Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0481 | 0.0481 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.1599 | 0.4885 |
Onchocerca volvulus | 0.0047 | 0.0481 | 0.5 | |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.1599 | 0.4885 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0158 | 0.218 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0271 | 0.0829 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.014 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.014 | 0.0427 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.014 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.1599 | 0.4885 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0203 | 0.2861 | 0.2861 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2861 | 0.8741 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.014 | 0.5 |
Echinococcus multilocularis | geminin | 0.0168 | 0.2322 | 0.2322 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0505 | 0.1544 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.023 | 0.3273 | 0.3273 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0203 | 0.2861 | 0.2861 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0158 | 0.218 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0.014 | 0.0427 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0481 | 0.1471 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0481 | 0.0481 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0505 | 0.1544 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.014 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0203 | 0.2861 | 0.2861 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.3273 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.014 | 0.5 |
Brugia malayi | hypothetical protein | 0.023 | 0.3273 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.023 | 0.3273 | 0.3273 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0271 | 0.0271 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0203 | 0.2861 | 0.2861 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0271 | 0.0829 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.014 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0505 | 0.1544 |
Echinococcus granulosus | geminin | 0.0168 | 0.2322 | 0.2322 |
Echinococcus granulosus | hormone sensitive lipase | 0.0203 | 0.2861 | 0.2861 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0505 | 0.1544 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.014 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.2322 | 0.2322 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0007 | 0.0023 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.014 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.2322 | 0.2322 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4.8 uM | Phototoxicity against human HL60 cells irradiated with 4.1 J/cm^2 broad spectrum light treated 2 hrs before irradiation measured after 24 hrs by MTT assay | ChEMBL. | 20199028 |
IC50 (functional) | = 5.4 uM | Phototoxicity against human HSC2 cells irradiated with 4.1 J/cm^2 broad spectrum light treated 2 hrs before irradiation measured after 24 hrs by MTT assay | ChEMBL. | 20199028 |
IC50 (functional) | > 100 uM | Cytotoxicity against human HL60 cells after 24 hrs by MTT assay | ChEMBL. | 20199028 |
IC50 (functional) | > 100 uM | Cytotoxicity against human HSC2 cells after 24 hrs by MTT assay | ChEMBL. | 20199028 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 20199028 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.