Detailed information for compound 1194806

Basic information

Technical information
  • TDR Targets ID: 1194806
  • Name: (5-methyl-2-propan-2-ylphenyl) 3-phenylprop-2 -enoate
  • MW: 280.361 | Formula: C19H20O2
  • H donors: 0 H acceptors: 1 LogP: 5.25 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Oc1cc(C)ccc1C(C)C)/C=C/c1ccccc1
  • InChi: 1S/C19H20O2/c1-14(2)17-11-9-15(3)13-18(17)21-19(20)12-10-16-7-5-4-6-8-16/h4-14H,1-3H3/b12-10+
  • InChiKey: VTMBHZWFGHDKAI-ZRDIBKRKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5-methyl-2-propan-2-ylphenyl) (E)-3-phenylprop-2-enoate
  • (2-isopropyl-5-methyl-phenyl) 3-phenylprop-2-enoate
  • (2-isopropyl-5-methyl-phenyl) (E)-3-phenylprop-2-enoate
  • 3-phenylprop-2-enoic acid (2-isopropyl-5-methylphenyl) ester
  • (E)-3-phenylprop-2-enoic acid (2-isopropyl-5-methylphenyl) ester
  • 3-phenylacrylic acid (2-isopropyl-5-methyl-phenyl) ester
  • (E)-3-phenylacrylic acid (2-isopropyl-5-methyl-phenyl) ester
  • (5-methyl-2-propan-2-yl-phenyl) (E)-3-phenylprop-2-enoate
  • (5-methyl-2-propan-2-yl-phenyl) 3-phenylprop-2-enoate
  • ZINC00299009
  • CBDivE_015649
  • 2-isopropyl-5-methylphenyl 3-phenylacrylate
  • MLS000576945
  • SMR000185423

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0046 0.0088
Mycobacterium ulcerans acetolactate synthase 0.0261 0.2894 0.537
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0121 0.5456
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0046 0.0102
Mycobacterium ulcerans acetolactate synthase large subunit IlvB 0.0261 0.2894 0.537
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0622 0.7464 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0024 0.0076
Brugia malayi nuclear receptor NHR-88 0.0037 0.0046 0.0086
Schistosoma mansoni glutaminase 0.0264 0.293 0.6471
Schistosoma mansoni survival motor neuron protein 0.0049 0.0202 0.0447
Brugia malayi glutaminase DH11.1 0.0264 0.293 0.5457
Mycobacterium ulcerans 2-oxoglutarate ferredoxin oxidoreductase subunit beta 0.0066 0.0425 0.075
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0046 0.0088
Mycobacterium ulcerans putative oxalyl-CoA decarboxylase 0.0457 0.537 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0622 0.7464 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0622 0.7464 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.015
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0046 0.0102
Trypanosoma cruzi phosphonopyruvate decarboxylase, putative 0.0148 0.1453 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0046 0.0086
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0046 0.0102
Loa Loa (eye worm) hypothetical protein 0.024 0.2621 0.8489
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0046 0.015
Loa Loa (eye worm) hypothetical protein 0.0048 0.0193 0.0626
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0046 0.015
Schistosoma mansoni hypothetical protein 0.0164 0.1658 0.3661
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.015
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0552 0.1029
Mycobacterium leprae Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) 0.0457 0.537 1
Trichomonas vaginalis glutaminase, putative 0.0264 0.293 0.3907
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0024 0.0052
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0066 0.0425 0.0539
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0066 0.0425 0.0539
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0552 0.122
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0046 0.0102
Echinococcus multilocularis thyroid hormone receptor alpha 0.0037 0.0046 0.0023
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0066 0.0425 0.0539
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0046 0.0088
Loa Loa (eye worm) glutaminase 0.0264 0.293 0.9492
Loa Loa (eye worm) hypothetical protein 0.0035 0.0024 0.0076
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0046 0.0102
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0046 0.0102
Schistosoma mansoni hypothetical protein 0.0049 0.0202 0.0447
Loa Loa (eye worm) hypothetical protein 0.0035 0.0024 0.0076
Loa Loa (eye worm) RNA binding protein 0.0076 0.0552 0.1789
Mycobacterium tuberculosis Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) 0.0457 0.537 1
Trypanosoma brucei phosphonopyruvate decarboxylase-like protein, putative 0.0148 0.1453 1
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0046 0.0023
Echinococcus granulosus survival motor neuron protein 1 0.024 0.2621 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0622 0.7464 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0046 0.0086
Trypanosoma cruzi phosphonopyruvate decarboxylase, putative 0.0148 0.1453 1
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0046 0.0086
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0046 0.0086
Loa Loa (eye worm) thiamine pyrophosphate enzyme 0.0262 0.29 0.9395
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0046 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0046 0.015
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0046 0.0086
Schistosoma mansoni chromobox protein 0.007 0.0475 0.105
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0193 0.036
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0046 0.0086
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0046 0.0088
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0046 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0083 0.008
Trichomonas vaginalis chromobox protein, putative 0.007 0.0475 0.0607
Mycobacterium ulcerans glutaminase 0.0264 0.293 0.5437
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0046 0.0086
Mycobacterium ulcerans hypothetical protein 0.0457 0.537 1
Echinococcus multilocularis chromobox protein 1 0.007 0.0475 0.0453
Loa Loa (eye worm) hypothetical protein 0.0035 0.0024 0.0076
Mycobacterium tuberculosis Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) 0.0195 0.2058 0.3806
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0046 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0046 0.0086
Mycobacterium ulcerans acetolactate synthase 1 catalytic subunit 0.0457 0.537 1
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0046 0.0102
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0046 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0552 0.122
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0622 0.7464 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0046 0.0023
Brugia malayi beta-lactamase family protein 0.0035 0.0024 0.0044
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0552 0.1789
Echinococcus multilocularis chromobox protein 1 0.007 0.0475 0.0453
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0024 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0552 0.122
Brugia malayi RNA binding protein 0.0076 0.0552 0.1029
Mycobacterium tuberculosis Probable oxalyl-CoA decarboxylase OxcA 0.0457 0.537 1
Echinococcus granulosus chromobox protein 1 0.007 0.0475 0.174
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0121 0.0131
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0046 0.0023
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0475 0.154
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0202 0.0377
Loa Loa (eye worm) glutaminase 2 0.0264 0.293 0.9492
Schistosoma mansoni hypothetical protein 0.0164 0.1658 0.3661
Brugia malayi chromobox protein homolog 3 0.0039 0.0083 0.0155
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.015
Trichomonas vaginalis chromobox protein, putative 0.007 0.0475 0.0607
Mycobacterium ulcerans pyruvate or indole-3-pyruvate decarboxylase Pdc 0.0261 0.2894 0.537
Leishmania major putative pyruvate/indole-pyruvate carboxylase, putative 0.0261 0.2894 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0046 0.015
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0046 0.0086
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0193 0.0626
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0622 0.7464 1
Schistosoma mansoni acetolactate synthase 0.039 0.4528 1
Brugia malayi TAR-binding protein 0.0076 0.0552 0.1029
Loa Loa (eye worm) beta-lactamase 0.0035 0.0024 0.0076
Plasmodium vivax acyl-CoA synthetase, putative 0.0261 0.2894 1
Toxoplasma gondii ABC1 family protein 0.0035 0.0024 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0046 0.015
Treponema pallidum fructose-bisphosphate aldolase 0.0622 0.7464 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0552 0.122
Echinococcus granulosus tar DNA binding protein 0.0076 0.0552 0.2036
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0046 0.0102
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.24 0.4444
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0046 0.0086
Loa Loa (eye worm) hypothetical protein 0.0035 0.0024 0.0076
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0024 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0622 0.7464 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0046 0.0023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0622 0.7464 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0024 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0046 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0046 0.0086
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0066 0.0425 0.0539
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0083 0.008
Echinococcus granulosus chromobox protein 1 0.007 0.0475 0.174
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0046 0.1277
Onchocerca volvulus 0.0049 0.0202 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0083 0.0269
Brugia malayi steroid hormone receptor 0.0037 0.0046 0.0086
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0046 0.0102
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.015
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0552 0.122
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0046 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0046 0.0086
Brugia malayi Thiamine pyrophosphate enzyme, central domain containing protein 0.0457 0.537 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0304 0.3433 0.6377
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0046 0.0086
Echinococcus granulosus geminin 0.0164 0.1658 0.6293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0046 0.015
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.015
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0552 0.1789
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0046 0.0086
Brugia malayi ecdysteroid receptor 0.0037 0.0046 0.0086
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.015
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0552 0.053
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0046 0.1277
Schistosoma mansoni coup transcription factor 0.0037 0.0046 0.0102
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0046 0.0088
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.015
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0024 0.0076
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0304 0.3433 0.6377
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0066 0.0425 0.0539
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0046 0.0086
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0046 0.0088
Mycobacterium ulcerans 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase 0.0081 0.0611 0.1099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0622 0.7464 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0046 0.015
Giardia lamblia Fructose-bisphosphate aldolase 0.0622 0.7464 1
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0121 0.0131
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.2621 0.2603
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0622 0.7464 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0046 0.0023
Leishmania major phosphonopyruvate decarboxylase-like protein 0.0148 0.1453 0.498
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0083 0.3329
Brugia malayi beta-lactamase family protein 0.0035 0.0024 0.0044
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0066 0.0425 0.0539
Mycobacterium ulcerans hypothetical protein 0.0148 0.1453 0.2674
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0193 0.036
Plasmodium falciparum acyl-CoA synthetase 0.0261 0.2894 0.5
Brugia malayi beta-lactamase 0.0035 0.0024 0.0044
Mycobacterium tuberculosis Probable oxidoreductase (beta subunit) 0.0066 0.0425 0.075
Schistosoma mansoni acetolactate synthase 0.039 0.4528 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0046 0.0088
Mycobacterium leprae PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) 0.0457 0.537 1
Brugia malayi Heterochromatin protein 1 0.007 0.0475 0.0885
Echinococcus multilocularis geminin 0.0164 0.1658 0.1638
Schistosoma mansoni chromobox protein 0.007 0.0475 0.105
Onchocerca volvulus 0.0037 0.0046 0.1277
Brugia malayi hypothetical protein 0.024 0.2621 0.488
Brugia malayi nuclear hormone receptor 0.0037 0.0046 0.0086
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0304 0.3433 0.6377
Loa Loa (eye worm) ILVBL protein 0.0276 0.3087 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0046 0.1277
Trypanosoma brucei phosphonopyruvate decarboxylase-like protein, putative 0.0148 0.1453 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0046 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0046 0.015
Mycobacterium leprae PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SH 0.0081 0.0611 0.1099
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0046 0.0088
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0046 0.0023

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (binding) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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