Detailed information for compound 1235987

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 544.584 | Formula: C25H31F3N2O6S
  • H donors: 1 H acceptors: 5 LogP: 1.58 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.CCCSc1ccc(cc1)[C@@H]1[C@H]2C(=O)N(C(=O)[C@H]2[C@]2(N1CCCC2)C(=O)OC)CC
  • InChi: 1S/C23H30N2O4S.C2HF3O2/c1-4-14-30-16-10-8-15(9-11-16)19-17-18(21(27)24(5-2)20(17)26)23(22(28)29-3)12-6-7-13-25(19)23;3-2(4,5)1(6)7/h8-11,17-19H,4-7,12-14H2,1-3H3;(H,6,7)/t17-,18-,19+,23-;/m0./s1
  • InChiKey: RJYAGZQXNCSLAB-OWMDVXATSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0291 0.1153 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0076 0.0065
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0076 1
Brugia malayi Protein kinase domain containing protein 0.0394 0.1606 0.1606
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0475 0.1955 0.1946
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0172 0.0161
Brugia malayi Serine/threonine-protein kinase Pim-3 0.2321 1 1
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0503 0.208 0.2071
Echinococcus multilocularis protoporphyrinogen oxidase 0.0043 0.0072 0.0061
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0042 0.0085
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0629 0.2627 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0094 0.0287
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0094 0.0817
Brugia malayi hypothetical protein 0.0039 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0031 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0043 0.0076 0.0076
Echinococcus multilocularis aldo keto reductase 0.0131 0.0459 0.0449
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0042 0.007 0.1518
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0138 0.0126
Schistosoma mansoni sodium/solute symporter 0.0042 0.007 0.0059
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.022 0.022
Brugia malayi ShTK domain containing protein 0.0095 0.0301 0.0301
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0076 0.1286
Loa Loa (eye worm) hypothetical protein 0.0048 0.0094 0.0094
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0031 0.0019 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0076 0.0076
Echinococcus multilocularis muscleblind protein 0.0146 0.0523 0.0512
Schistosoma mansoni hypothetical protein 0.0205 0.0778 0.0768
Brugia malayi RE40412p 0.0029 0.0011 0.0011
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0042 0.5775
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.0876 0.0866
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0066 0.0055
Onchocerca volvulus 0.0131 0.0459 0.0449
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Leishmania major aldo-keto reductase-like protein 0.0131 0.0459 0.3982
Toxoplasma gondii zinc finger cdgsh type protein 0.0029 0.0011 0.0244
Schistosoma mansoni high-affinity choline transporter 0.0381 0.1548 0.1538
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0131 0.0459 0.0459
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0038 0.0052 0.0041
Chlamydia trachomatis protoporphyrinogen oxidase 0.0043 0.0072 1
Schistosoma mansoni polycystin 1-related 0.0039 0.0057 0.0046
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0306 0.0295
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0038 0.0052 0.0454
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0291 0.1153 0.1153
Brugia malayi hypothetical protein 0.0043 0.0072 0.0072
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0019 0.0019
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0057 0.0046
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0342 0.1377 0.1368
Schistosoma mansoni lipoxygenase 0.0234 0.0906 0.0896
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0042 0.0033
Plasmodium falciparum replication factor C subunit 1, putative 0.0031 0.0019 0.2689
Mycobacterium ulcerans hypothetical protein 0.0339 0.1362 0.5149
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0031 0.0019 0.0019
Schistosoma mansoni topbp1 0.0031 0.0019 0.0008
Mycobacterium tuberculosis Conserved protein 0.0043 0.0076 0.0165
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0094 0.0094
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.2321 1 1
Trichomonas vaginalis protein kinase inhibitor, putative 0.0063 0.0162 0.325
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Schistosoma mansoni hypothetical protein 0.004 0.006 0.0049
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0131 0.0459 1
Loa Loa (eye worm) oxidoreductase 0.0131 0.0459 0.0459
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0234 0.0906 0.0896
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Trypanosoma brucei aldo-keto reductase, putative 0.0131 0.0459 0.3982
Echinococcus multilocularis nibrin 0.0031 0.0019 0.0008
Schistosoma mansoni hypothetical protein 0.0039 0.0057 0.0046
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Brugia malayi DnaJ domain containing protein 0.0063 0.0162 0.0162
Echinococcus multilocularis epidermal growth factor receptor 0.0179 0.0668 0.0658
Brugia malayi Protein kinase domain containing protein 0.0218 0.0837 0.0837
Loa Loa (eye worm) TK/EGFR protein kinase 0.0179 0.0668 0.0668
Trypanosoma cruzi FHA domain containing protein, putative 0.0031 0.0019 0.0168
Echinococcus multilocularis expressed conserved protein 0.009 0.028 0.0269
Loa Loa (eye worm) oxidoreductase 0.0131 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Schistosoma mansoni tar DNA-binding protein 0.0076 0.022 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0052 0.0749
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0076 0.0217
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0031 0.0019 0.0019
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0291 0.1153 1
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0076 0.0165
Mycobacterium ulcerans beta-lactamase 0.0043 0.0076 0.0217
Schistosoma mansoni inositol transporter 0.0042 0.007 0.0059
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0076 0.0165
Onchocerca volvulus Dual oxidase homolog 0.0156 0.0568 0.0558
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0072 0.015
Loa Loa (eye worm) hypothetical protein 0.0146 0.0523 0.0523
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0149 0.0149
Echinococcus multilocularis aldo keto reductase 0.0131 0.0459 0.0449
Onchocerca volvulus Peroxidasin homolog 0.0156 0.0568 0.0558
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0057 0.0046
Mycobacterium ulcerans hypothetical protein 0.0038 0.0052 0.0126
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0138 0.0126
Echinococcus multilocularis RUN 0.0039 0.0057 0.0046
Onchocerca volvulus 0.0043 0.0076 0.0065
Echinococcus granulosus replication factor c subunit 1 0.0031 0.0019 0.0008
Trypanosoma brucei aldo/keto reductase, putative 0.0038 0.0052 0.0454
Echinococcus multilocularis protein dispatched 1 0.0047 0.0092 0.0081
Mycobacterium leprae Conserved hypothetical protein 0.0093 0.0293 0.6228
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0523 0.0512
Trichomonas vaginalis aldo/keto reductase, putative 0.0131 0.0459 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0156 0.0568 0.0568
Onchocerca volvulus 0.0131 0.0459 0.0449
Loa Loa (eye worm) hypothetical protein 0.0066 0.0172 0.0172
Echinococcus granulosus sodium:myo inositol cotransporter 0.0042 0.007 0.0059
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Schistosoma mansoni tyrosinase precursor 0.0095 0.0301 0.029
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0076 0.0076
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.0568 0.0568
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0131 0.0459 1
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0042 0.007 0.0059
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0076 0.0065
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0291 0.1153 1
Echinococcus granulosus geminin 0.0205 0.0778 0.0768
Loa Loa (eye worm) TK/INSR protein kinase 0.0394 0.1606 0.1606
Schistosoma mansoni tyrosine kinase 0.0394 0.1606 0.1596
Loa Loa (eye worm) hypothetical protein 0.0146 0.0523 0.0523
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0076 0.0065
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0052 0.0749
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0276 0.1089 0.1089
Loa Loa (eye worm) hypothetical protein 0.0096 0.0306 0.0306
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0291 0.1153 1
Brugia malayi DKFZp564C0469 protein 0.0031 0.0019 0.0019
Onchocerca volvulus 0.0131 0.0459 0.0449
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Mycobacterium leprae Possible oxidoreductase 0.0038 0.0052 0.0749
Entamoeba histolytica alcohol dehydrogenase, putative 0.0038 0.0052 0.0291
Echinococcus multilocularis aldo keto reductase 0.0131 0.0459 0.0449
Toxoplasma gondii ABC1 family protein 0.0043 0.0076 0.1654
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0057 0.0046
Echinococcus granulosus nibrin 0.0031 0.0019 0.0008
Brugia malayi Animal haem peroxidase family protein 0.0156 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Loa Loa (eye worm) oxidoreductase 0.0131 0.0459 0.0459
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0127 0.0116
Loa Loa (eye worm) TAR-binding protein 0.0076 0.022 0.022
Onchocerca volvulus 0.0043 0.0072 0.0061
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0563 0.2338 0.8885
Onchocerca volvulus 0.0095 0.0301 0.029
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.0568 0.0568
Entamoeba histolytica aldose reductase, putative 0.0131 0.0459 0.3879
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0031 0.0019 0.0423
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Schistosoma mansoni tyrosine kinase 0.0394 0.1606 0.1596
Leishmania major prostaglandin f synthase, putative 0.0131 0.0459 0.3982
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0019 0.0168
Echinococcus granulosus dnaJ subfamily C 6 0.0063 0.0162 0.0151
Schistosoma mansoni hypothetical protein 0.035 0.1413 0.1403
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0172 0.0161
Mycobacterium leprae Probable lipase LipE 0.0043 0.0076 0.1286
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0131 0.0459 0.0459
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0043 0.0072 0.0061
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Toxoplasma gondii PfMNL-2 CISD1 family iron-sulfur protein, putative 0.0029 0.0011 0.0244
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Brugia malayi hypothetical protein 0.0031 0.0019 0.0019
Echinococcus granulosus insulin receptor 0.0394 0.1606 0.1596
Brugia malayi MH2 domain containing protein 0.0144 0.0515 0.0515
Echinococcus granulosus dual specificity 0.0291 0.1153 0.1143
Brugia malayi Pax transcription activation domain interacting protein 0.0031 0.0019 0.0019
Leishmania major UDP-galactopyranose mutase 0.0043 0.0072 0.0626
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Echinococcus granulosus epidermal growth factor receptor 0.0179 0.0668 0.0658
Loa Loa (eye worm) DnaJ domain-containing protein 0.0063 0.0162 0.0162
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0138 0.0138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0127 0.0116
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0475 0.1955 0.1946
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.0568 0.0568
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0605 0.2524 0.9603
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0072 0.0061
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0043 0.0072 0.9505
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0052 0.0749
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0042
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0394 0.1606 0.1596
Giardia lamblia Aldose reductase 0.0131 0.0459 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0042
Trichomonas vaginalis aldo/keto reductase, putative 0.0131 0.0459 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0043 0.0072 0.0061
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0057
Brugia malayi Animal haem peroxidase family protein 0.0156 0.0568 0.0568
Schistosoma mansoni tyrosine kinase 0.0179 0.0668 0.0658
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0076 0.0065
Onchocerca volvulus 0.0156 0.0568 0.0558
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0057 0.0057
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Brugia malayi beta-lactamase family protein 0.0043 0.0076 0.0076
Brugia malayi GH02984p 0.0381 0.1548 0.1548
Mycobacterium ulcerans monoamine oxidase 0.0043 0.0072 0.0202
Onchocerca volvulus 0.0131 0.0459 0.0449
Onchocerca volvulus 0.0095 0.0301 0.029
Echinococcus multilocularis protein patched 0.0041 0.0066 0.0055
Schistosoma mansoni lipoxygenase 0.0164 0.0599 0.0589
Onchocerca volvulus Peroxidasin homolog 0.0156 0.0568 0.0558
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0172 0.0172
Echinococcus multilocularis geminin 0.0205 0.0778 0.0768
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0076 0.0065
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.0301 0.0301
Brugia malayi NADH-dependent xylose reductase 0.0038 0.0052 0.0052
Plasmodium falciparum protoporphyrinogen oxidase 0.0043 0.0072 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0076 0.1286
Echinococcus granulosus aldo keto reductase 0.0131 0.0459 0.0449
Echinococcus multilocularis tar DNA binding protein 0.0076 0.022 0.0209
Onchocerca volvulus 0.0043 0.0076 0.0065
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0094 0.0287
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0094 0.0235
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Onchocerca volvulus 0.0131 0.0459 0.0449
Giardia lamblia Aldose reductase 0.0131 0.0459 1
Toxoplasma gondii ATPase, AAA family protein 0.0031 0.0019 0.0423
Echinococcus granulosus voltage gated potassium channel subunit 0.0038 0.0052 0.0041
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0094 0.066
Echinococcus granulosus sodium:glucose cotransporter 2 0.0042 0.007 0.0059
Schistosoma mansoni tar DNA-binding protein 0.0076 0.022 0.0209
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0138 0.0126
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0043 0.0072 0.9505
Schistosoma mansoni tar DNA-binding protein 0.0076 0.022 0.0209
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0342 0.1377 0.1377
Mycobacterium tuberculosis Possible oxidoreductase 0.0043 0.0072 0.015
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0011 0.1473
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0057
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Trypanosoma cruzi aldo/keto reductase, putative 0.0131 0.0459 0.3982
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0094 0.1701
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.2321 1 1
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0038 0.0052 0.6894
Schistosoma mansoni tyrosine kinase 0.0179 0.0668 0.0658
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0038 0.0052 0.0749
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0127 0.0116
Echinococcus granulosus muscleblind protein 0.0146 0.0523 0.0512
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.0052 0.0454
Entamoeba histolytica aldose reductase, putative 0.0131 0.0459 0.3879
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0043 0.0072 1
Toxoplasma gondii aldo-keto reductase 0.0038 0.0052 0.114
Schistosoma mansoni serine/threonine protein kinase 0.2321 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0149 0.0149
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0076 0.0065
Echinococcus granulosus epidermal growth factor receptor 0.0179 0.0668 0.0658
Brugia malayi hypothetical protein 0.0156 0.0568 0.0568
Schistosoma mansoni aldo-keto reductase 0.0131 0.0459 0.0449
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0076 0.0076
Leishmania major hypothetical protein, unknown function 0.0029 0.0011 0.0097
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0076 0.0165
Entamoeba histolytica protein kinase, putative 0.0291 0.1153 1
Schistosoma mansoni loxhd1 0.0039 0.0057 0.0046
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0042
Brugia malayi RNA binding protein 0.0076 0.022 0.022
Onchocerca volvulus 0.0043 0.0076 0.0065
Echinococcus granulosus tar DNA binding protein 0.0076 0.022 0.0209
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Brugia malayi beta-lactamase family protein 0.0043 0.0076 0.0076
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0138 0.0126
Loa Loa (eye worm) hypothetical protein 0.0031 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0063 0.0162 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0019 0.0168
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0076 0.0659
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.2321 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0094 0.0287
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0094 0.066
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0029 0.0011 0.1549
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0072 0.0626
Brugia malayi TAR-binding protein 0.0076 0.022 0.022
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0066 0.0066
Onchocerca volvulus Peroxidase homolog 0.0156 0.0568 0.0558
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Toxoplasma gondii aldose reductase, putative 0.0131 0.0459 1
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0629 0.2627 1
Trypanosoma cruzi aldo-keto reductase 0.0131 0.0459 0.3982
Toxoplasma gondii zinc finger CDGSH-type domain-containing protein 0.0029 0.0011 0.0244
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Schistosoma mansoni DNA ligase IV 0.0031 0.0019 0.0008
Brugia malayi topoisomerase 0.0031 0.0019 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.0291 0.1153 0.1143
Echinococcus granulosus aldo keto reductase 0.0131 0.0459 0.0449
Schistosoma mansoni potassium channel beta 0.0038 0.0052 0.0041
Echinococcus multilocularis dual specificity 0.0291 0.1153 0.1143
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0057 0.0046
Brugia malayi hypothetical protein 0.0039 0.0057 0.0057
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0605 0.2524 0.9603
Onchocerca volvulus 0.0095 0.0301 0.029
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0076 0.0659
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0172 0.0161
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0076 0.1286
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Onchocerca volvulus 0.0039 0.0057 0.0046
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0042
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0486 0.0475
Mycobacterium ulcerans hypothetical protein 0.0048 0.0094 0.0287
Brugia malayi CHE-14 protein 0.0041 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0291 0.1153 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0076 0.1286
Schistosoma mansoni amine oxidase 0.0043 0.0072 0.0061
Schistosoma mansoni inositol transporter 0.0042 0.007 0.0059
Loa Loa (eye worm) hypothetical protein 0.0043 0.0076 0.0076
Loa Loa (eye worm) CAMK/PIM protein kinase 0.2321 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0094 0.0287
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0072 0.0061
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0011 0.1473
Echinococcus granulosus expressed conserved protein 0.009 0.028 0.0269
Plasmodium vivax replication factor C subunit 1, putative 0.0031 0.0019 0.2556
Onchocerca volvulus Chorion peroxidase homolog 0.0156 0.0568 0.0558
Loa Loa (eye worm) hypothetical protein 0.0131 0.0459 0.0459
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Mycobacterium ulcerans hypothetical protein 0.0043 0.0076 0.0217
Onchocerca volvulus Peroxidase homolog 0.0156 0.0568 0.0558
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0094 0.0817
Loa Loa (eye worm) tyrosinase 1 0.0095 0.0301 0.0301
Schistosoma mansoni amine oxidase 0.0043 0.0072 0.0061
Echinococcus multilocularis high affinity choline transporter 1 0.0381 0.1548 0.1538
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0127 0.0116
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0094 0.0235
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0038 0.0052 0.0052
Onchocerca volvulus 0.0095 0.0301 0.029
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0029 0.0011 0.1549
Leishmania major hypothetical protein, conserved 0.0043 0.0076 0.0659
Echinococcus multilocularis epidermal growth factor receptor 0.0179 0.0668 0.0658
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0306 0.0295
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0076 0.0065
Loa Loa (eye worm) hypothetical protein 0.0031 0.0019 0.0019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0149 0.0149
Echinococcus multilocularis dnaJ subfamily C 6 0.0063 0.0162 0.0151
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.0876 0.0866
Loa Loa (eye worm) RNA binding protein 0.0076 0.022 0.022
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0043 0.0072 1
Trypanosoma brucei prostaglandin f synthase 0.0131 0.0459 0.3982
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0066 0.0055
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0072 0.0626
Loa Loa (eye worm) hypothetical protein 0.0051 0.0107 0.0107
Brugia malayi Animal haem peroxidase family protein 0.0156 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0011
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0342 0.1377 0.1368
Onchocerca volvulus 0.0042 0.007 0.0059
Onchocerca volvulus 0.0039 0.0057 0.0046
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0094 0.066
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0342 0.1377 0.1377
Schistosoma mansoni hypothetical protein 0.004 0.006 0.0049
Echinococcus multilocularis solute carrier family 5 0.0042 0.007 0.0059
Brugia malayi Animal haem peroxidase family protein 0.0156 0.0568 0.0568
Schistosoma mansoni tar DNA-binding protein 0.0076 0.022 0.0209
Schistosoma mansoni rab6-interacting 0.0039 0.0057 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0072 0.9505
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0043 0.0072 0.1572
Loa Loa (eye worm) hypothetical protein 0.0043 0.0076 0.0076
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0057 0.0046
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0029 0.0011 0.1549
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0179 0.0668 0.0658
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Loa Loa (eye worm) hypothetical protein 0.0048 0.0094 0.0094
Echinococcus multilocularis peroxidasin 0.0156 0.0568 0.0558
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0042 0.5489
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0095 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0276 0.1089 0.1089
Treponema pallidum DNA ligase (lig) 0.0031 0.0019 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.0301 0.0301
Echinococcus multilocularis voltage gated potassium channel subunit 0.0038 0.0052 0.0041
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0043 0.0072 0.0061
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0076 0.0165
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0138 0.0126
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.0568 0.0568
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0094 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0094 0.0287
Loa Loa (eye worm) ShTK domain-containing protein 0.0095 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Schistosoma mansoni hypothetical protein 0.004 0.006 0.0049
Schistosoma mansoni topbp1 0.0031 0.0019 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0076 0.022 0.0209
Brugia malayi hypothetical protein 0.0031 0.0019 0.0019
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.2321 1 1
Entamoeba histolytica hypothetical protein 0.0043 0.0076 0.0497
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0515 0.0515
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0042 0.4221
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0019 0.0168
Schistosoma mansoni tyrosine kinase 0.0179 0.0668 0.0658
Trichomonas vaginalis aldo/keto reductase, putative 0.0131 0.0459 1
Loa Loa (eye worm) beta-lactamase 0.0043 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0043 0.0076 0.0065
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0076 0.0659
Echinococcus multilocularis 0.0052 0.0111 0.01
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0127 0.0116
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Plasmodium vivax aldehyde reductase, putative 0.0038 0.0052 0.6894
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0312 0.0301
Schistosoma mansoni aldo-keto reductase 0.0131 0.0459 0.0449
Mycobacterium ulcerans dehydrogenase 0.0043 0.0072 0.0202
Mycobacterium ulcerans oxidoreductase 0.0131 0.0459 0.1686
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0038 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.004 0.006 0.0049
Schistosoma mansoni peroxidasin 0.0156 0.0568 0.0558
Schistosoma mansoni tyrosine kinase 0.0176 0.0655 0.0644
Onchocerca volvulus 0.0048 0.0094 0.0083
Echinococcus granulosus aldehyde reductase 0.0093 0.0293 0.0282
Mycobacterium tuberculosis Conserved protein 0.0043 0.0076 0.0165
Brugia malayi Common central domain of tyrosinase family protein 0.0095 0.0301 0.0301
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0094 0.0094
Brugia malayi Muscleblind-like protein 0.0146 0.0523 0.0523
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0127 0.0116
Brugia malayi mbt repeat family protein 0.0058 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0381 0.1548 0.1548
Loa Loa (eye worm) hypothetical protein 0.0058 0.0138 0.0138
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Brugia malayi Furin-like cysteine rich region family protein 0.0179 0.0668 0.0668
Brugia malayi SWIRM domain containing protein 0.0043 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0041 0.0066 0.0055
Schistosoma mansoni tyrosinase precursor 0.0095 0.0301 0.029
Brugia malayi Peroxidasin 0.0156 0.0568 0.0568
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0394 0.1606 0.1596
Toxoplasma gondii histone lysine-specific demethylase 0.0043 0.0072 0.1572
Entamoeba histolytica aldose reductase, putative 0.0131 0.0459 0.3879
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0486 0.0475
Loa Loa (eye worm) hypothetical protein 0.0095 0.0301 0.0301
Echinococcus granulosus aldo keto reductase 0.0131 0.0459 0.0449
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0076 0.1286
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Brugia malayi mbt repeat family protein 0.0058 0.0138 0.0138
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0057 0.0046
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.0301 0.0301
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0131 0.0459 0.3982
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0042
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0306 0.2525
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0043 0.0072 0.0202
Loa Loa (eye worm) hypothetical protein 0.0202 0.0766 0.0766
Echinococcus multilocularis aldehyde reductase 0.0093 0.0293 0.0282
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Echinococcus multilocularis 0.0043 0.0072 0.0061
Brugia malayi Blistered cuticle protein 3 0.0156 0.0568 0.0568
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0172 0.0161
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0038 0.0052 0.114
Echinococcus multilocularis insulin receptor 0.0394 0.1606 0.1596
Onchocerca volvulus 0.0058 0.0138 0.0126
Mycobacterium tuberculosis Conserved protein 0.0043 0.0076 0.0165
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0342 0.1377 0.1368
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0094 0.1701
Echinococcus granulosus solute carrier family 5 0.0042 0.007 0.0059
Brugia malayi Doublecortin family protein 0.0039 0.0057 0.0057
Schistosoma mansoni tyrosine kinase 0.0176 0.0655 0.0644
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Schistosoma mansoni pol-related 0.0131 0.0459 0.0449
Brugia malayi Animal haem peroxidase family protein 0.0156 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0202 0.0766 0.0766
Entamoeba histolytica hypothetical protein 0.0043 0.0076 0.0497
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0042 0.007 0.0059
Trichomonas vaginalis esterase, putative 0.0043 0.0076 0.1286
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0042 0.007 0.0059
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0138 0.0126
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0038 0.0052 0.114
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0052 0.0749
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0076 0.0165
Echinococcus multilocularis replication factor c subunit 1 0.0031 0.0019 0.0008
Entamoeba histolytica protein kinase domain containing protein 0.0291 0.1153 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0094 0.0287
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0234 0.0906 0.0896
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Schistosoma mansoni hypothetical protein 0.0503 0.208 0.2071
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0066 0.0055
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0094 0.0817
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0306 0.0306
Brugia malayi Protein kinase domain containing protein 0.0291 0.1153 0.1153
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0011 0.1473
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0043 0.0076 0.0076
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0043 0.0072 0.12
Mycobacterium tuberculosis Conserved protein 0.0038 0.0052 0.0074
Onchocerca volvulus 0.0202 0.0766 0.0756
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0076 0.0165
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0131 0.0459 0.0459
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0131 0.0459 1
Entamoeba histolytica hypothetical protein 0.0043 0.0076 0.0497
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0076 0.0165
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0138 0.0126
Onchocerca volvulus 0.0156 0.0568 0.0558
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0019 0.0168
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0076 0.0217
Schistosoma mansoni hypothetical protein 0.0205 0.0778 0.0768
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.0459 0.1642
Echinococcus granulosus peroxidasin 0.0156 0.0568 0.0558
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0131 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0031 0.0019 0.0019
Onchocerca volvulus 0.0031 0.0019 0.0008
Brugia malayi hypothetical protein 0.0043 0.0076 0.0076
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0042 0.007 0.0059
Schistosoma mansoni chromosome transmission fidelity factor 0.0031 0.0019 0.0008
Schistosoma mansoni tyrosine kinase 0.0176 0.0655 0.0644
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Mycobacterium ulcerans oxidoreductase 0.0043 0.0072 0.0202
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0515 0.0515
Loa Loa (eye worm) oxidoreductase 0.0131 0.0459 0.0459
Schistosoma mansoni patched 1 0.0041 0.0066 0.0055
Entamoeba histolytica alcohol dehydrogenase, putative 0.0038 0.0052 0.0291
Onchocerca volvulus 0.0131 0.0459 0.0449
Plasmodium falciparum aldehyde reductase, putative 0.0038 0.0052 0.7254
Brugia malayi Sodium:solute symporter family protein 0.0042 0.007 0.007
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1097 0.4101
Brugia malayi amine oxidase, flavin-containing family protein 0.0043 0.0072 0.0072
Echinococcus multilocularis aldo keto reductase 0.0131 0.0459 0.0449
Entamoeba histolytica protein kinase, putative 0.0291 0.1153 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.007 0.007
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Loa Loa (eye worm) MBCTL1 0.0066 0.0172 0.0172
Loa Loa (eye worm) oxidoreductase 0.0131 0.0459 0.0459
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0066 0.1068
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0138 0.0126
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0172 0.0161
Echinococcus granulosus sodium:glucose cotransporter 0.0042 0.007 0.0059
Plasmodium falciparum aldo-keto reductase, putative 0.0038 0.0052 0.7254
Loa Loa (eye worm) hypothetical protein 0.0043 0.0076 0.0076
Echinococcus granulosus hypothetical protein 0.0131 0.0459 0.0449
Brugia malayi beta-lactamase 0.0043 0.0076 0.0076
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0076 0.1286
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0149 0.0149
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0057 0.7891
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0127 0.0127
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0094 0.0287
Loa Loa (eye worm) hypothetical protein 0.0215 0.0824 0.0824
Loa Loa (eye worm) hypothetical protein 0.0048 0.0094 0.0094
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0131 0.0459 1
Echinococcus granulosus high affinity choline transporter 1 0.0381 0.1548 0.1538
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0072 0.9505
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.0301 0.0301
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0131 0.0459 0.3982
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0127 0.0116
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0066
Mycobacterium ulcerans lipase LipD 0.0043 0.0076 0.0217
Onchocerca volvulus 0.0156 0.0568 0.0558
Schistosoma mansoni peroxidasin 0.0156 0.0568 0.0558
Loa Loa (eye worm) ShTK domain-containing protein 0.0095 0.0301 0.0301
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0057 0.75
Schistosoma mansoni rab6-interacting 0.0039 0.0057 0.0046
Onchocerca volvulus 0.0038 0.0052 0.0041
Echinococcus granulosus RUN 0.0039 0.0057 0.0046
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0127 0.0127
Entamoeba histolytica hypothetical protein 0.0043 0.0076 0.0497
Brugia malayi RE40412p 0.0029 0.0011 0.0011

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.092 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Saccharomyces cerevisiae ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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