Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0087 | 0.0087 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0206 | 0.1375 | 0.7949 |
Loa Loa (eye worm) | ctsf protein | 0.0017 | 0.0007 | 0.0038 |
Echinococcus granulosus | tumor protein p63 | 0.0355 | 0.2453 | 0.2453 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Mycobacterium ulcerans | imidazoleglycerol-phosphate dehydratase | 0.1206 | 0.8632 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.0362 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0007 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0465 | 0.0465 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0017 | 0.0007 | 0.0038 |
Trichomonas vaginalis | set domain proteins, putative | 0.0234 | 0.1581 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0017 | 0.0007 | 0.0038 |
Brugia malayi | Pre-SET motif family protein | 0.0206 | 0.1375 | 0.7949 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0242 | 0.1639 | 0.9475 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0007 | 0.0007 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0095 | 0.0095 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Onchocerca volvulus | 0.0052 | 0.0257 | 0.1589 | |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0465 | 0.0465 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0255 | 0.173 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0095 | 1 |
Mycobacterium tuberculosis | Probable imidazole glycerol-phosphate dehydratase HisB | 0.1206 | 0.8632 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0242 | 0.1639 | 0.9475 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0465 | 0.269 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0017 | 0.0007 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0081 | 0.0465 | 0.269 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0081 | 0.0465 | 0.0465 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0007 | 0.0038 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1395 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | fibroinase | 0.0017 | 0.0007 | 0.0038 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0007 | 0.0007 |
Echinococcus granulosus | GPCR family 2 | 0.0081 | 0.0465 | 0.0465 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0095 | 0.0095 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0017 | 0.0007 | 0.0038 |
Mycobacterium leprae | Probable imidazole glycerol-phosphate dehydratase HisB | 0.0595 | 0.4196 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.0465 | 0.0465 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0095 | 0.0547 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0174 | 0.1145 | 0.6617 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0007 | 0.0007 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0257 | 0.1484 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.0362 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1395 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.1145 | 0.6617 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0081 | 0.0465 | 0.269 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0061 | 0.032 | 0.8824 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0066 | 0.0362 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0007 | 0.0007 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0081 | 0.0465 | 0.0465 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0465 | 0.0465 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0095 | 0.0095 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.1145 | 0.1145 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.0362 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.0362 | 1 |
Onchocerca volvulus | 0.003 | 0.0095 | 0.0559 | |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.173 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0017 | 0.0007 | 0.0007 |
Onchocerca volvulus | 0.0234 | 0.1581 | 1 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0095 | 0.0095 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0095 | 0.0095 |
Entamoeba histolytica | cysteine protease, putative | 0.0017 | 0.0007 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0095 | 0.0095 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0095 | 0.0095 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.0257 | 0.0257 |
Loa Loa (eye worm) | cysteine protease | 0.0017 | 0.0007 | 0.0038 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0465 | 0.0465 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0052 | 0.0258 | 0.7098 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0007 | 0.0007 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0081 | 0.0465 | 0.0465 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.0362 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0095 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0255 | 0.173 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0017 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0255 | 0.173 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0017 | 0.0007 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.0465 | 0.0465 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0017 | 0.0007 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0017 | 0.0007 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0355 | 0.2453 | 0.2453 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0242 | 0.1639 | 0.9475 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0017 | 0.0007 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0081 | 0.0465 | 0.269 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0095 | 0.0547 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0007 | 0.0007 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.0362 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0017 | 0.0007 | 0.0007 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 15 % | Activation of nitrogen-starved wild type sigma1278b yeast Gap1-mediated amino acid uptake at 5 mM after 60 secs relative to L-citrulline | ChEMBL. | 19060912 |
Inhibition (binding) | >= 30 % | Inhibition of nitrogen-starved wild type sigma1278b yeast Gap1-mediated amino acid uptake at 5 mM after 60 secs relative to L-citrulline | ChEMBL. | 19060912 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.