Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0246 | 0.0681 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0246 | 0.0681 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0123 | 0.3604 | 0.5 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0123 | 0.3604 | 0.5 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0123 | 0.3604 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0246 | 0.0681 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0123 | 0.3604 | 1 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0123 | 0.3604 | 1 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0076 | 0.1379 | 0.3826 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0123 | 0.3604 | 1 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0047 | 0 | 0.5 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0047 | 0 | 0.5 |
Brugia malayi | methionyl-tRNA synthetase | 0.0123 | 0.3604 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0246 | 0.0681 |
Onchocerca volvulus | 0.0076 | 0.1379 | 0.5 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0246 | 0.0681 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0246 | 0.0681 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0123 | 0.3604 | 1 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0123 | 0.3604 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0246 | 0.0681 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0123 | 0.3604 | 1 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0123 | 0.3604 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0246 | 0.0681 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0123 | 0.3604 | 1 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0047 | 0 | 0.5 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0123 | 0.3604 | 1 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0123 | 0.3604 | 1 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0123 | 0.3604 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0246 | 0.0681 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0123 | 0.3604 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 20 uM | Inhibition of indoleamine-2,3-dioxygenase in human A431 cells assessed as inhibition of IFN-gamma-stimulated kynurenine production | ChEMBL. | 20688518 |
IC50 (binding) | > 100 uM | Inhibition of indoleamine-2,3-dioxygenase | ChEMBL. | 20688518 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.