Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | 0.0364 | 0.7727 | 0.7727 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E type 5, putative | 0.0055 | 0.0651 | 0.0171 |
Giardia lamblia | Hypothetical protein | 0.0055 | 0.0651 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0218 | 0.4381 | 0.4381 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0065 | 0.0882 | 0.0882 |
Giardia lamblia | Hypothetical protein | 0.0055 | 0.0651 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0521 | 0.0521 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-3 | 0.0055 | 0.0651 | 0.0171 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.3593 | 0.3593 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1697 | 0.1697 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0049 | 0.0511 | 0.7856 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Brugia malayi | Isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1697 | 0.1697 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0118 | 0.2082 | 0.2082 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0464 | 1 | 1 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0065 | 0.0882 | 0.0882 |
Leishmania major | eukaryotic translation initiation factor 4e, putative | 0.0055 | 0.0651 | 0.0171 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0118 | 0.2082 | 0.2082 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0118 | 0.2082 | 0.1676 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-4 | 0.0055 | 0.0651 | 0.0171 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E-1 | 0.0055 | 0.0651 | 0.0651 |
Leishmania major | eukaryotic translation initiation factor, putative | 0.0055 | 0.0651 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4381 | 0.4381 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0521 | 0.0521 |
Plasmodium vivax | translation initiation factor 4E, putative | 0.0055 | 0.0651 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0101 | 0.1697 | 0.1697 |
Plasmodium vivax | hypothetical protein, conserved | 0.0055 | 0.0651 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0065 | 0.0882 | 0.0882 |
Loa Loa (eye worm) | translation initiation factor 4E | 0.0464 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0882 | 0.0882 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E type 5, putative | 0.0055 | 0.0651 | 0.0171 |
Onchocerca volvulus | 0.0065 | 0.0882 | 0.0371 | |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0065 | 0.0882 | 0.0882 |
Leishmania major | eukaryotic translation initiation factor-like protein | 0.0464 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0882 | 0.0882 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0048 | 0.0488 | 0.5 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0118 | 0.2082 | 0.2082 |
Trypanosoma cruzi | eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative | 0.0055 | 0.0651 | 0.0171 |
Schistosoma mansoni | hypothetical protein | 0.0218 | 0.4381 | 0.4381 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.3593 | 0.3593 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.0651 | 0.0171 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0118 | 0.2082 | 0.2082 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0055 | 0.0651 | 0.0651 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0118 | 0.2082 | 0.2082 |
Echinococcus multilocularis | geminin | 0.0184 | 0.3593 | 0.3593 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-4 | 0.0055 | 0.0651 | 0.0171 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0048 | 0.0488 | 0.7498 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.6693 | 0.6693 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0364 | 0.7727 | 0.7727 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0101 | 0.1697 | 0.1697 |
Onchocerca volvulus | Deterin homolog | 0.0065 | 0.0882 | 0.0371 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E, putative | 0.0055 | 0.0651 | 1 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E | 0.0055 | 0.0651 | 1 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E type | 0.0055 | 0.0651 | 0.0651 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0521 | 0.0521 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1697 | 0.1697 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0511 | 0.0511 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0118 | 0.2082 | 0.2082 |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.0464 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0101 | 0.1697 | 0.1697 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0364 | 0.7727 | 0.7727 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.0464 | 1 | 1 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-3 | 0.0055 | 0.0651 | 0.0171 |
Brugia malayi | eukaryotic translation initiation factor 4E-1 | 0.0055 | 0.0651 | 0.0651 |
Leishmania major | carbonic anhydrase-like protein | 0.0118 | 0.2082 | 0.1676 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0055 | 0.0651 | 0.0651 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1697 | 0.1697 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0464 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0049 | 0.0511 | 0.0025 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-2 | 0.0055 | 0.0651 | 0.0171 |
Onchocerca volvulus | 0.0328 | 0.6892 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1697 | 0.1697 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.0464 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0049 | 0.0511 | 0.0025 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0049 | 0.0511 | 0.1432 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0065 | 0.0882 | 0.0882 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0049 | 0.0511 | 0.0025 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0521 | 0.0521 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0101 | 0.1697 | 0.1697 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0101 | 0.1697 | 0.1697 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0049 | 0.0511 | 0.0511 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0521 | 0.0521 |
Echinococcus multilocularis | GPCR, family 2 | 0.0101 | 0.1697 | 0.1697 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0521 | 0.0521 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0319 | 0.6693 | 0.6693 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0319 | 0.6693 | 0.6693 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0118 | 0.2082 | 0.1676 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0049 | 0.0511 | 0.0025 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Brugia malayi | Eukaryotic translation initiation factor 4E type 3, putative | 0.0055 | 0.0651 | 0.0651 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0118 | 0.2082 | 0.2082 |
Trypanosoma cruzi | eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative | 0.0055 | 0.0651 | 0.0171 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-4 | 0.0055 | 0.0651 | 0.0171 |
Brugia malayi | hypothetical protein | 0.0328 | 0.6892 | 0.6892 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.0651 | 0.0171 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0101 | 0.1697 | 0.1697 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0118 | 0.2082 | 0.2082 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0049 | 0.0511 | 0.0511 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0118 | 0.2082 | 0.1676 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0101 | 0.1697 | 0.1697 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0065 | 0.0882 | 0.0882 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0464 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0184 | 0.3593 | 0.3593 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0521 | 0.0521 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0065 | 0.0882 | 0.0882 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0049 | 0.0511 | 0.7856 |
Leishmania major | eukaryotic translation initiation factor-like | 0.0464 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.6892 | 0.6892 |
Giardia lamblia | Translation elongation factor | 0.0055 | 0.0651 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0101 | 0.1697 | 0.1697 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0319 | 0.6693 | 0.6693 |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.0464 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0882 | 0.0882 |
Giardia lamblia | hypothetical protein | 0.0055 | 0.0651 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E type 5 | 0.0055 | 0.0651 | 0.0171 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E type 3 | 0.0055 | 0.0651 | 0.0651 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0521 | 0.0521 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0521 | 0.0521 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0065 | 0.0882 | 0.0882 |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.0464 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0048 | 0.0488 | 0.0488 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 76.5 uM | PUBCHEM_BIOASSAY: SAR analysis of Antagonists of XIAP-Bir3 domain of IAP-family anti-apoptotic proteins. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1018, AID1449, AID1513, AID1514, AID1638] | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | PUBCHEM_BIOASSAY: SAR analysis of Antagonists of IAP-family anti-apoptotic proteins. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1018, AID1449, AID1513, AID1514, AID1638] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.