Detailed information for compound 1231657

Basic information

Technical information
  • TDR Targets ID: 1231657
  • Name: N-[3-[2-(4-chlorophenyl)ethylamino]-3-oxoprop yl]-4-nitrobenzamide
  • MW: 375.806 | Formula: C18H18ClN3O4
  • H donors: 2 H acceptors: 4 LogP: 2.86 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCCc1ccc(cc1)Cl)CCNC(=O)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C18H18ClN3O4/c19-15-5-1-13(2-6-15)9-11-20-17(23)10-12-21-18(24)14-3-7-16(8-4-14)22(25)26/h1-8H,9-12H2,(H,20,23)(H,21,24)
  • InChiKey: KTRSIOKROPMRNI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-[2-(4-chlorophenyl)ethylamino]-3-oxo-propyl]-4-nitro-benzamide
  • N-[3-[2-(4-chlorophenyl)ethylamino]-3-keto-propyl]-4-nitro-benzamide
  • T5505371
  • ZINC07813919

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens fatty acid synthase Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Soraphen polyketide synthase A, related Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) acyl carrier protein Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Polyketide synthase Pks2 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks12 Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium tuberculosis Probable polyketide synthase Pks5 Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum KR domain domain-containing protein, putative Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Get druggable targets OG5_126633 All targets in OG5_126633
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Toxoplasma gondii AMP-binding enzyme domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks8 Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks7 Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable polyketide synthase Pks15 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas Get druggable targets OG5_126633 All targets in OG5_126633
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein Get druggable targets OG5_126633 All targets in OG5_126633
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium parvum polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Onchocerca volvulus Fatty acid synthase homolog Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0029 0.0034 0.0776
Echinococcus granulosus tumor protein p63 0.0726 0.1793 0.18
Leishmania major phosphatidylinositol 3-kinase, putative 0.005 0.0088 0.2173
Loa Loa (eye worm) hypothetical protein 0.1172 0.2919 0.2929
Loa Loa (eye worm) hypothetical protein 0.0051 0.0088 0.0088
Echinococcus granulosus serine:threonine protein kinase mig 15 0.3964 0.9964 1
Echinococcus multilocularis lamin 0.0032 0.0042 0.0055
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0024 0.0022 0.0282
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.0032 0.0028
Loa Loa (eye worm) TAR-binding protein 0.0071 0.014 0.0141
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0018 0.0362
Schistosoma mansoni protein kinase 0.2806 0.7042 0.704
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0064 0.0059
Loa Loa (eye worm) hypothetical protein 0.3964 0.9964 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0851 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.005 0.0088 0.0275
Schistosoma mansoni transcription factor LCR-F1 0.0118 0.0258 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0032 0.0291
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0851 1
Loa Loa (eye worm) phosphatidylinositol 3 0.005 0.0088 0.0088
Brugia malayi intermediate filament protein 0.0032 0.0042 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.1187 0.2955 0.2952
Onchocerca volvulus 0.1172 0.2919 1
Echinococcus multilocularis muscleblind protein 0.018 0.0416 0.0546
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0151 0.034 0.0336
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0151 0.034 0.1142
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0263 0.3022
Echinococcus multilocularis tar DNA binding protein 0.0071 0.014 0.0184
Trypanosoma cruzi target of rapamycin kinase 3 0.012 0.0263 0.0876
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0088 0.0949
Entamoeba histolytica hypothetical protein 0.0028 0.0032 0.0175
Schistosoma mansoni hypothetical protein 0.1172 0.2919 0.2915
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.0036 0.0668
Leishmania major phosphatidylinositol 3-related kinase, putative 0.005 0.0088 0.2173
Echinococcus granulosus lamin 0.0032 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0151 0.034 0.3944
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0026 0.0026
Brugia malayi MH2 domain containing protein 0.0026 0.0026 0.0022
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.0032 0.0028
Toxoplasma gondii type I fatty acid synthase, putative 0.0021 0.0015 0.0205
Brugia malayi RNA binding protein 0.0071 0.014 0.0136
Loa Loa (eye worm) transcription factor SMAD2 0.0382 0.0924 0.0928
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.0041 0.0955
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.1187 0.2955 0.2966
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0036 0.0668
Onchocerca volvulus 0.0032 0.0042 0.0037
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.005 0.0088 0.0088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0851 1
Schistosoma mansoni vam6/vps39 related 0.1172 0.2919 0.2915
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0031 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0188 0.2131
Schistosoma mansoni tar DNA-binding protein 0.0071 0.014 0.0135
Schistosoma mansoni hypothetical protein 0.0041 0.0064 0.0059
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0151 0.034 0.3871
Schistosoma mansoni cellular tumor antigen P53 0.0106 0.0229 0.0224
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.005 0.0088 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0243 0.2789
Mycobacterium ulcerans thioesterase TesA 0.0025 0.0024 0.0339
Mycobacterium leprae Polyketide synthase Pks13 0.0045 0.0074 0.1642
Schistosoma mansoni Smad4 0.0026 0.0026 0.0022
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0045 0.0074 0.1792
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0151 0.034 0.0447
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.0851 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0032 0.0041 0.079
Echinococcus granulosus lamin dm0 0.0032 0.0042 0.0042
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.005 0.0088 0.0242
Onchocerca volvulus Fatty acid synthase homolog 0.0054 0.0097 0.0228
Loa Loa (eye worm) hypothetical protein 0.0041 0.0064 0.0064
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0022 0.0016 0.0016
Echinococcus multilocularis microtubule associated protein 2 0.3036 0.7621 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0151 0.034 0.3871
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0057 0.0104 0.01
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0018 0.0034
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0036 0.0668
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0018 0.0186
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0004
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0026 0.0026
Mycobacterium ulcerans polyketide synthase 0.003 0.0036 0.0668
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0151 0.034 0.1112
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0151 0.034 0.1112
Loa Loa (eye worm) hypothetical protein 0.0032 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.018 0.0416 0.0417
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0029 0.0034 0.0776
Brugia malayi MH1 domain containing protein 0.0026 0.0026 0.0022
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0018 0.0018
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0118 0.0258 0.0259
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0151 0.034 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0026 0.0026
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1187 0.2955 0.2966
Echinococcus granulosus Vam6:Vps39 protein 0.1172 0.2919 0.2929
Trichomonas vaginalis PIKK family atypical protein kinase 0.0151 0.034 0.3944
Schistosoma mansoni smad1 5 8 and 0.0026 0.0026 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0243 0.2789
Brugia malayi MH1 domain containing protein 0.0026 0.0026 0.0022
Schistosoma mansoni rap gtpase-activating protein 0.1172 0.2919 0.2915
Mycobacterium ulcerans thioesterase 0.0025 0.0024 0.0339
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.1172 0.2919 0.2915
Schistosoma mansoni hypothetical protein 0.0118 0.0258 0.0253
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0028 0.0032 0.0033
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.003 0.0036 0.0835
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.1172 0.2919 0.2915
Schistosoma mansoni smad1 5 8 and 0.0026 0.0026 0.0022
Toxoplasma gondii exonuclease III APE 0.0023 0.0018 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0041 0.0388
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1187 0.2955 0.3877
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0088 0.0949
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0851 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.0041 0.079
Echinococcus multilocularis musashi 0.0032 0.0042 0.0055
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.003 0.0036 0.0668
Echinococcus multilocularis smad 0.0026 0.0026 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0071 0.014 0.0135
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.005 0.0088 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0263 0.3022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0243 0.2789
Echinococcus granulosus serine protein kinase ATM 0.0028 0.0032 0.0033
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0042 0.0042
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0026 0.0034
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0022 0.0016 0.0021
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0018 0.0118
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0026 0.0022
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0088 0.0949
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.1187 0.2955 0.2966
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0032 0.0041 0.0955
Brugia malayi MH2 domain containing protein 0.0026 0.0026 0.0022
Echinococcus granulosus tar DNA binding protein 0.0071 0.014 0.0141
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0018 0.5
Brugia malayi FAT domain containing protein 0.0022 0.0016 0.0012
Brugia malayi Muscleblind-like protein 0.018 0.0416 0.0412
Loa Loa (eye worm) Smad1 0.0026 0.0026 0.0026
Echinococcus multilocularis GPCR, family 2 0.0019 0.0008 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0166 0.1871
Toxoplasma gondii FATC domain-containing protein 0.0028 0.0032 0.097
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0088 0.0949
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0185 0.2104
Schistosoma mansoni tar DNA-binding protein 0.0071 0.014 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0088 0.0949
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0063 0.0118 0.0346
Trypanosoma brucei target of rapamycin kinase 3, putative 0.012 0.0263 0.0845
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.005 0.0088 0.0084
Brugia malayi hypothetical protein 0.1172 0.2919 0.2916
Schistosoma mansoni protein kinase 0.3979 1 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.0416 0.0546
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0112 0.0112
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0018 0.0018
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0024 0.0022 0.0282
Schistosoma mansoni fkbp-rapamycin associated protein 0.0028 0.0032 0.0028
Brugia malayi MH2 domain containing protein 0.0382 0.0924 0.092
Entamoeba histolytica hypothetical protein 0.0118 0.0258 0.2882
Schistosoma mansoni microtubule-associated protein tau 0.3036 0.7621 0.762
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0032 0.0041 0.1322
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0851 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0008 0.0011
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0042 0.0038
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0036 0.0668
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.0032 0.0028
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.0851 1
Brugia malayi Temporarily assigned gene name protein 59 0.1172 0.2919 0.2916
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0025 0.0024 0.0339
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0032 0.0041 0.079
Schistosoma mansoni intermediate filament proteins 0.0032 0.0042 0.0038
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0031 0.0032
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0026 0.0026
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0151 0.034 0.0342
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0188 0.2131
Loa Loa (eye worm) MH2 domain-containing protein 0.0382 0.0924 0.0928
Mycobacterium tuberculosis Probable thioesterase TesA 0.0025 0.0024 0.0512
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.014 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0166 0.1871
Onchocerca volvulus 0.0106 0.0229 0.0684
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0851 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0026 0.0034
Loa Loa (eye worm) hypothetical protein 0.0028 0.0032 0.0033
Echinococcus granulosus muscleblind protein 0.018 0.0416 0.0417
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0032 0.0041 0.0955
Echinococcus granulosus smad 0.0026 0.0026 0.0026
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.003 0.0036 0.0835
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0008 0.0008
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0112 0.0107
Entamoeba histolytica hypothetical protein 0.0118 0.0258 0.2882
Loa Loa (eye worm) fatty acid synthase 0.003 0.0035 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0032 0.0291
Entamoeba histolytica protein kinase rad3, putative 0.0028 0.0032 0.0175
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0018 0.5
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.1172 0.2919 0.383
Loa Loa (eye worm) hypothetical protein 0.1172 0.2919 0.2929
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0118 0.0258 0.0339
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.012 0.0263 0.76
Schistosoma mansoni serine/threonine protein kinase 0.1187 0.2955 0.2952
Onchocerca volvulus 0.0052 0.0093 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0165 0.1867
Echinococcus multilocularis tumor protein p63 0.0726 0.1793 0.2353
Onchocerca volvulus 0.0032 0.0042 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0243 0.2789
Schistosoma mansoni lamin 0.0032 0.0042 0.0038
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0032 0.0041 0.079
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.003 0.0036 0.0032
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0008 0.0004
Mycobacterium ulcerans polyketide synthase 0.0032 0.0041 0.079
Loa Loa (eye worm) RNA binding protein 0.0071 0.014 0.0141
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0018 0.5
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.003 0.0036 0.0668
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0022 0.0282
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0008 0.0011
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.005 0.0088 0.0242
Echinococcus granulosus GPCR family 2 0.0019 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0263 0.3022
Mycobacterium leprae Probable polyketide synthase Pks1 0.0032 0.0041 0.079
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0018 0.0118
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.0036 0.0835
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0018 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0851 1
Schistosoma mansoni lamin 0.0032 0.0042 0.0038
Echinococcus granulosus protein kinase 0.2806 0.7042 0.7067
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0063 0.0647
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0008 0.0004
Schistosoma mansoni ap endonuclease 0.0023 0.0018 0.0013
Brugia malayi hypothetical protein 0.0118 0.0258 0.0254
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.1172 0.2919 0.2929
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0151 0.034 0.1142
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0032 0.0084
Schistosoma mansoni protein kinase 0.1187 0.2955 0.2952
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0022 0.0015 0.029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0003
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0004 0.0004
Brugia malayi Protein kinase domain containing protein 0.1187 0.2955 0.2952
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0166 0.1871
Toxoplasma gondii type I fatty acid synthase, putative 0.0032 0.0041 0.1344
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0396 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0018 0.0034
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0263 0.3022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0165 0.1867
Loa Loa (eye worm) hypothetical protein 0.0106 0.0229 0.023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0851 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.1172 0.2919 0.2929
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0151 0.034 0.0336
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.005 0.0088 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0165 0.1867
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.2806 0.7042 0.7067
Loa Loa (eye worm) hypothetical protein 0.0032 0.0041 0.0041
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0028 0.0032 0.0084
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0396 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0112 0.0243 1
Loa Loa (eye worm) hypothetical protein 0.018 0.0416 0.0417
Loa Loa (eye worm) phosphatidylinositol 3 0.0151 0.034 0.0342
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0188 0.2131
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.1187 0.2955 0.3877
Echinococcus multilocularis 0.2806 0.7042 0.924
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.014 0.0136
Echinococcus multilocularis lamin dm0 0.0032 0.0042 0.0055
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0045 0.0074 0.1792
Entamoeba histolytica hypothetical protein 0.0118 0.0258 0.2882
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0207 0.2363
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0151 0.034 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0243 0.2789
Schistosoma mansoni tar DNA-binding protein 0.0071 0.014 0.0135
Echinococcus granulosus Smad4 0.0026 0.0026 0.0026
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0008 0.0008
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0071 0.014 0.0422
Giardia lamblia GTOR 0.0151 0.034 0.3871
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.1172 0.2919 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0008 0.0008
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.0032 0.0043
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0025 0.0023 0.0482
Schistosoma mansoni ap endonuclease 0.0023 0.0018 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0851 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0215 0.246
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.0032 0.005
Schistosoma mansoni tar DNA-binding protein 0.0071 0.014 0.0135
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0031 0.0708
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0166 0.1871
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0396 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0041 0.0041
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0018 0.0023
Mycobacterium ulcerans polyketide synthase Pks13 0.0045 0.0074 0.1642
Schistosoma mansoni smad 0.0026 0.0026 0.0022
Brugia malayi Smad1 0.0026 0.0026 0.0022
Schistosoma mansoni smad1 5 8 and 0.0026 0.0026 0.0022
Echinococcus granulosus microtubule associated protein 2 0.3036 0.7621 0.7649
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0185 0.2104
Schistosoma mansoni hypothetical protein 0.0022 0.0016 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0263 0.3022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0243 0.2789
Entamoeba histolytica hypothetical protein 0.0118 0.0258 0.2882
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0016 0.0097
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1187 0.2955 0.3877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0285 0.3285
Echinococcus multilocularis Smad4 0.0026 0.0026 0.0034
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1187 0.2955 0.2966
Loa Loa (eye worm) hypothetical protein 0.006 0.0112 0.0112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0851 1
Echinococcus granulosus intermediate filament protein 0.0032 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0151 0.034 0.3944
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0243 0.2789
Loa Loa (eye worm) hypothetical protein 0.0022 0.0016 0.0016
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.1172 0.2919 1
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.1172 0.2919 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0112 0.0107
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0028 0.0032 0.0043
Brugia malayi TAR-binding protein 0.0071 0.014 0.0136
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0028 0.0032 0.0175
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0032 0.0291

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 7.38 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a kinetic, fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 8.77 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.6213 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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