Detailed information for compound 1202899

Basic information

Technical information
  • TDR Targets ID: 1202899
  • Name: 2-(3-chlorophenyl)sulfonyl-N-methyl-N-phenyla cetamide
  • MW: 323.795 | Formula: C15H14ClNO3S
  • H donors: 0 H acceptors: 3 LogP: 2.87 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)S(=O)(=O)CC(=O)N(c1ccccc1)C
  • InChi: 1S/C15H14ClNO3S/c1-17(13-7-3-2-4-8-13)15(18)11-21(19,20)14-9-5-6-12(16)10-14/h2-10H,11H2,1H3
  • InChiKey: SLLOIXJZWAYOAL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(3-chlorophenyl)sulfonyl-N-methyl-N-phenyl-acetamide
  • 2-(3-chlorophenyl)sulfonyl-N-methyl-N-phenyl-ethanamide
  • MLS000692070
  • SMR000333750
  • 9H-394S
  • ZINC01402879
  • 2-[(3-chlorophenyl)sulfonyl]-N-methyl-N-phenylacetamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0503 0.0503
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0503 0.0503
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0503 0.0503
Echinococcus granulosus nuclear receptor nhr 48 0.0006 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0006 0.0088 0.0088
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0503 0.0503
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0006 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0006 0.0088 0.0088
Brugia malayi MH1 domain containing protein 0.001 0.035 0.035
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.3603 0.5907
Brugia malayi hypothetical protein 0.0038 0.2194 0.2194
Brugia malayi ecdysone receptor 0.0006 0.0088 0.0088
Loa Loa (eye worm) nuclear hormone receptor 0.0006 0.0088 0.0088
Schistosoma mansoni cpg binding protein 0.003 0.1654 0.2711
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0132 0.0132
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.3517 0.9946
Plasmodium vivax methionine--tRNA ligase, putative 0.0059 0.3533 1
Schistosoma mansoni methionine-tRNA synthetase 0.0023 0.1174 0.1925
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.226 0.6256
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.3517 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0503 0.0825
Onchocerca volvulus 0.0012 0.0484 0.0518
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.6099 0.6099
Echinococcus granulosus Smad4 0.001 0.035 0.035
Brugia malayi Smad1 0.001 0.035 0.035
Brugia malayi nuclear receptor RXR 0.0006 0.0088 0.0088
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0503 0.0503
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0484 0.0484
Schistosoma mansoni leucyl-tRNA synthetase 0.0023 0.1174 0.1925
Entamoeba histolytica hypothetical protein 0.0038 0.2194 0.5637
Brugia malayi nuclear receptor NHR-67 0.0006 0.0088 0.0088
Onchocerca volvulus 0.015 0.9356 1
Leishmania major leucyl-tRNA synthetase, putative 0.0023 0.1174 0.2262
Echinococcus multilocularis smad 0.001 0.035 0.035
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0484 0.0794
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0503 0.0503
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0484 0.0484
Toxoplasma gondii tRNA ligases class I (M) protein 0.0023 0.1174 0.2262
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.226 0.5823
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0484 0.0484
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0503 0.0825
Loa Loa (eye worm) hypothetical protein 0.0006 0.0132 0.0132
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0059 0.3533 1
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.226 0.226
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0503 0.0503
Loa Loa (eye worm) nuclear receptor NHR-67 0.0006 0.0088 0.0088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.3517 0.9946
Brugia malayi nuclear receptor NHR-88 0.0006 0.0088 0.0088
Schistosoma mansoni smad1 5 8 and 0.001 0.035 0.0573
Brugia malayi Inositol-1 0.0039 0.226 0.226
Loa Loa (eye worm) hypothetical protein 0.0023 0.1174 0.1174
Echinococcus multilocularis cpg binding protein 0.003 0.1654 0.1654
Loa Loa (eye worm) hypothetical protein 0.0012 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0012 0.0503 0.0503
Schistosoma mansoni zinc finger protein 0.0006 0.0088 0.0144
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0484 0.0484
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.9001 0.9001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0503 0.0503
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0484 0.0484
Treponema pallidum methionyl-tRNA synthetase 0.0023 0.1174 0.2274
Schistosoma mansoni inositol monophosphatase 0.0039 0.226 0.3705
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0059 0.3533 1
Brugia malayi MH2 domain containing protein 0.0144 0.9001 0.9001
Plasmodium falciparum methionine--tRNA ligase, putative 0.0023 0.1174 0.2262
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0006 0.0088 0.0088
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.226 0.5823
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0484 0.0484
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0503 0.0825
Loa Loa (eye worm) hypothetical protein 0.015 0.9356 0.9356
Brugia malayi protein ZK524.3 0.0023 0.1174 0.1174
Loa Loa (eye worm) hypothetical protein 0.0005 0.0067 0.0067
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0023 0.1174 0.1174
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0132 0.0132
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.226 0.4602
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0172 0.0172
Giardia lamblia Methionyl-tRNA synthetase 0.0059 0.3533 1
Entamoeba histolytica hypothetical protein 0.0038 0.2194 0.5637
Brugia malayi nuclear receptor NHR-88 0.0012 0.0503 0.0503
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.3517 0.9946
Plasmodium vivax methionine--tRNA ligase, putative 0.0023 0.1174 0.2262
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0503 0.0503
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.1993 0.4949
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.6099 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0088 0.0088
Schistosoma mansoni nuclear receptor 0.0006 0.0088 0.0144
Schistosoma mansoni hypothetical protein 0.0012 0.0484 0.0794
Loa Loa (eye worm) hypothetical protein 0.0006 0.0088 0.0088
Loa Loa (eye worm) DR-78 0.0006 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0006 0.0088 0.0088
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0012 0.0484 0.1035
Onchocerca volvulus 0.0028 0.1549 0.1656
Onchocerca volvulus 0.0006 0.0088 0.0094
Loa Loa (eye worm) hypothetical protein 0.0006 0.0088 0.0088
Brugia malayi hypothetical protein 0.015 0.9356 0.9356
Trichomonas vaginalis Phospholipase C precursor, putative 0.0012 0.0484 0.1035
Brugia malayi hypothetical protein 0.0006 0.0132 0.0132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.6099 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.226 0.6256
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0503 0.0825
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.3517 0.9946
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0484 0.0484
Brugia malayi tailless protein 0.0006 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0006 0.0132 0.0132
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0503 0.0825
Echinococcus granulosus cpg binding protein 0.003 0.1654 0.1654
Echinococcus granulosus thyroid hormone receptor alpha 0.0006 0.0088 0.0088
Schistosoma mansoni nocturnin 0.0012 0.0484 0.0794
Loa Loa (eye worm) hypothetical protein 0.0006 0.0088 0.0088
Onchocerca volvulus 0.0006 0.0088 0.0094
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.3517 1
Onchocerca volvulus Putative neutral sphingomyelinase 0.0012 0.0484 0.0518
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0503 0.0503
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0006 0.0088 0.0094
Brugia malayi steroid hormone receptor 0.0012 0.0503 0.0503
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0484 0.0484
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0484 0.0484
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0284 0.0284
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0088 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0503 0.0503
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0006 0.0088 0.0088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.6099 1
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0088 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0503 0.0503
Treponema pallidum leucyl-tRNA synthetase 0.0023 0.1174 0.2274
Loa Loa (eye worm) hypothetical protein 0.0012 0.0503 0.0503
Schistosoma mansoni ap endonuclease 0.0059 0.3517 0.5766
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0503 0.0503
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0503 0.0503
Schistosoma mansoni synaptojanin 0.0012 0.0484 0.0794
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0132 0.0217
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0503 0.0503
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0503 0.0503
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0088 0.0144
Schistosoma mansoni hypothetical protein 0.0038 0.2194 0.3597
Schistosoma mansoni cpg binding protein 0.003 0.1654 0.2711
Loa Loa (eye worm) hypothetical protein 0.0006 0.0088 0.0088
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.3517 0.9952
Echinococcus multilocularis methionine tRNA synthetase 0.0059 0.3533 0.3533
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0172 0.0283
Onchocerca volvulus 0.0012 0.0484 0.0518
Brugia malayi nuclear hormone receptor family member nhr-6 0.0006 0.0088 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0503 0.0503
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0503 0.0503
Chlamydia trachomatis leucine--tRNA ligase 0.0023 0.1174 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0503 0.0503
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.3517 0.9946
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0503 0.0503
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.035 0.035
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.3517 0.993
Plasmodium vivax hypothetical protein, conserved 0.0023 0.1174 0.2262
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0484 0.0484
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0484 0.0484
Schistosoma mansoni smad1 5 8 and 0.001 0.035 0.0573
Schistosoma mansoni synaptojanin 0.0012 0.0484 0.0794
Schistosoma mansoni Smad4 0.001 0.035 0.0573
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0484 0.0484
Brugia malayi orphan nuclear receptor NR2E1 0.0006 0.0088 0.0088
Schistosoma mansoni methionine-tRNA synthetase 0.0059 0.3533 0.5793
Brugia malayi methionyl-tRNA synthetase 0.0059 0.3533 0.3533
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0503 0.0503
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0503 0.0503
Brugia malayi nuclear hormone receptor 0.0006 0.0088 0.0088
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0023 0.1174 0.1174
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.3517 0.3517
Echinococcus granulosus Nuclear hormone receptor HR96 0.0006 0.0088 0.0088
Entamoeba histolytica hypothetical protein 0.0038 0.2194 0.5637
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.035 0.0573
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0503 0.0503
Schistosoma mansoni cript-related 0.0012 0.0484 0.0794
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0277 0.0277
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0006 0.0088 0.0088
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0503 0.0538
Plasmodium falciparum methionine--tRNA ligase 0.0059 0.3533 1
Loa Loa (eye worm) hypothetical protein 0.016 1 1
Schistosoma mansoni ap endonuclease 0.0059 0.3517 0.5766
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0484 0.0484
Onchocerca volvulus 0.0037 0.2077 0.222
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0484 0.0484
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0132 0.0217
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0059 0.3533 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0503 0.0825
Echinococcus granulosus muscleblind protein 0.016 1 1
Schistosoma mansoni cpg binding protein 0.0028 0.1549 0.254
Toxoplasma gondii methionyl-tRNA synthetase 0.0059 0.3533 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0503 0.0503
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0006 0.0132 0.0132
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0503 0.0503
Brugia malayi nuclear receptor RXR 0.0006 0.0132 0.0132
Loa Loa (eye worm) Smad1 0.001 0.035 0.035
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.3517 0.9946
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0503 0.0538
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0503 0.0503
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0503 0.0503
Echinococcus multilocularis leucyl tRNA synthetase 0.0023 0.1174 0.1174
Loa Loa (eye worm) hypothetical protein 0.0006 0.0132 0.0132
Echinococcus multilocularis Smad4 0.001 0.035 0.035
Brugia malayi MH1 domain containing protein 0.0005 0.0067 0.0067
Echinococcus granulosus Nuclear hormone receptor HR96 0.0006 0.0088 0.0088
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0484 0.0484
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.6099 0.6099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0503 0.0503
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0484 0.1035
Brugia malayi ecdysteroid receptor 0.0012 0.0503 0.0503
Brugia malayi hypothetical protein 0.0006 0.0088 0.0088
Brugia malayi nuclear hormone receptor family member odr-7 0.0006 0.0088 0.0088
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0172 0.0172
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0012 0.0484 0.0484
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0023 0.1174 0.2274
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0006 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0012 0.0484 0.0484
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0037 0.2077 0.2077
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0484 0.0484
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.035 0.035
Brugia malayi hypothetical protein 0.0006 0.0132 0.0132
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.035 0.035
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0006 0.0088 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0503 0.0503
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0503 0.0503
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0006 0.0088 0.0088
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.3517 0.9946
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0006 0.0088 0.0088
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0484 0.0484
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0012 0.0484 0.0484
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0006 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0012 0.0484 0.0484
Loa Loa (eye worm) nuclear factor I 0.0005 0.0067 0.0067
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.1549 0.1549
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0503 0.0825
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.3517 0.9952
Brugia malayi MH1 domain containing protein 0.001 0.035 0.035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.6099 0.6099
Loa Loa (eye worm) hypothetical protein 0.0006 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0006 0.0088 0.0088
Brugia malayi conserved hypotetical protein 0.0006 0.0088 0.0088
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0503 0.0825
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.035 0.035
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0059 0.3533 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0484 0.0484
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0088 0.0144
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.6099 0.6099
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0503 0.0825
Loa Loa (eye worm) hypothetical protein 0.0023 0.1174 0.1174
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.226 0.6256
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0172 0.0172
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.035 0.035
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0503 0.0503
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.226 0.5823
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0503 0.0503
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.226 0.5855
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.3517 0.993
Schistosoma mansoni smad1 5 8 and 0.001 0.035 0.0573
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0006 0.0088 0.0088
Chlamydia trachomatis methionine--tRNA ligase 0.0023 0.1174 0.5
Schistosoma mansoni smad 0.001 0.035 0.0573
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0059 0.3533 0.3533
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.226 0.4602
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0132 0.0132
Echinococcus multilocularis synaptojanin 1 0.0012 0.0484 0.0484
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0503 0.0503
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0503 0.0503
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0503 0.0825
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0484 0.0794
Echinococcus granulosus methionine tRNA synthetase 0.0059 0.3533 0.3533
Loa Loa (eye worm) inositol-1 0.0039 0.226 0.226
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0503 0.0503
Echinococcus granulosus smad 0.001 0.035 0.035
Schistosoma mansoni nuclear receptor nhr-48 0.0006 0.0088 0.0144
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0484 0.0484
Echinococcus multilocularis nuclear receptor nhr 48 0.0006 0.0088 0.0088
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0172 0.0172
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.016 1 1
Schistosoma mansoni nuclear receptor 0.0006 0.0088 0.0144
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.226 0.5823
Brugia malayi hypothetical protein 0.0006 0.0088 0.0088
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.226 0.226
Brugia malayi methionyl-tRNA synthetase 0.0023 0.1174 0.1174
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0006 0.0088 0.0144
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0484 0.1035
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0012 0.0484 0.0484
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0023 0.1174 0.1174
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0012 0.0503 0.0503
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.3517 0.3517
Loa Loa (eye worm) hypothetical protein 0.0012 0.0484 0.0484
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0059 0.3533 1
Entamoeba histolytica hypothetical protein 0.0038 0.2194 0.5637
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0012 0.0484 0.1035
Brugia malayi MH2 domain containing protein 0.001 0.035 0.035
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0484 0.1035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0503 0.0503
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0284 0.0284
Giardia lamblia Leucyl-tRNA synthetase 0.0023 0.1174 0.2262
Schistosoma mansoni coup transcription factor 0.0012 0.0503 0.0825
Brugia malayi MH2 domain containing protein 0.001 0.035 0.035
Schistosoma mansoni inositol monophosphatase 0.0039 0.226 0.3705
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.035 0.035
Brugia malayi CCR4 0.0012 0.0484 0.0484
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.6099 0.6099
Brugia malayi nuclear hormone receptor 0.0012 0.0503 0.0503
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0006 0.0088 0.0088
Onchocerca volvulus 0.0012 0.0503 0.0538
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0059 0.3533 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0503 0.0503
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.2194 0.2194
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0012 0.0484 0.1035
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.2194 0.2194
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.226 0.5823
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.2194 0.3597
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.3188 0.8867
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.6099 0.6099
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0503 0.0825
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.3517 0.3517
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0503 0.0825
Loa Loa (eye worm) hypothetical protein 0.0012 0.0503 0.0503
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0503 0.0503
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.3517 0.3517
Brugia malayi MH1 domain containing protein 0.0005 0.0067 0.0067
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0503 0.0503
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0012 0.0484 0.1035
Leishmania major methionyl-tRNA synthetase, putative 0.0059 0.3533 1
Echinococcus multilocularis muscleblind protein 0.016 1 1
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0012 0.0484 0.1035
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.9001 0.9001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0503 0.0503
Echinococcus granulosus synaptojanin 1 0.0012 0.0484 0.0484
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.3517 0.9946
Loa Loa (eye worm) hypothetical protein 0.0006 0.0088 0.0088
Brugia malayi CXXC zinc finger family protein 0.0028 0.1549 0.1549
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0006 0.0088 0.0144
Echinococcus multilocularis muscleblind protein 1 0.016 1 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0484 0.0484
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0484 0.0484
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0059 0.3533 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0006 0.0088 0.0094
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0503 0.0538
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0006 0.0132 0.0132
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0284 0.0284
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0503 0.0503
Toxoplasma gondii exonuclease III APE 0.0059 0.3517 0.9946
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0484 0.0794

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7375 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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