Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) | Transcriptional activator protein lasR | Starlite/ChEMBL | References |
Agrobacterium tumefaciens | Transcriptional activator protein traR | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | snurportin 1 | 0.0355 | 1 | 1 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (probably LuxR/UhpA-family) | 0.0159 | 0.4018 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0043 | 0.0477 | 0.029 |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.0159 | 0.4018 | 1 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein | 0.0159 | 0.4018 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0033 | 0.0192 | 0.5 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.0159 | 0.4018 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0043 | 0.0477 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0043 | 0.0477 | 1 |
Mycobacterium tuberculosis | Possible nitrate/nitrite response transcriptional regulatory protein NarL | 0.0159 | 0.4018 | 1 |
Echinococcus granulosus | geminin | 0.0195 | 0.5135 | 0.504 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (LuxR-family) | 0.0159 | 0.4018 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.0477 | 1 |
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.0159 | 0.4018 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0477 | 1 |
Mycobacterium tuberculosis | Possible two component transcriptional regulatory protein (probably LuxR-family) | 0.0159 | 0.4018 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0043 | 0.0477 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0477 | 0.029 |
Plasmodium vivax | importin-beta 2, putative | 0.0033 | 0.0192 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0477 | 1 |
Mycobacterium leprae | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN | 0.0159 | 0.4018 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.0477 | 1 |
Mycobacterium ulcerans | putative regulatory protein | 0.0159 | 0.4018 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0477 | 0.029 |
Mycobacterium ulcerans | hypothetical protein | 0.0159 | 0.4018 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0355 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.5135 | 0.504 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0043 | 0.0477 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0043 | 0.0477 | 0.029 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0355 | 1 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0043 | 0.0477 | 0.029 |
Brugia malayi | RNA, U transporter 1 | 0.0095 | 0.2061 | 1 |
Mycobacterium tuberculosis | Possible transcriptional regulatory protein | 0.0159 | 0.4018 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0477 | 1 |
Echinococcus multilocularis | geminin | 0.0195 | 0.5135 | 0.504 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0477 | 1 |
Brugia malayi | Inositol-1 | 0.0043 | 0.0477 | 0.1524 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.5135 | 0.504 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | Agonist activity at Vibrio fischeri ES114 LuxR receptor by luciferase reporter gene assay | ChEMBL. | 18760602 | |
EC50 (functional) | Agonist activity at Agrobacterium tumefaciens WCF47 TraR receptor by beta-galctosidase reporter gene assay | ChEMBL. | 18760602 | |
IC50 (functional) | Antagonist activity at Vibrio fischeri luxR receptor in presence of 5 uM 3-oxo-C6-HSL | ChEMBL. | 20669927 | |
IC50 (functional) | Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay | ChEMBL. | 18760602 | |
IC50 (functional) | = 0.46 uM | Antagonist activity at Agrobacterium tumefaciens WCF47 TraR receptor assessed as inhibition of OOHL-induced response by beta-galctosidase reporter gene assay | ChEMBL. | 18760602 |
IC50 (functional) | = 0.46 uM | Antagonist activity at Agrobacterium tumefaciens TraR receptor in presence of 100 nM 3-oxo-C8-HSL | ChEMBL. | 20669927 |
IC50 (functional) | = 4.67 uM | Antagonist activity at Pseudomonas aeruginosa LasR receptor expressed in Escherichia coli in presence of 7.5 nM natural auto-inducer 3-oxo-C12-HSL | ChEMBL. | 20669927 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.