Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1048 | 0.2429 |
Brugia malayi | hypothetical protein | 0.0086 | 0.1048 | 0.2429 |
Brugia malayi | Doublecortin family protein | 0.0086 | 0.1048 | 0.2429 |
Loa Loa (eye worm) | doublecortin family protein | 0.0086 | 0.1048 | 0.2429 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0086 | 0.1048 | 0.1859 |
Schistosoma mansoni | rab6-interacting | 0.0086 | 0.1048 | 0.182 |
Schistosoma mansoni | loxhd1 | 0.0086 | 0.1048 | 0.182 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.0065 | 0.5 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0086 | 0.1048 | 0.1859 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1048 | 0.2429 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.5001 | 0.5 |
Onchocerca volvulus | 0.0286 | 0.5001 | 1 | |
Onchocerca volvulus | 0.0036 | 0.0065 | 0.013 | |
Schistosoma mansoni | lipoxygenase | 0.0155 | 0.2417 | 0.4354 |
Onchocerca volvulus | 0.0086 | 0.1048 | 0.2096 | |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0539 | 1 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0539 | 1 | 0.5 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0086 | 0.1048 | 0.182 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0065 | 0.0151 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0086 | 0.1048 | 0.5 |
Brugia malayi | hypothetical protein | 0.0086 | 0.1048 | 0.2429 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0086 | 0.1048 | 0.182 |
Echinococcus granulosus | RUN | 0.0086 | 0.1048 | 0.1859 |
Schistosoma mansoni | lipoxygenase | 0.031 | 0.5468 | 1 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0539 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.1048 | 0.182 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0539 | 1 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0539 | 1 | 0.5 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0086 | 0.1048 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.031 | 0.5468 | 1 |
Schistosoma mansoni | rab6-interacting | 0.0086 | 0.1048 | 0.182 |
Schistosoma mansoni | polycystin 1-related | 0.0086 | 0.1048 | 0.182 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0086 | 0.1048 | 0.182 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.4316 | 1 |
Echinococcus multilocularis | RUN | 0.0086 | 0.1048 | 0.182 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.031 | 0.5468 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0086 | 0.1048 | 0.1859 |
Onchocerca volvulus | 0.0086 | 0.1048 | 0.2096 | |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0065 | 0.0048 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0065 | 0.0151 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.4316 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.2239 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.8584 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.