Detailed information for compound 1193528

Basic information

Technical information
  • TDR Targets ID: 1193528
  • Name: methyl (4R,5S,6R)-6-methyl-2-oxo-4-phenyl-1-( phenylmethyl)-1,3-diazinane-5-carboxylate
  • MW: 338.4 | Formula: C20H22N2O3
  • H donors: 1 H acceptors: 2 LogP: 2.64 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)[C@@H]1[C@@H](C)N(Cc2ccccc2)C(=O)N[C@H]1c1ccccc1
  • InChi: 1S/C20H22N2O3/c1-14-17(19(23)25-2)18(16-11-7-4-8-12-16)21-20(24)22(14)13-15-9-5-3-6-10-15/h3-12,14,17-18H,13H2,1-2H3,(H,21,24)/t14-,17-,18+/m1/s1
  • InChiKey: CQMXGKREJGXFPL-OLMNPRSZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl (4R,5S,6R)-6-methyl-2-oxo-4-phenyl-1-(phenylmethyl)hexahydropyrimidine-5-carboxylate
  • (4R,5S,6R)-6-methyl-2-oxo-4-phenyl-1-(phenylmethyl)-5-hexahydropyrimidinecarboxylic acid methyl ester
  • (4R,5S,6R)-1-(benzyl)-2-keto-6-methyl-4-phenyl-hexahydropyrimidine-5-carboxylic acid methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0078 0.0063
Echinococcus granulosus tar DNA binding protein 0.0062 0.0875 0.0875
Brugia malayi TAR-binding protein 0.0062 0.0875 0.0875
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0197 0.0197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0561 0.1098
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0043 0.0561 0.1098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.1711 0.3442
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0537 0.8897 0.8897
Loa Loa (eye worm) hypothetical protein 0.0537 0.8897 0.8897
Leishmania major cathepsin L-like protease 0.0111 0.1711 0.1904
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.3748 0.3748
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0078 0.0056
Brugia malayi Cathepsin L-like precursor 0.0111 0.1711 0.1711
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.1177 0.1177
Echinococcus granulosus thioredoxin glutathione reductase 0.0063 0.0886 0.0886
Loa Loa (eye worm) hypothetical protein 0.0111 0.1711 0.1711
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0043 0.0561 0.0607
Trypanosoma brucei trypanothione reductase 0.0063 0.0886 0.0974
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0043 0.0561 0.0561
Onchocerca volvulus Peroxidasin homolog 0.0239 0.387 0.4349
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.1062 0.1062
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.0197 0.0197
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0111 0.1711 0.3442
Brugia malayi Cathepsin L-like precursor 0.0111 0.1711 0.1711
Echinococcus multilocularis peroxidasin 0.0239 0.387 0.387
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.061 0.061
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.0197 0.0331
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0043 0.0561 0.0561
Giardia lamblia Cathepsin L precursor 0.0043 0.0561 0.0769
Brugia malayi hypothetical protein 0.0239 0.387 0.387
Giardia lamblia Cathepsin B precursor 0.0216 0.348 0.6936
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.1154 0.2956
Onchocerca volvulus Protein cereblon homolog 0.0296 0.4837 0.5437
Onchocerca volvulus 0.0073 0.1062 0.1193
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Mycobacterium ulcerans lipase LipD 0.0073 0.1062 0.2671
Loa Loa (eye worm) hypothetical protein 0.0073 0.1062 0.1062
Loa Loa (eye worm) hypothetical protein 0.0073 0.1062 0.1062
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0056 0.0782 0.0782
Plasmodium vivax unspecified product 0.0043 0.0561 0.2979
Toxoplasma gondii hypothetical protein 0.0056 0.0782 0.0807
Brugia malayi beta-lactamase family protein 0.0073 0.1062 0.1062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.1711 0.3442
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.1062 0.1062
Brugia malayi hypothetical protein 0.0121 0.1869 0.1869
Echinococcus multilocularis protein cereblon 0.0296 0.4837 0.4837
Schistosoma mansoni hypothetical protein 0.0333 0.5462 0.5462
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0043 0.0561 0.2979
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0078 0.0063
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0568 0.0568
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0137 0.013
Entamoeba histolytica hypothetical protein 0.0043 0.0561 0.1098
Echinococcus multilocularis neuropeptide s receptor 0.0449 0.7422 0.7422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0229 0.0422
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.1177 0.1158
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0078 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0078 0.0115
Echinococcus multilocularis thyroid hormone receptor alpha 0.0135 0.2108 0.2108
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.4931 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0043 0.0561 0.0561
Brugia malayi prolyl oligopeptidase family protein 0.0537 0.8897 0.8897
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0056 0.0782 0.0856
Onchocerca volvulus Cathepsin L homolog 0.0111 0.1711 0.1923
Echinococcus multilocularis cathepsin L 0.0043 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0043 0.0561 0.0561
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0043 0.0561 0.1098
Onchocerca volvulus 0.0239 0.387 0.4349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0379 0.0728
Onchocerca volvulus 0.0111 0.1711 0.1923
Plasmodium vivax vivapain-3 0.0043 0.0561 0.2979
Giardia lamblia Alanyl dipeptidyl peptidase 0.0056 0.0782 0.1236
Toxoplasma gondii cathepsin CPL 0.0111 0.1711 0.186
Brugia malayi Peroxidasin 0.0239 0.387 0.387
Loa Loa (eye worm) hypothetical protein 0.0043 0.0561 0.0561
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0819 0.192
Trypanosoma cruzi cruzipain precursor, putative 0.0111 0.1711 0.1693
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0568 0.0568
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0043 0.0561 0.0769
Brugia malayi Blistered cuticle protein 3 0.0239 0.387 0.387
Leishmania major cathepsin L-like protease 0.0111 0.1711 0.1904
Brugia malayi Calcitonin receptor-like protein seb-1 0.0146 0.2293 0.2293
Giardia lamblia Cathepsin L precursor 0.0043 0.0561 0.0769
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.061 0.061
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.1177 0.1177
Leishmania major oligopeptidase b 0.0213 0.3436 0.3847
Entamoeba histolytica hypothetical protein 0.0071 0.1033 0.206
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.387 0.387
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1356 0.1356
Giardia lamblia Cysteine protease 0.0043 0.0561 0.0769
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.0197 0.0197
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.387 0.387
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0078 0.0063
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Brugia malayi Papain family cysteine protease containing protein 0.0043 0.0561 0.0561
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0043 0.0561 0.2979
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1069 0.2693
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0043 0.0561 0.1098
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0698 0.0647
Echinococcus multilocularis thioredoxin glutathione reductase 0.0063 0.0886 0.0886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.1711 0.3442
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0819 0.0819
Echinococcus multilocularis cysteine protease 0.0111 0.1711 0.1711
Schistosoma mansoni cathepsin F (C01 family) 0.0111 0.1711 0.1711
Trypanosoma brucei prolyl oligopeptidase, putative 0.0213 0.3436 0.3847
Plasmodium falciparum serine repeat antigen 8 0.0043 0.0561 0.2655
Loa Loa (eye worm) hypothetical protein 0.0239 0.387 0.387
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0216 0.348 0.3896
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1062 0.2119
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.1356 0.1356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0561 0.1098
Plasmodium vivax unspecified product 0.0043 0.0561 0.2979
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0213 0.3436 0.3847
Echinococcus granulosus protein cereblon 0.0296 0.4837 0.4837
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0561 0.1098
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0875 0.0875
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0228 0.0421
Onchocerca volvulus Peroxidase homolog 0.0239 0.387 0.4349
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0287 0.0278
Mycobacterium tuberculosis Conserved protein 0.0073 0.1062 0.1117
Giardia lamblia Cathepsin L precursor 0.0043 0.0561 0.0769
Mycobacterium tuberculosis Probable peptidase 0.0213 0.3436 0.418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.1711 0.3442
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0056 0.0782 0.0782
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0216 0.348 0.3466
Echinococcus multilocularis geminin 0.0333 0.5462 0.5462
Loa Loa (eye worm) hypothetical protein 0.0017 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0046 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.0239 0.387 0.387
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0197 0.0175
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.1356 0.1356
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.1514 0.1514
Echinococcus multilocularis cysteine protease 0.0111 0.1711 0.1711
Loa Loa (eye worm) prolyl oligopeptidase 0.0056 0.0782 0.0782
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0568 0.1112
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0602 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0568 0.0547
Trypanosoma cruzi cysteine protease, putative 0.0043 0.0561 0.054
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0819 0.0819
Trypanosoma cruzi trypanothione reductase, putative 0.0063 0.0886 0.0867
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.1033 0.1033
Echinococcus granulosus cathepsin L cysteine proteinase 0.0111 0.1711 0.1711
Loa Loa (eye worm) hypothetical protein 0.0146 0.2293 0.2293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0561 0.1098
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0043 0.0561 0.1098
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0063 0.0886 0.089
Schistosoma mansoni cathepsin F (C01 family) 0.0111 0.1711 0.1711
Toxoplasma gondii cathepsin CPC2 0.0043 0.0561 0.0556
Loa Loa (eye worm) hypothetical protein 0.0073 0.1062 0.1062
Brugia malayi follicle stimulating hormone receptor 0.0232 0.3748 0.3748
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1356 0.1356
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0043 0.0561 0.0561
Brugia malayi Animal haem peroxidase family protein 0.0239 0.387 0.387
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0043 0.0561 0.0561
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0698 0.1548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0379 0.0728
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0056 0.0782 0.0856
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0698 0.0698
Plasmodium falciparum serine repeat antigen 1 0.0043 0.0561 0.2655
Trypanosoma cruzi oligopeptidase b 0.0213 0.3436 0.3422
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0698 0.0647
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.046 0.0893
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0197 0.0175
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0561 0.1098
Loa Loa (eye worm) prolyl oligopeptidase 0.0056 0.0782 0.0782
Leishmania major cathepsin L-like protease 0.0111 0.1711 0.1904
Leishmania major cathepsin L-like protease 0.0111 0.1711 0.1904
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0287 0.1308
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Mycobacterium tuberculosis Conserved protein 0.0073 0.1062 0.1117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.1711 0.3442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0267 0.0499
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.1711 0.3442
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0099 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0561 0.1098
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0188 0.0339
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0568 0.0547
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0216 0.348 0.7045
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0819 0.0898
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0043 0.0561 0.0561
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0537 0.8897 0.8897
Giardia lamblia Cysteine protease 0.0043 0.0561 0.0769
Schistosoma mansoni hypothetical protein 0.01 0.1514 0.1514
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.061 0.061
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0043 0.0561 0.0561
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.1154 0.2956
Loa Loa (eye worm) hypothetical protein 0.0111 0.1711 0.1711
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0056 0.0782 0.0782
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0056 0.0782 0.0807
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0239 0.387 0.387
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0302 0.4931 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.1033 0.1033
Plasmodium falciparum serine repeat antigen 2 0.0043 0.0561 0.2655
Plasmodium vivax serine-repeat antigen (SERA) 0.0043 0.0561 0.2979
Trypanosoma cruzi prolyl endopeptidase 0.0537 0.8897 0.8895
Plasmodium falciparum glutathione reductase 0.0063 0.0886 0.4735
Echinococcus multilocularis cathepsin b 0.0602 1 1
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Brugia malayi Thioredoxin reductase 0.0063 0.0886 0.0886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.1711 0.3442
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0043 0.0561 0.0561
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.1154 0.2956
Trypanosoma cruzi major cysteine proteinase, putative 0.0043 0.0561 0.054
Plasmodium falciparum thioredoxin reductase 0.0063 0.0886 0.4735
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.1154 1
Schistosoma mansoni hypothetical protein 0.0333 0.5462 0.5462
Entamoeba histolytica hypothetical protein 0.0071 0.1033 0.206
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0782 0.4328
Echinococcus multilocularis cathepsin b 0.0602 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0561 0.0561
Trypanosoma cruzi cysteine peptidase, putative 0.0111 0.1711 0.1693
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.1154 0.1154
Plasmodium falciparum cysteine proteinase falcipain 1 0.0043 0.0561 0.2655
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.1154 0.1229
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0819 0.0819
Onchocerca volvulus 0.0111 0.1711 0.1923
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0111 0.1711 0.1711
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0197 0.0197
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.1939 0.1939
Entamoeba histolytica cysteine proteinase, putative 0.0111 0.1711 0.3442
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0197 0.0175
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0056 0.0782 0.0782
Onchocerca volvulus 0.0073 0.1062 0.1193
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.1062 0.1172
Entamoeba histolytica cysteine proteinase 1, putative 0.0043 0.0561 0.1098
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.0197 0.0197
Giardia lamblia GTOR 0.0044 0.0568 0.0784
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0417 0.0805
Toxoplasma gondii hypothetical protein 0.0027 0.0287 0.0246
Entamoeba histolytica cysteine proteinase 2 0.0043 0.0561 0.1098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1711 0.1904
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.1154 1
Echinococcus granulosus GPCR family 2 0.0046 0.061 0.061
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Loa Loa (eye worm) hypothetical protein 0.0239 0.387 0.387
Echinococcus granulosus cathepsin b 0.0602 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0197 0.0175
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0197 0.0175
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1069 0.118
Echinococcus granulosus cathepsin l1 0.0111 0.1711 0.1711
Brugia malayi Cathepsin L-like cysteine proteinase 0.0111 0.1711 0.1711
Echinococcus multilocularis cathepsin L cysteine protease 0.0111 0.1711 0.1711
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.1711 0.3442
Brugia malayi cathepsin F-like cysteine proteinase 0.0043 0.0561 0.0561
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.1154 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.1711 0.3442
Plasmodium falciparum serine repeat antigen 7 0.0043 0.0561 0.2655
Brugia malayi Animal haem peroxidase family protein 0.0239 0.387 0.387
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0875 0.0875
Brugia malayi RNA binding protein 0.0062 0.0875 0.0875
Toxoplasma gondii cathepsin CPC1 0.0043 0.0561 0.0556
Loa Loa (eye worm) thioredoxin reductase 0.0063 0.0886 0.0886
Giardia lamblia Cysteine protease 0.0043 0.0561 0.0769
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1356 0.1356
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0043 0.0561 0.1098
Echinococcus granulosus transcription factor Dp 1 0.0046 0.061 0.061
Onchocerca volvulus 0.0111 0.1711 0.1923
Brugia malayi Papain family cysteine protease containing protein 0.0111 0.1711 0.1711
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.1711 0.3442
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0056 0.0782 0.0879
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0819 0.192
Schistosoma mansoni hypothetical protein 0.0046 0.061 0.061
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.0197 0.0144
Giardia lamblia Cathepsin B precursor 0.0216 0.348 0.6936
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0213 0.3436 0.3422
Leishmania major hypothetical protein, conserved 0.0073 0.1062 0.1172
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.0197 0.0758
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1069 0.2693
Giardia lamblia Cathepsin B precursor 0.0043 0.0561 0.0769
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0078 0.0078
Trypanosoma cruzi cysteine peptidase, putative 0.0043 0.0561 0.054
Plasmodium falciparum thioredoxin reductase 0.0022 0.0197 0.0331
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.1154 0.1154
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0056 0.0782 0.0782
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0561 0.1098
Loa Loa (eye worm) hypothetical protein 0.0239 0.387 0.387
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.1939 0.1939
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0698 0.0698
Toxoplasma gondii ABC1 family protein 0.0073 0.1062 0.1124
Toxoplasma gondii thioredoxin reductase 0.0063 0.0886 0.0925
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.4931 1
Onchocerca volvulus 0.0043 0.0561 0.063
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0568 0.0568
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0043 0.0561 0.2979
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0782 0.1548
Brugia malayi Animal haem peroxidase family protein 0.0239 0.387 0.387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0561 0.1098
Schistosoma mansoni cathepsin S (C01 family) 0.0043 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0239 0.387 0.387
Echinococcus granulosus geminin 0.0333 0.5462 0.5462
Brugia malayi Papain family cysteine protease containing protein 0.0043 0.0561 0.0561
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1711 0.1904
Brugia malayi Latrophilin receptor protein 2 0.0046 0.061 0.061
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0602 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0819 0.0803
Brugia malayi Papain family cysteine protease containing protein 0.0043 0.0561 0.0561
Loa Loa (eye worm) fibroinase 0.0111 0.1711 0.1711
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1711 0.1904
Loa Loa (eye worm) hypothetical protein 0.0043 0.0561 0.0561
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0179 0.0178
Schistosoma mansoni cathepsin C 0.0043 0.0561 0.0561
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0146 0.2293 0.2293
Leishmania major cathepsin L-like protease 0.0111 0.1711 0.1904
Brugia malayi Animal haem peroxidase family protein 0.0239 0.387 0.387
Loa Loa (eye worm) hypothetical protein 0.0078 0.1154 0.1154
Trypanosoma cruzi cysteine peptidase, putative 0.0111 0.1711 0.1693
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0188 0.0188
Giardia lamblia Hypothetical protein 0.0043 0.0561 0.0769
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0602 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1711 0.1904
Brugia malayi prolyl oligopeptidase family protein 0.0056 0.0782 0.0782
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.1177 0.2354
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1356 0.1356
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0078 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1711 0.1904
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0302 0.4931 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.1711 0.3442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0325 0.0618
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0043 0.0561 0.0561
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.0197 0.0197
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.4931 1
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0782 0.0762
Plasmodium vivax vivapain-2 0.0111 0.1711 1
Onchocerca volvulus 0.0239 0.387 0.4349
Giardia lamblia Cathepsin L-like protease 0.0043 0.0561 0.0769
Brugia malayi Cathepsin L-like precursor 0.0111 0.1711 0.1711
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.0197 0.0331
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0188 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.1711 0.3442
Brugia malayi Papain family cysteine protease containing protein 0.0043 0.0561 0.0561
Giardia lamblia Cathepsin L precursor 0.0043 0.0561 0.0769
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0043 0.0561 0.0769
Entamoeba histolytica prolyl oligopeptidase family protein 0.0056 0.0782 0.1548
Loa Loa (eye worm) hypothetical protein 0.0239 0.387 0.387
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0287 0.019
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0197 0.0197
Schistosoma mansoni hypothetical protein 0.0046 0.061 0.061
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0568 0.1112
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0043 0.0561 0.1098
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0418 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0271 0.0508
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0561 0.1098
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0213 0.3436 0.3422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1711 0.1904
Toxoplasma gondii prolyl endopeptidase 0.0537 0.8897 1
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0056 0.0782 0.0856
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0056 0.0782 0.1548
Giardia lamblia Alanyl dipeptidyl peptidase 0.0056 0.0782 0.1236
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0111 0.1711 0.1693
Trichomonas vaginalis esterase, putative 0.0073 0.1062 0.2119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1711 0.1904
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.4931 1
Entamoeba histolytica cysteine proteinase, putative 0.0043 0.0561 0.1098
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.061 0.061
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0043 0.0561 0.054
Treponema pallidum fructose-bisphosphate aldolase 0.0302 0.4931 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1711 0.1904
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0056 0.0782 0.0762
Loa Loa (eye worm) hypothetical protein 0.0111 0.1711 0.1711
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.1062 0.1117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.1711 0.3442
Entamoeba histolytica prolyl oligopeptidase family protein 0.0056 0.0782 0.1548
Schistosoma mansoni cathepsin F (C01 family) 0.0111 0.1711 0.1711
Brugia malayi prolyl oligopeptidase family protein 0.0056 0.0782 0.0782
Echinococcus multilocularis cathepsin L 0.0043 0.0561 0.0561
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0043 0.0561 0.2979
Brugia malayi Cathepsin L-like precursor 0.0111 0.1711 0.1711
Schistosoma mansoni hypothetical protein 0.0125 0.1939 0.1939
Trypanosoma cruzi major cysteine proteinase, putative 0.0043 0.0561 0.054
Schistosoma mansoni thyroid hormone receptor 0.0135 0.2108 0.2108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.1711 0.3442
Onchocerca volvulus Chorion peroxidase homolog 0.0239 0.387 0.4349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0417 0.0805
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0568 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0043 0.0561 0.1098
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.1062 0.1117
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0111 0.1711 1
Plasmodium falciparum serine repeat antigen 4 0.0043 0.0561 0.2655
Plasmodium falciparum serine repeat antigen 5 0.0043 0.0561 0.2655
Loa Loa (eye worm) hypothetical protein 0.0073 0.1062 0.1062
Loa Loa (eye worm) hypothetical protein 0.0239 0.387 0.387
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0568 0.0615
Mycobacterium ulcerans hypothetical protein 0.0073 0.1062 0.2671
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0043 0.0561 0.2979
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.4931 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.387 0.387
Echinococcus granulosus Dipeptidyl peptidase 9 0.0056 0.0782 0.0782
Mycobacterium tuberculosis Conserved protein 0.0073 0.1062 0.1117
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0213 0.3436 0.418
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1069 0.2693
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0875 0.0875
Plasmodium falciparum serine repeat antigen 3 0.0043 0.0561 0.2655
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0043 0.0561 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0271 0.0508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.1711 0.3442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0029 0.0014
Giardia lamblia Cathepsin B precursor 0.0043 0.0561 0.0769
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0197 0.0175
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1069 0.1069
Brugia malayi prolyl oligopeptidase family protein 0.0056 0.0782 0.0782
Brugia malayi Animal haem peroxidase family protein 0.0239 0.387 0.387
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0056 0.0782 0.0807
Leishmania major cathepsin L-like protease 0.0111 0.1711 0.1904
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0043 0.0561 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0568 0.1112
Giardia lamblia Hypothetical protein 0.0043 0.0561 0.0769
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0875 0.0875
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0418 0.0446
Loa Loa (eye worm) hypothetical protein 0.0602 1 1
Onchocerca volvulus 0.0111 0.1711 0.1923
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.1033 0.1033
Echinococcus multilocularis acylamino acid releasing enzyme 0.0056 0.0782 0.0782
Leishmania major cathepsin L-like protease 0.0111 0.1711 0.1904
Echinococcus granulosus neuropeptide s receptor 0.0449 0.7422 0.7422
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1062 0.2119
Trypanosoma brucei cysteine peptidase C (CPC) 0.0216 0.348 0.3896
Loa Loa (eye worm) hypothetical protein 0.0239 0.387 0.387
Entamoeba histolytica hypothetical protein 0.0071 0.1033 0.206
Giardia lamblia Cathepsin B precursor 0.0043 0.0561 0.0769
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.0197 0.0356
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.0197 0.0197
Onchocerca volvulus 0.0111 0.1711 0.1923
Plasmodium vivax hypothetical protein, conserved 0.0073 0.1062 0.6038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0379 0.0728
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.0197 0.0356
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0111 0.1711 0.1711
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0043 0.0561 0.0561
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.1711 0.3442
Trypanosoma brucei prolyl endopeptidase 0.0537 0.8897 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.1711 0.3442
Entamoeba histolytica cysteine proteinase, putative 0.0111 0.1711 0.3442
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0078 0.0078
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.1154 0.6444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0379 0.0728
Brugia malayi hypothetical protein 0.0296 0.4837 0.4837
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Giardia lamblia Cathepsin B precursor 0.0043 0.0561 0.0769
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0043 0.0561 0.1098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.1711 0.3442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.1711 0.3442
Echinococcus multilocularis GPCR, family 2 0.0046 0.061 0.061
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1062 0.2119
Echinococcus granulosus peroxidasin 0.0239 0.387 0.387
Echinococcus multilocularis cathepsin L cysteine protease 0.0111 0.1711 0.1711
Trypanosoma cruzi cysteine peptidase, putative 0.0111 0.1711 0.1693
Onchocerca volvulus Prolyl endopeptidase homolog 0.0537 0.8897 1
Giardia lamblia Cathepsin B precursor 0.0216 0.348 0.6936
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0568 0.0615
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.061 0.061
Schistosoma mansoni peroxidasin 0.0239 0.387 0.387
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0111 0.1711 0.3442
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.1062 0.1117
Entamoeba histolytica cysteine proteinase, putative 0.0043 0.0561 0.1098
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0213 0.3436 0.3847
Onchocerca volvulus 0.0111 0.1711 0.1923
Plasmodium vivax vivapain-1 0.0043 0.0561 0.2979
Loa Loa (eye worm) hypothetical protein 0.0056 0.0782 0.0782
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0043 0.0561 0.2655
Plasmodium falciparum cysteine proteinase falcipain 3 0.0111 0.1711 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.1062 0.2671
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0099 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0875 0.0875
Loa Loa (eye worm) hypothetical protein 0.01 0.1514 0.1514
Loa Loa (eye worm) hypothetical protein 0.0043 0.0561 0.0561
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0043 0.0561 0.2655
Plasmodium falciparum peptidase, putative 0.0056 0.0782 0.4066
Loa Loa (eye worm) hypothetical protein 0.0239 0.387 0.387
Mycobacterium ulcerans beta-lactamase 0.0073 0.1062 0.2671
Echinococcus granulosus cathepsin l cysteine peptidase 0.0111 0.1711 0.1711
Mycobacterium leprae conserved hypothetical protein 0.0073 0.1062 0.2671
Loa Loa (eye worm) hypothetical protein 0.0073 0.1062 0.1062
Entamoeba histolytica cysteine proteinase, putative 0.0111 0.1711 0.3442
Loa Loa (eye worm) hypothetical protein 0.0073 0.1062 0.1062
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.1062 0.1062
Plasmodium vivax vivapain-2 0.0111 0.1711 1
Brugia malayi glutathione reductase 0.0063 0.0886 0.0886
Plasmodium vivax glutathione reductase, putative 0.0063 0.0886 0.4968
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0379 0.0728
Schistosoma mansoni peroxidasin 0.0239 0.387 0.387
Echinococcus granulosus cysteine protease 0.0043 0.0561 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0228 0.0421
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0466 0.7696 0.9677
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.4931 1
Entamoeba histolytica hypothetical protein 0.0071 0.1033 0.206
Giardia lamblia Encystation-specific protease 0.0043 0.0561 0.0769
Echinococcus multilocularis neuropeptide receptor A26 0.0449 0.7422 0.7422
Leishmania major cysteine peptidase A (CPA) 0.0111 0.1711 0.1904
Schistosoma mansoni hypothetical protein 0.0046 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0379 0.0728
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0043 0.0561 0.2655
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.1177 0.1158
Brugia malayi Probable ClpP-like protease 0.0078 0.1154 0.1154
Loa Loa (eye worm) hypothetical protein 0.0056 0.0782 0.0782
Echinococcus granulosus cathepsin b 0.0602 1 1
Onchocerca volvulus Dual oxidase homolog 0.0239 0.387 0.4349
Onchocerca volvulus Cathepsin L homolog 0.0111 0.1711 0.1923
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.0197 0.0197
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1069 0.1126
Schistosoma mansoni hypothetical protein 0.0296 0.4837 0.4837
Brugia malayi Cathepsin L-like precursor 0.0111 0.1711 0.1711
Plasmodium falciparum serine repeat antigen 6 0.0043 0.0561 0.2655
Giardia lamblia Cathepsin B precursor 0.0043 0.0561 0.0769
Brugia malayi beta-lactamase 0.0073 0.1062 0.1062
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0481 0.7947 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0043 0.0561 0.0561
Loa Loa (eye worm) cysteine protease 0.0111 0.1711 0.1711
Loa Loa (eye worm) blistered cuticle protein 3 0.0239 0.387 0.387
Echinococcus granulosus neuropeptide receptor A26 0.0449 0.7422 0.7422
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0111 0.1711 0.1711
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.1062 0.1062
Schistosoma mansoni hypothetical protein 0.0071 0.1033 0.1033
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0043 0.0561 0.1098
Brugia malayi cathepsin Z-like cysteine proteinase 0.0043 0.0561 0.0561
Giardia lamblia Fructose-bisphosphate aldolase 0.0302 0.4931 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1069 0.1069
Giardia lamblia Cysteine protease 0.0043 0.0561 0.0769
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0602 1 1
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0213 0.3436 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0561 0.0561
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0078 0.0056
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1062 0.2119
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0043 0.0561 0.2979
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.4931 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0561 0.1098
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0216 0.348 0.348
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.1154 0.6601
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0875 0.0875
Entamoeba histolytica prolyl oligopeptidase family protein 0.0056 0.0782 0.1548
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.1062 0.1117
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1062 0.1042
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.387 0.387
Loa Loa (eye worm) beta-lactamase 0.0073 0.1062 0.1062
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1069 0.1069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0309 0.0586
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0197 0.0197
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.1062 0.1117
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0197 0.0175
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1711 0.1904
Onchocerca volvulus Peroxidase homolog 0.0239 0.387 0.4349
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0043 0.0561 0.2979
Plasmodium vivax serine-repeat antigen (SERA) 0.0043 0.0561 0.2979
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0197 0.0175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0417 0.0805
Loa Loa (eye worm) hypothetical protein 0.0111 0.1711 0.1711
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1062 0.1062
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0197 0.0175
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.1177 0.1177
Giardia lamblia Cathepsin L precursor 0.0043 0.0561 0.0769
Brugia malayi fibroinase precursor 0.0043 0.0561 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0568 0.1112
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0418 0.0397
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0043 0.0561 0.0561
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0056 0.0782 0.1548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0271 0.0508
Leishmania major cathepsin L-like protease 0.0111 0.1711 0.1904
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0417 0.0805
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.1177 0.1177
Loa Loa (eye worm) RNA binding protein 0.0062 0.0875 0.0875
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0229 0.0422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0078 0.0115
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Giardia lamblia Cathepsin L precursor 0.0043 0.0561 0.0769
Leishmania major trypanothione reductase 0.0063 0.0886 0.0974
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0056 0.0782 0.1548
Loa Loa (eye worm) hypothetical protein 0.0239 0.387 0.387
Onchocerca volvulus 0.0111 0.1711 0.1923
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.1177 0.1302
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.1154 0.1154
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.0197 0.0758
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0561 0.1098
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0043 0.0561 0.0769
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1711 0.1904
Brugia malayi Papain family cysteine protease containing protein 0.0043 0.0561 0.0561
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.2322 0.656
Loa Loa (eye worm) glutathione reductase 0.0063 0.0886 0.0886
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.2322 0.2743
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Echinococcus granulosus cathepsin l1 0.0111 0.1711 0.1711
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.1062 0.1117
Echinococcus granulosus prolyl endopeptidase 0.0537 0.8897 0.8897
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0752 0.0752
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.0197 0.0197
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1069 0.1132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0417 0.0805
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0188 0.0339
Onchocerca volvulus 0.0239 0.387 0.4349
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0078 0.0063
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0043 0.0561 0.2979
Brugia malayi cathepsin L-like precursor 0.0111 0.1711 0.1711
Entamoeba histolytica cysteine proteinase, putative 0.0043 0.0561 0.1098
Giardia lamblia Cathepsin L-like protease 0.0043 0.0561 0.0769
Trypanosoma cruzi cysteine proteinase, putative 0.0043 0.0561 0.054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0267 0.0499
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Loa Loa (eye worm) hypothetical protein 0.0315 0.5143 0.5143
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1062 0.2119
Brugia malayi Cathepsin L-like precursor 0.0111 0.1711 0.1711
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0568 0.1112
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.1711 0.3442
Echinococcus granulosus cathepsin L cysteine protease 0.0043 0.0561 0.0561
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0043 0.0561 0.0561
Onchocerca volvulus Cathepsin F homolog 0.0111 0.1711 0.1923
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0229 0.0422
Trypanosoma brucei oligopeptidase b 0.0213 0.3436 0.3847
Entamoeba histolytica cysteine protease, putative 0.0111 0.1711 0.3442
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.2322 0.656
Brugia malayi prolyl oligopeptidase family protein 0.0056 0.0782 0.0782
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1062 0.1042
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0111 0.1711 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0561 0.1098
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Brugia malayi Cathepsin L-like precursor 0.0111 0.1711 0.1711
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0043 0.0561 0.0561
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.1177 0.1177
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0568 0.0568
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1356 0.1356
Trypanosoma cruzi oligopeptidase b 0.0213 0.3436 0.3422
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0056 0.0782 0.0782
Brugia malayi cathepsin L precursor 0.0043 0.0561 0.0561
Entamoeba histolytica hypothetical protein, conserved 0.0056 0.0782 0.1548
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0056 0.0782 0.0856
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0043 0.0561 0.0607
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.1062 0.1117
Entamoeba histolytica cysteine proteinase, putative 0.0043 0.0561 0.1098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0111 0.1711 0.1904
Echinococcus granulosus acylamino acid releasing enzyme 0.0056 0.0782 0.0782
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1062 0.1062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0229 0.0422
Echinococcus granulosus cathepsin L 0.0043 0.0561 0.0561
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0043 0.0561 0.1098
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0056 0.0782 0.0762
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0782 0.0762
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1356 0.1356
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0568 0.0568
Onchocerca volvulus Peroxidasin homolog 0.0239 0.387 0.4349
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1356 0.1356
Onchocerca volvulus 0.0111 0.1711 0.1923
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0056 0.0782 0.1548
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0043 0.0561 0.0769
Trypanosoma cruzi cysteine peptidase, putative 0.0111 0.1711 0.1693
Mycobacterium leprae Probable lipase LipE 0.0073 0.1062 0.2671
Brugia malayi hypothetical protein 0.0071 0.1033 0.1033
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0875 0.0875
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.1177 0.1302
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.1711 0.3442
Entamoeba histolytica hypothetical protein, conserved 0.0296 0.4837 0.981
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0078 0.0115
Brugia malayi beta-lactamase family protein 0.0073 0.1062 0.1062
Brugia malayi cathepsin L-like cysteine proteinase 0.0043 0.0561 0.0561
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.0197 0.0197
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0819 0.0819
Plasmodium vivax thioredoxin reductase, putative 0.0063 0.0886 0.4968
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.1711 0.3442
Plasmodium falciparum serine repeat antigen 9 0.0043 0.0561 0.2655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.1711 0.3442
Schistosoma mansoni cathepsin B (C01 family) 0.0043 0.0561 0.0561
Brugia malayi Cathepsin L-like precursor 0.0111 0.1711 0.1711
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.387 0.387
Toxoplasma gondii cathepsin B 0.0216 0.348 0.3863
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0111 0.1711 0.1711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0379 0.0728
Echinococcus multilocularis prolyl endopeptidase 0.0537 0.8897 0.8897
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0228 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0078 0.0115
Trypanosoma cruzi cysteine proteinase, putative 0.0043 0.0561 0.054
Toxoplasma gondii preprocathepsin c precursor, putative 0.0043 0.0561 0.0556
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0875 0.0875
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0875 0.0875
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.1062 0.2671
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0146 0.2293 0.2293
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0213 0.3436 1
Loa Loa (eye worm) ctsf protein 0.0111 0.1711 0.1711
Loa Loa (eye worm) hypothetical protein 0.0239 0.387 0.387
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0537 0.8897 1
Loa Loa (eye worm) cathepsin B 0.0216 0.348 0.348
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Onchocerca volvulus Cathepsin L homolog 0.0043 0.0561 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0078 0.0115
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0043 0.0561 0.2979
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0561 0.1098
Onchocerca volvulus 0.0073 0.1062 0.1193
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0287 0.0907
Schistosoma mansoni hypothetical protein 0.0046 0.061 0.061
Loa Loa (eye worm) RecQ helicase 0.0021 0.0188 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.1711 0.3442
Loa Loa (eye worm) hypothetical protein 0.0296 0.4837 0.4837
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0056 0.0782 0.0782
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0379 0.035
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.061 0.061
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0602 1 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.0197 0.0144
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1069 0.1069
Loa Loa (eye worm) hypothetical protein 0.0239 0.387 0.387
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.1711 0.3442
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0043 0.0561 0.0561
Echinococcus granulosus bloom syndrome protein 0.0021 0.0188 0.0188
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0078 0.0078
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0043 0.0561 0.2979
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.1154 0.2023
Schistosoma mansoni thyroid hormone receptor 0.0135 0.2108 0.2108
Entamoeba histolytica cysteine protease, putative 0.0043 0.0561 0.1098
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.4931 1
Echinococcus granulosus cathepsin L 0.0043 0.0561 0.0561
Plasmodium falciparum glutathione reductase 0.0022 0.0197 0.0331
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.1154 0.1229
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0568 0.0615

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.