Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 4-coumarate:coa ligase-like protein | 0.005 | 0.0235 | 0.7416 |
Schistosoma mansoni | patched 1 | 0.0043 | 0.0183 | 0.0183 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0013 | 0.0417 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0013 | 0.0013 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0479 | 0.3316 | 0.3316 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0075 | 0.0092 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.0316 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0059 | 0.0304 | 0.0373 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0181 | 0.0222 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0035 | 0.013 | 0.4099 |
Onchocerca volvulus | 0.005 | 0.0235 | 0.0262 | |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.002 | 0.0022 | 0.0496 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0075 | 0.2367 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0111 | 0.0111 |
Treponema pallidum | DNA ligase (lig) | 0.002 | 0.0022 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.1154 | 0.8156 | 0.8156 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0059 | 0.0304 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.0381 | 0.0468 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0022 | 0.0496 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0022 | 0.0496 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.005 | 0.0235 | 0.7416 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0022 | 0.0026 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.0615 | 0.0754 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.005 | 0.0235 | 0.7416 |
Echinococcus multilocularis | expressed conserved protein | 0.0093 | 0.0546 | 0.0546 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0022 | 0.0496 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.002 | 0.0022 | 0.071 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0144 | 0.0177 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.002 | 0.0022 | 0.0496 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0022 | 0.0026 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0479 | 0.3316 | 0.3316 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.002 | 0.0022 | 0.0022 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0005 | 0.0006 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0013 | 0.0417 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0059 | 0.0304 | 0.0373 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.005 | 0.0235 | 0.7416 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0013 | 0.0013 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0111 | 0.0111 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.002 | 0.0022 | 0.0641 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.1154 | 0.8156 | 0.8156 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0235 | 0.0288 |
Echinococcus granulosus | neuropeptide s receptor | 0.0479 | 0.3316 | 0.3316 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0172 | 0.0172 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.005 | 0.0235 | 0.7416 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.005 | 0.0235 | 0.3844 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.005 | 0.0235 | 0.7416 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0013 | 0.0434 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.005 | 0.0235 | 0.7416 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.005 | 0.0235 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0316 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.0316 | 0.0316 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0059 | 0.0304 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0037 | 0.0144 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0144 | 0.0177 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0111 | 0.0111 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0043 | 0.0183 | 0.0224 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.005 | 0.0235 | 0.7416 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0099 | 0.0589 | 0.0589 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.002 | 0.0022 | 0.0026 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.002 | 0.0022 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0037 | 0.0144 | 0.456 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.0316 | 0.0316 |
Schistosoma mansoni | DNA ligase IV | 0.002 | 0.0022 | 0.0022 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1411 | 1 | 1 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.002 | 0.0022 | 0.0641 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.0316 | 0.0316 |
Brugia malayi | AMP-binding enzyme family protein | 0.005 | 0.0235 | 0.0288 |
Echinococcus multilocularis | nibrin | 0.002 | 0.0022 | 0.0022 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0043 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0381 | 0.0468 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0099 | 0.0589 | 1 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.002 | 0.0022 | 0.071 |
Leishmania major | cytochrome p450-like protein | 0.0059 | 0.0304 | 0.9613 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.1154 | 0.8156 | 1 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.002 | 0.0022 | 0.0496 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0817 | 0.5742 | 0.5742 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0142 | 0.0895 | 0.0895 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0022 | 0.0496 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0013 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0144 | 0.0177 |
Brugia malayi | Cytochrome P450 family protein | 0.0059 | 0.0304 | 0.0373 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0022 | 0.0496 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0172 | 0.0172 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0316 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0111 | 0.0136 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.002 | 0.0022 | 0.0026 |
Brugia malayi | DKFZp564C0469 protein | 0.002 | 0.0022 | 0.0026 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.002 | 0.0022 | 0.071 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0075 | 0.4707 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0043 | 0.0183 | 0.0183 |
Echinococcus granulosus | nibrin | 0.002 | 0.0022 | 0.0022 |
Echinococcus multilocularis | protein dispatched 1 | 0.0049 | 0.0226 | 0.0226 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.005 | 0.0235 | 0.3844 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.005 | 0.0235 | 0.7416 |
Brugia malayi | AMP-binding enzyme family protein | 0.005 | 0.0235 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0589 | 0.0722 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0142 | 0.0895 | 0.0895 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0013 | 0.0013 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0013 | 0.0434 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0013 | 0.0013 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.002 | 0.0022 | 0.071 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.002 | 0.0022 | 0.071 |
Echinococcus granulosus | expressed conserved protein | 0.0093 | 0.0546 | 0.0546 |
Brugia malayi | topoisomerase | 0.002 | 0.0022 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0111 | 0.0136 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0075 | 0.2462 |
Mycobacterium ulcerans | hypothetical protein | 0.005 | 0.0235 | 0.7416 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0035 | 0.013 | 0.4099 |
Brugia malayi | hypothetical protein | 0.002 | 0.0022 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0022 | 0.0026 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0075 | 0.4707 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.005 | 0.0235 | 0.3844 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0111 | 0.0111 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0111 | 0.0111 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.002 | 0.0022 | 0.0496 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.002 | 0.0022 | 0.0921 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0054 | 0.0265 | 0.0265 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1411 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0013 | 0.0434 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.0615 | 0.0754 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.0183 | 1 |
Schistosoma mansoni | topbp1 | 0.002 | 0.0022 | 0.0022 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0037 | 0.0144 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0013 | 0.0417 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0043 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.1154 | 0.8156 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0111 | 0.0111 |
Trypanosoma brucei | cytochrome P450, putative | 0.0059 | 0.0304 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.1154 | 0.8156 | 0.8156 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0172 | 0.0172 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.0316 | 0.0316 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.005 | 0.0235 | 0.7416 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0615 | 0.0754 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.0316 | 1 |
Echinococcus granulosus | replication factor c subunit 1 | 0.002 | 0.0022 | 0.0022 |
Onchocerca volvulus | 0.0054 | 0.0265 | 0.0299 | |
Brugia malayi | CHE-14 protein | 0.0043 | 0.0183 | 0.0224 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0316 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0111 | 0.0111 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0099 | 0.0589 | 0.0722 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0099 | 0.0589 | 0.0589 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0037 | 0.0144 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.005 | 0.0235 | 0.7416 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0059 | 0.0304 | 0.0373 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.005 | 0.0235 | 1 |
Toxoplasma gondii | ATPase, AAA family protein | 0.002 | 0.0022 | 0.0683 |
Echinococcus multilocularis | tumor protein p63 | 0.0369 | 0.2527 | 0.2527 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0013 | 0.0016 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0075 | 0.4707 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0265 | 0.0325 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.002 | 0.0022 | 0.0683 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0059 | 0.0304 | 0.0373 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0035 | 0.013 | 0.4099 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0075 | 0.2367 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0111 | 0.0111 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.005 | 0.0235 | 0.7416 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0022 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0172 | 0.0172 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.1154 | 0.8156 | 0.8156 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.0615 | 0.0754 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0111 | 0.0111 |
Schistosoma mansoni | topbp1 | 0.002 | 0.0022 | 0.0022 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0479 | 0.3316 | 0.3316 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0013 | 0.0417 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0144 | 0.0177 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0381 | 0.0381 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.0316 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.005 | 0.0235 | 0.0288 |
Brugia malayi | hypothetical protein | 0.002 | 0.0022 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0251 | 0.0308 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0523 | 0.363 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0022 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0022 | 0.0026 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0111 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0235 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0144 | 0.0177 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0035 | 0.013 | 0.4099 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0183 | 0.0224 |
Entamoeba histolytica | hypothetical protein | 0.002 | 0.0022 | 0.0146 |
Echinococcus multilocularis | protein patched | 0.0043 | 0.0183 | 0.0183 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.002 | 0.0022 | 0.0496 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.002 | 0.0022 | 0.0022 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0111 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0075 | 0.0092 |
Brugia malayi | Ceramide glucosyltransferase | 0.1154 | 0.8156 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0075 | 0.2462 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.002 | 0.0022 | 0.0683 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0037 | 0.0144 | 0.456 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0101 | 0.06 | 0.06 |
Echinococcus granulosus | tumor protein p63 | 0.0369 | 0.2527 | 0.2527 |
Giardia lamblia | Replication factor C, subunit 1 | 0.002 | 0.0022 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0235 | 0.0288 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0111 | 0.0111 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.002 | 0.0022 | 0.0146 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0059 | 0.0304 | 0.9613 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0075 | 0.2462 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.