Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | polycystin 1-related | 0.004 | 0.0341 | 0.0318 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.004 | 0.0341 | 0.0544 |
Schistosoma mansoni | lipoxygenase | 0.0178 | 0.5862 | 0.5852 |
Trypanosoma cruzi | UDP-galactose 4-epimerase, putative | 0.0101 | 0.2787 | 0.5 |
Brugia malayi | Doublecortin family protein | 0.004 | 0.0341 | 0.0318 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0602 | 0.099 |
Echinococcus granulosus | RUN | 0.004 | 0.0341 | 0.0544 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0602 | 0.0579 |
Trypanosoma brucei | UDP-galactose 4-epimerase | 0.0105 | 0.2953 | 0.5 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.004 | 0.0341 | 0.5 |
Brugia malayi | UDP galactose 4'-epimerase | 0.0101 | 0.2787 | 0.277 |
Leishmania major | udp-glc 4-epimerase, putative | 0.0105 | 0.2953 | 0.5 |
Plasmodium falciparum | LCCL domain-containing protein | 0.004 | 0.0341 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0024 | 0.0024 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0602 | 0.099 |
Echinococcus multilocularis | UDP glucose 4 epimerase | 0.0101 | 0.2787 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.6058 | 0.6058 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.004 | 0.0341 | 0.0544 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0341 | 0.0341 |
Schistosoma mansoni | rab6-interacting | 0.004 | 0.0341 | 0.0318 |
Brugia malayi | hypothetical protein | 0.004 | 0.0341 | 0.0318 |
Echinococcus multilocularis | RUN | 0.004 | 0.0341 | 0.0544 |
Onchocerca volvulus | 0.004 | 0.0341 | 0.0526 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0024 | 0.0024 |
Trypanosoma cruzi | UDP-galactose 4-epimerase | 0.0101 | 0.2787 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0602 | 0.0579 |
Loa Loa (eye worm) | UDP galactose 4'-epimerase | 0.0101 | 0.2787 | 0.2787 |
Toxoplasma gondii | UDP-glucose 4-epimerase | 0.0101 | 0.2787 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0602 | 0.0579 |
Schistosoma mansoni | rab6-interacting | 0.004 | 0.0341 | 0.0318 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.004 | 0.0341 | 0.0544 |
Schistosoma mansoni | UDP-glucose 4-epimerase | 0.0101 | 0.2787 | 0.277 |
Brugia malayi | hypothetical protein | 0.004 | 0.0341 | 0.0318 |
Schistosoma mansoni | loxhd1 | 0.004 | 0.0341 | 0.0318 |
Entamoeba histolytica | UDP-glucose 4-epimerase, putative | 0.0101 | 0.2787 | 0.5 |
Giardia lamblia | UDP-glucose 4-epimerase | 0.0105 | 0.2953 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0602 | 0.0579 |
Loa Loa (eye worm) | doublecortin family protein | 0.004 | 0.0341 | 0.0341 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0178 | 0.5862 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0341 | 0.0341 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.004 | 0.0341 | 0.0544 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0602 | 0.099 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0178 | 0.5862 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0341 | 0.0318 |
Echinococcus granulosus | UDP glucose 4 epimerase | 0.0101 | 0.2787 | 0.4733 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0602 | 0.0602 |
Brugia malayi | hypothetical protein | 0.0182 | 0.6058 | 0.6048 |
Onchocerca volvulus | 0.004 | 0.0341 | 0.0526 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0602 | 0.099 |
Schistosoma mansoni | lipoxygenase | 0.0105 | 0.2932 | 0.2915 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.004 | 0.0341 | 0.0544 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0024 | 0.0024 |
Onchocerca volvulus | 0.0182 | 0.6058 | 1 | |
Echinococcus granulosus | Polycystic kidney disease protein | 0.004 | 0.0341 | 0.0544 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.