Detailed information for compound 1282618

Basic information

Technical information
  • TDR Targets ID: 1282618
  • Name: T5568358
  • MW: 330.353 | Formula: C18H19FN2O3
  • H donors: 1 H acceptors: 2 LogP: 2.78 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)F)COC(=O)c1cc(n(c1C)C1CC1)C
  • InChi: 1S/C18H19FN2O3/c1-11-8-16(12(2)21(11)15-6-7-15)18(23)24-10-17(22)20-14-5-3-4-13(19)9-14/h3-5,8-9,15H,6-7,10H2,1-2H3,(H,20,22)
  • InChiKey: NHRFFDNXDYJGTQ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis set domain proteins, putative 0.0231 0.4728 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0156 0.2988 0.2971
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0087 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0169 0.3275 0.6746
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0047 0.0431 0.0407
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.2197 0.2177
Schistosoma mansoni hypothetical protein 0.0032 0.0087 0.0062
Schistosoma mansoni cathepsin S (C01 family) 0.0039 0.0264 0.024
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1687 0.1666
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0087 0.0087
Brugia malayi glutathione reductase 0.0037 0.0206 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Schistosoma mansoni hypothetical protein 0.0176 0.3451 0.3435
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1494 0.1494
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0039 0.0264 0.0209
Echinococcus granulosus cathepsin b 0.0457 1 1
Leishmania major cathepsin L-like protease 0.0298 0.6298 1
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0087 0.1369 0.1347
Echinococcus multilocularis cysteine protease 0.0156 0.2988 0.2971
Echinococcus multilocularis GPCR, family 2 0.0032 0.0087 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1494 0.1473
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0169 0.3275 0.5038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Onchocerca volvulus 0.0156 0.2988 0.6301
Onchocerca volvulus 0.0147 0.2779 0.5857
Trypanosoma cruzi cysteine peptidase, putative 0.0298 0.6298 0.6221
Plasmodium vivax glutathione reductase, putative 0.0037 0.0206 0.0611
Plasmodium vivax unspecified product 0.0087 0.1369 0.4534
Plasmodium falciparum cysteine proteinase falcipain 1 0.0087 0.1369 0.4179
Echinococcus granulosus cathepsin L 0.0087 0.1369 0.1369
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.2197 0.3268
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Echinococcus multilocularis cathepsin L 0.0087 0.1369 0.1347
Plasmodium vivax vivapain-2 0.0156 0.2988 1
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Brugia malayi hypothetical protein 0.0036 0.0178 0.0154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Toxoplasma gondii TIM10 family protein, putative 0.0047 0.0431 0.125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Brugia malayi MH2 domain containing protein 0.0116 0.2059 0.2039
Toxoplasma gondii preprocathepsin c precursor, putative 0.0039 0.0264 0.0737
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Giardia lamblia Cathepsin B precursor 0.0169 0.3275 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.1884 0.1864
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Plasmodium vivax serine-repeat antigen (SERA) 0.0039 0.0264 0.0808
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.1884 0.3629
Plasmodium falciparum serine repeat antigen 5 0.0039 0.0264 0.0209
Trypanosoma cruzi cysteine proteinase, putative 0.0087 0.1369 0.1187
Toxoplasma gondii cathepsin B 0.0169 0.3275 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0156 0.2988 0.2971
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.1369 0.2474
Brugia malayi hypothetical protein 0.0147 0.2779 0.2761
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.2197 0.2177
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.2197 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.1526 0.6628
Trypanosoma cruzi cysteine proteinase, putative 0.0087 0.1369 0.1187
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1687 0.1666
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0062
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Schistosoma mansoni cathepsin B (C01 family) 0.0039 0.0264 0.024
Brugia malayi Thioredoxin reductase 0.0037 0.0206 0.0182
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0039 0.0264 0.0808
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Loa Loa (eye worm) glutathione reductase 0.0037 0.0206 0.0182
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0039 0.0264 0.0808
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.1526 1
Schistosoma mansoni hypothetical protein 0.0032 0.0087 0.0062
Schistosoma mansoni hypothetical protein 0.0032 0.0087 0.0062
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0264 0.024
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.2988 0.2971
Onchocerca volvulus 0.0156 0.2988 0.6301
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0264 0.024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.2197 0.5
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0047 0.0431 0.0407
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0264 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Onchocerca volvulus 0.0156 0.2988 0.6301
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0431 0.125
Echinococcus granulosus cathepsin b 0.0457 1 1
Plasmodium vivax unspecified product 0.0047 0.0451 0.1438
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.1369 0.1908
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0268 0.0819
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0268 0.0243
Schistosoma mansoni hypothetical protein 0.0032 0.0087 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Schistosoma mansoni cathepsin F (C01 family) 0.0109 0.1884 0.1864
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0039 0.0264 0.0808
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.2988 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0264 0.024
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0268 0.0243
Echinococcus multilocularis cathepsin L cysteine protease 0.0156 0.2988 0.2971
Loa Loa (eye worm) hypothetical protein 0.0047 0.0451 0.0427
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0264 0.024
Brugia malayi cathepsin L-like cysteine proteinase 0.0039 0.0264 0.024
Onchocerca volvulus Cathepsin F homolog 0.0156 0.2988 0.6301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.1369 0.2474
Trypanosoma cruzi cysteine peptidase, putative 0.0298 0.6298 0.6221
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0025 0.0025
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0169 0.3275 0.3259
Trypanosoma cruzi cruzipain precursor, putative 0.0298 0.6298 0.6221
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.1494 0.1473
Brugia malayi cathepsin F-like cysteine proteinase 0.0047 0.0451 0.0427
Giardia lamblia Cathepsin B precursor 0.0169 0.3275 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0264 0.024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.1369 0.1908
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0039 0.0264 0.024
Trypanosoma cruzi cysteine peptidase, putative 0.0087 0.1369 0.1187
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0451 0.025
Echinococcus multilocularis expressed protein 0.0047 0.0431 0.0407
Toxoplasma gondii cathepsin CPL 0.0156 0.2988 0.9117
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0457 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0039 0.0264 0.024
Plasmodium falciparum serine repeat antigen 6 0.0039 0.0264 0.0209
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0268 0.0243
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0087 0.0087
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Plasmodium falciparum cysteine proteinase falcipain 3 0.0156 0.2988 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0039 0.0264 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Trypanosoma cruzi cysteine protease, putative 0.0087 0.1369 0.1187
Onchocerca volvulus Cathepsin L homolog 0.0156 0.2988 0.6301
Brugia malayi Cathepsin L-like precursor 0.0156 0.2988 0.2971
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0039 0.0264 0.024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0156 0.2988 0.2988
Entamoeba histolytica cysteine proteinase 1, putative 0.0087 0.1369 0.4054
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0156 0.2988 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.1494 0.1473
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.1307 0.553
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.2197 0.2197
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1494 0.1473
Brugia malayi Cathepsin L-like precursor 0.0156 0.2988 0.2971
Toxoplasma gondii cathepsin CPC1 0.0039 0.0264 0.0737
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0047 0.0431 0.0407
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.2197 0.6682
Toxoplasma gondii thioredoxin reductase 0.0037 0.0206 0.0557
Echinococcus granulosus cathepsin L cysteine proteinase 0.0156 0.2988 0.2988
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.1369 0.4054
Echinococcus granulosus cathepsin l1 0.0156 0.2988 0.2988
Onchocerca volvulus Cathepsin L homolog 0.0156 0.2988 0.6301
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0039 0.0264 0.0808
Giardia lamblia Cathepsin B precursor 0.0169 0.3275 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Entamoeba histolytica cysteine proteinase, putative 0.0109 0.1884 0.5946
Plasmodium falciparum serine repeat antigen 7 0.0039 0.0264 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Brugia malayi cathepsin F-like cysteine proteinase 0.0039 0.0264 0.024
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0156 0.2988 1
Leishmania major cathepsin L-like protease 0.0156 0.2988 0.4567
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0251 0.5194 0.5093
Leishmania major cathepsin L-like protease 0.0156 0.2988 0.4567
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1687 0.1666
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1494 0.1473
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0156 0.2988 0.2971
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0039 0.0264 0.0808
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0047 0.0451 0.0427
Onchocerca volvulus Cathepsin L homolog 0.0039 0.0264 0.0509
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.2197 0.2177
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0087 0.1369 0.1347
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.1307 0.553
Plasmodium falciparum serine repeat antigen 3 0.0039 0.0264 0.0209
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0039 0.0264 0.0808
Brugia malayi Cathepsin L-like precursor 0.0156 0.2988 0.2971
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0457 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.1307 0.553
Schistosoma mansoni cathepsin F (C01 family) 0.0156 0.2988 0.2971
Plasmodium falciparum serine repeat antigen 1 0.0039 0.0264 0.0209
Plasmodium falciparum serine repeat antigen 9 0.0039 0.0264 0.0209
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0431 0.081
Onchocerca volvulus 0.0156 0.2988 0.6301
Onchocerca volvulus 0.0039 0.0264 0.0509
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0087 0.0062
Toxoplasma gondii cathepsin CPC2 0.0039 0.0264 0.0737
Schistosoma mansoni cathepsin F (C01 family) 0.0156 0.2988 0.2971
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0039 0.0264 0.024
Plasmodium vivax vivapain-1 0.0087 0.1369 0.4534
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0087 0.1369 0.1187
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0087 0.0062
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.1884 0.1864
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2059 0.2039
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.1369 0.4054
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0218 0.0218
Plasmodium vivax serine-repeat antigen (SERA) 0.0039 0.0264 0.0808
Loa Loa (eye worm) fibroinase 0.0156 0.2988 0.2971
Loa Loa (eye worm) hypothetical protein 0.0069 0.0946 0.0924
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.1307 0.553
Echinococcus granulosus cathepsin L cysteine protease 0.0087 0.1369 0.1369
Brugia malayi hypothetical protein 0.0036 0.0178 0.0154
Brugia malayi Pre-SET motif family protein 0.0203 0.4075 0.406
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0268 0.0746
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0047 0.0451 0.0427
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0039 0.0264 0.0808
Echinococcus granulosus cathepsin l1 0.0109 0.1884 0.1884
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Echinococcus granulosus expressed protein 0.0047 0.0431 0.0431
Trypanosoma cruzi cysteine peptidase, putative 0.0298 0.6298 0.6221
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0039 0.0264 0.024
Plasmodium vivax unspecified product 0.0039 0.0264 0.0808
Leishmania major cysteine peptidase A (CPA) 0.0156 0.2988 0.4567
Brugia malayi Cathepsin L-like precursor 0.0047 0.0451 0.0427
Plasmodium falciparum serine repeat antigen 4 0.0039 0.0264 0.0209
Schistosoma mansoni hypothetical protein 0.0176 0.3451 0.3435
Leishmania major cathepsin L-like protease 0.0298 0.6298 1
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0206 0.0182
Echinococcus multilocularis cysteine protease 0.0156 0.2988 0.2971
Leishmania major cathepsin L-like protease 0.0156 0.2988 0.4567
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0457 1 1
Schistosoma mansoni cathepsin C 0.0039 0.0264 0.024
Loa Loa (eye worm) cathepsin B 0.0169 0.3275 0.3259
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Brugia malayi Cathepsin L-like precursor 0.0156 0.2988 0.2971
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0431 0.1372
Echinococcus multilocularis geminin 0.0176 0.3451 0.3435
Echinococcus granulosus cathepsin L 0.0039 0.0264 0.0264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0264 0.024
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0039 0.0264 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.1526 0.6628
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0264 0.024
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0039 0.0264 0.0808
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0087 0.1369 0.1347
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0457 1 1
Onchocerca volvulus 0.0231 0.4728 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0087 0.0062
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0039 0.0264 0.0209
Echinococcus multilocularis cathepsin L 0.0039 0.0264 0.024
Brugia malayi cathepsin L precursor 0.0039 0.0264 0.024
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0264 0.024
Schistosoma mansoni hypothetical protein 0.0069 0.0946 0.0924
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Echinococcus multilocularis cathepsin b 0.0457 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.1884 0.3629
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0457 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.1369 0.4054
Leishmania major cathepsin L-like protease 0.0156 0.2988 0.4567
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Plasmodium vivax vivapain-3 0.0087 0.1369 0.4534
Brugia malayi Papain family cysteine protease containing protein 0.0087 0.1369 0.1347
Loa Loa (eye worm) hypothetical protein 0.0039 0.0264 0.024
Plasmodium vivax vivapain-2 0.0156 0.2988 1
Brugia malayi Cathepsin L-like precursor 0.0109 0.1884 0.1864
Brugia malayi cathepsin L-like precursor 0.0109 0.1884 0.1864
Loa Loa (eye worm) hypothetical protein 0.0047 0.0451 0.0427
Leishmania major cathepsin L-like protease 0.0298 0.6298 1
Onchocerca volvulus 0.0156 0.2988 0.6301
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.1526 0.6628
Loa Loa (eye worm) hypothetical protein 0.0109 0.1884 0.1864
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.2988 0.2841
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.4075 0.406
Brugia malayi Cathepsin L-like precursor 0.0156 0.2988 0.2971
Schistosoma mansoni cathepsin s 0.0047 0.0451 0.0427
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0087 0.0062
Loa Loa (eye worm) hypothetical protein 0.004 0.0268 0.0243
Plasmodium falciparum serine repeat antigen 2 0.0039 0.0264 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1494 0.1473
Loa Loa (eye worm) hypothetical protein 0.0047 0.0451 0.0427
Trypanosoma brucei cysteine peptidase C (CPC) 0.0169 0.3275 0.5038
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.2197 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1494 0.1473
Plasmodium falciparum serine repeat antigen 8 0.0039 0.0264 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Trypanosoma cruzi major cysteine proteinase, putative 0.0181 0.3574 0.3439
Mycobacterium tuberculosis Probable reductase 0.0084 0.1307 0.553
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0264 0.024
Loa Loa (eye worm) ctsf protein 0.0156 0.2988 0.2971
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0169 0.3275 0.3134
Loa Loa (eye worm) hypothetical protein 0.0147 0.2779 0.2761
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0039 0.0264 0.0808
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0946 0.0924
Leishmania major cathepsin L-like protease 0.0156 0.2988 0.4567
Brugia malayi cathepsin Z-like cysteine proteinase 0.0039 0.0264 0.024
Echinococcus multilocularis cathepsin b 0.0457 1 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0039 0.0264 0.024
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0156 0.2988 0.2971
Loa Loa (eye worm) hypothetical protein 0.0156 0.2988 0.2971
Onchocerca volvulus 0.0156 0.2988 0.6301
Trypanosoma cruzi cruzipain precursor, putative 0.0047 0.0451 0.025
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Entamoeba histolytica cysteine proteinase 2 0.0087 0.1369 0.4054
Onchocerca volvulus 0.0109 0.1884 0.3953
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0206 0.0611
Brugia malayi cathepsin Z-like cysteine proteinase 0.0039 0.0264 0.024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.2197 0.5
Onchocerca volvulus 0.0156 0.2988 0.6301
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0156 0.2988 0.2971
Loa Loa (eye worm) hypothetical protein 0.0039 0.0264 0.024
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0268 0.0243
Brugia malayi fibroinase precursor 0.0039 0.0264 0.024
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0039 0.0264 0.024
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2059 0.2039
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0039 0.0264 0.0209
Loa Loa (eye worm) cysteine protease 0.0156 0.2988 0.2971
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1494 0.1494
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.1369 0.4054
Entamoeba histolytica cysteine protease, putative 0.0156 0.2988 1
Schistosoma mansoni hypothetical protein 0.004 0.0268 0.0243
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.2988 1
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0268 0.0221
Loa Loa (eye worm) hypothetical protein 0.0039 0.0264 0.024
Brugia malayi Cathepsin L-like cysteine proteinase 0.0109 0.1884 0.1864
Echinococcus granulosus geminin 0.0176 0.3451 0.3451
Brugia malayi Cathepsin L-like precursor 0.0156 0.2988 0.2971
Echinococcus granulosus cysteine protease 0.0087 0.1369 0.1369
Loa Loa (eye worm) hypothetical protein 0.01 0.1687 0.1666
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0039 0.0264 0.0808
Loa Loa (eye worm) hypothetical protein 0.0457 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0156 0.2988 0.6103
Brugia malayi Cathepsin L-like precursor 0.0109 0.1884 0.1864
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.1307 0.553
Loa Loa (eye worm) hypothetical protein 0.0039 0.0264 0.024
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0218 0.0193
Echinococcus granulosus GPCR family 2 0.0032 0.0087 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0087 0.1369 0.1347
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0156 0.2988 0.6103

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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