Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Giardia intestinalis | Putative fructose-1,6-bisphosphate aldolase | Starlite/ChEMBL | No references |
Homo sapiens | arachidonate 15-lipoxygenase | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific demethylase 4E | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium ulcerans | fructose-bisphosphate aldolase | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 361 aa | 26.9 % |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 361 aa | 25.5 % |
Candida albicans | fructose-bisphosphate aldolase | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 358 aa | 22.6 % |
Echinococcus granulosus | arachidonate 5 lipoxygenase | arachidonate 15-lipoxygenase | 662 aa | 590 aa | 23.9 % |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 361 aa | 25.8 % |
Candida albicans | fructose-bisphosphate aldolase | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 358 aa | 22.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0067 | 0.0744 | 0.8408 |
Brugia malayi | jmjC domain containing protein | 0.0071 | 0.0885 | 0.5783 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0071 | 0.0885 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0071 | 0.0885 | 0.5783 |
Trypanosoma cruzi | sterol 24-c-methyltransferase, putative | 0.0187 | 0.4624 | 1 |
Leishmania major | sterol 24-c-methyltransferase, putative | 0.0187 | 0.4624 | 1 |
Brugia malayi | S-adenosyl-methionine cycloartenol-C24-methyltransferase | 0.0091 | 0.153 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0071 | 0.0885 | 1 |
Trypanosoma cruzi | sterol 24-c-methyltransferase, putative | 0.0187 | 0.4624 | 1 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0044 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.153 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0071 | 0.0885 | 1 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.0044 | 0 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 1 | 1 |
Trypanosoma brucei | Sterol methyltransferase, putative | 0.0187 | 0.4624 | 1 |
Trypanosoma brucei | sterol 24-c-methyltransferase, putative | 0.0187 | 0.4624 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0172 | 0.4163 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0067 | 0.0744 | 0.8408 |
Trypanosoma cruzi | sterol 24-c-methyltransferase, putative | 0.0187 | 0.4624 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0353 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 1 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0172 | 0.4163 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 1 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0071 | 0.0885 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.0885 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0071 | 0.0885 | 0.5783 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 1 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0353 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 1 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0067 | 0.0744 | 0.8408 |
Trypanosoma brucei | sterol 24-c-methyltransferase, putative | 0.0097 | 0.1736 | 0.3754 |
Schistosoma mansoni | jumonji domain containing protein | 0.0071 | 0.0885 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 1 | 1 |
Trypanosoma brucei | sterol 24-c-methyltransferase, putative | 0.0187 | 0.4624 | 1 |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.0044 | 0 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.0885 | 1 |
Leishmania major | sterol 24-c-methyltransferase, putative | 0.0187 | 0.4624 | 1 |
Plasmodium falciparum | methionine aminopeptidase 2 | 0.0044 | 0 | 0.5 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0172 | 0.4163 | 0.5 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0353 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 15.8114 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (binding) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.