Detailed information for compound 1205468

Basic information

Technical information
  • TDR Targets ID: 1205468
  • Name: 3-[(3-fluorophenyl)sulfamoyl]-N-phenylbenzami de
  • MW: 370.397 | Formula: C19H15FN2O3S
  • H donors: 2 H acceptors: 3 LogP: 3.38 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)NS(=O)(=O)c1cccc(c1)C(=O)Nc1ccccc1
  • InChi: 1S/C19H15FN2O3S/c20-15-7-5-10-17(13-15)22-26(24,25)18-11-4-6-14(12-18)19(23)21-16-8-2-1-3-9-16/h1-13,22H,(H,21,23)
  • InChiKey: FESXZBJLUYCWOL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[(3-fluorophenyl)sulfamoyl]-N-phenyl-benzamide
  • 3-(3-Fluoro-phenylsulfamoyl)-N-phenyl-benzamide
  • ZINC00844929
  • NCGC00141875-01
  • BAS 00190208

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0608 0.0948
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0043 0.0043
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0608 0.0948
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0043 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0608 0.0618
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.1063 0.16
Loa Loa (eye worm) cytochrome P450 0.0016 0.0165 0.0204
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.022 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0043 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0043 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0043 0.0014
Mycobacterium leprae Probable lipase LipE 0.0036 0.0608 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0343 0.7337 1
Schistosoma mansoni hypothetical protein 0.0039 0.067 0.067
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0608 0.0624
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0608 0.0708
Mycobacterium ulcerans hypothetical protein 0.0181 0.3781 0.5773
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0879 0.0996
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0043 0.0014
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0207 0.4346 0.4346
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0537 0.0786
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0044 0.0044
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.2105 0.2705
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0961 0.144
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0608 0.0948
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.3379 0.4481
Echinococcus multilocularis geminin 0.0167 0.3479 0.3479
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0376 0.0295
Brugia malayi beta-lactamase 0.0036 0.0608 0.0888
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0043 0.0003
Brugia malayi steroid hormone receptor 0.001 0.0043 0.0003
Echinococcus granulosus FTZ F1 alpha 0.001 0.0043 0.0043
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0215 0.0273
Toxoplasma gondii ABC1 family protein 0.0036 0.0608 0.394
Mycobacterium ulcerans glutaminase 0.0302 0.6428 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.001 0.0043 0.0014
Brugia malayi Cytochrome P450 family protein 0.0058 0.1087 0.1638
Mycobacterium tuberculosis Conserved protein 0.0036 0.0608 0.0948
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.129 0.2407
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.1063 0.16
Loa Loa (eye worm) hypothetical protein 0.0036 0.0608 0.0897
Schistosoma mansoni glutaminase 0.0302 0.6428 0.6428
Loa Loa (eye worm) glutaminase 0.0302 0.6428 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0608 0.0608
Schistosoma mansoni ap endonuclease 0.0018 0.022 0.022
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0215 0.0273
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0608 0.0624
Onchocerca volvulus 0.0036 0.0608 0.2739
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0961 0.0961
Loa Loa (eye worm) hypothetical protein 0.0036 0.0608 0.0897
Echinococcus multilocularis cpg binding protein 0.0034 0.0578 0.0578
Brugia malayi nuclear hormone receptor 0.001 0.0043 0.0003
Brugia malayi beta-lactamase family protein 0.0036 0.0608 0.0888
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0961 0.0961
Schistosoma mansoni hypothetical protein 0.0167 0.3479 0.3479
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0043 0.0043
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.1338 0.1338
Mycobacterium ulcerans lipase LipD 0.0036 0.0608 0.0708
Brugia malayi cytochrome P450 0.0016 0.0165 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0043 0.0003
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.129 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0043 0.0014
Echinococcus multilocularis GPCR, family 2 0.0018 0.0215 0.0215
Loa Loa (eye worm) glutaminase 2 0.0302 0.6428 1
Onchocerca volvulus 0.0036 0.0608 0.2739
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0104 0.2105 0.2105
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0043 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0952 0.1179
Mycobacterium tuberculosis Conserved hypothetical protein 0.0181 0.3781 0.7735
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.484 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0608 0.0608
Brugia malayi Cytochrome P450 family protein 0.0016 0.0165 0.0194
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.1063 0.1609
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0608 0.0708
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0608 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0608 0.0897
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.129 0.129
Brugia malayi ecdysteroid receptor 0.001 0.0043 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2105 0.3036
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0961 0.1449
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0043 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0043 0.0043
Onchocerca volvulus 0.0033 0.0537 0.2396
Loa Loa (eye worm) hypothetical protein 0.0036 0.0608 0.0897
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0043 0.0043
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0043 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0043 0.0014
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.3379 0.4481
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0104 0.2105 0.3239
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0608 0.0624
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0879 0.0996
Echinococcus multilocularis hormone sensitive lipase 0.0207 0.4346 0.4346
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0608 0.0618
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0376 0.0295
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.2105 0.2105
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.022 0.022
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0608 0.0948
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0043 0.0043
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0043 0.0003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0215 0.0215
Schistosoma mansoni cpg binding protein 0.0034 0.0578 0.0578
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0043 0.0043
Brugia malayi Cytochrome P450 family protein 0.0025 0.0376 0.0525
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.1176 0.8992
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0043 0.0014
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0043 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0608 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.022 0.5
Mycobacterium tuberculosis Conserved protein 0.0036 0.0608 0.0948
Echinococcus granulosus cpg binding protein 0.0034 0.0578 0.0578
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0215 0.0283
Schistosoma mansoni cpg binding protein 0.0033 0.0537 0.0537
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0608 0.0897
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0215 0.0215
Echinococcus granulosus geminin 0.0167 0.3479 0.3479
Echinococcus multilocularis dnaJ subfamily B 0.0465 1 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.129 0.1569
Brugia malayi CXXC zinc finger family protein 0.0033 0.0537 0.0777
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0043 0.0003
Brugia malayi serine/threonine-protein kinase plk-2 0.0104 0.2105 0.3232
Leishmania major mitochondrial DNA polymerase beta 0.0343 0.7337 1
Onchocerca volvulus 0.0036 0.0608 0.2739
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0043 0.0043
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.129 0.1796
Schistosoma mansoni hypothetical protein 0.0016 0.0165 0.0165
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0043 0.0043
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0043 0.0043
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.129 0.129
Giardia lamblia Kinase, PLK 0.0104 0.2105 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.022 0.0281
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0043 0.0043
Schistosoma mansoni thyroid hormone receptor 0.001 0.0043 0.0043
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0879 0.0996
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0043 0.0014
Onchocerca volvulus Serine\/threonine kinase homolog 0.0104 0.2105 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0608 0.0608
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0608 0.0948
Leishmania major hypothetical protein, conserved 0.0036 0.0608 0.0618
Mycobacterium ulcerans hypothetical protein 0.0036 0.0608 0.0708
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.129 0.129
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0043 0.0003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0043 0.0043
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.129 0.1796
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0167 0.3479 0.3479
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0043 0.0043
Mycobacterium ulcerans beta-lactamase 0.0036 0.0608 0.0708
Schistosoma mansoni thyroid hormone receptor 0.001 0.0043 0.0043
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0043 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2105 0.3036
Schistosoma mansoni cytochrome P450 0.0016 0.0165 0.0165
Trichomonas vaginalis glutaminase, putative 0.0302 0.6428 1
Echinococcus granulosus GPCR family 2 0.0018 0.0215 0.0215
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0104 0.2105 0.2705
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.022 0.012
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.022 0.022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.001 0.0043 0.0014
Mycobacterium tuberculosis Conserved protein 0.0036 0.0608 0.0948
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0608 0.0624
Loa Loa (eye worm) hypothetical protein 0.0018 0.0215 0.0283
Trichomonas vaginalis esterase, putative 0.0036 0.0608 0.0624
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0043 0.0003
Toxoplasma gondii exonuclease III APE 0.0018 0.022 0.0497
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0043 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0043 0.0003
Schistosoma mansoni hypothetical protein 0.0018 0.0215 0.0215
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.022 0.0291
Echinococcus granulosus hormone sensitive lipase 0.0207 0.4346 0.4346
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0043 0.0043
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0043 0.0003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0608 0.0888
Loa Loa (eye worm) hypothetical protein 0.001 0.0043 0.0014
Schistosoma mansoni kinase 0.0053 0.0983 0.0983
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0043 0.0003
Schistosoma mansoni coup transcription factor 0.001 0.0043 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0608 0.0618
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2105 0.3036
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0207 0.4346 0.4346
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0043 0.0043
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0043 0.0043
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0215 0.0215
Schistosoma mansoni hypothetical protein 0.0018 0.0215 0.0215
Trypanosoma brucei polo-like protein kinase 0.0104 0.2105 0.2705
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.129 0.129
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0043 0.0043
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0608 0.0948
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0608 0.0948
Schistosoma mansoni ap endonuclease 0.0018 0.022 0.022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0961 0.0961
Loa Loa (eye worm) hypothetical protein 0.0036 0.0608 0.0897
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0376 0.0338
Loa Loa (eye worm) beta-lactamase 0.0036 0.0608 0.0897
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.022 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0043 0.0014
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.022 0.0078
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0961 0.0961
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.2105 0.2705
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0043 0.0043
Echinococcus multilocularis 0.0016 0.0165 0.0165
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.022 0.0078
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0376 0.0295
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.022 0.0078
Toxoplasma gondii hypothetical protein 0.0055 0.1035 0.7732
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0343 0.7337 1
Leishmania major cytochrome p450-like protein 0.0025 0.0376 0.0295
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.001 0.0043 0.0014
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0044 0.0044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0961 0.0961
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0952 0.1179
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.0165 0.0165
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.1087 0.1646
Schistosoma mansoni nuclear hormone receptor 0.001 0.0043 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0043 0.0014
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0608 0.0608
Brugia malayi nuclear receptor NHR-88 0.001 0.0043 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0961 0.0961
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0207 0.4346 0.4346
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0961 0.0961
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2105 0.3036
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0043 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0608 0.0897
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2105 0.3036
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0043 0.0003
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.2105 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.022 0.0078
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2105 0.3036
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0376 0.0535
Schistosoma mansoni hypothetical protein 0.0465 1 1
Schistosoma mansoni hypothetical protein 0.0018 0.0215 0.0215
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0043 0.0043
Schistosoma mansoni cpg binding protein 0.0034 0.0578 0.0578
Brugia malayi glutaminase DH11.1 0.0302 0.6428 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0343 0.7337 1
Schistosoma mansoni hypothetical protein 0.0018 0.0215 0.0215
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.129 0.1796
Brugia malayi Cytochrome P450 family protein 0.0025 0.0376 0.0525
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0608 0.0624
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0104 0.2105 0.2105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0043 0.0014
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.022 0.0089
Loa Loa (eye worm) hypothetical protein 0.0207 0.4346 0.6744
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0043 0.0003
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0162 0.3379 0.4481
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.111 0.1319
Loa Loa (eye worm) hypothetical protein 0.0057 0.1063 0.1609
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0879 0.0996
Loa Loa (eye worm) hypothetical protein 0.0039 0.067 0.0995
Brugia malayi beta-lactamase family protein 0.0036 0.0608 0.0888
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.067 0.0986
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0376 0.0535
Loa Loa (eye worm) histone methyltransferase 0.001 0.0044 0.0015
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0043 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2105 0.3036
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0376 0.0535
Loa Loa (eye worm) hypothetical protein 0.001 0.0043 0.0014

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.