Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Ceramide glucosyltransferase | 0.00860407 | 0.436807 | 0.5 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0189084 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.000612125 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.000612125 | 0 | 0.5 |
Brugia malayi | Ceramide glucosyltransferase | 0.0189084 | 1 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0189084 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.000612125 | 0 | 0.5 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0189084 | 1 | 0.5 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0189084 | 1 | 0.5 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0189084 | 1 | 0.5 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0189084 | 1 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.000612125 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.000612125 | 0 | 0.5 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei | ChEMBL23 | 20666371 | |
Trypanosoma brucei gambiense | 20666371 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.