TDR Targets

Basic information

Technical information

TDR Targets ID: 1279535
Name: N-(2,6-difluorophenyl)-5-methyl-[1,2,4]triazo lo[1,5-a]pyrimidine-2-sulfonamide
MW: 325.294 | Formula: C12H9F2N5O2S
H donors: 1 H acceptors: 5 LogP: 1.55 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccn2c(n1)nc(n2)S(=O)(=O)Nc1c(F)cccc1F
InChi: 1S/C12H9F2N5O2S/c1-7-5-6-19-11(15-7)16-12(17-19)22(20,21)18-10-8(13)3-2-4-9(10)14/h2-6,18H,1H3
InChiKey: RXCPQSJAVKGONC-UHFFFAOYSA-N

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

98967-40-9
MLS000704301
N-(2,6-difluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
SMR000231089
ZINC00481639
NCGC00163836-01
(1,2,4)Triazolo(1,5-a)pyrimidine-2-sulfonamide, N-(2,6-difluorophenyl)-5-methyl-
Broadstrike
DE 498
EPA Pesticide Chemical Code 129016
Flumetsulam
N-(2,6-Difluorophenyl)-5-methyl-(1,2,4)triazolo(1,5-a)pyrimidine-2-sulfonamide
XRD 498
AK-105/40832077

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Arabidopsis thaliana	acetolactate synthase	Starlite/ChEMBL	References
Raphanus raphanistrum	Acetolactate synthase	Starlite/ChEMBL	References
Nicotiana tabacum	Acetolactate synthase	Starlite/ChEMBL	References
Homo sapiens	thyroid hormone receptor, beta	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable oxalyl-CoA decarboxylase OxcA	Get druggable targets OG5_126899	All targets in OG5_126899
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Mycobacterium ulcerans	putative oxalyl-CoA decarboxylase	Get druggable targets OG5_126899	All targets in OG5_126899
Mycobacterium leprae	Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS)	Get druggable targets OG5_126899	All targets in OG5_126899
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	ko:K01651 acetolactate synthase [EC2.2.1.6], putative	Get druggable targets OG5_126899	All targets in OG5_126899
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_126899	All targets in OG5_126899
Loa Loa (eye worm)	thiamine pyrophosphate enzyme	Get druggable targets OG5_126899	All targets in OG5_126899
Loa Loa (eye worm)	ILVBL protein	Get druggable targets OG5_126899	All targets in OG5_126899
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Mycobacterium tuberculosis	Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS)	Get druggable targets OG5_126899	All targets in OG5_126899
Schistosoma japonicum	ko:K01651 acetolactate synthase [EC2.2.1.6], putative	Get druggable targets OG5_126899	All targets in OG5_126899
Candida albicans	Acetolactate synthase	Get druggable targets OG5_126899	All targets in OG5_126899
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Candida albicans	Acetolactate synthase	Get druggable targets OG5_126899	All targets in OG5_126899
Schistosoma mansoni	acetolactate synthase	Get druggable targets OG5_126899	All targets in OG5_126899
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_134830	All targets in OG5_134830
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Schistosoma japonicum	expressed protein	Get druggable targets OG5_134830	All targets in OG5_134830
Mycobacterium leprae	PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE)	Get druggable targets OG5_126899	All targets in OG5_126899
Schistosoma japonicum	ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus multilocularis	thyroid hormone receptor alpha	Get druggable targets OG5_134830	All targets in OG5_134830
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Schistosoma mansoni	acetolactate synthase	Get druggable targets OG5_126899	All targets in OG5_126899
Brugia malayi	Thiamine pyrophosphate enzyme, central domain containing protein	Get druggable targets OG5_126899	All targets in OG5_126899
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Mycobacterium ulcerans	acetolactate synthase 1 catalytic subunit	Get druggable targets OG5_126899	All targets in OG5_126899
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Mycobacterium tuberculosis	Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase)	Get druggable targets OG5_126899	All targets in OG5_126899

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	photoreceptor-specific nuclear receptor	thyroid hormone receptor, beta	461 aa	414 aa	24.6 %
Candida albicans	putative indole-3-pyruvate decarboxylase	Acetolactate synthase	604 aa	529 aa	22.3 %
Candida albicans	putative indole-3-pyruvate decarboxylase	Acetolactate synthase	604 aa	529 aa	22.3 %
Onchocerca volvulus	UPF0553 protein C9orf64 homolog	Acetolactate synthase	604 aa	534 aa	25.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0038	0.0257	0.4673
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0101	0.0941	0.1895
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0043	0.0308	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0091	0.028
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0237	0.0229
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0091	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0091	0.028
Mycobacterium ulcerans	hypothetical protein	0.0398	0.4136	1
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0257	0.0708
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.0514	0.1027
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0068	0.055
Toxoplasma gondii	thioredoxin reductase	0.0043	0.0308	0.5936
Brugia malayi	intermediate filament protein	0.0027	0.0139	0.0326
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0068	0.055
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0192	0.0184
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0091	0.021
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0091	0.028
Echinococcus granulosus	geminin	0.0342	0.3525	0.7148
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0191	0.0604
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0125	0.1012
Trypanosoma brucei	phosphonopyruvate decarboxylase-like protein, putative	0.0129	0.1235	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0588	0.1414
Loa Loa (eye worm)	thioredoxin reductase	0.0043	0.0308	0.0983
Brugia malayi	Pre-SET motif family protein	0.0251	0.2553	0.6168
Loa Loa (eye worm)	ILVBL protein	0.0241	0.2445	0.7891
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0068	0.0487
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0058	0.0473	0.1592
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0068	0.0487
Brugia malayi	hypothetical protein	0.0302	0.3097	0.7486
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.0514	0.0506
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0091	0.021
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0068	0.055
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0091	0.021
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0068	0.017
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0091	0.0168
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0015	0.0008	0.5
Toxoplasma gondii	isocitrate dehydrogenase	0.0032	0.0192	0.3632
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0237	0.065
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0091	0.0083
Echinococcus granulosus	thioredoxin glutathione reductase	0.0043	0.0314	0.0622
Schistosoma mansoni	hypothetical protein	0.0032	0.0191	0.052
Schistosoma mansoni	hypothetical protein	0.0038	0.0257	0.0708
Mycobacterium tuberculosis	Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS)	0.0398	0.4136	1
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0139	0.0435
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0091	0.021
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0101	0.0941	0.1895
Plasmodium falciparum	thioredoxin reductase	0.0043	0.0308	0.1308
Mycobacterium leprae	PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE)	0.0398	0.4136	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0101	0.0941	0.2652
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0101	0.0941	0.3028
Plasmodium vivax	thioredoxin reductase, putative	0.0043	0.0308	0.1308
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.0237	0.4523
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.0091	0.021
Mycobacterium leprae	Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS)	0.0398	0.4136	1
Onchocerca volvulus		0.0036	0.0237	0.0485
Onchocerca volvulus		0.0027	0.0139	0.0159
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0191	0.0452
Brugia malayi	glutathione reductase	0.0043	0.0308	0.0736
Giardia lamblia	Pyruvate-flavodoxin oxidoreductase	0.0058	0.0473	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0097	0.0897	0.2152
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0091	0.021
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0068	0.0487
Mycobacterium ulcerans	hypothetical protein	0.0129	0.1235	0.2971
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0068	0.0145
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0237	0.065
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0097	0.0897	0.2152
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.2553	0.824
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0068	0.026
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0091	0.0235
Schistosoma mansoni	DNA polymerase eta	0.002	0.0068	0.017
Leishmania major	phosphonopyruvate decarboxylase-like protein	0.0129	0.1235	0.5346
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0125	0.0952
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0058	0.0473	0.1592
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0068	0.055
Schistosoma mansoni	lamin	0.0027	0.0139	0.0372
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0068	0.0487
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0091	0.0235
Loa Loa (eye worm)	thiamine pyrophosphate enzyme	0.0228	0.2306	0.7443
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0091	0.021
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0097	0.0897	0.2152
Loa Loa (eye worm)	hypothetical protein	0.0302	0.3097	1
Trypanosoma brucei	unspecified product	0.002	0.0068	0.055
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0191	0.0183
Mycobacterium ulcerans	putative oxalyl-CoA decarboxylase	0.0398	0.4136	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0068	0.055
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0068	0.0206
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0058	0.0473	0.1592
Brugia malayi	hypothetical protein	0.0038	0.0257	0.0612
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0015	0.0008	0.0067
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0125	0.0509
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0015	0.0008	0.0009
Brugia malayi	hypothetical protein	0.0017	0.0027	0.0055
Schistosoma mansoni	hypothetical protein	0.0342	0.3525	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0514	0.1437
Entamoeba histolytica	hypothetical protein	0.0038	0.0257	0.4673
Trypanosoma cruzi	trypanothione reductase, putative	0.0043	0.0308	0.2447
Trypanosoma cruzi	phosphonopyruvate decarboxylase, putative	0.0129	0.1235	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0091	0.028
Schistosoma mansoni	thyroid hormone receptor	0.0175	0.1726	0.4886
Schistosoma mansoni	hypothetical protein	0.0069	0.0588	0.165
Loa Loa (eye worm)	hypothetical protein	0.0101	0.093	0.2995
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0068	0.0154
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0068	0.0154
Treponema pallidum	pyruvate oxidoreductase	0.0058	0.0473	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0091	0.021
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0091	0.028
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0068	0.055
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0032	0.0192	0.0606
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0068	0.055
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0238	0.241	0.778
Mycobacterium ulcerans	acetolactate synthase large subunit IlvB	0.0228	0.2302	0.5557
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0058	0.0473	0.1592
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0514	0.1225
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0091	0.0083
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0091	0.028
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0091	0.021
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0192	0.1497
Entamoeba histolytica	hypothetical protein	0.0038	0.0257	0.4673
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0152	0.1485	0.3001
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0139	0.0435
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0043	0.0314	0.0306
Brugia malayi	hypothetical protein	0.0026	0.0125	0.0292
Schistosoma mansoni	acetolactate synthase	0.0341	0.3512	0.9964
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0068	0.0145
Schistosoma mansoni	coup transcription factor	0.0022	0.0091	0.0235
Echinococcus granulosus	dna polymerase eta	0.002	0.0068	0.0121
Echinococcus multilocularis	dna polymerase eta	0.002	0.0068	0.006
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0191	0.0372
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0125	0.231
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0091	0.0168
Echinococcus multilocularis	lamin	0.0027	0.0139	0.0131
Leishmania major	DNA polymerase eta, putative	0.002	0.0068	0.026
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0035	0.0223	0.0436
Loa Loa (eye worm)	hypothetical protein	0.002	0.0068	0.0206
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0257	0.0506
Brugia malayi	Pre-SET motif family protein	0.0036	0.0237	0.0563
Schistosoma mansoni	hypothetical protein	0.0032	0.0191	0.052
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0191	0.0604
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.093	0.2242
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0091	0.028
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0068	0.0121
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0257	0.0249
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0091	0.0083
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0191	0.0183
Loa Loa (eye worm)	MH2 domain-containing protein	0.0135	0.1298	0.4184
Echinococcus granulosus	neuropeptide s receptor	0.0472	0.4928	1
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0058	0.0473	0.1592
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0097	0.0299
Trypanosoma brucei	phosphonopyruvate decarboxylase-like protein, putative	0.0129	0.1235	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0125	0.0509
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0068	0.055
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0192	0.0184
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0514	0.1225
Trichomonas vaginalis	set domain proteins, putative	0.0286	0.2926	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0472	0.4928	0.4924
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0101	0.0941	0.2267
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0032	0.0192	0.08
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0068	0.055
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0068	0.0145
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0091	0.0235
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0091	0.0235
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0514	0.1437
Brugia malayi	steroid hormone receptor	0.0022	0.0091	0.021
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0015	0.0008	0.5
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0152	0.1485	0.1478
Plasmodium falciparum	glutathione reductase	0.0043	0.0308	0.1308
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0091	0.028
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0091	0.0168
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0108	0.1014	0.2436
Schistosoma mansoni	thyroid hormone receptor	0.0175	0.1726	0.4886
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0091	0.021
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0139	0.0326
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0091	0.0083
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0091	0.0083
Entamoeba histolytica	hypothetical protein	0.0038	0.0257	0.4673
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.0237	0.065
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0108	0.1014	0.1142
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0091	0.028
Brugia malayi	Thioredoxin reductase	0.0043	0.0308	0.0736
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0091	0.021
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0101	0.0941	0.2652
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0125	0.039
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0091	0.028
Mycobacterium ulcerans	pyruvate or indole-3-pyruvate decarboxylase Pdc	0.0228	0.2302	0.5557
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0091	0.028
Leishmania major	DNA polymerase kappa, putative	0.002	0.0068	0.026
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0139	0.0372
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0015	0.0008	0.5
Mycobacterium tuberculosis	Probable oxalyl-CoA decarboxylase OxcA	0.0398	0.4136	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0091	0.021
Onchocerca volvulus		0.0286	0.2926	0.9432
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0091	0.0235
Mycobacterium tuberculosis	Probable oxidoreductase (beta subunit)	0.0058	0.0473	0.1125
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0015	0.0008	0.0067
Echinococcus granulosus	lamin dm0	0.0027	0.0139	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0139	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0091	0.028
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0192	0.1554
Loa Loa (eye worm)	transcription factor SMAD2	0.0135	0.1298	0.4184
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0068	0.055
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0091	0.021
Echinococcus multilocularis	lamin dm0	0.0027	0.0139	0.0131
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0091	0.0168
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.0068	0.0205
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0068	0.006
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0091	0.028
Echinococcus granulosus	histone lysine methyltransferase setb	0.0036	0.0237	0.0465
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.0514	0.2204
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0032	0.0192	0.08
Loa Loa (eye worm)	glutathione reductase	0.0043	0.0308	0.0983
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0237	0.065
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0068	0.055
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.0068	0.0205
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0091	0.0168
Echinococcus multilocularis	musashi	0.0027	0.0139	0.0131
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0032	0.0192	0.0184
Schistosoma mansoni	acetolactate synthase	0.0341	0.3512	0.9964
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0125	0.0952
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0015	0.0008	0.0067
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0091	0.0168
Giardia lamblia	DINP protein human, muc B family	0.002	0.0068	0.1286
Schistosoma mansoni	hypothetical protein	0.0152	0.1485	0.4198
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0237	0.0752
Schistosoma mansoni	hypothetical protein	0.0342	0.3525	1
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0097	0.0223
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0091	0.0235
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0101	0.0941	0.0933
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0091	0.021
Brugia malayi	nuclear hormone receptor	0.0022	0.0091	0.021
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0091	0.0235
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0032	0.0192	0.1554
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0068	0.055
Plasmodium vivax	glutathione reductase, putative	0.0043	0.0308	0.1308
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0032	0.0192	0.0522
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0091	0.028
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0191	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0588	0.1888
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0108	0.1014	0.2436
Mycobacterium ulcerans	acetolactate synthase	0.0228	0.2302	0.5557
Echinococcus multilocularis	isocitrate dehydrogenase	0.0032	0.0192	0.0184
Echinococcus granulosus	intermediate filament protein	0.0027	0.0139	0.0266
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0091	0.0235
Leishmania major	trypanothione reductase	0.0043	0.0308	0.1308
Plasmodium vivax	SET domain protein, putative	0.0036	0.0237	0.0997
Brugia malayi	isocitrate dehydrogenase	0.0032	0.0192	0.0454
Mycobacterium tuberculosis	Probable dehydrogenase	0.0097	0.0897	0.2152
Trypanosoma brucei	trypanothione reductase	0.0043	0.0308	0.2497
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0101	0.0941	0.0933
Mycobacterium ulcerans	acetolactate synthase 1 catalytic subunit	0.0398	0.4136	1
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0192	0.08
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0068	0.0487
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0068	0.017
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0091	0.0235
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0068	0.055
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0091	0.021
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0091	0.028
Mycobacterium tuberculosis	Probable reductase	0.0097	0.0897	0.2152
Brugia malayi	MH2 domain containing protein	0.0135	0.1298	0.3132
Echinococcus granulosus	lamin	0.0027	0.0139	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0134	0.0418
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0192	0.0184
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0191	0.0452
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0032	0.0192	0.0445
Echinococcus granulosus	dna polymerase kappa	0.002	0.0068	0.0121
Leishmania major	putative pyruvate/indole-pyruvate carboxylase, putative	0.0228	0.2302	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0097	0.0897	0.081
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0091	0.028
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0058	0.0473	0.1592
Brugia malayi	ecdysteroid receptor	0.0022	0.0091	0.021
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0015	0.0008	0.0067
Plasmodium vivax	acyl-CoA synthetase, putative	0.0228	0.2302	1
Mycobacterium ulcerans	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	0.0071	0.0611	0.1461
Schistosoma mansoni	lamin	0.0027	0.0139	0.0372
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.093	0.2242
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0091	0.0083
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0091	0.0168
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0068	0.055
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0097	0.0897	0.2152
Mycobacterium ulcerans	2-oxoglutarate ferredoxin oxidoreductase subunit beta	0.0058	0.0473	0.1125
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0091	0.0168
Echinococcus multilocularis	geminin	0.0342	0.3525	0.352
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0091	0.0083
Mycobacterium tuberculosis	Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase)	0.017	0.1683	0.4057
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0191	0.0372
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0068	0.006
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0091	0.0083
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0032	0.0192	0.1497
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.0068	0.0145
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0175	0.1726	0.172
Toxoplasma gondii	isocitrate dehydrogenase	0.0032	0.0192	0.3632
Onchocerca volvulus		0.0027	0.0139	0.0159
Echinococcus granulosus	neuropeptide receptor A26	0.0472	0.4928	1
Entamoeba histolytica	pyruvate:ferredoxin oxidoreductase	0.0058	0.0473	1
Trypanosoma cruzi	phosphonopyruvate decarboxylase, putative	0.0129	0.1235	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0091	0.021
Schistosoma mansoni	hypothetical protein	0.0032	0.0191	0.052
Brugia malayi	Thiamine pyrophosphate enzyme, central domain containing protein	0.0398	0.4136	1
Echinococcus multilocularis	neuropeptide s receptor	0.0472	0.4928	0.4924
Schistosoma mansoni	hypothetical protein	0.0032	0.0191	0.052
Mycobacterium tuberculosis	Probable oxidoreductase	0.0108	0.1014	0.2436
Brugia malayi	Isocitrate dehydrogenase	0.0032	0.0192	0.0454
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0091	0.021
Plasmodium falciparum	acyl-CoA synthetase	0.0228	0.2302	1
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0091	0.0235
Echinococcus granulosus	GPCR family 2	0.0032	0.0191	0.0372
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0125	0.0509
Onchocerca volvulus		0.0302	0.3097	1
Brugia malayi	follicle stimulating hormone receptor	0.0238	0.241	0.5823
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0125	0.0509
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0101	0.0941	0.2652
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.093	0.2995
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.0514	0.1225
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0514	0.1225
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0036	0.0237	0.0229
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.0514	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0032	0.0192	0.0373

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 31.6 nM	Inhibition of wild type Nicotiana tabacum (tobacco) GST-tagged acetolactate synthase expressed in Escherichia coli by modified Westerfeld method	ChEMBL.	10329466
IC50 (binding)	= 938.5 nM	Inhibition of wild type Nicotiana tabacum (tobacco) S4-Hra GST-tagged acetolactate synthase mutant expressed in Escherichia coli by modified Westerfeld method	ChEMBL.	10329466
IC50 (binding)	= 1.658 uM	Inhibition of ALS in ALS-herbicide-susceptible Raphanus raphanistrum WARR33 (wild radish)	ChEMBL.	22431132
IC50 (binding)	= 1.658 uM	Inhibition of ALS in ALS-herbicide-susceptible Raphanus raphanistrum WARR7 (wild radish)	ChEMBL.	22431132
IC50 (binding)	> 100 uM	Inhibition of ALS Ala122Tyr mutant in ALS-herbicide-resistant Raphanus raphanistrum WARR30 (wild radish) expressing ALS Ala122Tyr mutant	ChEMBL.	22431132
Ki (binding)	= 0.36 uM	Inhibition of wild type Arabidopsis thaliana acetolactate synthase by colorimetry	ChEMBL.	20598554
Potency (functional)	0.0035 uM	PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of thyroid hormone receptor beta signaling. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	32.6427 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (binding)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1389671

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1279535