Detailed information for compound 1209040

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 582.941 | Formula: C25H26ClF7N4O2
  • H donors: 2 H acceptors: 3 LogP: 6.62 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN([C@@H]1CC[C@@H]([C@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)Cc1n[nH]c(n1)O.Cl
  • InChi: 1S/C25H25F7N4O2.ClH/c1-13(15-9-16(24(27,28)29)11-17(10-15)25(30,31)32)38-20-8-7-19(22(20)14-3-5-18(26)6-4-14)36(2)12-21-33-23(37)35-34-21;/h3-6,9-11,13,19-20,22H,7-8,12H2,1-2H3,(H2,33,34,35,37);1H/t13-,19-,20+,22+;/m1./s1
  • InChiKey: FUCSKBZQBHJLCL-WICBNPBRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0205 0.1486 0.1477
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0211 0.0406
Brugia malayi beta-lactamase family protein 0.0037 0.0204 0.0193
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0204 0.0193
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0017 0.005 0.0039
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0274 0.0263
Brugia malayi cathepsin Z-like cysteine proteinase 0.0151 0.1071 0.106
Brugia malayi beta-lactamase family protein 0.0037 0.0204 0.0193
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0053 0.0326 0.0937
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.005 0.0078
Onchocerca volvulus Cathepsin L homolog 0.0151 0.1071 0.1833
Entamoeba histolytica cysteine proteinase, putative 0.0451 0.3367 0.6826
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0014 0.0024 0.0013
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0151 0.1071 0.217
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0151 0.1071 0.217
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0205 0.1486 0.1477
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0204 0.0193
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0039
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.031 0.0607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0451 0.3367 0.6819
Brugia malayi RNA binding protein 0.0138 0.0977 0.0966
Entamoeba histolytica cysteine proteinase, putative 0.0355 0.2636 0.5345
Brugia malayi NAD-dependent deacetylase SIRT1 0.0017 0.005 0.0039
Onchocerca volvulus Cathepsin L homolog 0.0656 0.4933 1
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0977 0.0966
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0151 0.1071 0.217
Entamoeba histolytica hypothetical protein, conserved 0.0017 0.005 0.0101
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0014 0.0024 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.1071 0.2152
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0077 0.0155
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0151 0.1071 0.106
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0014 0.0024 0.0013
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0138 0.0977 0.0966
Leishmania major cathepsin L-like protease 0.0656 0.4933 1
Giardia lamblia Cysteine protease 0.0151 0.1071 0.2748
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.005 0.0039
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0014 0.0024 0.0013
Plasmodium vivax vivapain-2 0.0656 0.4933 1
Plasmodium falciparum serine repeat antigen 3 0.0151 0.1071 0.2152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0355 0.2636 0.5334
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.1071 0.2152
Entamoeba histolytica cysteine proteinase, putative 0.0656 0.4933 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0077 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1319 1 1
Brugia malayi TAR-binding protein 0.0138 0.0977 0.0966
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0017 0.005 0.0026
Loa Loa (eye worm) hypothetical protein 0.0656 0.4933 0.4927
Schistosoma mansoni chromatin regulatory protein sir2 0.0053 0.0326 0.0315
Schistosoma mansoni cathepsin B (C01 family) 0.0151 0.1071 0.106
Loa Loa (eye worm) inositol-1 0.0038 0.0211 0.02
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0151 0.1071 0.2152
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0014 0.0024 0.0013
Leishmania major cysteine peptidase A (CPA) 0.0656 0.4933 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0077 0.0065
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0274 0.0251
Plasmodium vivax serine-repeat antigen (SERA) 0.0151 0.1071 0.217
Toxoplasma gondii cathepsin CPL 0.0656 0.4933 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.1071 0.106
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.1071 0.2152
Plasmodium falciparum serine repeat antigen 6 0.0151 0.1071 0.2152
Loa Loa (eye worm) fibroinase 0.0656 0.4933 0.4927
Giardia lamblia Cathepsin L precursor 0.0151 0.1071 0.2748
Echinococcus granulosus cathepsin L cysteine proteinase 0.0656 0.4933 0.4927
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0151 0.1071 0.2152
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0014 0.0024 0.0049
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0014 0.0024 0.0026
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0151 0.1071 0.2748
Brugia malayi Pip kinase protein 1 0.0014 0.0024 0.0013
Echinococcus multilocularis cathepsin L 0.0151 0.1071 0.106
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0151 0.1071 0.217
Onchocerca volvulus 0.0656 0.4933 1
Schistosoma mansoni hypothetical protein 0.0175 0.1255 0.1245
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0017 0.005 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0656 0.4933 1
Plasmodium vivax vivapain-1 0.0355 0.2636 0.5345
Entamoeba histolytica cysteine proteinase, putative 0.0355 0.2636 0.5345
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0014 0.0024 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0151 0.1071 0.2152
Echinococcus multilocularis snurportin 1 0.0672 0.5053 0.5048
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0656 0.4933 0.4927
Loa Loa (eye worm) hypothetical protein 0.0451 0.3367 0.336
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0977 0.0966
Entamoeba histolytica Ran family GTPase 0.0046 0.0274 0.0556
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0274 0.0657
Giardia lamblia Hypothetical protein 0.0017 0.005 0.0068
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0014 0.0024 0.0026
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0011 0.0023
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0077 0.0138
Schistosoma mansoni DNA helicase recq1 0.002 0.0077 0.0065
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0355 0.2636 0.2628
Onchocerca volvulus 0.0656 0.4933 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0656 0.4933 1
Loa Loa (eye worm) transcriptional regulator 0.0017 0.005 0.0039
Onchocerca volvulus 0.0656 0.4933 1
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0204 0.0149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.1071 0.2152
Brugia malayi Papain family cysteine protease containing protein 0.0151 0.1071 0.106
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0204 0.0193
Giardia lamblia Cysteine protease 0.0151 0.1071 0.2748
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1319 1 1
Mycobacterium ulcerans beta-lactamase 0.0037 0.0204 0.5576
Onchocerca volvulus 0.0656 0.4933 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.1071 0.106
Giardia lamblia Sirtuin type 2 0.0017 0.005 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0151 0.1071 0.217
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0204 0.0149
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0151 0.1071 0.106
Loa Loa (eye worm) pip kinase 1 0.0014 0.0024 0.0013
Plasmodium vivax transportin, putative 0.0012 0.0011 0.0023
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0017 0.005 0.0039
Loa Loa (eye worm) hypothetical protein 0.0451 0.3367 0.336
Loa Loa (eye worm) hypothetical protein 0.0205 0.1486 0.1477
Entamoeba histolytica cysteine protease, putative 0.0151 0.1071 0.217
Giardia lamblia Cathepsin B precursor 0.0512 0.3832 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0077 0.0065
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0017 0.005 0.0101
Plasmodium falciparum serine repeat antigen 7 0.0151 0.1071 0.2152
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0218 0.0442
Loa Loa (eye worm) cathepsin B 0.0512 0.3832 0.3825
Brugia malayi cathepsin F-like cysteine proteinase 0.0151 0.1071 0.106
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.005 0.0039
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.0036 0.0197 0.6915
Echinococcus granulosus cathepsin L 0.0151 0.1071 0.106
Trypanosoma cruzi cysteine peptidase, putative 0.0355 0.2636 0.2619
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0355 0.2636 0.5334
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.005 0.0078
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0077 0.0065
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0211 0.02
Loa Loa (eye worm) hypothetical protein 0.0037 0.0204 0.0193
Brugia malayi RNA recognition motif domain containing protein 0.0138 0.0977 0.0966
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.005 0.0078
Trypanosoma brucei cysteine peptidase C (CPC) 0.0512 0.3832 0.7764
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0218 0.042
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0211 0.0406
Loa Loa (eye worm) hypothetical protein 0.0037 0.0204 0.0193
Schistosoma mansoni cathepsin C 0.0151 0.1071 0.106
Echinococcus granulosus bloom syndrome protein 0.002 0.0077 0.0065
Loa Loa (eye worm) transcriptional regulator 0.0017 0.005 0.0039
Schistosoma mansoni ap endonuclease 0.0039 0.0218 0.0207
Plasmodium vivax vivapain-3 0.0355 0.2636 0.5345
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0218 0.0509
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0205 0.1486 0.1477
Giardia lamblia Cathepsin L precursor 0.0151 0.1071 0.2748
Giardia lamblia Hypothetical protein 0.0151 0.1071 0.2748
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0204 0.0149
Plasmodium vivax serine-repeat antigen (SERA) 0.0151 0.1071 0.217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0977 0.0966
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0401 0.0792
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0274 0.0556
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0151 0.1071 0.2152
Toxoplasma gondii histone deacetylase SIR2 0.0053 0.0326 0.0662
Toxoplasma gondii cathepsin CPC2 0.0151 0.1071 0.217
Entamoeba histolytica HEAT repeat domain containing protein 0.0012 0.0011 0.0023
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0274 0.0534
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0014 0.0024 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Trypanosoma cruzi cysteine peptidase, putative 0.0656 0.4933 0.4921
Echinococcus multilocularis chromatin regulatory protein sir2 0.0017 0.005 0.0039
Trypanosoma cruzi major cysteine proteinase, putative 0.0151 0.1071 0.1049
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0274 0.0263
Echinococcus granulosus importin subunit beta 1 0.0063 0.0401 0.039
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0512 0.3832 0.7764
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0211 0.0406
Plasmodium vivax importin-beta 2, putative 0.0063 0.0401 0.0813
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0211 0.0428
Schistosoma mansoni inositol monophosphatase 0.0038 0.0211 0.02
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0017 0.005 0.0039
Entamoeba histolytica cysteine protease, putative 0.0151 0.1071 0.217
Onchocerca volvulus 0.0169 0.1211 0.213
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0017 0.005 0.0078
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0204 0.0391
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0053 0.0326 0.0303
Brugia malayi Papain family cysteine protease containing protein 0.0355 0.2636 0.2628
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0274 0.0534
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1319 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Giardia lamblia Cathepsin L-like protease 0.0151 0.1071 0.2748
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0218 0.0194
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Plasmodium falciparum serine repeat antigen 1 0.0151 0.1071 0.2152
Giardia lamblia Cathepsin B precursor 0.0151 0.1071 0.2748
Brugia malayi Cathepsin L-like precursor 0.0656 0.4933 0.4927
Toxoplasma gondii HEAT repeat-containing protein 0.0063 0.0401 0.0813
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0977 0.0966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Giardia lamblia Cysteine protease 0.0151 0.1071 0.2748
Echinococcus granulosus cathepsin L 0.0355 0.2636 0.2628
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.1071 0.2152
Echinococcus granulosus chromatin regulatory protein sir2 0.0017 0.005 0.0039
Echinococcus multilocularis geminin 0.0175 0.1255 0.1245
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0218 0.0207
Mycobacterium leprae Probable lipase LipE 0.0037 0.0204 1
Schistosoma mansoni ap endonuclease 0.0039 0.0218 0.0207
Brugia malayi cathepsin F-like cysteine proteinase 0.0205 0.1486 0.1477
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0151 0.1071 0.2748
Schistosoma mansoni cathepsin S (C01 family) 0.0151 0.1071 0.106
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0656 0.4933 0.4927
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0218 0.0239
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0355 0.2636 0.2628
Entamoeba histolytica cysteine protease, putative 0.0656 0.4933 1
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0014 0.0024 0.0026
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0204 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0204 0.0193
Entamoeba histolytica cysteine proteinase 1, putative 0.0355 0.2636 0.5345
Brugia malayi Cathepsin L-like cysteine proteinase 0.0451 0.3367 0.336
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0065
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0014 0.0024 0.0026
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0211 0.0188
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0169 0.1211 0.1201
Echinococcus multilocularis importin subunit beta 1 0.0063 0.0401 0.039
Entamoeba histolytica cysteine proteinase, putative 0.0355 0.2636 0.5345
Loa Loa (eye worm) ctsf protein 0.0656 0.4933 0.4927
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0451 0.3367 0.3351
Giardia lamblia Cysteine protease 0.0151 0.1071 0.2748
Entamoeba histolytica phosphoinositide kinase, putative 0.0014 0.0024 0.0049
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0401 0.0792
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0077 0.0132
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0204 0.0149
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0204 0.0391
Echinococcus multilocularis tar DNA binding protein 0.0138 0.0977 0.0966
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0151 0.1071 0.2152
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0024 0.0049
Onchocerca volvulus 0.0656 0.4933 1
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0014 0.0024 0.0026
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0274 0.0263
Schistosoma mansoni DNA helicase recq5 0.002 0.0077 0.0065
Giardia lamblia Cathepsin B precursor 0.0151 0.1071 0.2748
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0977 0.0966
Onchocerca volvulus 0.0151 0.1071 0.1833
Loa Loa (eye worm) hypothetical protein 0.0151 0.1071 0.106
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0151 0.1071 0.2748
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0014 0.0024 0.0013
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0211 0.0406
Onchocerca volvulus 0.0656 0.4933 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.1071 0.106
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.1071 0.106
Plasmodium falciparum serine repeat antigen 2 0.0151 0.1071 0.2152
Entamoeba histolytica hypothetical protein 0.0151 0.1071 0.217
Onchocerca volvulus 0.0656 0.4933 1
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0017 0.005 0.0068
Trichomonas vaginalis importin beta-1, putative 0.0051 0.031 0.0607
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0053 0.0326 0.064
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Brugia malayi Cathepsin L-like precursor 0.0656 0.4933 0.4927
Echinococcus multilocularis cysteine protease 0.0656 0.4933 0.4927
Giardia lamblia Transcriptional regulator, Sir2 family 0.0053 0.0326 0.0794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.0204 0.5576
Schistosoma mansoni cathepsin s 0.0205 0.1486 0.1477
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.1071 0.2152
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0204 0.0414
Echinococcus granulosus cathepsin b 0.1319 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0151 0.1071 0.106
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0151 0.1071 0.217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Brugia malayi Cathepsin L-like precursor 0.0656 0.4933 0.4927
Entamoeba histolytica cysteine protease, putative 0.0151 0.1071 0.217
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0151 0.1071 0.2152
Loa Loa (eye worm) cysteine protease 0.0656 0.4933 0.4927
Loa Loa (eye worm) transcriptional regulator 0.0017 0.005 0.0039
Toxoplasma gondii cathepsin CPC1 0.0151 0.1071 0.217
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0017 0.005 0.0101
Plasmodium falciparum serine repeat antigen 9 0.0151 0.1071 0.2152
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0204 0.0149
Entamoeba histolytica cysteine protease, putative 0.0151 0.1071 0.217
Plasmodium falciparum cysteine proteinase falcipain 1 0.0355 0.2636 0.5334
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0017 0.005 0.0039
Brugia malayi cathepsin L-like precursor 0.0451 0.3367 0.336
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0169 0.1211 0.1201
Leishmania major cathepsin L-like protease 0.0656 0.4933 1
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0151 0.1071 0.217
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0204 0.0149
Mycobacterium tuberculosis Conserved protein 0.0037 0.0204 0.0149
Leishmania major cathepsin L-like protease 0.0656 0.4933 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0656 0.4933 0.4927
Trypanosoma cruzi cruzipain precursor, putative 0.0205 0.1486 0.1466
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0512 0.3832 0.7764
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0218 0.0207
Plasmodium falciparum serine repeat antigen 8 0.0151 0.1071 0.2152
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0014 0.0024 0.0049
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0151 0.1071 0.106
Brugia malayi Papain family cysteine protease containing protein 0.0151 0.1071 0.106
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0218 0.042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0151 0.1071 0.2152
Brugia malayi Cathepsin L-like precursor 0.0451 0.3367 0.336
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.1732 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0204 0.0149
Brugia malayi transcriptional regulator, Sir2 family protein 0.0017 0.005 0.0039
Plasmodium falciparum importin beta, putative 0.0063 0.0401 0.0792
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0151 0.1071 0.106
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0211 0.5842
Echinococcus multilocularis cathepsin b 0.1319 1 1
Loa Loa (eye worm) sirtuin 4 0.0017 0.005 0.0039
Onchocerca volvulus Cathepsin L homolog 0.0656 0.4933 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.1071 0.2152
Brugia malayi fibroinase precursor 0.0151 0.1071 0.106
Toxoplasma gondii ABC1 family protein 0.0037 0.0204 0.0414
Plasmodium vivax unspecified product 0.0205 0.1486 0.3013
Plasmodium vivax unspecified product 0.0355 0.2636 0.5345
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0151 0.1071 0.106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0014 0.0024 0.0013
Loa Loa (eye worm) pip kinase 2 0.0169 0.1211 0.1201
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0024 0.0049
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0151 0.1071 0.217
Brugia malayi RNA, U transporter 1 0.0179 0.1288 0.1278
Toxoplasma gondii preprocathepsin c precursor, putative 0.0151 0.1071 0.217
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0274 0.0556
Leishmania major GTP-binding protein, putative 0.0046 0.0274 0.0534
Mycobacterium ulcerans NAD-dependent deacetylase 0.0053 0.0326 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0151 0.1071 0.2748
Loa Loa (eye worm) hypothetical protein 0.0037 0.0204 0.0193
Giardia lamblia Cathepsin L precursor 0.0151 0.1071 0.2748
Schistosoma mansoni cathepsin F (C01 family) 0.0656 0.4933 0.4927
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0204 0.0149
Loa Loa (eye worm) hypothetical protein 0.0037 0.0204 0.0193
Trypanosoma cruzi cysteine peptidase, putative 0.0656 0.4933 0.4921
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0017 0.005 0.0039
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0274 0.0263
Giardia lamblia Cathepsin B precursor 0.0151 0.1071 0.2748
Schistosoma mansoni inositol monophosphatase 0.0038 0.0211 0.02
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0211 0.0188
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.005 0.0078
Loa Loa (eye worm) hypothetical protein 0.0151 0.1071 0.106
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Echinococcus granulosus snurportin 1 0.0672 0.5053 0.5048
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.005 0.0078
Plasmodium vivax NAD-dependent deacetylase, putative 0.0053 0.0326 0.0662
Brugia malayi Cathepsin L-like precursor 0.0656 0.4933 0.4927
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0014 0.0024 0.0026
Trypanosoma cruzi cruzipain precursor, putative 0.0656 0.4933 0.4921
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0053 0.0326 0.064
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0017 0.005 0.0039
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0024 0.0049
Brugia malayi cathepsin L-like cysteine proteinase 0.0151 0.1071 0.106
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0053 0.0326 0.0303
Brugia malayi Pip kinase protein 2 0.0169 0.1211 0.1201
Echinococcus multilocularis cathepsin b 0.1319 1 1
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0017 0.005 0.0101
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0211 0.0428
Loa Loa (eye worm) hypothetical protein 0.1319 1 1
Entamoeba histolytica recQ family helicase, putative 0.002 0.0077 0.0155
Giardia lamblia Cathepsin L precursor 0.0151 0.1071 0.2748
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0151 0.1071 0.217
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0053 0.0326 0.0662
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0401 0.039
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.1071 0.2152
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.1071 0.2152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.1071 0.106
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1319 1 1
Leishmania major cathepsin L-like protease 0.0656 0.4933 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0151 0.1071 0.217
Echinococcus granulosus cathepsin L cysteine protease 0.0355 0.2636 0.2628
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0204 0.0193
Loa Loa (eye worm) hypothetical protein 0.0151 0.1071 0.106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0151 0.1071 0.2152
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.005 0.0039
Trypanosoma cruzi cysteine proteinase, putative 0.0355 0.2636 0.2619
Echinococcus granulosus cathepsin l cysteine peptidase 0.0656 0.4933 0.4927
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0218 0.0207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Brugia malayi Cathepsin L-like precursor 0.0656 0.4933 0.4927
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0211 0.02
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0077 0.0065
Brugia malayi transcriptional regulator, Sir2 family protein 0.0017 0.005 0.0039
Loa Loa (eye worm) hypothetical protein 0.0037 0.0204 0.0193
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.005 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0672 0.5053 0.5048
Plasmodium vivax unspecified product 0.0151 0.1071 0.217
Loa Loa (eye worm) hypothetical protein 0.0205 0.1486 0.1477
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0355 0.2636 0.5334
Leishmania major cathepsin L-like protease 0.0656 0.4933 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0204 0.018
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0218 0.0207
Brugia malayi Inositol-1 0.0038 0.0211 0.02
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0151 0.1071 0.106
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0014 0.0024 0.0026
Toxoplasma gondii cathepsin B 0.0512 0.3832 0.7769
Brugia malayi Papain family cysteine protease containing protein 0.0151 0.1071 0.106
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0656 0.4933 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0077 0.0132
Trypanosoma cruzi major cysteine proteinase, putative 0.0151 0.1071 0.1049
Onchocerca volvulus 0.0451 0.3367 0.6689
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0204 0.5576
Brugia malayi cathepsin L precursor 0.0151 0.1071 0.106
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0218 0.0194
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0053 0.0326 0.064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0204 0.0391
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0077 0.0155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0204 0.0193
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0014 0.0024 0.0013
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.1071 0.106
Loa Loa (eye worm) beta-lactamase 0.0037 0.0204 0.0193
Trypanosoma cruzi cysteine peptidase, putative 0.0656 0.4933 0.4921
Loa Loa (eye worm) RecQ helicase 0.002 0.0077 0.0065
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0017 0.005 0.0039
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0656 0.4933 0.4927
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0077 0.0132
Giardia lamblia Cathepsin L-like protease 0.0151 0.1071 0.2748
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Echinococcus granulosus cathepsin l1 0.0451 0.3367 0.336
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.005 0.0039
Echinococcus granulosus cathepsin b 0.1319 1 1
Trichomonas vaginalis ran, putative 0.0046 0.0274 0.0534
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0014 0.0024 0.0013
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.1071 0.106
Entamoeba histolytica cysteine proteinase, putative 0.0355 0.2636 0.5345
Loa Loa (eye worm) TAR-binding protein 0.0138 0.0977 0.0966
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0017 0.005 0.0039
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0218 0.0442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Brugia malayi Cathepsin L-like precursor 0.0451 0.3367 0.336
Brugia malayi Papain family cysteine protease containing protein 0.0656 0.4933 0.4927
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0024 0.0026
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0077 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.1071 0.2152
Plasmodium vivax hypothetical protein, conserved 0.0017 0.005 0.0101
Leishmania major cathepsin L-like protease 0.0656 0.4933 1
Schistosoma mansoni hypothetical protein 0.0672 0.5053 0.5048
Entamoeba histolytica cysteine proteinase, putative 0.0656 0.4933 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0218 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0451 0.3367 0.336
Trypanosoma cruzi cysteine proteinase, putative 0.0355 0.2636 0.2619
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0017 0.005 0.0078
Plasmodium falciparum cysteine proteinase falcipain 3 0.0656 0.4933 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0077 0.0132
Leishmania major sir2-family protein-like protein 0.0017 0.005 0.0078
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0218 1
Brugia malayi transcriptional regulator, Sir2 family protein 0.0017 0.005 0.0039
Brugia malayi Papain family cysteine protease containing protein 0.0355 0.2636 0.2628
Loa Loa (eye worm) hypothetical protein 0.0169 0.1211 0.1201
Schistosoma mansoni ran 0.0046 0.0274 0.0263
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0204 0.0391
Giardia lamblia Cathepsin L precursor 0.0151 0.1071 0.2748
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0077 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.031 0.0287
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0274 0.0251
Leishmania major cathepsin L-like protease 0.0656 0.4933 1
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0169 0.1211 0.1201
Trypanosoma cruzi cysteine peptidase, putative 0.0656 0.4933 0.4921
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0077 0.0132
Echinococcus granulosus cysteine protease 0.0355 0.2636 0.2628
Entamoeba histolytica cysteine proteinase 2 0.0355 0.2636 0.5345
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0077 0.0065
Entamoeba histolytica hypothetical protein 0.0051 0.031 0.0629
Schistosoma mansoni hypothetical protein 0.0175 0.1255 0.1245
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0151 0.1071 0.217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.1071 0.106
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0053 0.0326 0.064
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.005 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Echinococcus granulosus geminin 0.0175 0.1255 0.1245
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0204 0.0391
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0077 0.0132
Schistosoma mansoni cathepsin F (C01 family) 0.0656 0.4933 0.4927
Brugia malayi Importin beta-1 subunit 0.0063 0.0401 0.039
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0151 0.1071 0.217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Echinococcus granulosus cathepsin l1 0.0656 0.4933 0.4927
Toxoplasma gondii exonuclease III APE 0.0039 0.0218 0.0442
Plasmodium falciparum serine repeat antigen 5 0.0151 0.1071 0.2152
Echinococcus granulosus tar DNA binding protein 0.0138 0.0977 0.0966
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0151 0.1071 0.106
Toxoplasma gondii histone deacetylase SIR2-like 0.0017 0.005 0.0101
Echinococcus multilocularis cathepsin L 0.0355 0.2636 0.2628
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1319 1 1
Leishmania major hypothetical protein, conserved 0.0037 0.0204 0.0391
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0218 0.042
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0204 0.0391
Entamoeba histolytica cysteine protease, putative 0.0151 0.1071 0.217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.1071 0.2152
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.031 0.0607
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0355 0.2636 0.2628
Loa Loa (eye worm) hypothetical protein 0.0451 0.3367 0.336
Giardia lamblia Hypothetical protein 0.0151 0.1071 0.2748
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0053 0.0326 0.064
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0218 0.042
Leishmania major importin beta-1 subunit, putative 0.0051 0.031 0.0607
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0014 0.0024 0.0013
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0077 0.0065
Echinococcus multilocularis bloom syndrome protein 0.002 0.0077 0.0065
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.005 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.1071 0.2152
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0011 0.0023
Giardia lamblia Cathepsin B precursor 0.0151 0.1071 0.2748
Echinococcus multilocularis cysteine protease 0.0656 0.4933 0.4927
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0204 0.5576
Leishmania major silent information regulator 2, putative 0.0017 0.005 0.0078
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0656 0.4933 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0204 0.018
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0014 0.0024 0.0026
Trichomonas vaginalis esterase, putative 0.0037 0.0204 0.0391
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0211 0.0406
Entamoeba histolytica cysteine protease, putative 0.0151 0.1071 0.217
Loa Loa (eye worm) hypothetical protein 0.0205 0.1486 0.1477
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0077 0.0132
Brugia malayi beta-lactamase 0.0037 0.0204 0.0193
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0151 0.1071 0.106
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0169 0.1211 0.1201
Leishmania major cathepsin L-like protease 0.0656 0.4933 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0451 0.3367 0.6819
Trypanosoma cruzi cysteine peptidase, putative 0.0205 0.1486 0.1466
Schistosoma mansoni importin beta-1 0.0063 0.0401 0.039
Giardia lamblia Cathepsin B precursor 0.0151 0.1071 0.2748
Brugia malayi Cathepsin L-like precursor 0.0656 0.4933 0.4927
Mycobacterium tuberculosis Conserved protein 0.0037 0.0204 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0151 0.1071 0.2152
Giardia lamblia Cathepsin B precursor 0.0512 0.3832 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.005 0.0078
Mycobacterium ulcerans lipase LipD 0.0037 0.0204 0.5576
Loa Loa (eye worm) FYVE zinc finger family protein 0.0014 0.0024 0.0013
Onchocerca volvulus Cathepsin F homolog 0.0656 0.4933 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.005 0.0078
Loa Loa (eye worm) RNA binding protein 0.0138 0.0977 0.0966
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0024 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Trypanosoma cruzi cysteine protease, putative 0.0355 0.2636 0.2619
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0512 0.3832 0.3825
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0355 0.2636 0.5334
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0053 0.0326 0.064
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0218 0.6079
Giardia lamblia Encystation-specific protease 0.0151 0.1071 0.2748
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0512 0.3832 0.3817
Giardia lamblia Cathepsin L precursor 0.0151 0.1071 0.2748
Trypanosoma brucei SIR2-like protein 4, putative 0.0017 0.005 0.0078
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0656 0.4933 0.4927
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0151 0.1071 0.2152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Schistosoma mansoni ran 0.0046 0.0274 0.0263
Plasmodium falciparum serine repeat antigen 4 0.0151 0.1071 0.2152
Giardia lamblia Cathepsin B precursor 0.0512 0.3832 1
Plasmodium vivax vivapain-2 0.0656 0.4933 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0204 0.0193
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0218 0.042
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0355 0.2636 0.2619
Echinococcus multilocularis cathepsin L cysteine protease 0.0656 0.4933 0.4927
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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