Detailed information for compound 1260034

Basic information

Technical information
  • TDR Targets ID: 1260034
  • Name: 3-(2-chloro-6-fluorophenyl)-5-methyl-N-(pyrid in-2-ylmethyl)-1,2-oxazole-4-carboxamide
  • MW: 345.755 | Formula: C17H13ClFN3O2
  • H donors: 1 H acceptors: 3 LogP: 2.9 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1c(C)onc1c1c(F)cccc1Cl)NCc1ccccn1
  • InChi: 1S/C17H13ClFN3O2/c1-10-14(17(23)21-9-11-5-2-3-8-20-11)16(22-24-10)15-12(18)6-4-7-13(15)19/h2-8H,9H2,1H3,(H,21,23)
  • InChiKey: OCTMCARSHRCCNV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(2-chloro-6-fluoro-phenyl)-5-methyl-N-(2-pyridylmethyl)isoxazole-4-carboxamide
  • 3-(2-chloro-6-fluorophenyl)-5-methyl-N-(2-pyridylmethyl)-4-isoxazolecarboxamide
  • 3-(2-chloro-6-fluoro-phenyl)-5-methyl-N-(pyridin-2-ylmethyl)-1,2-oxazole-4-carboxamide
  • BIM-0046716.P001
  • CBMicro_046927
  • Oprea1_443906
  • T0506-3960
  • MLS000110215
  • SMR000106146
  • ZINC00083827

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0048 0.0399 0.0386
Schistosoma mansoni hypothetical protein 0.0165 0.1932 0.4579
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0509 0.642 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.034 0.0529
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0339 0.4202 0.6545
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0377 0.0363
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0174 0.2053 0.3184
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0208 0.0463
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0176 0.0536
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0775 0.0762
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0176 0.0536
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0066
Echinococcus granulosus protein kinase shaggy 0.0048 0.0399 0.0783
Brugia malayi hypothetical protein 0.0049 0.0415 0.0626
Brugia malayi TAR-binding protein 0.0076 0.0775 0.1188
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0775 0.1817
Echinococcus granulosus aldehyde reductase 0.0022 0.006 0.0094
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.1111 0.173
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0079 0.0805 0.1608
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0108 0.1189 0.1177
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0113 0.0282
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0212 0.2538 0.2527
Brugia malayi hypothetical protein 0.0286 0.3503 0.5447
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.034 0.1191
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.034 0.1191
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0048 0.0399 0.9583
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0076 0.0097
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0299 0.068
Trypanosoma brucei polo-like protein kinase 0.0212 0.2538 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0165 0.0491
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0208 0.5009
Echinococcus granulosus nibrin 0.002 0.0042 0.0058
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0042 0.102
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0014 0.0022
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0063 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0076 0.0096
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0048 0.0399 0.0622
Trypanosoma brucei unspecified product 0.003 0.0165 0.0491
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.2538 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0294 0.0569
Schistosoma mansoni ran 0.0023 0.0082 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.034 0.1191
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0616 0.7814 1
Trypanosoma brucei protein kinase, putative 0.0048 0.0399 0.1431
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.2538 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0076 0.2486
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0176 0.0162
Loa Loa (eye worm) Smad1 0.0018 0.0014 0.0022
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0048 0.0399 0.1431
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0082 0.0158
Trichomonas vaginalis hypothetical protein 0.0038 0.0278 0.0943
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0176 0.0329
Echinococcus multilocularis aldo keto reductase 0.0031 0.0176 0.0162
Onchocerca volvulus 0.0031 0.0176 0.0212
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0042 0.102
Brugia malayi topoisomerase 0.002 0.0042 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.034 0.1191
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0048 0.0399 0.0622
Loa Loa (eye worm) hypothetical protein 0.0048 0.04 0.0623
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.034 0.0778
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.034 0.0435
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0076 0.0097
Loa Loa (eye worm) hypothetical protein 0.0174 0.2053 0.3197
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0076 0.0097
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.1111 0.2228
Schistosoma mansoni topbp1 0.002 0.0042 0.0068
Brugia malayi jmjC domain containing protein 0.004 0.0299 0.0444
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0118
Echinococcus granulosus peregrin 0.0033 0.0208 0.0394
Loa Loa (eye worm) oxidoreductase 0.0031 0.0176 0.0274
Loa Loa (eye worm) oxidoreductase 0.0031 0.0176 0.0274
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0294 0.028
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0176 0.0329
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0399 0.1431
Loa Loa (eye worm) hypothetical protein 0.0504 0.6357 0.9901
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.1111 0.2228
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0176 0.0536
Echinococcus granulosus tumor protein p63 0.0326 0.4037 0.8172
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0025 0.0106 0.0254
Entamoeba histolytica aldose reductase, putative 0.0031 0.0176 0.0536
Trypanosoma brucei DNA polymerase eta, putative 0.0072 0.0716 0.2701
Schistosoma mansoni jumonji domain containing protein 0.0086 0.0899 0.2113
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0208 0.0194
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0176 0.0162
Onchocerca volvulus Alhambra homolog 0.0033 0.0208 0.0262
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0299 0.0285
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1146 0.4425
Echinococcus multilocularis aldehyde reductase 0.0022 0.006 0.0047
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.034 0.0508
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.008 0.0818 0.1274
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0076 0.0097
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.2538 1
Onchocerca volvulus 0.0031 0.0176 0.0212
Giardia lamblia Aldose reductase 0.0031 0.0176 0.0536
Echinococcus granulosus importin subunit beta 1 0.0032 0.0191 0.036
Schistosoma mansoni DNA polymerase eta 0.0072 0.0716 0.1677
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.0042 0.5
Brugia malayi Importin beta-1 subunit 0.0032 0.0191 0.0277
Trypanosoma cruzi polo-like protein kinase, putative 0.0212 0.2538 1
Echinococcus multilocularis GA binding protein alpha chain 0.008 0.0818 0.0805
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0036 0.0246 0.069
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0113 0.0282
Plasmodium falciparum phd finger protein, putative 0.0033 0.0208 0.5009
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0208 0.0394
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.1111 0.2619
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0042 0.0000014045
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.002 0.0042 0.0054
Schistosoma mansoni topbp1 0.002 0.0042 0.0068
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0299 0.068
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0076 0.2486
Echinococcus multilocularis dna polymerase kappa 0.0043 0.034 0.0326
Echinococcus multilocularis tumor protein p63 0.0326 0.4037 0.4028
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0082 0.0158
Schistosoma mansoni ran 0.0023 0.0082 0.0162
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0415 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0176 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.2538 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0176 0.0536
Brugia malayi Ets-domain containing protein 0.008 0.0818 0.1255
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0537 0.0816
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.034 0.1191
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0176 0.0536
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0415 1
Schistosoma mansoni tsg101-related 0.0054 0.0476 0.1104
Echinococcus granulosus expressed protein 0.0037 0.0257 0.0494
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0076 0.0096
Trypanosoma cruzi polo-like protein kinase, putative 0.0212 0.2538 1
Echinococcus multilocularis geminin 0.0165 0.1932 0.192
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0399 0.1431
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.034 0.1191
Echinococcus granulosus GA binding protein alpha chain 0.008 0.0818 0.1633
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.034 0.1191
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0191 0.0178
Entamoeba histolytica hypothetical protein 0.0026 0.0113 0.0282
Trypanosoma brucei unspecified product 0.0043 0.034 0.1191
Echinococcus multilocularis dna polymerase eta 0.0072 0.0716 0.0703
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0176 0.0162
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0048 0.0399 0.1316
Echinococcus multilocularis nibrin 0.002 0.0042 0.0028
Echinococcus granulosus dna polymerase eta 0.0072 0.0716 0.1427
Giardia lamblia Kinase, CMGC GSK 0.0048 0.0399 0.1431
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0031 0.0176 0.0408
Echinococcus granulosus tar DNA binding protein 0.0076 0.0775 0.1546
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0113 0.0282
Schistosoma mansoni importin beta-1 0.0032 0.0191 0.0423
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0464 0.0702
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0076 0.0133
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0176 0.0162
Brugia malayi hypothetical protein 0.0032 0.0189 0.0273
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0176 0.0253
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.034 0.1191
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0246 0.0814
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0076 0.0133
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0176 0.0536
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0042 0.000009404
Loa Loa (eye worm) hypothetical protein 0.0033 0.0208 0.0324
Trypanosoma brucei unspecified product 0.003 0.0165 0.0491
Echinococcus granulosus aldo keto reductase 0.0031 0.0176 0.0329
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.034 0.1191
Loa Loa (eye worm) hypothetical protein 0.0286 0.3503 0.5456
Entamoeba histolytica protein kinase, putative 0.0048 0.0399 0.1431
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.034 0.1191
Chlamydia trachomatis DNA ligase 0.002 0.0042 1
Giardia lamblia PHD finger protein 15 0.0033 0.0208 0.0663
Giardia lamblia Aldose reductase 0.0031 0.0176 0.0536
Treponema pallidum DNA ligase (lig) 0.002 0.0042 0.5
Echinococcus multilocularis aldo keto reductase 0.0031 0.0176 0.0162
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0066
Toxoplasma gondii aldose reductase, putative 0.0031 0.0176 0.3588
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0415 1
Onchocerca volvulus 0.0023 0.0076 0.0053
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0775 0.1817
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0036 0.0246 0.0814
Loa Loa (eye worm) transcription factor SMAD2 0.0267 0.3259 0.5076
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0176 0.0162
Echinococcus multilocularis snurportin 1 0.0339 0.4202 0.4194
Echinococcus granulosus aldo keto reductase 0.0031 0.0176 0.0329
Echinococcus granulosus aldo keto reductase 0.0031 0.0176 0.0329
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.034 0.0326
Loa Loa (eye worm) oxidoreductase 0.0031 0.0176 0.0274
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0191 0.3995
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0212 0.2538 0.3953
Entamoeba histolytica hypothetical protein 0.004 0.0294 0.1008
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0063 0.01
Giardia lamblia Kinase, PLK 0.0212 0.2538 1
Schistosoma mansoni aldo-keto reductase 0.0031 0.0176 0.0387
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0042 0.0044
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0399 0.1431
Entamoeba histolytica hypothetical protein 0.004 0.0294 0.1008
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0176 0.0536
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.034 0.1191
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.034 0.1191
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0113 0.0282
Trichomonas vaginalis ran, putative 0.0023 0.0082 0.0158
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0328 0.1145
Leishmania major GTP-binding protein, putative 0.0023 0.0082 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.2538 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0176 0.0329
Leishmania major prostaglandin f synthase, putative 0.0031 0.0176 0.0408
Leishmania major DNA polymerase kappa, putative 0.0043 0.034 0.1072
Schistosoma mansoni hypothetical protein 0.0114 0.1261 0.2977
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0257 0.086
Brugia malayi hypothetical protein 0.004 0.0294 0.0437
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0025 0.0106 0.0254
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0054 0.0476 0.1739
Onchocerca volvulus 0.0031 0.0176 0.0212
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.2538 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0176 0.0536
Plasmodium vivax importin-beta 2, putative 0.0032 0.0191 0.4607
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0079 0.0805 0.0792
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0082 0.0158
Echinococcus multilocularis expressed protein 0.0037 0.0257 0.0243
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.034 0.1191
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0076 0.0097
Brugia malayi latrophilin 2 splice variant baaae 0.0114 0.1261 0.1946
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0066
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0037 0.0257 0.04
Loa Loa (eye worm) hypothetical protein 0.0032 0.0191 0.0298
Loa Loa (eye worm) hypothetical protein 0.0114 0.1261 0.1963
Schistosoma mansoni survival motor neuron protein 0.0058 0.0537 0.1248
Leishmania major hypothetical protein, conserved 0.0049 0.0415 0.1379
Schistosoma mansoni hypothetical protein 0.0053 0.0464 0.1073
Leishmania major aldo-keto reductase-like protein 0.0031 0.0176 0.0408
Brugia malayi intracellular kinase 0.0048 0.0399 0.0602
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0176 0.0536
Trichomonas vaginalis rotamase, putative 0.0037 0.0257 0.086
Schistosoma mansoni hypothetical protein 0.0053 0.0464 0.1073
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0031 0.0176 0.0408
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0191 0.0597
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0108 0.1189 0.2387
Onchocerca volvulus 0.0048 0.0399 0.0566
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0048 0.0399 0.0921
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0415 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0464 0.0722
Brugia malayi DKFZp564C0469 protein 0.002 0.0042 0.0044
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0031 0.0176 1
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0299 0.0465
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0176 0.0162
Echinococcus granulosus replication factor c subunit 1 0.002 0.0042 0.0058
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0176 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0118
Echinococcus multilocularis protein kinase shaggy 0.0048 0.0399 0.0386
Brugia malayi jmjC domain containing protein 0.0108 0.1189 0.1834
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0616 0.7814 1
Brugia malayi Fli-1 protein 0.0242 0.2938 0.4563
Onchocerca volvulus 0.0048 0.04 0.0567
Loa Loa (eye worm) RNA binding protein 0.0076 0.0775 0.1207
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.034 0.1191
Trypanosoma cruzi aldo/keto reductase, putative 0.0031 0.0176 0.0536
Schistosoma mansoni hypothetical protein 0.0165 0.1932 0.4579
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.034 0.1191
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.0716 0.2701
Loa Loa (eye worm) hypothetical protein 0.0509 0.642 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0212 0.2538 1
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3503 0.3494
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0176 0.0329
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.034 0.1191
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0667 0.1039
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.034 0.1191
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.2538 0.6026
Schistosoma mansoni hypothetical protein 0.0053 0.0464 0.1073
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.04 0.0922
Brugia malayi hypothetical protein 0.002 0.0042 0.0044
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0415 0.1493
Leishmania major hypothetical protein, conserved 0.0025 0.0106 0.0122
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0082 0.0068
Echinococcus multilocularis aldo keto reductase 0.0031 0.0176 0.0162
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0042 0.0028
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.034 0.0662
Entamoeba histolytica hypothetical protein 0.004 0.0294 0.1008
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.034 0.0778
Giardia lamblia Kinase, CMGC GSK 0.0048 0.0399 0.1431
Loa Loa (eye worm) oxidoreductase 0.0031 0.0176 0.0274
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0176 0.0253
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0299 0.0578
Echinococcus granulosus hypothetical protein 0.0031 0.0176 0.0329
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0399 0.1431
Trypanosoma cruzi aldo-keto reductase 0.0031 0.0176 0.0536
Entamoeba histolytica hypothetical protein 0.004 0.0294 0.1008
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0208 0.4443
Loa Loa (eye worm) hypothetical protein 0.0072 0.0716 0.1116
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0042 0.0068
Echinococcus multilocularis peregrin 0.0033 0.0208 0.0194
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0176 0.0536
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0036 0.0246 0.0814
Schistosoma mansoni hypothetical protein 0.004 0.0294 0.0668
Onchocerca volvulus 0.0031 0.0176 0.0212
Loa Loa (eye worm) hypothetical protein 0.0079 0.0805 0.1254
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0775 0.1817
Onchocerca volvulus 0.0031 0.0176 0.0212
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.2538 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0212 0.2538 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0082 0.0138
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0176 0.0329
Echinococcus granulosus snurportin 1 0.0339 0.4202 0.8508
Leishmania major importin beta-1 subunit, putative 0.0026 0.0113 0.0151
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0082 0.0158
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.006 0.1349
Onchocerca volvulus 0.0031 0.0176 0.0212
Entamoeba histolytica aldose reductase, putative 0.0031 0.0176 0.0536
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.034 0.0435
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0042 0.0000014045
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0176 0.0536
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0176 0.0329
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0176 0.0536
Loa Loa (eye worm) hypothetical protein 0.0053 0.0464 0.0722
Trypanosoma brucei prostaglandin f synthase 0.0031 0.0176 0.0536
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0176 0.0329
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.1111 0.2619
Schistosoma mansoni gabp alpha 0.008 0.0818 0.1919
Onchocerca volvulus Serine\/threonine kinase homolog 0.0212 0.2538 0.3952
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0328 0.767
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0166 0.1947 0.3033
Schistosoma mansoni tsg101-related 0.0066 0.0633 0.1479
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0464 0.0702
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0775 0.1188
Leishmania major DNA polymerase eta, putative 0.0042 0.0328 0.1026
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0165 0.0491
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0176 0.0329
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.034 0.0435
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0775 0.1817
Loa Loa (eye worm) hypothetical protein 0.0031 0.0176 0.0274
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0082 0.0106
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0082 0.197
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.034 0.1191
Schistosoma mansoni hypothetical protein 0.0022 0.0063 0.0117
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0176 0.0536
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0042 0.0044
Echinococcus granulosus geminin 0.0165 0.1932 0.3896
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0176 0.0329
Brugia malayi RNA binding protein 0.0076 0.0775 0.1188
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0176 0.0162
Mycobacterium ulcerans oxidoreductase 0.0031 0.0176 0.0225
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0082 0.197
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.034 0.1191
Brugia malayi hypothetical protein 0.0504 0.6357 0.99
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0176 0.0253
Loa Loa (eye worm) MH2 domain-containing protein 0.0267 0.3259 0.5076
Toxoplasma gondii peptidylprolyl isomerase 0.0036 0.0246 0.5453
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.1111 0.1098
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0212 0.2538 0.5127
Brugia malayi RNA, U transporter 1 0.009 0.0956 0.147
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0042 0.0000014045
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0775 0.1207
Schistosoma mansoni hypothetical protein 0.0058 0.0537 0.1248
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0377 0.0737
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.034 0.0435
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0176 0.0536
Echinococcus multilocularis GPCR, family 2 0.0053 0.0464 0.045
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0395 0.4937 0.4929
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0208 0.0324
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0076 0.0097
Loa Loa (eye worm) hypothetical protein 0.0049 0.0415 0.0646
Brugia malayi hypothetical protein 0.002 0.0042 0.0044
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.0716 0.1096
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0076 0.0097
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0037 0.0257 0.0379
Entamoeba histolytica aldose reductase, putative 0.0031 0.0176 0.0536
Schistosoma mansoni ets-related 0.0242 0.2938 0.698
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.1111 0.2619
Echinococcus granulosus GPCR family 2 0.0053 0.0464 0.0913
Echinococcus multilocularis aldo keto reductase 0.0031 0.0176 0.0162
Brugia malayi Calcitonin receptor-like protein seb-1 0.0166 0.1947 0.3018
Schistosoma mansoni pol-related 0.0031 0.0176 0.0387
Schistosoma mansoni aldo-keto reductase 0.0031 0.0176 0.0387
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0176 0.0536
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1146 0.4425
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.034 0.1072
Brugia malayi Bromodomain containing protein 0.0033 0.0208 0.0303
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0395 0.4937 1
Schistosoma mansoni DNA ligase IV 0.002 0.0042 0.0068
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0464 0.0913
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0048 0.0399 0.0783
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0165 0.0491
Schistosoma mansoni tsg101-related 0.0066 0.0633 0.1479
Entamoeba histolytica Ran family GTPase 0.0023 0.0082 0.0158
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0082 0.0127
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.1111 0.1712
Schistosoma mansoni kinase 0.0108 0.1183 0.2791
Schistosoma mansoni hypothetical protein 0.0339 0.4202 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0516 0.0804
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0076 0.0097
Schistosoma mansoni hypothetical protein 0.0033 0.0208 0.0463
Brugia malayi MH2 domain containing protein 0.0267 0.3259 0.5065
Brugia malayi hypothetical protein 0.0079 0.0805 0.1235
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0042 0.0000014045
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0176 0.0536
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0176 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0118
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0775 0.1207
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0176 0.0162
Loa Loa (eye worm) fli-1 protein 0.0242 0.2938 0.4575
Brugia malayi serine/threonine-protein kinase plk-2 0.0212 0.2538 0.394
Loa Loa (eye worm) hypothetical protein 0.0068 0.0667 0.1039
Brugia malayi Ets-domain containing protein 0.008 0.0818 0.1255
Brugia malayi N-terminal motif family protein 0.0174 0.2053 0.3182
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.034 0.1191
Plasmodium vivax glycogen synthase kinase 3, putative 0.0048 0.0399 0.9626
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3503 0.7088
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0294 0.0668
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0415 0.1493
Plasmodium falciparum glycogen synthase kinase 3 0.0048 0.0399 0.9626
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0176 0.0536
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0176 0.0536
Mycobacterium ulcerans hypothetical protein 0.0023 0.0076 0.0097
Trichomonas vaginalis rotamase, putative 0.0036 0.0246 0.0814
Loa Loa (eye worm) oxidoreductase 0.0031 0.0176 0.0274
Brugia malayi PHD-finger family protein 0.0033 0.0208 0.0303
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0076 0.0097
Trypanosoma brucei aldo-keto reductase, putative 0.0031 0.0176 0.0536
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0082 0.1058
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0246 0.0814
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0415 0.1493
Schistosoma mansoni rotamase 0.0037 0.0257 0.058
Onchocerca volvulus 0.0058 0.0537 0.0783
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.1111 0.1098
Schistosoma mansoni hypothetical protein 0.0053 0.0464 0.1073
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0076 0.0096
Plasmodium falciparum importin beta, putative 0.0032 0.0191 0.4607
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0208 0.4443
Echinococcus granulosus dna polymerase kappa 0.0043 0.034 0.0662
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.0176 0.0225
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0076 0.0133
Giardia lamblia DINP protein human, muc B family 0.0043 0.034 0.1191
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0066
Leishmania major DNA polymerase eta, putative 0.0072 0.0716 0.2603
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0176 0.0162
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0775 0.1817
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0464 0.045
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0066
Onchocerca volvulus 0.0504 0.6357 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0191 0.0597

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3162 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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