Detailed information for compound 1196421

Basic information

Technical information
  • TDR Targets ID: 1196421
  • Name: 2-(4-amino-2,6-dioxo-5-piperidin-1-yl-3-propy lpyrimidin-1-yl)-N-[3-(dimethylsulfamoyl)phen yl]acetamide
  • MW: 492.592 | Formula: C22H32N6O5S
  • H donors: 2 H acceptors: 5 LogP: 1.04 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c(N)c(N2CCCCC2)c(=O)n(c1=O)CC(=O)Nc1cccc(c1)S(=O)(=O)N(C)C
  • InChi: 1S/C22H32N6O5S/c1-4-11-27-20(23)19(26-12-6-5-7-13-26)21(30)28(22(27)31)15-18(29)24-16-9-8-10-17(14-16)34(32,33)25(2)3/h8-10,14H,4-7,11-13,15,23H2,1-3H3,(H,24,29)
  • InChiKey: JJVFAATVZBABIA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[4-amino-2,6-dioxo-5-(1-piperidyl)-3-propyl-pyrimidin-1-yl]-N-[3-(dimethylsulfamoyl)phenyl]acetamide
  • 2-[4-amino-2,6-dioxo-5-(1-piperidyl)-3-propyl-1-pyrimidinyl]-N-[3-(dimethylsulfamoyl)phenyl]acetamide
  • 2-(4-amino-2,6-diketo-5-piperidino-3-propyl-pyrimidin-1-yl)-N-[3-(dimethylsulfamoyl)phenyl]acetamide
  • 2-(4-amino-2,6-dioxo-5-piperidin-1-yl-3-propyl-pyrimidin-1-yl)-N-[3-(dimethylsulfamoyl)phenyl]ethanamide
  • T5354326

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Smad4 0.0025 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0053 0.0089 0.0089
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.014 0.0348 0.0349
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0071 0.0071
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0133 0.0133
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.014 0.0348 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0082 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0095 0.0095
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1009 0.2934 0.349
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0258 0.0258
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0006 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.001 0.0275
Brugia malayi hypothetical protein 0.0997 0.2898 0.2898
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.014 0.0348 0.0414
Echinococcus multilocularis Smad4 0.0025 0.0006 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.018 0.5173
Echinococcus multilocularis tumor protein p63 0.0362 0.101 0.1201
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0133 0.0133
Schistosoma mansoni rap gtpase-activating protein 0.0997 0.2898 0.2898
Brugia malayi Temporarily assigned gene name protein 59 0.0997 0.2898 0.2898
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0133 0.0133
Entamoeba histolytica hypothetical protein 0.011 0.0258 0.7401
Schistosoma mansoni hypothetical protein 0.0205 0.054 0.054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0258 0.0306
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0006 0.0006
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0071 0.0071
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1009 0.2934 0.349
Mycobacterium ulcerans DNA polymerase IV 0.0023 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0071 0.2029
Trichomonas vaginalis PIKK family atypical protein kinase 0.014 0.0348 1
Schistosoma mansoni protein kinase 0.3383 1 1
Loa Loa (eye worm) hypothetical protein 0.0997 0.2898 0.2908
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0027 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0241 0.6927
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0019 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0156 0.4473
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0027 0.001 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0241 0.6927
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.014 0.0348 0.0348
Brugia malayi RNA binding protein 0.0068 0.0133 0.0133
Echinococcus multilocularis microtubule associated protein 2 0.2847 0.8406 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0006 0.0007
Schistosoma mansoni microtubule-associated protein tau 0.2847 0.8406 0.8406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0083 0.0178 0.5102
Echinococcus granulosus tumor protein p63 0.0362 0.101 0.1013
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0051 0.0082 0.0082
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.014 0.0348 0.0349
Loa Loa (eye worm) RNA binding protein 0.0068 0.0133 0.0133
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0047 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0016
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0047 0.0071 0.0244
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.014 0.0348 0.1201
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0133 0.0133
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0095 0.0095
Echinococcus granulosus smad 0.0025 0.0006 0.0006
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1009 0.2934 0.2945
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0997 0.2898 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0263 0.7546
Echinococcus multilocularis musashi 0.0028 0.0013 0.0015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0095 0.0095
Echinococcus granulosus lamin dm0 0.0028 0.0013 0.0013
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.014 0.0348 1
Onchocerca volvulus 0.0053 0.0089 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0156 0.4483
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0112 0.0263 0.0908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0211 0.6052
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0133 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0241 0.6927
Schistosoma mansoni intermediate filament proteins 0.0028 0.0013 0.0013
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0013 0.0013
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0027 0.001 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0095 0.0113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0095 0.0113
Schistosoma mansoni protein kinase 0.2386 0.7033 0.7033
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.001 0.0011
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0082 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0156 0.4483
Echinococcus multilocularis geminin 0.0205 0.054 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0263 0.7546
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0034 0.0034
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.014 0.0348 1
Schistosoma mansoni smad1 5 8 and 0.0025 0.0006 0.0006
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.1009 0.2934 0.2945
Loa Loa (eye worm) hypothetical protein 0.0027 0.001 0.001
Schistosoma mansoni fkbp-rapamycin associated protein 0.0027 0.001 0.001
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0133 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.014 0.0348 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.001 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.018 0.5173
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.2386 0.7033 0.7059
Loa Loa (eye worm) hypothetical protein 0.0997 0.2898 0.2908
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0066 0.0128 0.0442
Toxoplasma gondii non-specific serine/threonine protein kinase 0.003 0.0019 0.039
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.1009 0.2934 0.349
Entamoeba histolytica hypothetical protein 0.0027 0.001 0.0275
Brugia malayi TAR-binding protein 0.0068 0.0133 0.0133
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0997 0.2898 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0006 0.0006
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1009 0.2934 0.2945
Trypanosoma cruzi target of rapamycin kinase 3 0.0112 0.0263 0.0908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0156 0.4473
Mycobacterium ulcerans DNA polymerase IV 0.0023 0 0.5
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.014 0.0348 0.1201
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0258 0.0259
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.001 0.001
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.014 0.0348 0.0348
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0997 0.2898 0.3447
Entamoeba histolytica hypothetical protein 0.011 0.0258 0.7401
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0997 0.2898 0.2908
Echinococcus multilocularis smad 0.0025 0.0006 0.0007
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.014 0.0348 0.1201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0156 0.4483
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0133 0.0133
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0095 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0241 0.6927
Entamoeba histolytica hypothetical protein 0.011 0.0258 0.7401
Schistosoma mansoni hypothetical protein 0.0997 0.2898 0.2898
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0071 0.2029
Schistosoma mansoni serine/threonine protein kinase 0.1009 0.2934 0.2934
Echinococcus multilocularis lamin 0.0028 0.0013 0.0015
Schistosoma mansoni hypothetical protein 0.0035 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0011
Brugia malayi MH2 domain containing protein 0.0025 0.0006 0.0006
Echinococcus granulosus geminin 0.0205 0.054 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0263 0.7546
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0027 0.001 0.0033
Schistosoma mansoni smad1 5 8 and 0.0025 0.0006 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0095 0.0095
Brugia malayi Smad1 0.0025 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0071 0.2029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0263 0.7546
Echinococcus granulosus microtubule associated protein 2 0.2847 0.8406 0.8437
Entamoeba histolytica hypothetical protein 0.011 0.0258 0.7401
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0133 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.018 0.5173
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0013 0.0013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0082 0.0082
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0133 0.0133
Giardia lamblia GTOR 0.014 0.0348 1
Echinococcus granulosus protein kinase 0.2386 0.7033 0.7059
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0013 0.0013
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.001 0.001
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0997 0.2898 1
Echinococcus multilocularis lamin dm0 0.0028 0.0013 0.0015
Brugia malayi hypothetical protein 0.011 0.0258 0.0258
Brugia malayi intermediate filament protein 0.0028 0.0013 0.0013
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.1009 0.2934 0.2945
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0112 0.0263 0.7556
Onchocerca volvulus 0.0997 0.2898 1
Schistosoma mansoni lamin 0.0028 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0156 0.4483
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0047 0.0071 0.0244
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0006 0.0006
Entamoeba histolytica protein kinase rad3, putative 0.0027 0.001 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0263 0.7546
Toxoplasma gondii target of rapamycin (TOR), putative 0.0104 0.0241 1
Loa Loa (eye worm) Smad1 0.0025 0.0006 0.0006
Schistosoma mansoni smad 0.0025 0.0006 0.0006
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0006 0.0006
Brugia malayi Protein kinase domain containing protein 0.1009 0.2934 0.2934
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0089 0.0089
Loa Loa (eye worm) transcription factor SMAD2 0.0371 0.1034 0.1038
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.014 0.0348 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0047 0.0071 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0043 0.1225
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0095 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0241 0.6927
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.001 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0241 0.6927
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0287 0.8246
Schistosoma mansoni hypothetical protein 0.011 0.0258 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.014 0.0348 1
Brugia malayi MH2 domain containing protein 0.0025 0.0006 0.0006
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0006 0.0006
Echinococcus granulosus serine protein kinase ATM 0.0027 0.001 0.001
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0997 0.2898 0.2898
Schistosoma mansoni serine/threonine protein kinase 0.1009 0.2934 0.2934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.001 0.0275
Leishmania major phosphatidylinositol 3-kinase, putative 0.0047 0.0071 0.2029
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0047 0.0071 0.2029
Schistosoma mansoni vam6/vps39 related 0.0997 0.2898 0.2898
Brugia malayi MH1 domain containing protein 0.0025 0.0006 0.0006
Schistosoma mansoni Smad4 0.0025 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0071 0.2029
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.014 0.0348 0.1201
Echinococcus granulosus lamin 0.0028 0.0013 0.0013
Echinococcus granulosus serine:threonine protein kinase mig 15 0.3371 0.9964 1
Echinococcus multilocularis 0.2386 0.7033 0.8367
Schistosoma mansoni protein kinase 0.1009 0.2934 0.2934
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.001 0.001
Schistosoma mansoni lamin 0.0028 0.0013 0.0013
Echinococcus granulosus tar DNA binding protein 0.0068 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.0205 0.054 0.054
Echinococcus granulosus intermediate filament protein 0.0028 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0083 0.0178 0.5102
Brugia malayi MH2 domain containing protein 0.0371 0.1034 0.1034
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0058 0.0104 0.0359
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0047 0.0071 0.0244
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.001 0.0033
Loa Loa (eye worm) hypothetical protein 0.3371 0.9964 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0071 0.2029
Loa Loa (eye worm) hypothetical protein 0.0997 0.2898 0.2908
Schistosoma mansoni smad1 5 8 and 0.0025 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0241 0.6927
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0047 0.0071 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0202 0.5793
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0997 0.2898 0.2898
Echinococcus granulosus Vam6:Vps39 protein 0.0997 0.2898 0.2908
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0047 0.0071 0.0071
Brugia malayi MH1 domain containing protein 0.0025 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0156 0.4473
Loa Loa (eye worm) MH2 domain-containing protein 0.0371 0.1034 0.1038
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0058 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.