Detailed information for compound 1265860

Basic information

Technical information
  • TDR Targets ID: 1265860
  • Name: (12aS)-2-(5-hydroxypentyl)-6,7,12,12a-tetrahy dro-3H-pyrazino[4,3-b]$b-carboline-1,4-quinon e
  • MW: 341.404 | Formula: C19H23N3O3
  • H donors: 2 H acceptors: 3 LogP: 1.17 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCCCN1CC(=O)N2[C@H](C1=O)Cc1c(C2)[nH]c2c1cccc2
  • InChi: 1S/C19H23N3O3/c23-9-5-1-4-8-21-12-18(24)22-11-16-14(10-17(22)19(21)25)13-6-2-3-7-15(13)20-16/h2-3,6-7,17,20,23H,1,4-5,8-12H2/t17-/m0/s1
  • InChiKey: RCDWVMFOWRMSGY-KRWDZBQOSA-N  


Substructure search Similarity search

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Synonyms

  • ZINC02140329
  • STOCK1N-33502

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1863 1 1
Giardia lamblia Cysteine protease 0.0157 0.0729 0.2027
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0157 0.0729 0.0729
Onchocerca volvulus Cathepsin F homolog 0.0617 0.3227 1
Echinococcus granulosus cathepsin L 0.0157 0.0729 0.0729
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0157 0.0729 0.2027
Brugia malayi fibroinase precursor 0.0157 0.0729 0.0729
Brugia malayi Bromodomain containing protein 0.0046 0.0128 0.0128
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0025 0.0025
Plasmodium falciparum serine repeat antigen 3 0.0157 0.0729 0.2258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0617 0.3227 0.8974
Plasmodium vivax unspecified product 0.0343 0.1742 0.5397
Toxoplasma gondii preprocathepsin c precursor, putative 0.0157 0.0729 0.2027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0617 0.3227 0.8974
Trypanosoma cruzi cysteine peptidase, putative 0.1069 0.5687 0.5687
Brugia malayi Papain family cysteine protease containing protein 0.0157 0.0729 0.0729
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1069 0.5687 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0617 0.3227 1
Entamoeba histolytica cysteine protease, putative 0.0157 0.0729 0.2258
Loa Loa (eye worm) hypothetical protein 0.0052 0.0156 0.0156
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0157 0.0729 0.0729
Brugia malayi cathepsin Z-like cysteine proteinase 0.0157 0.0729 0.0729
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0617 0.3227 0.3227
Plasmodium falciparum serine repeat antigen 8 0.0157 0.0729 0.2258
Onchocerca volvulus 0.0617 0.3227 1
Giardia lamblia Cathepsin B precursor 0.0157 0.0729 0.2027
Brugia malayi Papain family cysteine protease containing protein 0.0343 0.1742 0.1742
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0617 0.3227 0.8974
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0157 0.0729 0.2258
Schistosoma mansoni cathepsin B (C01 family) 0.0157 0.0729 0.0729
Brugia malayi cathepsin F-like cysteine proteinase 0.0186 0.089 0.089
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0157 0.0729 0.2258
Echinococcus multilocularis cathepsin b 0.1863 1 1
Brugia malayi Cathepsin L-like precursor 0.043 0.2214 0.2214
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0157 0.0729 0.2027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0617 0.3227 0.8974
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0049 0.0144 0.0144
Entamoeba histolytica cysteine protease, putative 0.0157 0.0729 0.2258
Entamoeba histolytica cysteine protease, putative 0.0343 0.1742 0.5397
Giardia lamblia Cathepsin B precursor 0.0157 0.0729 0.2027
Brugia malayi Cathepsin L-like precursor 0.0617 0.3227 0.3227
Trypanosoma cruzi cysteine peptidase, putative 0.0343 0.1742 0.1742
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0343 0.1742 0.1742
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0883 0.4674 0.4674
Loa Loa (eye worm) cysteine protease 0.0617 0.3227 0.3227
Loa Loa (eye worm) fibroinase 0.0617 0.3227 0.3227
Onchocerca volvulus 0.0617 0.3227 1
Echinococcus multilocularis cysteine protease 0.0617 0.3227 0.3227
Trypanosoma cruzi cysteine peptidase, putative 0.0617 0.3227 0.3227
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0025 0.0025
Brugia malayi Cathepsin L-like precursor 0.0617 0.3227 0.3227
Entamoeba histolytica cysteine protease, putative 0.0343 0.1742 0.5397
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0157 0.0729 0.0729
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0268 0.0268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0617 0.3227 0.8974
Leishmania major cathepsin L-like protease 0.0617 0.3227 0.5675
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0617 0.3227 0.8974
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0186 0.089 0.089
Echinococcus multilocularis cathepsin L cysteine protease 0.0617 0.3227 0.3227
Entamoeba histolytica cysteine protease, putative 0.0343 0.1742 0.5397
Schistosoma mansoni hypothetical protein 0.0025 0.0012 0.0012
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0157 0.0729 0.2258
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0343 0.1742 0.1742
Onchocerca volvulus 0.0617 0.3227 1
Trypanosoma cruzi cysteine proteinase, putative 0.0343 0.1742 0.1742
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0157 0.0729 0.2027
Echinococcus multilocularis cysteine protease 0.0617 0.3227 0.3227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0729 0.2027
Leishmania major cysteine peptidase A (CPA) 0.0617 0.3227 0.5675
Plasmodium vivax vivapain-1 0.0343 0.1742 0.5397
Trypanosoma cruzi cysteine peptidase, putative 0.1069 0.5687 0.5687
Giardia lamblia Cathepsin L-like protease 0.0157 0.0729 0.2027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0617 0.3227 0.8974
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0617 0.3227 0.8974
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.2214 0.6158
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0157 0.0729 0.2258
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0157 0.0729 0.0729
Leishmania major cathepsin L-like protease 0.0617 0.3227 0.5675
Schistosoma mansoni cathepsin S (C01 family) 0.0157 0.0729 0.0729
Plasmodium vivax vivapain-2 0.0617 0.3227 1
Plasmodium falciparum serine repeat antigen 7 0.0157 0.0729 0.2258
Trypanosoma cruzi cysteine peptidase, putative 0.0186 0.089 0.089
Onchocerca volvulus Cathepsin L homolog 0.0617 0.3227 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0729 0.2027
Entamoeba histolytica cysteine protease, putative 0.0343 0.1742 0.5397
Loa Loa (eye worm) hypothetical protein 0.0157 0.0729 0.0729
Leishmania major cathepsin L-like protease 0.1069 0.5687 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0157 0.0729 0.2258
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0157 0.0729 0.2027
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0157 0.0729 0.2027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1069 0.5687 1
Echinococcus multilocularis zinc finger protein 0.0024 0.0005 0.0005
Leishmania major cathepsin L-like protease 0.1069 0.5687 1
Plasmodium vivax vivapain-2 0.0617 0.3227 1
Giardia lamblia Cathepsin B precursor 0.0685 0.3596 1
Onchocerca volvulus 0.043 0.2214 0.5946
Echinococcus granulosus cysteine protease 0.0343 0.1742 0.1742
Entamoeba histolytica cysteine proteinase, putative 0.0617 0.3227 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0617 0.3227 0.3227
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0157 0.0729 0.2027
Plasmodium falciparum serine repeat antigen 4 0.0157 0.0729 0.2258
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1863 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1069 0.5687 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0157 0.0729 0.2258
Entamoeba histolytica cysteine proteinase, putative 0.0343 0.1742 0.5397
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0617 0.3227 0.3227
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0685 0.3596 0.6324
Trypanosoma cruzi major cysteine proteinase, putative 0.061 0.3188 0.3188
Echinococcus granulosus zinc finger protein 0.0024 0.0005 0.0005
Giardia lamblia Hypothetical protein 0.0157 0.0729 0.2027
Echinococcus multilocularis cathepsin L 0.0343 0.1742 0.1742
Entamoeba histolytica cysteine protease, putative 0.0343 0.1742 0.5397
Plasmodium vivax unspecified product 0.0157 0.0729 0.2258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0617 0.3227 0.8974
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0685 0.3596 0.3596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0617 0.3227 0.8974
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0157 0.0729 0.2027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0617 0.3227 0.8974
Brugia malayi Cathepsin L-like precursor 0.0617 0.3227 0.3227
Giardia lamblia Cathepsin L-like protease 0.0157 0.0729 0.2027
Plasmodium falciparum cysteine proteinase falcipain 1 0.0343 0.1742 0.5397
Giardia lamblia Cathepsin L precursor 0.0157 0.0729 0.2027
Loa Loa (eye worm) hypothetical protein 0.0617 0.3227 0.3227
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0 0.5
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0157 0.0729 0.2027
Plasmodium falciparum serine repeat antigen 5 0.0157 0.0729 0.2258
Entamoeba histolytica cysteine protease, putative 0.0343 0.1742 0.5397
Entamoeba histolytica cysteine proteinase, putative 0.0617 0.3227 1
Plasmodium vivax vivapain-3 0.0343 0.1742 0.5397
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0157 0.0729 0.2258
Entamoeba histolytica cysteine proteinase 2 0.0343 0.1742 0.5397
Entamoeba histolytica cysteine protease, putative 0.0343 0.1742 0.5397
Echinococcus granulosus cathepsin l1 0.043 0.2214 0.2214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0617 0.3227 0.8974
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0157 0.0729 0.0729
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0617 0.3227 0.8974
Plasmodium falciparum serine repeat antigen 9 0.0157 0.0729 0.2258
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0157 0.0729 0.2258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0617 0.3227 0.8974
Entamoeba histolytica cysteine protease, putative 0.0343 0.1742 0.5397
Onchocerca volvulus 0.0617 0.3227 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0157 0.0729 0.2258
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0186 0.089 0.089
Entamoeba histolytica cysteine proteinase, putative 0.0343 0.1742 0.5397
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0617 0.3227 0.8974
Loa Loa (eye worm) hypothetical protein 0.0186 0.089 0.089
Trypanosoma cruzi cruzipain precursor, putative 0.1069 0.5687 0.5687
Trypanosoma cruzi cysteine peptidase, putative 0.1069 0.5687 0.5687
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0157 0.0729 0.2258
Entamoeba histolytica cysteine protease, putative 0.0343 0.1742 0.5397
Brugia malayi Bromodomain containing protein 0.0091 0.0369 0.0369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0617 0.3227 0.8974
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0729 0.2027
Echinococcus multilocularis cathepsin b 0.1863 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0617 0.3227 0.8974
Brugia malayi PHD-finger family protein 0.003 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0157 0.0729 0.0729
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0729 0.2027
Loa Loa (eye worm) hypothetical protein 0.043 0.2214 0.2214
Brugia malayi Cathepsin L-like precursor 0.0617 0.3227 0.3227
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0617 0.3227 0.8974
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1069 0.5687 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0157 0.0729 0.2027
Giardia lamblia Cathepsin L precursor 0.0157 0.0729 0.2027
Schistosoma mansoni cathepsin F (C01 family) 0.0617 0.3227 0.3227
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0157 0.0729 0.2027
Trypanosoma cruzi cysteine proteinase, putative 0.0343 0.1742 0.1742
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0685 0.3596 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0343 0.1742 0.4843
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0617 0.3227 0.8974
Brugia malayi Papain family cysteine protease containing protein 0.0157 0.0729 0.0729
Entamoeba histolytica cysteine proteinase, putative 0.0343 0.1742 0.5397
Loa Loa (eye worm) ctsf protein 0.0617 0.3227 0.3227
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0157 0.0729 0.0729
Plasmodium vivax serine-repeat antigen (SERA) 0.0157 0.0729 0.2258
Brugia malayi Cathepsin L-like precursor 0.0617 0.3227 0.3227
Toxoplasma gondii cathepsin B 0.0685 0.3596 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0157 0.0729 0.0729
Entamoeba histolytica cysteine proteinase, putative 0.043 0.2214 0.6861
Entamoeba histolytica cysteine protease, putative 0.0343 0.1742 0.5397
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0343 0.1742 0.1742
Leishmania major cathepsin L-like protease 0.0617 0.3227 0.5675
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1069 0.5687 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0617 0.3227 0.8974
Entamoeba histolytica cysteine proteinase 1, putative 0.0343 0.1742 0.5397
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0157 0.0729 0.0729
Echinococcus granulosus cathepsin L cysteine protease 0.0343 0.1742 0.1742
Onchocerca volvulus 0.0617 0.3227 1
Giardia lamblia Cysteine protease 0.0157 0.0729 0.2027
Brugia malayi Papain family cysteine protease containing protein 0.0157 0.0729 0.0729
Echinococcus multilocularis cathepsin L 0.0157 0.0729 0.0729
Echinococcus multilocularis cathepsin L cysteine protease 0.0617 0.3227 0.3227
Brugia malayi Papain family cysteine protease containing protein 0.0617 0.3227 0.3227
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0157 0.0729 0.0729
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1069 0.5687 1
Entamoeba histolytica cysteine protease, putative 0.0343 0.1742 0.5397
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1863 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0617 0.3227 0.3227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1069 0.5687 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0157 0.0729 0.0729
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0729 0.2027
Schistosoma mansoni cathepsin C 0.0157 0.0729 0.0729
Schistosoma mansoni cathepsin F (C01 family) 0.0617 0.3227 0.3227
Trypanosoma cruzi cysteine protease, putative 0.0343 0.1742 0.1742
Brugia malayi cathepsin L-like cysteine proteinase 0.0157 0.0729 0.0729
Echinococcus granulosus cathepsin b 0.1863 1 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.0729 0.0729
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0343 0.1742 0.1742
Brugia malayi cathepsin L-like precursor 0.043 0.2214 0.2214
Schistosoma mansoni zinc finger protein 0.0024 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0685 0.3596 0.3596
Entamoeba histolytica cysteine proteinase, putative 0.0343 0.1742 0.5397
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0157 0.0729 0.2258
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0157 0.0729 0.2258
Onchocerca volvulus 0.0617 0.3227 1
Plasmodium vivax unspecified product 0.0186 0.089 0.2756
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0617 0.3227 0.8974
Plasmodium falciparum cysteine proteinase falcipain 3 0.0617 0.3227 1
Echinococcus granulosus cathepsin L 0.0343 0.1742 0.1742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0343 0.1742 0.3063
Giardia lamblia Cathepsin L precursor 0.0157 0.0729 0.2027
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0157 0.0729 0.2258
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0012 0.0012
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0157 0.0729 0.2258
Giardia lamblia Cathepsin L precursor 0.0157 0.0729 0.2027
Brugia malayi Cathepsin L-like precursor 0.043 0.2214 0.2214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0617 0.3227 0.8974
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.0128 0.0128
Schistosoma mansoni cathepsin F (C01 family) 0.043 0.2214 0.2214
Entamoeba histolytica cysteine protease, putative 0.0343 0.1742 0.5397
Trichomonas vaginalis conserved hypothetical protein 0.0157 0.0729 0.2027
Toxoplasma gondii cathepsin CPC1 0.0157 0.0729 0.2027
Schistosoma mansoni cathepsin s 0.0186 0.089 0.089
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0617 0.3227 1
Loa Loa (eye worm) hypothetical protein 0.043 0.2214 0.2214
Brugia malayi Cathepsin L-like precursor 0.0617 0.3227 0.3227
Giardia lamblia Cathepsin B precursor 0.0157 0.0729 0.2027
Toxoplasma gondii cathepsin CPC2 0.0157 0.0729 0.2027
Plasmodium vivax serine-repeat antigen (SERA) 0.0157 0.0729 0.2258
Loa Loa (eye worm) cathepsin B 0.0685 0.3596 0.3596
Loa Loa (eye worm) hypothetical protein 0.0157 0.0729 0.0729
Plasmodium falciparum serine repeat antigen 2 0.0157 0.0729 0.2258
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0157 0.0729 0.0729
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.2214 0.6158
Entamoeba histolytica cysteine protease, putative 0.0343 0.1742 0.5397
Brugia malayi Papain family cysteine protease containing protein 0.0343 0.1742 0.1742
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0186 0.089 0.089
Giardia lamblia Cysteine protease 0.0157 0.0729 0.2027
Leishmania major cathepsin L-like protease 0.1069 0.5687 1
Plasmodium falciparum serine repeat antigen 1 0.0157 0.0729 0.2258
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0157 0.0729 0.2027
Giardia lamblia Encystation-specific protease 0.0157 0.0729 0.2027
Trichomonas vaginalis conserved hypothetical protein 0.0157 0.0729 0.2027
Onchocerca volvulus 0.0617 0.3227 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0617 0.3227 0.3227
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0025 0.0025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0157 0.0729 0.2027
Loa Loa (eye worm) hypothetical protein 0.0186 0.089 0.089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0617 0.3227 0.8974
Entamoeba histolytica cysteine protease, putative 0.0157 0.0729 0.2258
Brugia malayi cathepsin L precursor 0.0157 0.0729 0.0729
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0157 0.0729 0.2027
Echinococcus granulosus cathepsin b 0.1863 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0157 0.0729 0.2027
Onchocerca volvulus Cathepsin L homolog 0.0617 0.3227 1
Loa Loa (eye worm) hypothetical protein 0.043 0.2214 0.2214
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0157 0.0729 0.2027
Giardia lamblia Cysteine protease 0.0157 0.0729 0.2027
Loa Loa (eye worm) hypothetical protein 0.0186 0.089 0.089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0729 0.2027
Brugia malayi Cathepsin L-like precursor 0.0186 0.089 0.089
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0157 0.0729 0.2258
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0157 0.0729 0.0729
Brugia malayi Cathepsin L-like cysteine proteinase 0.043 0.2214 0.2214
Plasmodium falciparum serine repeat antigen 6 0.0157 0.0729 0.2258
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1863 1 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.0729 0.0729
Brugia malayi cathepsin Z-like cysteine proteinase 0.0157 0.0729 0.0729
Entamoeba histolytica cysteine protease, putative 0.0157 0.0729 0.2258
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0112 0.0112
Giardia lamblia Cathepsin B precursor 0.0685 0.3596 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0157 0.0729 0.0729
Loa Loa (eye worm) hypothetical protein 0.1863 1 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.0729 0.0729
Giardia lamblia Hypothetical protein 0.0157 0.0729 0.2027
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0157 0.0729 0.0729
Entamoeba histolytica cysteine protease, putative 0.0157 0.0729 0.2258
Giardia lamblia Cathepsin L precursor 0.0157 0.0729 0.2027
Echinococcus granulosus cathepsin L cysteine proteinase 0.0617 0.3227 0.3227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0343 0.1742 0.4843
Echinococcus granulosus cathepsin l1 0.0617 0.3227 0.3227
Giardia lamblia Cathepsin B precursor 0.0685 0.3596 1
Giardia lamblia Cathepsin B precursor 0.0157 0.0729 0.2027
Trypanosoma cruzi major cysteine proteinase, putative 0.0157 0.0729 0.0729
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1069 0.5687 1
Entamoeba histolytica cysteine protease, putative 0.0617 0.3227 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0617 0.3227 0.8974
Loa Loa (eye worm) hypothetical protein 0.0085 0.0341 0.0341
Toxoplasma gondii cathepsin CPL 0.0617 0.3227 0.8974
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1863 1 1
Leishmania major cathepsin L-like protease 0.0617 0.3227 0.5675
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1069 0.5687 1
Leishmania major cathepsin L-like protease 0.0617 0.3227 0.5675
Entamoeba histolytica hypothetical protein 0.0157 0.0729 0.2258
Giardia lamblia Cathepsin B precursor 0.0157 0.0729 0.2027
Trypanosoma brucei cysteine peptidase C (CPC) 0.0685 0.3596 0.6324
Giardia lamblia Cathepsin L precursor 0.0157 0.0729 0.2027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1069 0.5687 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0268 0.0268
Entamoeba histolytica cysteine protease, putative 0.0157 0.0729 0.2258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0617 0.3227 0.8974
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1069 0.5687 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0343 0.1742 0.3063
Schistosoma mansoni bromodomain containing protein 0.0076 0.0292 0.0292

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2378 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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