TDR Targets

Basic information

Technical information

TDR Targets ID: 1278938
Name: N-(2-chloro-4-methylphenyl)-2-[7-[(3-methyl-1 ,2,4-oxadiazol-5-yl)methyl]-6,8-dioxo-[1,3]di oxolo[4,5-g]quinazolin-5-yl]acetamide
MW: 483.861 | Formula: C22H18ClN5O6
H donors: 1 H acceptors: 5 LogP: 2.67 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(c(c1)Cl)NC(=O)Cn1c2cc3OCOc3cc2c(=O)n(c1=O)Cc1onc(n1)C
InChi: 1S/C22H18ClN5O6/c1-11-3-4-15(14(23)5-11)25-19(29)8-27-16-7-18-17(32-10-33-18)6-13(16)21(30)28(22(27)31)9-20-24-12(2)26-34-20/h3-7H,8-10H2,1-2H3,(H,25,29)
InChiKey: UTVXVSPBDRUNRZ-UHFFFAOYSA-N

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-chloro-4-methyl-phenyl)-2-[7-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]-6,8-dioxo-[1,3]dioxolo[4,5-g]quinazolin-5-yl]acetamide
N-(2-chloro-4-methyl-phenyl)-2-[6,8-diketo-7-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]-[1,3]dioxolo[4,5-g]quinazolin-5-yl]acetamide
N-(2-chloro-4-methyl-phenyl)-2-[7-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]-6,8-dioxo-[1,3]dioxolo[4,5-g]quinazolin-5-yl]ethanamide
E843-0050
NCGC00125857-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bacillus subtilis (strain 168)	ATP-dependent Clp protease proteolytic subunit	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	peptidase Clp S14 family	Get druggable targets OG5_127187	All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Babesia bovis	ATP-dependent Clp protease proteolytic subunit 1, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Brugia malayi	Probable ClpP-like protease	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma mansoni	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Neospora caninum	ATP-dependent Clp protease proteolytic subunit, related	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	ko:K06275 parvin, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium yoelii	ATP-dependent Clp protease, proteolytic subunit ClpP, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	ATP-dependent Clp protease proteolytic subunit	197 aa	172 aa	57.0 %
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Plasmodium yoelii	Clp protease	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.6 %
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	35.5 %
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	180 aa	36.7 %
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.1 %
Onchocerca volvulus	Putative V-type proton ATPase subunit F	ATP-dependent Clp protease proteolytic subunit	197 aa	194 aa	54.1 %
Chlamydia trachomatis	hypothetical protein	ATP-dependent Clp protease proteolytic subunit	197 aa	171 aa	22.8 %
Schistosoma mansoni	neuropeptide receptor	ATP-dependent Clp protease proteolytic subunit	197 aa	174 aa	20.1 %
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	186 aa	40.3 %
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	36.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1293	0.1208
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0062	0.121	0.2125
Echinococcus multilocularis	lamin	0.0032	0.0407	0.0312
Onchocerca volvulus		0.0032	0.0407	0.0962
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0041	0.0643	0.0994
Mycobacterium ulcerans	hypothetical protein	0.0139	0.3313	1
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0111	0.2555	0.7385
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0097	0.0106
Entamoeba histolytica	phosphofructokinase, putative	0.0111	0.2555	0.7443
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0097	0.0106
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0139	0.3313	0.3248
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1293	0.1208
Mycobacterium tuberculosis	Conserved protein	0.0139	0.3313	1
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0062	0.121	0.1124
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0033	0.0414	0.0221
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0097	0.0106
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0097	0.0106
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0094	0.2093	0.2015
Echinococcus granulosus	ETHE1 protein	0.0139	0.3313	0.3248
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0609	0.0517
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0976	0.0887
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0976	0.0887
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0139	0.3313	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0479	0.0521
Trichomonas vaginalis	beta lactamase domain, putative	0.0139	0.3313	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0097	0.0106
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0097	0.0106
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0976	0.0887
Plasmodium vivax	hydroxyacyl glutathione hydrolase, putative	0.0139	0.3313	1
Brugia malayi	nuclear hormone receptor	0.0021	0.0097	0.0106
Entamoeba histolytica	hypothetical protein	0.004	0.0609	0.088
Mycobacterium leprae	POSSIBLE HYDROLASE	0.0139	0.3313	1
Mycobacterium ulcerans	hypothetical protein	0.0139	0.3313	1
Wolbachia endosymbiont of Brugia malayi	metallo-beta-lactamase superfamily hydrolase	0.0139	0.3313	1
Schistosoma mansoni	lamin	0.0032	0.0407	0.0312
Schistosoma mansoni	6-phosphofructokinase	0.0111	0.2555	0.2482
Brugia malayi	phosphofructokinase	0.0111	0.2555	0.2777
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0097	0.0106
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0041	0.0643	0.0551
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3313	0.3601
Echinococcus multilocularis	solute carrier family 5	0.0039	0.0598	0.0505
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0041	0.0643	0.0994
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0097	0.0106
Schistosoma mansoni	zinc phosphodiesterase	0.0139	0.3313	0.3248
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0976	0.106
Treponema pallidum	ribonuclease Z	0.0139	0.3313	1
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0039	0.0598	0.0505
Entamoeba histolytica	hypothetical protein	0.004	0.0609	0.088
Onchocerca volvulus	Putative hydrolase PNKD	0.0139	0.3313	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0097	0.0106
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0039	0.0598	0.0505
Brugia malayi	ethe1-prov protein	0.0139	0.3313	0.3601
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0139	0.3313	0.3248
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0111	0.2555	0.7161
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0097	0.0106
Schistosoma mansoni	hypothetical protein	0.0386	1	1
Mycobacterium ulcerans	hypothetical protein	0.0139	0.3313	1
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0139	0.3313	0.3248
Mycobacterium tuberculosis	Possible hydrolase	0.0139	0.3313	1
Loa Loa (eye worm)	hypothetical protein	0.0094	0.2093	0.2275
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0039	0.0598	0.0505
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0097	0.0106
Entamoeba histolytica	metallo-beta-lactamase superfamily protein	0.0139	0.3313	1
Toxoplasma gondii	exonuclease III APE	0.0041	0.0643	0.0994
Echinococcus multilocularis	ETHE1 protein	0.0139	0.3313	0.3248
Loa Loa (eye worm)	hypothetical protein	0.0356	0.9202	1
Plasmodium vivax	unspecified product	0.0139	0.3313	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0918	0.0998
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0097	0.0106
Mycobacterium ulcerans	glyoxalase II, GloB	0.0139	0.3313	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.2093	0.5885
Brugia malayi	Sodium:solute symporter family protein	0.0039	0.0598	0.0649
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.2555	0.7443
Trichomonas vaginalis	A-type flavoprotein	0.0139	0.3313	1
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0111	0.2555	0.7161
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.1293	0.1208
Echinococcus multilocularis	6 phosphofructokinase	0.0111	0.2555	0.2482
Mycobacterium tuberculosis	Beta lactamase like protein	0.0139	0.3313	1
Trichomonas vaginalis	beta lactamase domain, putative	0.0139	0.3313	1
Leishmania major	hypothetical protein, conserved	0.0139	0.3313	1
Schistosoma mansoni	hypothetical protein	0.0139	0.3313	0.3248
Toxoplasma gondii	hydroxyacylglutathione hydrolase	0.0139	0.3313	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0041	0.0643	0.0994
Mycobacterium ulcerans	Zn-dependent glyoxylase	0.0139	0.3313	1
Brugia malayi	Probable ClpP-like protease	0.0094	0.2093	0.2275
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0139	0.3313	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.2555	0.7443
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0041	0.0643	0.0551
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0094	0.2093	0.543
Mycobacterium ulcerans	hydrolase	0.0139	0.3313	1
Brugia malayi	hypothetical protein	0.004	0.0609	0.0662
Brugia malayi	Intermediate filament tail domain containing protein	0.0032	0.0407	0.0442
Mycobacterium leprae	conserved hypothetical protein	0.0139	0.3313	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.2093	0.5885
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0139	0.3313	1
Echinococcus multilocularis	geminin	0.0386	1	1
Echinococcus granulosus	tar DNA binding protein	0.0065	0.1293	0.1208
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1293	0.1208
Echinococcus granulosus	hydroxyacylglutathione hydrolase	0.0139	0.3313	0.3248
Echinococcus granulosus	lamin dm0	0.0032	0.0407	0.0312
Trichomonas vaginalis	conserved hypothetical protein	0.0139	0.3313	1
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase	0.0139	0.3313	0.3601
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0976	0.0887
Schistosoma mansoni	hypothetical protein	0.0386	1	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.2093	0.5885
Onchocerca volvulus		0.0039	0.0598	0.1556
Brugia malayi	ecdysteroid receptor	0.0021	0.0097	0.0106
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0097	0.0106
Brugia malayi	6-phosphofructokinase	0.0111	0.2555	0.2777
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase cytoplasmic	0.0139	0.3313	0.3601
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0598	0.0649
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.2093	0.5885
Schistosoma mansoni	hypothetical protein	0.0139	0.3313	0.3248
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0976	0.0887
Trypanosoma cruzi	glyoxalase II	0.0139	0.3313	1
Chlamydia trachomatis	ribonuclease Z	0.0139	0.3313	1
Trichomonas vaginalis	beta lactamase domain, putative	0.0139	0.3313	1
Echinococcus multilocularis	musashi	0.0032	0.0407	0.0312
Trypanosoma cruzi	metallo-beta-lactamase superfamily, putative	0.0139	0.3313	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0097	0.0106
Echinococcus granulosus	sodium:glucose cotransporter	0.0039	0.0598	0.0505
Onchocerca volvulus		0.0032	0.0407	0.0962
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0097	0.0106
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0139	0.3313	0.3601
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0097	0.0106
Brugia malayi	Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site.	0.0139	0.3313	0.3601
Trypanosoma cruzi	glyoxalase II	0.0139	0.3313	1
Entamoeba histolytica	metallo-beta-lactamase superfamily protein	0.0139	0.3313	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.2093	0.5885
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0918	0.0998
Trichomonas vaginalis	ap endonuclease, putative	0.0041	0.0643	0.0994
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3313	0.3601
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0097	0.0106
Schistosoma mansoni	peptidase Clp (S14 family)	0.0094	0.2093	0.2015
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1293	0.1208
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0097	0.0106
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0097	0.0106
Schistosoma mansoni	inositol transporter	0.0039	0.0598	0.0505
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0094	0.2093	0.2015
Schistosoma mansoni	high-affinity choline transporter	0.0356	0.9202	0.9194
Leishmania major	metallo-beta-lactamase family protein-like protein	0.0139	0.3313	1
Trypanosoma cruzi	metallo-beta-lactamase-like protein, putative	0.0139	0.3313	1
Schistosoma mansoni	inositol transporter	0.0039	0.0598	0.0505
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0032	0.0407	0.0442
Brugia malayi	6-phosphofructokinase	0.0111	0.2555	0.2777
Mycobacterium tuberculosis	Possible hydrolase	0.0139	0.3313	1
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0039	0.0598	0.0505
Schistosoma mansoni	hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II)	0.0139	0.3313	0.3248
Echinococcus granulosus	peptidase Clp S14 family	0.0062	0.121	0.1124
Brugia malayi	TAR-binding protein	0.0065	0.1293	0.1406
Brugia malayi	hypothetical protein	0.0139	0.3313	0.3601
Trypanosoma cruzi	hydroxyacylglutathione hydrolase, putative	0.0139	0.3313	1
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0139	0.3313	0.3601
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.1293	0.1406
Schistosoma mansoni	intermediate filament proteins	0.0032	0.0407	0.0312
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1293	0.1208
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0097	0.0106
Trichomonas vaginalis	conserved hypothetical protein	0.0139	0.3313	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.2093	0.5885
Trypanosoma brucei	cleavage and polyadenylation specificity factor subunit, putative	0.0139	0.3313	1
Loa Loa (eye worm)	RNA binding protein	0.0065	0.1293	0.1406
Loa Loa (eye worm)	intermediate filament protein	0.0032	0.0407	0.0442
Trichomonas vaginalis	conserved hypothetical protein	0.0139	0.3313	1
Echinococcus granulosus	lamin	0.0032	0.0407	0.0312
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0479	0.0521
Schistosoma mansoni	sodium/solute symporter	0.0039	0.0598	0.0505
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0041	0.0643	0.0994
Mycobacterium leprae	Beta-lactamase-like protein	0.0139	0.3313	1
Mycobacterium ulcerans	6-phosphofructokinase	0.0111	0.2555	0.7161
Schistosoma mansoni	zinc phosphodiesterase	0.0139	0.3313	0.3248
Entamoeba histolytica	type A flavoprotein, putative	0.0139	0.3313	1
Entamoeba histolytica	phosphofructokinase, putative	0.0111	0.2555	0.7443
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0039	0.0598	0.0505
Echinococcus multilocularis	hydroxyacylglutathione hydrolase	0.0139	0.3313	0.3248
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0097	0.0106
Echinococcus granulosus	zinc phosphodiesterase	0.0139	0.3313	0.3248
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0097	0.0106
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0976	0.0887
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.2555	0.7443
Entamoeba histolytica	alkyl sulfatase, putative	0.0139	0.3313	1
Trypanosoma cruzi	glyoxalase II	0.0139	0.3313	1
Trypanosoma brucei	glyoxalase II	0.0139	0.3313	1
Mycobacterium ulcerans	beta lactamase-like protein	0.0139	0.3313	1
Brugia malayi	RNA binding protein	0.0065	0.1293	0.1406
Loa Loa (eye worm)	6-phosphofructokinase	0.0111	0.2555	0.2777
Trichomonas vaginalis	conserved hypothetical protein	0.0139	0.3313	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0391	0.0424
Leishmania major	hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative	0.0139	0.3313	1
Schistosoma mansoni	hypothetical protein	0.0139	0.3313	0.3248
Onchocerca volvulus		0.0139	0.3313	1
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0139	0.3313	1
Echinococcus granulosus	high affinity choline transporter 1	0.0356	0.9202	0.9194
Loa Loa (eye worm)	6-phosphofructokinase	0.0111	0.2555	0.2777
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.1293	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3313	0.3601
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0976	0.106
Echinococcus multilocularis	lamin dm0	0.0032	0.0407	0.0312
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0139	0.3313	1
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0111	0.2555	0.7161
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0039	0.0598	0.0505
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0094	0.2093	0.543
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0033	0.0414	0.0221
Toxoplasma gondii	hypothetical protein	0.0033	0.0414	0.0221
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0097	0.0106
Trichomonas vaginalis	conserved hypothetical protein	0.0139	0.3313	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0407	0.0442
Giardia lamblia	Hydroxyacylglutathione hydrolase	0.0139	0.3313	1
Plasmodium falciparum	cytosolic glyoxalase II	0.0139	0.3313	1
Leishmania major	cleavage and polyadenylation specificity factor, putative	0.0139	0.3313	1
Schistosoma mansoni	ap endonuclease	0.0041	0.0643	0.0551
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3313	0.3601
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0094	0.2093	0.5885
Toxoplasma gondii	metallo-beta-lactamase domain-containing protein	0.0139	0.3313	1
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0139	0.3313	1
Echinococcus multilocularis	zinc phosphodiesterase	0.0139	0.3313	0.3248
Giardia lamblia	Metallo-beta-lactamase superfamily protein	0.0139	0.3313	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0918	0.0998
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0097	0.0106
Schistosoma mansoni	lamin	0.0032	0.0407	0.0312
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.1293	0.1406
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0097	0.0106
Echinococcus multilocularis	high affinity choline transporter 1	0.0356	0.9202	0.9194
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0139	0.3313	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0097	0.0106
Trichomonas vaginalis	conserved hypothetical protein	0.0139	0.3313	1
Mycobacterium tuberculosis	Conserved protein	0.0139	0.3313	1
Schistosoma mansoni	6-phosphofructokinase	0.0111	0.2555	0.2482
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0039	0.0598	0.0842
Onchocerca volvulus	Hydroxyacylglutathione hydrolase, mitochondrial homolog	0.0139	0.3313	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0033	0.0414	0.0221
Trypanosoma cruzi	metallo-beta-lactamase superfamily, putative	0.0139	0.3313	1
Echinococcus granulosus	6 phosphofructokinase	0.0111	0.2555	0.2482
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0976	0.0887
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0609	0.0517
Brugia malayi	exodeoxyribonuclease III family protein	0.0041	0.0643	0.0699
Loa Loa (eye worm)	phosphofructokinase	0.0111	0.2555	0.2777
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0097	0.0106
Entamoeba histolytica	hypothetical protein	0.004	0.0609	0.088
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0097	0.0106
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0094	0.2093	0.5792
Mycobacterium ulcerans	hydrolase	0.0139	0.3313	1
Onchocerca volvulus		0.0139	0.3313	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0094	0.2093	0.543
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.2555	0.7443
Trichomonas vaginalis	ap endonuclease, putative	0.0041	0.0643	0.0994
Giardia lamblia	Hydroxyacylglutathione hydrolase	0.0139	0.3313	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0062	0.121	0.2747
Entamoeba histolytica	hypothetical protein	0.004	0.0609	0.088
Echinococcus granulosus	intermediate filament protein	0.0032	0.0407	0.0312
Schistosoma mansoni	hypothetical protein	0.0035	0.0479	0.0386
Trichomonas vaginalis	beta lactamase domain, putative	0.0139	0.3313	1
Mycobacterium ulcerans	hydrolase	0.0139	0.3313	1
Entamoeba histolytica	hypothetical protein, conserved	0.0139	0.3313	1
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0097	0.0106
Trichomonas vaginalis	beta lactamase domain, putative	0.0139	0.3313	1
Schistosoma mansoni	hypothetical protein	0.004	0.0609	0.0517
Brugia malayi	intermediate filament protein	0.0032	0.0407	0.0442
Leishmania major	ATP-dependent phosphofructokinase	0.0111	0.2555	0.7161
Trichomonas vaginalis	beta lactamase domain, putative	0.0139	0.3313	1
Leishmania major	metallo-beta-lactamase family-like protein	0.0139	0.3313	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0097	0.0106
Entamoeba histolytica	alkyl sulfatase, putative	0.0139	0.3313	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0139	0.3313	1
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0111	0.2555	0.7443
Mycobacterium tuberculosis	Conserved protein	0.0139	0.3313	1
Trypanosoma brucei	hydroxyacylglutathione hydrolase, putative	0.0139	0.3313	1
Loa Loa (eye worm)	metallo-beta-lactamase superfamily protein	0.0139	0.3313	0.3601
Schistosoma mansoni	ap endonuclease	0.0041	0.0643	0.0551
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0139	0.3313	0.3248
Entamoeba histolytica	phosphofructokinase, putative	0.0111	0.2555	0.7443
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0041	0.0643	0.0699
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0062	0.121	0.2125
Brugia malayi	GH02984p	0.0356	0.9202	1
Trypanosoma cruzi	metallo-beta-lactamase-like protein, putative	0.0139	0.3313	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0097	0.0106
Trypanosoma cruzi	hydroxyacylglutathione hydrolase, putative	0.0139	0.3313	1
Echinococcus granulosus	solute carrier family 5	0.0039	0.0598	0.0505
Mycobacterium ulcerans	hypothetical protein	0.0139	0.3313	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0097	0.0106
Mycobacterium leprae	conserved hypothetical protein	0.0139	0.3313	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0918	0.0998
Trypanosoma brucei	metallo-beta-lactamase-like protein, putative	0.0139	0.3313	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0609	0.0517
Brugia malayi	steroid hormone receptor	0.0021	0.0097	0.0106
Entamoeba histolytica	type A flavoprotein, putative	0.0139	0.3313	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0097	0.0106
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0041	0.0643	0.0994

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.9811 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 100 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1395766

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1278938