105 0.3867 1
Trichomonas vaginalis esterase, putative 0.0039 0.0065 0.012
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0054 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0259 0.0495
Schistosoma mansoni patched 1 0.0091 0.0259 0.0259
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0031 0.0028
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0065 0.0731
Entamoeba histolytica transcription factor BTF3, putative 0.0031 0.0035 0.0064
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0065 0.0731
Entamoeba histolytica cysteine protease, putative 0.0762 0.2787 0.5368
Entamoeba histolytica cysteine proteinase, putative 0.1401 0.5189 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1448 0.5366 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0062 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1401 0.5189 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1401 0.5189 1
Schistosoma mansoni hypothetical protein 0.0356 0.1256 0.1256
Brugia malayi beta-lactamase family protein 0.0039 0.0065 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1401 0.5189 1
Echinococcus multilocularis cathepsin L 0.0762 0.2787 0.2785
Echinococcus granulosus cathepsin L 0.0762 0.2787 0.2785
Onchocerca volvulus 0.0033 0.0043 0.0078
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.032 0.1122 0.1122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1448 0.5366 1
Loa Loa (eye worm) ICD-1 protein 0.0031 0.0035 0.0035
Toxoplasma gondii NAC domain-containing protein 0.0031 0.0035 0.0064
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.032 0.1122 0.2158
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0002 0.0002
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0054 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.032 0.1122 0.1122
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.032 0.1122 0.2158
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0031 0.0028
Brugia malayi cathepsin Z-like cysteine proteinase 0.032 0.1122 0.1121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1401 0.5189 1
Plasmodium vivax serine-repeat antigen (SERA) 0.032 0.1122 0.2158
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.032 0.1122 0.1122
Giardia lamblia Cysteine protease 0.032 0.1122 0.2843
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1401 0.5189 1
Brugia malayi cathepsin L-like cysteine proteinase 0.032 0.1122 0.1121
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2679 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1401 0.5189 1
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0065 0.0731
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.022 0.0745 0.8684
Trypanosoma cruzi cysteine peptidase, putative 0.1401 0.5189 0.5188
Plasmodium falciparum basic transcription factor 3b, putative 0.0031 0.0035 0.0064
Loa Loa (eye worm) hypothetical protein 0.0039 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0152 0.0488 0.0488
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.032 0.1122 0.1122
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0031 0.0028
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0206 0.2741
Schistosoma mansoni cathepsin C 0.032 0.1122 0.1122
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0035 0.0064
Echinococcus multilocularis cysteine protease 0.1401 0.5189 0.5188
Mycobacterium tuberculosis Conserved protein 0.0039 0.0065 0.0731
Plasmodium vivax glutathione reductase, putative 0.0087 0.0244 0.0466
Brugia malayi cathepsin Z-like cysteine proteinase 0.032 0.1122 0.1121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1401 0.5189 1
Toxoplasma gondii ABC1 family protein 0.0039 0.0065 0.012
Giardia lamblia Cathepsin L precursor 0.032 0.1122 0.2843
Schistosoma mansoni inositol monophosphatase 0.0036 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.032 0.1122 0.2158
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0031 0.0055
Trypanosoma cruzi cysteine peptidase, putative 0.1448 0.5366 0.5365
Trichomonas vaginalis conserved hypothetical protein 0.032 0.1122 0.2158
Entamoeba histolytica cysteine protease, putative 0.0762 0.2787 0.5368
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1401 0.5189 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1448 0.5366 1
Schistosoma mansoni transcription factor btf3 0.0031 0.0035 0.0035
Plasmodium falciparum serine repeat antigen 3 0.032 0.1122 0.2158
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0061 0.0059
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0031 0.0031
Giardia lamblia Hypothetical protein 0.032 0.1122 0.2843
Loa Loa (eye worm) hypothetical protein 0.0041 0.0071 0.0071
Entamoeba histolytica cysteine protease, putative 0.032 0.1122 0.2158
Loa Loa (eye worm) inositol-1 0.0036 0.0054 0.0054
Leishmania major cathepsin L-like protease 0.1401 0.5189 0.967
Echinococcus granulosus expressed conserved protein 0.0199 0.0665 0.0663
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0031 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1448 0.5366 1
Echinococcus multilocularis chromobox protein 1 0.0076 0.0202 0.02
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0287 0.0287
Brugia malayi cathepsin L-like precursor 0.0958 0.3524 0.3524
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0062 0.0115
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0062 0.0115
Plasmodium vivax vivapain-3 0.0762 0.2787 0.5368
Loa Loa (eye worm) hypothetical protein 0.0211 0.0713 0.0713
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1401 0.5189 1
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0002 0.0002
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0198 0.0662 0.7713
Schistosoma mansoni alpha-glucosidase 0.0149 0.0478 0.0478
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0031 0.0028
Echinococcus multilocularis chromobox protein 1 0.0076 0.0202 0.02
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0062 0.0115
Giardia lamblia Dipeptidyl-peptidase I precursor 0.032 0.1122 0.2843
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0054 0.2561
Brugia malayi Cathepsin L-like precursor 0.0958 0.3524 0.3524
Trypanosoma cruzi cruzipain precursor, putative 0.0442 0.1583 0.1581
Echinococcus granulosus cathepsin l1 0.1401 0.5189 0.5188
Plasmodium vivax serine-repeat antigen (SERA) 0.032 0.1122 0.2158
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.032 0.1122 0.2158
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0031 0.0028
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0031 0.0053
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0206 0.2741
Brugia malayi cathepsin F-like cysteine proteinase 0.0442 0.1583 0.1582
Loa Loa (eye worm) hypothetical protein 0.0057 0.0133 0.0133
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0077 0.0144
Loa Loa (eye worm) beta-lactamase 0.0039 0.0065 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.1122 0.2158
Echinococcus multilocularis sterol regulatory element binding protein 0.0091 0.0259 0.0257
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0002 0.0002
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0031 0.0055
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0762 0.2787 0.2787
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0031 0.0028
Brugia malayi glutathione reductase 0.0087 0.0244 0.0243
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0762 0.2787 0.2787
Entamoeba histolytica cysteine protease, putative 0.032 0.1122 0.2158
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0031 0.1397
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0102 0.0102
Leishmania major cathepsin L-like protease 0.1401 0.5189 0.967
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0121 0.1391
Plasmodium falciparum cysteine proteinase falcipain 3 0.1401 0.5189 1
Schistosoma mansoni cathepsin s 0.0442 0.1583 0.1583
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.105 0.3867 0.3867
Plasmodium falciparum serine repeat antigen 1 0.032 0.1122 0.2158
Schistosoma mansoni hypothetical protein 0.0051 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0251 0.0862 0.0862
Schistosoma mansoni cathepsin F (C01 family) 0.1401 0.5189 0.5189
Entamoeba histolytica cysteine proteinase, putative 0.0762 0.2787 0.5368
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0065 0.0731
Trypanosoma cruzi cysteine protease, putative 0.0762 0.2787 0.2785
Entamoeba histolytica cysteine protease, putative 0.032 0.1122 0.2158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1448 0.5366 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1401 0.5189 0.5189
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0062 0.0115
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0031 0.0053
Brugia malayi Papain family cysteine protease containing protein 0.032 0.1122 0.1121
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0062 0.006
Plasmodium falciparum thioredoxin reductase 0.003 0.0031 0.0055
Giardia lamblia Cathepsin B precursor 0.032 0.1122 0.2843
Trichomonas vaginalis conserved hypothetical protein 0.032 0.1122 0.2158
Brugia malayi cahepsin L-like non-peptiedase homolog 0.032 0.1122 0.1121
Schistosoma mansoni chromobox protein 0.0076 0.0202 0.0202
Echinococcus granulosus cathepsin b 0.2679 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1401 0.5189 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1401 0.5189 1
Entamoeba histolytica cysteine protease, putative 0.032 0.1122 0.2158
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.0862 0.0861
Trypanosoma cruzi cysteine peptidase, putative 0.1448 0.5366 0.5365
Plasmodium vivax vivapain-2 0.1401 0.5189 1
Brugia malayi hypothetical protein 0.0152 0.0488 0.0487
Brugia malayi PHD-finger family protein 0.0026 0.0017 0.0017
Treponema pallidum NADH oxidase 0.003 0.0031 0.5
Plasmodium falciparum acyl-CoA synthetase 0.0057 0.0133 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1448 0.5366 1
Brugia malayi Cathepsin L-like precursor 0.0442 0.1583 0.1582
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.032 0.1122 0.2158
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.032 0.1122 0.2158
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.032 0.1122 0.2158
Giardia lamblia Cathepsin B precursor 0.032 0.1122 0.2843
Onchocerca volvulus 0.1401 0.5189 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0062 0.0115
Trypanosoma cruzi cysteine proteinase, putative 0.0762 0.2787 0.2785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0287 0.0287
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0152 0.0488 0.0486
Schistosoma mansoni hypothetical protein 0.0087 0.0247 0.0247
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0065 0.0731
Giardia lamblia Cathepsin L precursor 0.032 0.1122 0.2843
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0198 0.0662 0.7713
Echinococcus granulosus Niemann Pick C1 protein 0.0302 0.1055 0.1053
Echinococcus granulosus cathepsin L 0.032 0.1122 0.112
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.1122 0.2158
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0054 0.0097
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0206 1
Entamoeba histolytica cysteine proteinase, putative 0.1401 0.5189 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0198 0.0662 0.7713
Onchocerca volvulus 0.0051 0.011 0.0208
Loa Loa (eye worm) hypothetical protein 0.0039 0.0065 0.0065
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0102 0.0102
Echinococcus granulosus Niemann Pick C1 protein 0.0211 0.0713 0.0711
Entamoeba histolytica cysteine protease, putative 0.0762 0.2787 0.5368
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0054 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.032 0.1122 0.2158
Schistosoma mansoni inositol monophosphatase 0.0036 0.0054 0.0054
Onchocerca volvulus Cathepsin F homolog 0.1401 0.5189 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2787 0.5368
Brugia malayi Heterochromatin protein 1 0.0076 0.0202 0.0202
Entamoeba histolytica cysteine protease, putative 0.0762 0.2787 0.5368
Trypanosoma cruzi transcription factor btf3, putative 0.0031 0.0035 0.0033
Leishmania major hypothetical protein, conserved 0.0039 0.0065 0.0116
Loa Loa (eye worm) hypothetical protein 0.0077 0.0206 0.0206
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0762 0.2787 0.2787
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.032 0.1122 0.1122
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.0569 0.0567
Entamoeba histolytica cysteine proteinase, putative 0.0762 0.2787 0.5368
Brugia malayi Cathepsin L-like cysteine proteinase 0.0958 0.3524 0.3524
Loa Loa (eye worm) cysteine protease 0.1401 0.5189 0.5189
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.032 0.1122 0.1122
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0002 0.0002
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0054 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1401 0.5189 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0031 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1401 0.5189 1
Entamoeba histolytica cysteine protease, putative 0.0762 0.2787 0.5368
Echinococcus multilocularis thioredoxin glutathione reductase 0.0087 0.0246 0.0244
Loa Loa (eye worm) hypothetical protein 0.0057 0.0133 0.0133
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0054 0.0052
Leishmania major trypanothione reductase 0.0087 0.0244 0.045
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0206 0.0392
Schistosoma mansoni chromobox protein 0.0076 0.0202 0.0202
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0442 0.1583 0.1582
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.1122 0.2158
Entamoeba histolytica cysteine protease, putative 0.032 0.1122 0.2158
Echinococcus multilocularis expressed conserved protein 0.0199 0.0665 0.0663
Plasmodium falciparum cysteine proteinase falcipain 1 0.0762 0.2787 0.5368
Trypanosoma cruzi cysteine peptidase, putative 0.1448 0.5366 0.5365
Plasmodium falciparum serine repeat antigen 8 0.032 0.1122 0.2158
Giardia lamblia Dipeptidyl-peptidase I precursor 0.032 0.1122 0.2843
Schistosoma mansoni cathepsin B (C01 family) 0.032 0.1122 0.1122
Mycobacterium leprae Probable lipase LipE 0.0039 0.0065 0.0841
Leishmania major cathepsin L-like protease 0.1401 0.5189 0.967
Loa Loa (eye worm) glutathione reductase 0.0087 0.0244 0.0244
Giardia lamblia Cathepsin L precursor 0.032 0.1122 0.2843
Leishmania major cathepsin L-like protease 0.1448 0.5366 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.022 0.0745 0.8684
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0002 0.0002
Schistosoma mansoni cathepsin S (C01 family) 0.032 0.1122 0.1122
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1401 0.5189 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0152 0.0488 0.0486
Onchocerca volvulus 0.032 0.1122 0.2158
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0065 0.0064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0102 0.0102
Brugia malayi Papain family cysteine protease containing protein 0.0762 0.2787 0.2786
Entamoeba histolytica hypothetical protein 0.0152 0.0488 0.0937
Loa Loa (eye worm) oxidoreductase 0.0022 0.0002 0.0002
Brugia malayi CHE-14 protein 0.0091 0.0259 0.0258
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2679 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0034 0.0044 0.0044
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0065 0.0841
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1401 0.5189 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1401 0.5189 0.5189
Loa Loa (eye worm) hypothetical protein 0.0077 0.0206 0.0206
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0198 0.0662 0.7713
Mycobacterium tuberculosis Probable oxidoreductase 0.022 0.0745 0.8684
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0091 0.0259 0.0259
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1005 0.3701 0.37
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0031 0.0053
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0206 0.0205
Echinococcus granulosus lysosomal alpha glucosidase 0.0173 0.0569 0.0567
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1401 0.5189 0.5188
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0077 0.0206 0.238
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0065 0.012
Giardia lamblia Cathepsin L precursor 0.032 0.1122 0.2843

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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