TDR Targets

Basic information

Technical information

TDR Targets ID: 1234506
Name: 6-cyclopropyl-N-(4-methylsulfonylphenyl)-1-pr opan-2-ylpyrazolo[5,4-b]pyridine-4-carboxamid e
MW: 398.479 | Formula: C20H22N4O3S
H donors: 1 H acceptors: 5 LogP: 2.19 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cc(nc2c1cnn2C(C)C)C1CC1)Nc1ccc(cc1)S(=O)(=O)C
InChi: 1S/C20H22N4O3S/c1-12(2)24-19-17(11-21-24)16(10-18(23-19)13-4-5-13)20(25)22-14-6-8-15(9-7-14)28(3,26)27/h6-13H,4-5H2,1-3H3,(H,22,25)
InChiKey: ROYIVHXCWSKKSX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-cyclopropyl-1-isopropyl-N-(4-methylsulfonylphenyl)pyrazolo[5,4-b]pyridine-4-carboxamide
6-cyclopropyl-1-isopropyl-N-(4-methylsulfonylphenyl)-4-pyrazolo[5,4-b]pyridinecarboxamide
6-cyclopropyl-1-isopropyl-N-(4-mesylphenyl)pyrazolo[5,4-b]pyridine-4-carboxamide
6-cyclopropyl-N-(4-methylsulfonylphenyl)-1-propan-2-yl-pyrazolo[5,4-b]pyridine-4-carboxamide
ZINC08395416
T5564015

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma brucei gambiense	ATP-dependent phosphofructokinase,6-phospho-1-fructokinase		No references
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma mansoni	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania infantum	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C)	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Echinococcus granulosus	6 phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania mexicana	6-phospho-1-fructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Echinococcus multilocularis	6 phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma congolense	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium ulcerans	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania major	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania donovani	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma mansoni	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania braziliensis	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma brucei gambiense	ATP-dependent phosphofructokinase,6-phospho-1-fructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C)	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C)	Get druggable targets OG5_126758	All targets in OG5_126758
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	hypothetical protein	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C)	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.0775	0.1091
Trypanosoma brucei	telomerase reverse transcriptase	0.0091	0.1593	0.1593
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0795	0.1118
Echinococcus granulosus	survival motor neuron protein 1	0.0242	0.5806	0.5972
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0289	0.7111	1
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.2709	0.381
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0645	0.0907
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0035	0.0029	0.0185
Echinococcus granulosus	eukaryotic translation initiation factor 4E	0.0289	0.7111	0.7315
Onchocerca volvulus		0.0089	0.1521	0.176
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0795	0.0668
Echinococcus multilocularis	p2X purinoceptor 4	0.0267	0.6494	0.6392
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0091	0.1593	0.224
Schistosoma mansoni	chromobox protein	0.0068	0.0931	0.0805
Loa Loa (eye worm)	6-phosphofructokinase	0.0131	0.2709	0.381
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0029	0.0041
Echinococcus multilocularis	ras gtpase	0.0143	0.3028	0.2517
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.2709	0.381
Leishmania major	eukaryotic translation initiation factor-like protein	0.0289	0.7111	1
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0795	0.0818
Giardia lamblia	Telomerase catalytic subunit	0.0091	0.1593	1
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0289	0.7111	1
Brugia malayi	phosphofructokinase	0.0131	0.2709	0.381
Leishmania major	telomerase reverse transcriptase, putative	0.0091	0.1593	0.224
Brugia malayi	6-phosphofructokinase	0.0131	0.2709	0.381
Echinococcus multilocularis	survival motor neuron protein 1	0.0242	0.5806	0.5623
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1521	0.2139
Echinococcus granulosus	ras gtpase	0.0143	0.3028	0.3114
Echinococcus multilocularis	p2X purinoceptor 4	0.0267	0.6494	0.6392
Plasmodium falciparum	telomerase reverse transcriptase	0.0091	0.1593	1
Brugia malayi	Heterochromatin protein 1	0.0068	0.0931	0.1309
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0137	0.0192
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0795	0.0668
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0775	0.0648
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.2709	0.381
Leishmania major	eukaryotic translation initiation factor eIF-4E, putative	0.0289	0.7111	1
Toxoplasma gondii	phosphofructokinase PFKII	0.0035	0.0029	0.0041
Leishmania major	ATP-dependent phosphofructokinase	0.0131	0.2709	0.381
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0091	0.1593	0.224
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0289	0.7111	1
Loa Loa (eye worm)	phosphofructokinase	0.0131	0.2709	0.381
Toxoplasma gondii	6-phosphofructokinase	0.0035	0.0029	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0137	0.0192
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0029	0.0041
Echinococcus multilocularis	expressed protein	0.0382	0.9722	1
Brugia malayi	GTP-binding protein	0.0143	0.3028	0.4257
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0035	0.0029	0.5
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0931	0.1309
Echinococcus granulosus	p2X purinoceptor 4	0.0267	0.6494	0.668
Loa Loa (eye worm)	hypothetical protein	0.0242	0.5806	0.8165
Echinococcus granulosus	chromobox protein 1	0.0068	0.0931	0.0957
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0029	0.0041
Brugia malayi	TAR-binding protein	0.0063	0.0795	0.1118
Schistosoma mansoni	cell polarity protein	0.0143	0.3028	0.2931
Echinococcus granulosus	chromobox protein 1	0.0068	0.0931	0.0957
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0099	0.0139
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0035	0.0029	0.0185
Echinococcus granulosus	p2X purinoceptor 4	0.0267	0.6494	0.668
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0289	0.7111	1
Schistosoma mansoni	6-phosphofructokinase	0.0131	0.2709	0.2608
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0089	0.1521	0.1403
Echinococcus multilocularis	6 phosphofructokinase	0.0131	0.2709	0.2161
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.0931	0.1309
Brugia malayi	Telomerase reverse transcriptase	0.0243	0.5838	0.8209
Echinococcus granulosus	expressed protein	0.0382	0.9722	1
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.2709	0.381
Leishmania major	eukaryotic translation initiation factor-like	0.0289	0.7111	1
Loa Loa (eye worm)	translation initiation factor 4E	0.0289	0.7111	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0795	0.1118
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0795	0.0668
Schistosoma mansoni	6-phosphofructokinase	0.0131	0.2709	0.2608
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0035	0.0029	0.0041
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0418	0.0285
Schistosoma mansoni	cell polarity protein	0.0143	0.3028	0.2931
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0931	0.1309
Echinococcus multilocularis	p2X purinoceptor 4	0.0267	0.6494	0.6392
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0131	0.2709	0.2709
Trypanosoma brucei	RNA helicase, putative	0.0392	1	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0029	0.0041
Schistosoma mansoni	chromobox protein	0.0068	0.0931	0.0805
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0795	0.0668
Schistosoma mansoni	P2X receptor subunit	0.0132	0.2735	0.2634
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0795	0.0668
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.0343	0.8642	1
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0289	0.7111	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.2709	0.381
Onchocerca volvulus		0.0049	0.0418	0.0484
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0179	0.0252
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.0775	0.1091
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0131	0.2709	1
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0035	0.0029	0.0041
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0029	0.0041
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0035	0.0029	0.5
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0179	0.0207
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0418	0.0588
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0131	0.2709	1
Plasmodium vivax	6-phosphofructokinase, putative	0.0035	0.0029	0.0185
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.2709	0.381
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0099	0.0114
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0035	0.0029	0.0185
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0179	0.0252
Echinococcus granulosus	6 phosphofructokinase	0.0131	0.2709	0.2787
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.0775	0.0798
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0289	0.7111	1
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0089	0.1521	0.2139
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0795	0.0022
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0131	0.2709	0.381
Brugia malayi	GTP-binding protein, identical	0.0143	0.3028	0.4257
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0775	0.0648
Echinococcus granulosus	p2X purinoceptor 4	0.0267	0.6494	0.668
Schistosoma mansoni	P2X receptor subunit	0.0267	0.6494	0.6445
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0645	0.0907
Loa Loa (eye worm)	GTP-binding protein	0.0143	0.3028	0.4257
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0289	0.7111	1
Plasmodium vivax	6-phosphofructokinase, putative	0.0035	0.0029	0.0185
Echinococcus granulosus	L aminoadipate semialdehyde	0.0089	0.1521	0.1564
Loa Loa (eye worm)	6-phosphofructokinase	0.0131	0.2709	0.381
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0089	0.1521	0.0833
Schistosoma mansoni	P2X receptor subunit	0.0132	0.2735	0.2634
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0131	0.2709	1
Brugia malayi	6-phosphofructokinase	0.0131	0.2709	0.381
Toxoplasma gondii	eukaryotic initiation factor-4E, putative	0.0289	0.7111	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0645	0.0907
Mycobacterium ulcerans	6-phosphofructokinase	0.0131	0.2709	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0418	0.0285
Brugia malayi	translation initiation factor 4E	0.0289	0.7111	1
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-1	0.0289	0.7111	0.7111
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0795	0.1118
Echinococcus multilocularis	eukaryotic translation initiation factor 4E	0.0289	0.7111	0.7082
Brugia malayi	hypothetical protein	0.0242	0.5806	0.8165
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.0775	0.2715
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0289	0.7111	1
Schistosoma mansoni	P2X receptor subunit	0.0267	0.6494	0.6445
Brugia malayi	chromobox protein homolog 3	0.0038	0.0099	0.0139
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0091	0.1593	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.2709	0.381
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0029	0.0041
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0931	0.0173
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.0645	0.0907
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0931	0.0173
Brugia malayi	RNA binding protein	0.0063	0.0795	0.1118
Toxoplasma gondii	RNA-directed DNA polymerase	0.0091	0.1593	0.224
Schistosoma mansoni	eukaryotic translation initiation factor 4e	0.0289	0.7111	0.7071
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0099	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0099	0.0139
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0795	0.1118
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0035	0.0029	0.0041

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.0131 uM	PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961]	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	29.081 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	32.6427 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1314774

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1234506