Detailed information for compound 1189165

Basic information

Technical information
  • TDR Targets ID: 1189165
  • Name: (2S)-2-dimethylamino-4-methylsulfanylbutanoic acid
  • MW: 177.264 | Formula: C7H15NO2S
  • H donors: 1 H acceptors: 2 LogP: -1.38 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCC[C@@H](C(=O)O)N(C)C
  • InChi: 1S/C7H15NO2S/c1-8(2)6(7(9)10)4-5-11-3/h6H,4-5H2,1-3H3,(H,9,10)/t6-/m0/s1
  • InChiKey: FLEXUHXAXRFRAU-LURJTMIESA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-dimethylamino-4-methylsulfanyl-butanoic acid
  • (2S)-2-dimethylamino-4-(methylthio)butanoic acid
  • (2S)-2-dimethylamino-4-(methylthio)butyric acid
  • NCIStruc2_000012
  • NCI45514
  • NCGC00013544
  • NSC-45514
  • NCIStruc1_000211

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0109 0.0241 0.0453
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0038 0.0069
Entamoeba histolytica hypothetical protein 0.0109 0.0241 0.0453
Giardia lamblia GTOR 0.0051 0.0096 0.0208
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.0539 1
Entamoeba histolytica cysteine protease, putative 0.047 0.1143 0.2269
Loa Loa (eye worm) hypothetical protein 0.1376 0.3403 0.3403
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0058 0.0053
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0058 0.0086
Echinococcus multilocularis conserved hypothetical protein 0.0833 0.2049 0.2048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.007 0.0134
Schistosoma mansoni hypothetical protein 0.0049 0.0092 0.008
Echinococcus granulosus cathepsin b 0.4018 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.007 0.0134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.047 0.1143 0.2288
Brugia malayi Papain family cysteine protease containing protein 0.047 0.1143 0.1139
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0086 0.0074
Onchocerca volvulus 0.0036 0.0058 0.0045
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0058
Loa Loa (eye worm) ctsf protein 0.2009 0.4985 0.4985
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0018 0.003
Plasmodium vivax unspecified product 0.047 0.1143 0.2269
Leishmania major cysteine peptidase A (CPA) 0.2009 0.4985 0.8029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.047 0.1143 0.2288
Loa Loa (eye worm) hypothetical protein 0.0047 0.0086 0.0086
Toxoplasma gondii cathepsin B 0.1568 0.3882 0.7781
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0086 0.0084
Loa Loa (eye worm) hypothetical protein 0.0047 0.0086 0.0086
Schistosoma mansoni lamin 0.0027 0.0036 0.0024
Plasmodium falciparum cysteine proteinase falcipain 1 0.1104 0.2725 0.5452
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.047 0.1143 0.1133
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0684 0.1676 0.3341
Plasmodium vivax serine-repeat antigen (SERA), putative 0.047 0.1143 0.2269
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0701 0.1719 0.3444
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0012 0.0007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0058 0.0057
Loa Loa (eye worm) hypothetical protein 0.0047 0.0086 0.0086
Treponema pallidum sodium- and chloride- dependent transporter 0.0275 0.0657 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Entamoeba histolytica cysteine protease, putative 0.047 0.1143 0.2269
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0018 0.0005
Onchocerca volvulus Cathepsin L homolog 0.047 0.1143 0.2237
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0086 0.0084
Giardia lamblia Cathepsin B precursor 0.1568 0.3882 1
Leishmania major cathepsin L-like protease 0.2009 0.4985 0.8029
Echinococcus multilocularis microtubule associated protein 2 0.0685 0.1679 0.1678
Echinococcus granulosus cathepsin l1 0.1376 0.3403 0.3402
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0016 0.5
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1568 0.3882 0.3875
Trypanosoma cruzi major cysteine proteinase, putative 0.0959 0.2364 0.2355
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0016 0.0014
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2009 0.4985 0.4984
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.0357 0.0357
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0051 0.0096 0.0085
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.047 0.1143 0.2269
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0053 0.0052
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0086 0.0074
Echinococcus multilocularis cathepsin L cysteine protease 0.2009 0.4985 0.4984
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0053 0.0042
Brugia malayi intermediate filament protein 0.0027 0.0036 0.0031
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0018 0.003
Schistosoma mansoni biogenic amine (5HT) receptor 0.0306 0.0732 0.0721
Onchocerca volvulus 0.2009 0.4985 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0016 0.0016
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0241 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.047 0.1143 0.2288
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0018 0.003
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0058 0.0111
Giardia lamblia Cathepsin B precursor 0.1568 0.3882 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.2009 0.4985 0.4984
Schistosoma mansoni tar DNA-binding protein 0.0333 0.08 0.079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0086 0.0141
Entamoeba histolytica cysteine proteinase, putative 0.2009 0.4985 1
Entamoeba histolytica cysteine proteinase 2 0.1104 0.2725 0.5452
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0092 0.0087
Leishmania major cathepsin L-like protease 0.2009 0.4985 0.8029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.047 0.1143 0.1133
Loa Loa (eye worm) cathepsin B 0.1568 0.3882 0.3882
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Echinococcus granulosus cathepsin L 0.1104 0.2725 0.2724
Brugia malayi Cathepsin L-like precursor 0.2009 0.4985 0.4982
Trypanosoma cruzi cysteine proteinase, putative 0.1104 0.2725 0.2716
Brugia malayi cathepsin L-like cysteine proteinase 0.047 0.1143 0.1139
Loa Loa (eye worm) hypothetical protein 0.0275 0.0657 0.0657
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0058
Echinococcus granulosus GPCR family 2 0.0049 0.0092 0.0091
Onchocerca volvulus 0.047 0.1143 0.2237
Loa Loa (eye worm) hypothetical protein 0.0034 0.0053 0.0053
Trypanosoma cruzi cruzipain precursor, putative 0.2498 0.6205 0.6201
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0018 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0121
Loa Loa (eye worm) papain family cysteine protease containing protein 0.2009 0.4985 0.4985
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0058 0.0058
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0058 0.0813
Brugia malayi Cathepsin L-like precursor 0.1376 0.3403 0.34
Schistosoma mansoni DNA helicase recq5 0.002 0.0018 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Schistosoma mansoni hypothetical protein 0.0049 0.0092 0.008
Echinococcus granulosus cathepsin L cysteine protease 0.1104 0.2725 0.2724
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0058 0.0813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0096 0.0187
Trypanosoma cruzi cysteine peptidase, putative 0.0634 0.1551 0.1541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0121
Loa Loa (eye worm) cysteine protease 0.2009 0.4985 0.4985
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0049 0.0092 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0037 0.0069
Echinococcus granulosus survival motor neuron protein 1 0.0738 0.1811 0.181
Loa Loa (eye worm) hypothetical protein 0.0634 0.1551 0.1551
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0684 0.1676 0.3341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0058 0.0111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1104 0.2725 0.438
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0241 0.024
Loa Loa (eye worm) hypothetical protein 0.0106 0.0234 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0012 0.0017
Brugia malayi Cathepsin L-like precursor 0.2009 0.4985 0.4982
Giardia lamblia Cathepsin B precursor 0.047 0.1143 0.2916
Echinococcus granulosus hypothetical protein 0.0845 0.2078 0.2077
Schistosoma mansoni survival motor neuron protein 0.015 0.0345 0.0333
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0058 0.0813
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0241 0.024
Mycobacterium tuberculosis Conserved protein 0.0036 0.0058 0.0813
Entamoeba histolytica cysteine proteinase, putative 0.1104 0.2725 0.5452
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.047 0.1143 0.2288
Schistosoma mansoni microtubule-associated protein tau 0.0685 0.1679 0.1669
Onchocerca volvulus 0.0036 0.0058 0.0045
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0016 0.0025
Onchocerca volvulus Cathepsin L homolog 0.2009 0.4985 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0684 0.1676 0.3341
Brugia malayi Cathepsin L-like precursor 0.2009 0.4985 0.4982
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0047 0.0086 0.0084
Plasmodium falciparum serine repeat antigen 8 0.047 0.1143 0.2269
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0092 0.0091
Loa Loa (eye worm) hypothetical protein 0.047 0.1143 0.1143
Loa Loa (eye worm) hypothetical protein 0.0306 0.0732 0.0732
Schistosoma mansoni lamin 0.0027 0.0036 0.0024
Leishmania major cathepsin L-like protease 0.2009 0.4985 0.8029
Plasmodium vivax vivapain-2 0.2009 0.4985 1
Giardia lamblia Cysteine protease 0.047 0.1143 0.2916
Loa Loa (eye worm) solute carrier family 6 member 4 0.0275 0.0657 0.0657
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4018 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.1104 0.2725 0.2716
Loa Loa (eye worm) hypothetical protein 0.0634 0.1551 0.1551
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.047 0.1143 0.2269
Echinococcus multilocularis cysteine protease 0.2009 0.4985 0.4984
Giardia lamblia Cathepsin L precursor 0.047 0.1143 0.2916
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0058 0.0047
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0005 0.0005
Plasmodium vivax serine-repeat antigen (SERA) 0.047 0.1143 0.2269
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Plasmodium vivax vivapain-3 0.1104 0.2725 0.5452
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0086 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.047 0.1143 0.2288
Plasmodium falciparum serine repeat antigen 1 0.047 0.1143 0.2269
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0047 0.0086 0.5
Entamoeba histolytica cysteine protease, putative 0.2009 0.4985 1
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0049 0.0092 0.008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Brugia malayi Cathepsin L-like precursor 0.2009 0.4985 0.4982
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1104 0.2725 0.2716
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Schistosoma mansoni ap endonuclease 0.0019 0.0016 0.0004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1568 0.3882 0.3875
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0058 0.0047
Trypanosoma cruzi cysteine peptidase, putative 0.2498 0.6205 0.6201
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0551 0.1345 0.2675
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0044 0.0082
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0047 0.0086 0.0084
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0096 0.0091
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0047 0.0086 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0086 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0701 0.1719 0.3444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1104 0.2725 0.5463
Toxoplasma gondii ABC1 family protein 0.0036 0.0058 0.0086
Leishmania major cathepsin L-like protease 0.2009 0.4985 0.8029
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0086 0.0084
Brugia malayi cathepsin L-like precursor 0.1376 0.3403 0.34
Giardia lamblia Cathepsin L-like protease 0.047 0.1143 0.2916
Giardia lamblia Cathepsin B precursor 0.047 0.1143 0.2916
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0092 0.0087
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0333 0.08 0.08
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0036 0.0031
Trypanosoma brucei cysteine peptidase C (CPC) 0.1568 0.3882 0.6249
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.047 0.1143 0.1133
Onchocerca volvulus 0.2009 0.4985 1
Loa Loa (eye worm) RecQ helicase 0.002 0.0018 0.0018
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0086 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.0357 0.0357
Mycobacterium tuberculosis Conserved protein 0.0036 0.0058 0.0813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0077 0.0149
Echinococcus multilocularis cathepsin L 0.1104 0.2725 0.2724
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0058
Toxoplasma gondii cathepsin CPC2 0.0551 0.1345 0.2675
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0058 0.0111
Entamoeba histolytica cysteine proteinase, putative 0.1376 0.3403 0.6817
Loa Loa (eye worm) hypothetical protein 0.4018 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0051 0.0096 0.0085
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0022 0.0016
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.047 0.1143 0.2269
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0086 0.0081
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0058 0.0075
Loa Loa (eye worm) beta-lactamase 0.0036 0.0058 0.0058
Echinococcus granulosus cathepsin L cysteine proteinase 0.2009 0.4985 0.4984
Trypanosoma cruzi cysteine peptidase, putative 0.2498 0.6205 0.6201
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0018 0.0017
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.047 0.1143 0.2288
Loa Loa (eye worm) hypothetical protein 0.0738 0.1811 0.1811
Plasmodium vivax serine-repeat antigen (SERA) 0.047 0.1143 0.2269
Giardia lamblia Cathepsin B precursor 0.047 0.1143 0.2916
Echinococcus granulosus lamin dm0 0.0027 0.0036 0.0035
Loa Loa (eye worm) papain family cysteine protease containing protein 0.047 0.1143 0.1143
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0051 0.0096 0.0095
Onchocerca volvulus 0.2009 0.4985 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0053 0.0042
Echinococcus granulosus cathepsin b 0.4018 1 1
Entamoeba histolytica cysteine protease, putative 0.047 0.1143 0.2269
Toxoplasma gondii hypothetical protein 0.0047 0.0086 0.0141
Giardia lamblia Cysteine protease 0.047 0.1143 0.2916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.007 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0045 0.0084
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0047 0.0086 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0333 0.08 0.079
Loa Loa (eye worm) norepinephrine transporter 0.0275 0.0657 0.0657
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0036 0.0036
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.2009 0.4985 0.4985
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0684 0.1676 0.4293
Giardia lamblia Hypothetical protein 0.047 0.1143 0.2916
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0551 0.1345 0.3438
Echinococcus granulosus microtubule associated protein 2 0.0685 0.1679 0.1678
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.047 0.1143 0.1143
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0701 0.1719 0.3444
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1104 0.2725 0.438
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0634 0.1551 0.1547
Onchocerca volvulus 0.0047 0.0086 0.0101
Brugia malayi cathepsin L precursor 0.047 0.1143 0.1139
Schistosoma mansoni ap endonuclease 0.0019 0.0016 0.0004
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0051 0.0096 0.0136
Entamoeba histolytica hypothetical protein 0.0109 0.0241 0.0453
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0018 0.0017
Onchocerca volvulus 0.015 0.0345 0.0624
Plasmodium falciparum transporter, putative 0.0047 0.0086 0.0141
Mycobacterium tuberculosis Conserved protein 0.0036 0.0058 0.0813
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0051 0.0096 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Plasmodium falciparum serine repeat antigen 6 0.047 0.1143 0.2269
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0041 0.007 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2009 0.4985 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0016 0.0025
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.015 0.0345 0.034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Toxoplasma gondii cathepsin CPL 0.2009 0.4985 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2009 0.4985 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.0558 0.0558
Schistosoma mansoni intermediate filament proteins 0.0027 0.0036 0.0024
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0047 0.0086 0.0084
Onchocerca volvulus 0.0047 0.0086 0.0101
Giardia lamblia Cathepsin L precursor 0.047 0.1143 0.2916
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0058 0.0047
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0063 0.0096
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.4018 1 1
Plasmodium vivax unspecified product 0.0634 0.1551 0.3089
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0086 0.0141
Brugia malayi MH2 domain containing protein 0.0118 0.0265 0.026
Schistosoma mansoni cathepsin C 0.047 0.1143 0.1133
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0275 0.0657 0.0652
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Mycobacterium leprae Probable lipase LipE 0.0036 0.0058 0.5
Giardia lamblia Cysteine protease 0.047 0.1143 0.2916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0038 0.0069
Brugia malayi Pre-SET motif family protein 0.0034 0.0053 0.0049
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.4018 1 1
Brugia malayi Cathepsin L-like precursor 0.0634 0.1551 0.1547
Schistosoma mansoni hypothetical protein 0.015 0.0345 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.047 0.1143 0.2288
Entamoeba histolytica papain family cysteine protease domain containing protein 0.047 0.1143 0.2269
Brugia malayi Papain family cysteine protease containing protein 0.047 0.1143 0.1139
Echinococcus granulosus lamin 0.0027 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.0047 0.0086 0.0086
Onchocerca volvulus Cathepsin L homolog 0.2009 0.4985 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0051 0.0096 0.0136
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0058 0.0813
Plasmodium falciparum serine repeat antigen 7 0.047 0.1143 0.2269
Loa Loa (eye worm) hypothetical protein 0.0275 0.0657 0.0657
Onchocerca volvulus Cathepsin F homolog 0.2009 0.4985 1
Leishmania major hypothetical protein, conserved 0.0036 0.0058 0.0075
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.0357 0.0353
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0265 0.0265
Giardia lamblia Cathepsin L precursor 0.047 0.1143 0.2916
Giardia lamblia Cathepsin B precursor 0.047 0.1143 0.2916
Giardia lamblia Cysteine protease 0.047 0.1143 0.2916
Echinococcus granulosus cathepsin L 0.047 0.1143 0.1142
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0016 0.0007
Leishmania major cathepsin L-like protease 0.2498 0.6205 1
Toxoplasma gondii hypothetical protein 0.0047 0.0086 0.0141
Brugia malayi cathepsin Z-like cysteine proteinase 0.0701 0.1719 0.1715
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Trypanosoma cruzi cysteine peptidase, putative 0.2009 0.4985 0.4979
Onchocerca volvulus 0.0268 0.0639 0.1219
Schistosoma mansoni cathepsin F (C01 family) 0.2009 0.4985 0.4979
Plasmodium vivax serine-repeat antigen (SERA), putative 0.047 0.1143 0.2269
Schistosoma mansoni tar DNA-binding protein 0.0333 0.08 0.079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.047 0.1143 0.2288
Plasmodium falciparum serine repeat antigen 2 0.047 0.1143 0.2269
Giardia lamblia Cathepsin L precursor 0.047 0.1143 0.2916
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0086 0.0084
Echinococcus multilocularis cathepsin b 0.4018 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.2009 0.4985 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0053 0.0052
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0018 0.0005
Schistosoma mansoni cathepsin F (C01 family) 0.2009 0.4985 0.4979
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0044 0.0082
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0012 0.0012
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.047 0.1143 0.1133
Toxoplasma gondii preprocathepsin c precursor, putative 0.0684 0.1676 0.3341
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.047 0.1143 0.2269
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0086 0.0084
Echinococcus granulosus tar DNA binding protein 0.0333 0.08 0.0799
Echinococcus multilocularis cathepsin L cysteine protease 0.2009 0.4985 0.4984
Entamoeba histolytica cysteine proteinase, putative 0.1104 0.2725 0.5452
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0058 0.0813
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Echinococcus multilocularis survival motor neuron protein 1 0.0738 0.1811 0.181
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1568 0.3882 0.7787
Plasmodium vivax vivapain-1 0.1104 0.2725 0.5452
Brugia malayi cahepsin L-like non-peptiedase homolog 0.047 0.1143 0.1139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0012 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.007 0.0134
Loa Loa (eye worm) fibroinase 0.2009 0.4985 0.4985
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0047 0.0086 0.0084
Echinococcus multilocularis cysteine protease 0.2009 0.4985 0.4984
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0018 0.0017
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0018 0.0013
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0051 0.0096 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0012 0.0017
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0086 0.0086
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0275 0.0657 0.0646
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0086 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Brugia malayi beta-lactamase 0.0036 0.0058 0.0053
Brugia malayi Papain family cysteine protease containing protein 0.047 0.1143 0.1139
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0058
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2009 0.4985 0.4984
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Brugia malayi hypothetical protein 0.0047 0.0086 0.0081
Onchocerca volvulus 0.1376 0.3403 0.6804
Loa Loa (eye worm) serotonin transporter b 0.0275 0.0657 0.0657
Echinococcus multilocularis tar DNA binding protein 0.0333 0.08 0.0799
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0051 0.0096 0.0085
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1104 0.2725 0.2716
Trichomonas vaginalis set domain proteins, putative 0.0268 0.0639 0.1277
Schistosoma mansoni hypothetical protein 0.0109 0.0241 0.0229
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4018 1 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0684 0.1676 0.3341
Onchocerca volvulus 0.0047 0.0086 0.0101
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0058 0.0047
Loa Loa (eye worm) hypothetical protein 0.0634 0.1551 0.1551
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Loa Loa (eye worm) hypothetical protein 0.0275 0.0657 0.0657
Leishmania major cathepsin L-like protease 0.2009 0.4985 0.8029
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0051 0.0096 0.0162
Schistosoma mansoni cathepsin s 0.0634 0.1551 0.1541
Leishmania major cathepsin L-like protease 0.2498 0.6205 1
Loa Loa (eye worm) RNA binding protein 0.0333 0.08 0.08
Echinococcus granulosus cysteine protease 0.1104 0.2725 0.2724
Leishmania major cathepsin L-like protease 0.2498 0.6205 1
Giardia lamblia Encystation-specific protease 0.0551 0.1345 0.3438
Brugia malayi cathepsin F-like cysteine proteinase 0.0634 0.1551 0.1547
Toxoplasma gondii cathepsin CPC1 0.0684 0.1676 0.3341
Trichomonas vaginalis esterase, putative 0.0036 0.0058 0.0111
Echinococcus multilocularis serotonin receptor 0.0306 0.0732 0.0731
Brugia malayi cathepsin Z-like cysteine proteinase 0.0701 0.1719 0.1715
Entamoeba histolytica cysteine protease, putative 0.047 0.1143 0.2269
Entamoeba histolytica cysteine protease, putative 0.047 0.1143 0.2269
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0051 0.0096 0.0136
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0092 0.0091
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0086 0.0074
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1104 0.2725 0.2716
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0092 0.0091
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0086 0.0141
Echinococcus granulosus intermediate filament protein 0.0027 0.0036 0.0035
Plasmodium falciparum cysteine proteinase falcipain 2b 0.2009 0.4985 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1376 0.3403 0.6825
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0603 0.1474 0.2952
Brugia malayi Cathepsin L-like precursor 0.2009 0.4985 0.4982
Echinococcus multilocularis musashi 0.0027 0.0036 0.0035
Trypanosoma cruzi cysteine peptidase, putative 0.1104 0.2725 0.2716
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0086 0.0074
Plasmodium vivax amine transporter, putative 0.0047 0.0086 0.0141
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0018 0.0007
Mycobacterium ulcerans beta-lactamase 0.0036 0.0058 1
Plasmodium vivax unspecified product 0.1104 0.2725 0.5452
Entamoeba histolytica cysteine proteinase 1, putative 0.1104 0.2725 0.5452
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0634 0.1551 0.1551
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Echinococcus granulosus serotonin transporter 0.0275 0.0657 0.0655
Loa Loa (eye worm) TAR-binding protein 0.0333 0.08 0.08
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.007 0.0134
Brugia malayi Papain family cysteine protease containing protein 0.1104 0.2725 0.2721
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0036
Onchocerca volvulus 0.2009 0.4985 1
Giardia lamblia Hypothetical protein 0.047 0.1143 0.2916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0038 0.0069
Schistosoma mansoni sodium/chloride dependent transporter 0.0275 0.0657 0.0646
Plasmodium falciparum amino acid transporter, putative 0.0047 0.0086 0.0141
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0058 0.0813
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0551 0.1345 0.2675
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Mycobacterium ulcerans lipase LipD 0.0036 0.0058 1
Brugia malayi Papain family cysteine protease containing protein 0.2009 0.4985 0.4982
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0684 0.1676 0.1666
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Entamoeba histolytica cysteine proteinase, putative 0.1104 0.2725 0.5452
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0121
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0018 0.0005
Brugia malayi beta-lactamase family protein 0.0036 0.0058 0.0053
Trypanosoma cruzi cysteine proteinase, putative 0.1104 0.2725 0.2716
Onchocerca volvulus 0.2009 0.4985 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.005 0.0049
Loa Loa (eye worm) hypothetical protein 0.1376 0.3403 0.3403
Echinococcus multilocularis serotonin transporter 0.0275 0.0657 0.0655
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1568 0.3882 0.6249
Echinococcus multilocularis lamin 0.0027 0.0036 0.0035
Brugia malayi beta-lactamase family protein 0.0036 0.0058 0.0053
Schistosoma mansoni hypothetical protein 0.0106 0.0234 0.0223
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0234 0.023
Loa Loa (eye worm) hypothetical protein 0.0047 0.0086 0.0086
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0086 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.047 0.1143 0.2288
Echinococcus granulosus cathepsin l1 0.2009 0.4985 0.4984
Loa Loa (eye worm) hypothetical protein 0.047 0.1143 0.1143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0054 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0041 0.007 0.0059
Loa Loa (eye worm) hypothetical protein 0.047 0.1143 0.1143
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0018 0.0005
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.047 0.1143 0.2916
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0018 0.0017
Schistosoma mansoni cathepsin F (C01 family) 0.1376 0.3403 0.3396
Onchocerca volvulus 0.0034 0.0053 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.047 0.1143 0.2288
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0012 0.001
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0086 0.0074
Echinococcus multilocularis cathepsin b 0.4018 1 1
Schistosoma mansoni tar DNA-binding protein 0.0333 0.08 0.079
Onchocerca volvulus 0.2009 0.4985 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.047 0.1143 0.2288
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0051 0.0096 0.0095
Loa Loa (eye worm) hypothetical protein 0.1376 0.3403 0.3403
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0058 0.0813
Entamoeba histolytica cysteine protease, putative 0.047 0.1143 0.2269
Giardia lamblia Cathepsin B precursor 0.1568 0.3882 1
Giardia lamblia Cathepsin B precursor 0.0701 0.1719 0.4405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0051 0.0097
Mycobacterium ulcerans hypothetical protein 0.0036 0.0058 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0086 0.0074
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0092 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0053 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0333 0.08 0.079
Brugia malayi Cathepsin L-like cysteine proteinase 0.1376 0.3403 0.34
Entamoeba histolytica recQ family helicase, putative 0.002 0.0018 0.0005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0092 0.0091
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0058 0.0057
Entamoeba histolytica papain family cysteine protease domain containing protein 0.047 0.1143 0.2269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0121
Entamoeba histolytica hypothetical protein 0.047 0.1143 0.2269
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0016 0.0007
Entamoeba histolytica cysteine proteinase, putative 0.1104 0.2725 0.5452
Plasmodium vivax SET domain protein, putative 0.0034 0.0053 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1104 0.2725 0.5463
Schistosoma mansoni hypothetical protein 0.0049 0.0092 0.008
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0701 0.1719 0.1719
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.047 0.1143 0.2288
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0041 0.007 0.0095
Loa Loa (eye worm) hypothetical protein 0.2009 0.4985 0.4985
Plasmodium falciparum serine repeat antigen 4 0.047 0.1143 0.2269
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0086 0.0074
Loa Loa (eye worm) hypothetical protein 0.0047 0.0086 0.0086
Echinococcus multilocularis GPCR, family 2 0.0049 0.0092 0.0091
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0053 0.0042
Onchocerca volvulus 0.0036 0.0058 0.0045
Brugia malayi TAR-binding protein 0.0333 0.08 0.0796
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0265 0.0265
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0018 0.0013
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.047 0.1143 0.1133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0096 0.0187
Plasmodium falciparum serine repeat antigen 3 0.047 0.1143 0.2269
Brugia malayi Papain family cysteine protease containing protein 0.1104 0.2725 0.2721
Plasmodium vivax vivapain-2 0.2009 0.4985 1
Echinococcus granulosus bloom syndrome protein 0.002 0.0018 0.0017
Trypanosoma cruzi cruzipain precursor, putative 0.0634 0.1551 0.1541
Onchocerca volvulus 0.0275 0.0657 0.1254
Brugia malayi hypothetical protein 0.0109 0.0241 0.0236
Echinococcus granulosus biogenic amine 5HT receptor 0.0306 0.0732 0.0731
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0096 0.0096
Brugia malayi cathepsin F-like cysteine proteinase 0.047 0.1143 0.1139
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0086 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0701 0.1719 0.3444
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0086 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0121
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0058 0.0111
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0551 0.1345 0.3438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0038 0.0069
Brugia malayi Cathepsin L-like precursor 0.1376 0.3403 0.34
Brugia malayi hypothetical protein 0.0738 0.1811 0.1807
Onchocerca volvulus 0.2009 0.4985 1
Echinococcus multilocularis cathepsin L 0.047 0.1143 0.1142
Giardia lamblia Cathepsin L precursor 0.047 0.1143 0.2916
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0016 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0012 0.0017
Echinococcus multilocularis bloom syndrome protein 0.002 0.0018 0.0017
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.0357 0.0353
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0086 0.0081
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0053 0.0052
Plasmodium falciparum cysteine proteinase falcipain 2a 0.2009 0.4985 1
Echinococcus multilocularis serotonin receptor 0.0306 0.0732 0.0731
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0086 0.0086
Entamoeba histolytica hypothetical protein 0.0109 0.0241 0.0453
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1376 0.3403 0.6825
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0045 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0045 0.0084
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Brugia malayi RNA binding protein 0.0333 0.08 0.0796
Trypanosoma cruzi major cysteine proteinase, putative 0.047 0.1143 0.1133
Giardia lamblia Cathepsin L precursor 0.047 0.1143 0.2916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0121
Echinococcus multilocularis lamin dm0 0.0027 0.0036 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0306 0.0732 0.0732
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0018 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.047 0.1143 0.2288
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0053 0.0076
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0016 0.0011
Schistosoma mansoni cathepsin B (C01 family) 0.047 0.1143 0.1133
Trypanosoma cruzi cysteine protease, putative 0.1104 0.2725 0.2716
Brugia malayi Cathepsin L-like precursor 0.2009 0.4985 0.4982
Trypanosoma cruzi cysteine peptidase, putative 0.2498 0.6205 0.6201
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0058 0.0111
Plasmodium falciparum serine repeat antigen 9 0.047 0.1143 0.2269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0037 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.047 0.1143 0.1143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0047 0.0086 0.0074
Loa Loa (eye worm) hypothetical protein 0.047 0.1143 0.1143
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0018 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0096 0.0187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.047 0.1143 0.1133
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0058 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4018 1 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0058 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1865 0.4624 0.4618
Brugia malayi RNA recognition motif domain containing protein 0.0333 0.08 0.0796
Brugia malayi Pre-SET motif family protein 0.0236 0.0558 0.0553
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0058 1
Schistosoma mansoni DNA helicase recq1 0.002 0.0018 0.0007
Schistosoma mansoni cathepsin S (C01 family) 0.047 0.1143 0.1133
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0016 0.0004
Plasmodium falciparum serine repeat antigen 5 0.047 0.1143 0.2269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Brugia malayi fibroinase precursor 0.047 0.1143 0.1139
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.047 0.1143 0.1133
Entamoeba histolytica cysteine proteinase, putative 0.2009 0.4985 1
Giardia lamblia Cathepsin L-like protease 0.047 0.1143 0.2916
Loa Loa (eye worm) papain family cysteine protease containing protein 0.047 0.1143 0.1143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0037 0.0069
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.047 0.1143 0.1133
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.047 0.1143 0.2269
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0018
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0018 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.047 0.1143 0.2288

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.