Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cathepsin L-like protease | 0.0564 | 0.3616 | 0.1078 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0483 | 0.2844 | 0.663 |
Echinococcus multilocularis | cysteine protease | 0.0564 | 0.3616 | 0.4458 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0564 | 0.3616 | 0.4446 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0323 | 0.1327 | 0.1312 |
Onchocerca volvulus | 0.0564 | 0.3616 | 1 | |
Echinococcus multilocularis | cathepsin L | 0.0323 | 0.1327 | 0.1635 |
Onchocerca volvulus | Cathepsin F homolog | 0.0564 | 0.3616 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1038 | 0.8111 | 0.8108 |
Toxoplasma gondii | cathepsin CPL | 0.0564 | 0.3616 | 1 |
Onchocerca volvulus | 0.0564 | 0.3616 | 1 | |
Echinococcus granulosus | cysteine protease | 0.0323 | 0.1327 | 0.1635 |
Plasmodium vivax | vivapain-1 | 0.0323 | 0.1327 | 0.3639 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0564 | 0.3616 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0564 | 0.3616 | 0.4458 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1237 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0379 | 0.1857 | 0.2289 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1237 | 1 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0564 | 0.3616 | 0.1078 |
Leishmania major | cathepsin L-like protease | 0.1237 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0379 | 0.1857 | 0.2316 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0323 | 0.1327 | 0.1312 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1237 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1237 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0564 | 0.3616 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0379 | 0.1857 | 0.2316 |
Entamoeba histolytica | cysteine protease, putative | 0.0564 | 0.3616 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.0514 | 0.3144 | 0.8245 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1237 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1038 | 0.8111 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0564 | 0.3616 | 0.4458 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0564 | 0.3616 | 0.4458 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0372 | 0.1787 | 0.201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1038 | 0.8111 | 1 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.0514 | 0.3144 | 0.8245 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0564 | 0.3616 | 0.3605 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.0514 | 0.3144 | 0.8688 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0323 | 0.1327 | 0.1312 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0379 | 0.1857 | 0.2316 |
Brugia malayi | Cathepsin L-like precursor | 0.0564 | 0.3616 | 0.4446 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0323 | 0.1327 | 0.1618 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0483 | 0.2844 | 0.175 |
Toxoplasma gondii | cathepsin CPC1 | 0.0514 | 0.3144 | 0.8245 |
Plasmodium vivax | vivapain-2 | 0.0564 | 0.3616 | 1 |
Onchocerca volvulus | 0.0564 | 0.3616 | 1 | |
Brugia malayi | cathepsin L-like precursor | 0.0379 | 0.1857 | 0.2273 |
Echinococcus multilocularis | cathepsin b | 0.1038 | 0.8111 | 1 |
Plasmodium vivax | unspecified product | 0.0323 | 0.1327 | 0.3639 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0564 | 0.3616 | 0.4446 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0514 | 0.3144 | 1 |
Toxoplasma gondii | cathepsin B | 0.0483 | 0.2844 | 0.7134 |
Giardia lamblia | Cathepsin B precursor | 0.0483 | 0.2844 | 0.8652 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0514 | 0.3144 | 0.3875 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0564 | 0.3616 | 0.4446 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1038 | 0.8111 | 1 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.0514 | 0.3144 | 0.8245 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0323 | 0.1327 | 0.1635 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0323 | 0.1327 | 0.1618 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1237 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0564 | 0.3616 | 0.4446 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1038 | 0.8111 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0483 | 0.2844 | 0.3507 |
Echinococcus granulosus | cathepsin L | 0.0323 | 0.1327 | 0.1635 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Plasmodium vivax | vivapain-2 | 0.0564 | 0.3616 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0564 | 0.3616 | 0.4446 |
Onchocerca volvulus | 0.0564 | 0.3616 | 1 | |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0323 | 0.1327 | 0.1635 |
Loa Loa (eye worm) | cathepsin B | 0.0483 | 0.2844 | 0.3493 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.0514 | 0.3144 | 0.8688 |
Onchocerca volvulus | 0.0564 | 0.3616 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0564 | 0.3616 | 0.1078 |
Leishmania major | cathepsin L-like protease | 0.0564 | 0.3616 | 0.1078 |
Leishmania major | cathepsin L-like protease | 0.0564 | 0.3616 | 0.1078 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1038 | 0.8111 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1237 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0564 | 0.3616 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1237 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0483 | 0.2844 | 0.2832 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0564 | 0.3616 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0564 | 0.3616 | 0.4458 |
Giardia lamblia | Cathepsin B precursor | 0.0483 | 0.2844 | 0.8652 |
Plasmodium vivax | dipeptidyl aminopeptidase 3, putative | 0.0281 | 0.0924 | 0.2521 |
Brugia malayi | Cathepsin L-like precursor | 0.0379 | 0.1857 | 0.2273 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0379 | 0.1857 | 0.2273 |
Brugia malayi | Cathepsin L-like precursor | 0.0564 | 0.3616 | 0.4446 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0564 | 0.3616 | 0.4458 |
Brugia malayi | Cathepsin L-like precursor | 0.0564 | 0.3616 | 0.4446 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0564 | 0.3616 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0379 | 0.1857 | 0.2289 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1237 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0483 | 0.2844 | 0.8652 |
Echinococcus granulosus | cathepsin b | 0.1038 | 0.8111 | 1 |
Plasmodium vivax | vivapain-3 | 0.0323 | 0.1327 | 0.3639 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0323 | 0.1327 | 0.1635 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0379 | 0.1857 | 0.2273 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0564 | 0.3616 | 0.4458 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1237 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1237 | 1 | 1 |
Onchocerca volvulus | 0.0564 | 0.3616 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0564 | 0.3616 | 0.4446 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0564 | 0.3616 | 0.4458 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0564 | 0.3616 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0564 | 0.3616 | 0.4446 |
Leishmania major | cathepsin L-like protease | 0.1237 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0323 | 0.1327 | 0.1635 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0564 | 0.3616 | 0.4458 |
Brugia malayi | Cathepsin L-like precursor | 0.0564 | 0.3616 | 0.4446 |
Echinococcus granulosus | cathepsin b | 0.1038 | 0.8111 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0564 | 0.3616 | 0.4446 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0564 | 0.3616 | 0.4458 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0323 | 0.1327 | 0.1312 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.1038 | 0.8111 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1038 | 0.8111 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0323 | 0.1327 | 0.1312 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.1051 | 0.8241 | 0.8238 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1237 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0564 | 0.3616 | 0.4458 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0323 | 0.1327 | 0.1494 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1237 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0564 | 0.3616 | 0.4446 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Onchocerca volvulus | 0.0564 | 0.3616 | 1 | |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.081 | 0.5952 | 0.5945 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1237 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Schistosoma mansoni | cathepsin s | 0.0185 | 0.0017 | 0.0021 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0379 | 0.1857 | 0.2273 |
Loa Loa (eye worm) | hypothetical protein | 0.0379 | 0.1857 | 0.2273 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0379 | 0.1857 | 0.2273 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0564 | 0.3616 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0564 | 0.3616 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1237 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0564 | 0.3616 | 0.1078 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 1.22 10'-5M | Cytotoxicity against human A549 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
GI50 (functional) | = 1.3 10'-5M | Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
GI50 (functional) | > 1.88 10'-5M | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
LC50 (functional) | > 1.62 10'-5M | Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
LC50 (functional) | > 1.88 10'-5M | Cytotoxicity against human A549 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
LC50 (functional) | > 1.88 10'-5M | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
TGI (functional) | > 1.62 10'-5M | Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
TGI (functional) | > 1.88 10'-5M | Cytotoxicity against human A549 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
TGI (functional) | > 1.88 10'-5M | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.