Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase D1 | Starlite/ChEMBL | References |
Homo sapiens | protein kinase D2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | fatty acid desaturase, putative | 0.0232 | 0.2909 | 1 |
Onchocerca volvulus | 0.0231 | 0.2899 | 0.8377 | |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.044 | 0.1444 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.004 | 0.0252 | 1 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0039 | 0.0242 | 0.0793 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.004 | 0.0252 | 0.0037 |
Schistosoma mansoni | vav2 | 0.0024 | 0.0025 | 0.0025 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0193 | 0.2378 | 0.7797 |
Loa Loa (eye worm) | FAT-3 protein | 0.0242 | 0.3049 | 1 |
Schistosoma mansoni | protein kinase C mu | 0.0193 | 0.2378 | 0.2378 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0232 | 0.2909 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0192 | 0.2363 | 0.7953 |
Onchocerca volvulus | 0.0243 | 0.3059 | 1 | |
Brugia malayi | Fatty acid desaturase family protein | 0.0039 | 0.0242 | 0.0793 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.3049 | 1 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0039 | 0.0242 | 0.0242 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.2074 | 0.68 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.2074 | 0.68 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0743 | 1 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0039 | 0.0242 | 0.0242 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.2369 | 0.7768 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0242 | 0.3049 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0205 | 0.0205 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.044 | 0.1444 |
Echinococcus granulosus | myotubularin protein 13 | 0.0024 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0025 | 0.0083 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.044 | 0.1444 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0743 | 1 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0039 | 0.0242 | 0.0242 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0192 | 0.2353 | 0.5 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0039 | 0.0242 | 0.0242 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0192 | 0.2353 | 0.7717 |
Leishmania major | delta-5 fatty acid desaturase | 0.0242 | 0.3049 | 1 |
Onchocerca volvulus | 0.0195 | 0.2403 | 0.3342 | |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.004 | 0.0252 | 0.0037 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0039 | 0.0242 | 0.5 |
Onchocerca volvulus | 0.0193 | 0.2369 | 0.2994 | |
Onchocerca volvulus | 0.0231 | 0.2899 | 0.8377 | |
Schistosoma mansoni | fatty acid desaturase | 0.0243 | 0.3059 | 0.3059 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0205 | 0.0671 |
Brugia malayi | C1-like domain containing protein | 0.0193 | 0.2378 | 0.7797 |
Brugia malayi | Pleckstrin Homology Domain | 0.0024 | 0.0025 | 0.0083 |
Brugia malayi | Fatty acid desaturase family protein | 0.0039 | 0.0242 | 0.0793 |
Leishmania major | fatty-acid desaturase, putative | 0.0232 | 0.2909 | 0.95 |
Leishmania major | stearic acid desaturase, putative | 0.0232 | 0.2909 | 0.95 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0252 | 1 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0172 | 0.2083 | 0.683 |
Leishmania major | delta-6 fatty acid desaturase | 0.004 | 0.0252 | 0.0035 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0039 | 0.0242 | 0.0242 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.044 | 0.1444 |
Brugia malayi | acyl-CoA desaturase | 0.0192 | 0.2353 | 0.7717 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0039 | 0.0242 | 0.0793 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0024 | 0.0025 | 0.0025 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0192 | 0.2353 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.2403 | 0.788 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2503 | 0.8209 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0192 | 0.2363 | 0.7953 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0193 | 0.2378 | 0.7797 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0205 | 0.0671 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 1000 nM | Inhibition of PKD1 assessed as inhibition of HDAC5 neuclear export | ChEMBL. | 20684592 |
IC50 (binding) | = 14 nM | Inhibition of PKD1 by TR-FRET assay | ChEMBL. | 20684592 |
IC50 (binding) | = 168 nM | Inhibition of PKD2 by TR-FRET assay | ChEMBL. | 20684592 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.