Detailed information for compound 1287696

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 558.61 | Formula: C26H33F3N2O6S
  • H donors: 1 H acceptors: 5 LogP: 2.01 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.CCC(Sc1ccc(cc1)[C@@H]1[C@H]2C(=O)N(C(=O)[C@H]2[C@]2(N1CCCC2)C(=O)OC)CC)C
  • InChi: 1S/C24H32N2O4S.C2HF3O2/c1-5-15(3)31-17-11-9-16(10-12-17)20-18-19(22(28)25(6-2)21(18)27)24(23(29)30-4)13-7-8-14-26(20)24;3-2(4,5)1(6)7/h9-12,15,18-20H,5-8,13-14H2,1-4H3;(H,6,7)/t15?,18-,19-,20+,24-;/m0./s1
  • InChiKey: AXGWJTOVBYCSDE-KSIBEGPGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Animal haem peroxidase family protein 0.0156 0.0568 0.0568
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0029 0.0011 0.1549
Echinococcus granulosus epidermal growth factor receptor 0.0179 0.0668 0.0658
Echinococcus multilocularis peroxidasin 0.0156 0.0568 0.0558
Schistosoma mansoni hypothetical protein 0.0039 0.0057 0.0046
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0076 0.1286
Brugia malayi beta-lactamase family protein 0.0043 0.0076 0.0076
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0038 0.0052 0.114
Echinococcus multilocularis solute carrier family 5 0.0042 0.007 0.0059
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0043 0.0072 0.0202
Loa Loa (eye worm) TK/EGFR protein kinase 0.0179 0.0668 0.0668
Schistosoma mansoni hypothetical protein 0.0063 0.0162 0.0151
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0038 0.0052 0.0454
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0234 0.0906 0.0896
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0127 0.0116
Schistosoma mansoni tyrosine kinase 0.0176 0.0655 0.0644
Giardia lamblia Aldose reductase 0.0131 0.0459 1
Mycobacterium ulcerans hypothetical protein 0.0048 0.0094 0.0287
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0094 0.066
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0042 0.007 0.1518
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0043 0.0072 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0076 0.1286
Brugia malayi Animal haem peroxidase family protein 0.0156 0.0568 0.0568
Entamoeba histolytica aldose reductase, putative 0.0131 0.0459 0.3879
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0503 0.208 0.2071
Loa Loa (eye worm) hypothetical protein 0.0051 0.0107 0.0107
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0172 0.0161
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0172 0.0172
Onchocerca volvulus 0.0131 0.0459 0.0449
Schistosoma mansoni tyrosine kinase 0.0179 0.0668 0.0658
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0515 0.0515
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0019 0.0168
Entamoeba histolytica aldose reductase, putative 0.0131 0.0459 0.3879
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0095 0.0301 0.0301
Onchocerca volvulus Peroxidasin homolog 0.0156 0.0568 0.0558
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0031 0.0019 0.0423
Mycobacterium leprae Conserved hypothetical protein 0.0093 0.0293 0.6228
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0094 0.0287
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0094 0.066
Brugia malayi SWIRM domain containing protein 0.0043 0.0072 0.0072
Loa Loa (eye worm) oxidoreductase 0.0131 0.0459 0.0459
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0094 0.0094
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0029 0.0011 0.1549
Schistosoma mansoni tyrosine kinase 0.0394 0.1606 0.1596
Echinococcus multilocularis 0.0052 0.0111 0.01
Brugia malayi Animal haem peroxidase family protein 0.0156 0.0568 0.0568
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0127 0.0116
Mycobacterium tuberculosis Conserved protein 0.0038 0.0052 0.0074
Entamoeba histolytica alcohol dehydrogenase, putative 0.0038 0.0052 0.0291
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.0568 0.0568
Schistosoma mansoni tar DNA-binding protein 0.0076 0.022 0.0209
Schistosoma mansoni DNA ligase IV 0.0031 0.0019 0.0008
Echinococcus multilocularis high affinity choline transporter 1 0.0381 0.1548 0.1538
Entamoeba histolytica hypothetical protein 0.0043 0.0076 0.0497
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0291 0.1153 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0076 0.0076
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0057 0.0046
Plasmodium vivax aldehyde reductase, putative 0.0038 0.0052 0.6894
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0138 0.0126
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0076 0.0659
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0029 0.0011 0.1549
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0042 0.007 0.0059
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0042
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0306 0.0295
Toxoplasma gondii ABC1 family protein 0.0043 0.0076 0.1654
Mycobacterium ulcerans oxidoreductase 0.0043 0.0072 0.0202
Echinococcus granulosus aldehyde reductase 0.0093 0.0293 0.0282
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0042 0.007 0.0059
Onchocerca volvulus Dual oxidase homolog 0.0156 0.0568 0.0558
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0306 0.0306
Brugia malayi mbt repeat family protein 0.0058 0.0138 0.0138
Trichomonas vaginalis aldo/keto reductase, putative 0.0131 0.0459 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0094 0.0287
Plasmodium vivax replication factor C subunit 1, putative 0.0031 0.0019 0.2556
Plasmodium falciparum aldehyde reductase, putative 0.0038 0.0052 0.7254
Echinococcus multilocularis aldo keto reductase 0.0131 0.0459 0.0449
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0043 0.0072 0.9505
Echinococcus multilocularis nibrin 0.0031 0.0019 0.0008
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0291 0.1153 0.1153
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0131 0.0459 0.0459
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0042 0.007 0.0059
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Schistosoma mansoni chromosome transmission fidelity factor 0.0031 0.0019 0.0008
Schistosoma mansoni high-affinity choline transporter 0.0381 0.1548 0.1538
Schistosoma mansoni tyrosine kinase 0.0176 0.0655 0.0644
Loa Loa (eye worm) hypothetical protein 0.0031 0.0019 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0127 0.0116
Brugia malayi GH02984p 0.0381 0.1548 0.1548
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0094 0.0094
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0043 0.0072 0.0061
Schistosoma mansoni hypothetical protein 0.0503 0.208 0.2071
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0138 0.0126
Onchocerca volvulus 0.0042 0.007 0.0059
Echinococcus multilocularis aldo keto reductase 0.0131 0.0459 0.0449
Schistosoma mansoni peroxidasin 0.0156 0.0568 0.0558
Leishmania major UDP-galactopyranose mutase 0.0043 0.0072 0.0626
Loa Loa (eye worm) beta-lactamase 0.0043 0.0076 0.0076
Mycobacterium ulcerans beta-lactamase 0.0043 0.0076 0.0217
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0052 0.0749
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0042 0.0033
Onchocerca volvulus Chorion peroxidase homolog 0.0156 0.0568 0.0558
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Schistosoma mansoni serine/threonine protein kinase 0.0291 0.1153 0.1143
Loa Loa (eye worm) hypothetical protein 0.0048 0.0094 0.0094
Echinococcus granulosus epidermal growth factor receptor 0.0179 0.0668 0.0658
Plasmodium falciparum aldo-keto reductase, putative 0.0038 0.0052 0.7254
Brugia malayi mbt repeat family protein 0.0058 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0486 0.0475
Schistosoma mansoni hypothetical protein 0.004 0.006 0.0049
Loa Loa (eye worm) hypothetical protein 0.0048 0.0094 0.0094
Onchocerca volvulus 0.0043 0.0072 0.0061
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0094 0.066
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0094 0.0094
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0076 0.0065
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0052 0.0749
Mycobacterium ulcerans lipase LipD 0.0043 0.0076 0.0217
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Mycobacterium tuberculosis Conserved protein 0.0043 0.0076 0.0165
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0094 0.0235
Schistosoma mansoni inositol transporter 0.0042 0.007 0.0059
Treponema pallidum DNA ligase (lig) 0.0031 0.0019 0.5
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.0052 0.0454
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0127 0.0116
Entamoeba histolytica protein kinase, putative 0.0291 0.1153 1
Mycobacterium ulcerans hypothetical protein 0.0038 0.0052 0.0126
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0094 0.0287
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0038 0.0052 0.6894
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Schistosoma mansoni amine oxidase 0.0043 0.0072 0.0061
Onchocerca volvulus 0.0039 0.0057 0.0046
Loa Loa (eye worm) oxidoreductase 0.0131 0.0459 0.0459
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0094 0.1701
Loa Loa (eye worm) hypothetical protein 0.0042 0.007 0.007
Onchocerca volvulus 0.0131 0.0459 0.0449
Brugia malayi amine oxidase, flavin-containing family protein 0.0043 0.0072 0.0072
Loa Loa (eye worm) TAR-binding protein 0.0076 0.022 0.022
Mycobacterium ulcerans hypothetical protein 0.0043 0.0076 0.0217
Schistosoma mansoni tar DNA-binding protein 0.0076 0.022 0.0209
Echinococcus multilocularis protein dispatched 1 0.0047 0.0092 0.0081
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0394 0.1606 0.1596
Loa Loa (eye worm) oxidoreductase 0.0131 0.0459 0.0459
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0066 0.0066
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0031 0.0019 0.5
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0138 0.0138
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0094 0.0817
Brugia malayi DnaJ domain containing protein 0.0063 0.0162 0.0162
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0043 0.0072 0.0061
Brugia malayi Animal haem peroxidase family protein 0.0156 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0043 0.0076 0.0076
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.0568 0.0568
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0072 0.9505
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.0876 0.0866
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0605 0.2524 0.9603
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1097 0.4101
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0031 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0043 0.0076 0.0065
Giardia lamblia Aldose reductase 0.0131 0.0459 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0127 0.0116
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.0568 0.0568
Plasmodium falciparum replication factor C subunit 1, putative 0.0031 0.0019 0.2689
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.0301 0.0301
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0138 0.0126
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0042 0.0085
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0057 0.0046
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0011
Echinococcus granulosus sodium:myo inositol cotransporter 0.0042 0.007 0.0059
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0011 0.1473
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0131 0.0459 1
Leishmania major hypothetical protein, unknown function 0.0029 0.0011 0.0097
Brugia malayi hypothetical protein 0.0031 0.0019 0.0019
Echinococcus multilocularis dnaJ subfamily C 6 0.0063 0.0162 0.0151
Leishmania major aldo-keto reductase-like protein 0.0131 0.0459 0.3982
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.0301 0.0301
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0094 0.0287
Loa Loa (eye worm) hypothetical protein 0.0031 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0205 0.0778 0.0768
Echinococcus multilocularis RUN 0.0039 0.0057 0.0046
Brugia malayi MH2 domain containing protein 0.0144 0.0515 0.0515
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Brugia malayi Sodium:solute symporter family protein 0.0042 0.007 0.007
Echinococcus granulosus geminin 0.0205 0.0778 0.0768
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0031 0.0019 0.0019
Onchocerca volvulus 0.0095 0.0301 0.029
Loa Loa (eye worm) hypothetical protein 0.0146 0.0523 0.0523
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0291 0.1153 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0094 0.0094
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0149 0.0149
Schistosoma mansoni hypothetical protein 0.0205 0.0778 0.0768
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0306 0.0295
Onchocerca volvulus 0.0095 0.0301 0.029
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0076 0.0065
Echinococcus granulosus RUN 0.0039 0.0057 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0011 0.1473
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0138 0.0126
Brugia malayi hypothetical protein 0.0043 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0058 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.0041 0.0066 0.0055
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0052 0.0749
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0291 0.1153 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0057 0.75
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0131 0.0459 1
Entamoeba histolytica protein kinase domain containing protein 0.0291 0.1153 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Loa Loa (eye worm) hypothetical protein 0.0043 0.0076 0.0076
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0072 0.0061
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0043 0.0072 0.12
Entamoeba histolytica hypothetical protein 0.0291 0.1153 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0076 0.0065
Loa Loa (eye worm) RNA binding protein 0.0076 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Echinococcus multilocularis epidermal growth factor receptor 0.0179 0.0668 0.0658
Echinococcus granulosus high affinity choline transporter 1 0.0381 0.1548 0.1538
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0131 0.0459 0.0459
Echinococcus granulosus aldo keto reductase 0.0131 0.0459 0.0449
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0043 0.0072 0.0061
Onchocerca volvulus 0.0131 0.0459 0.0449
Loa Loa (eye worm) hypothetical protein 0.0043 0.0076 0.0076
Schistosoma mansoni tyrosine kinase 0.0394 0.1606 0.1596
Toxoplasma gondii ATPase, AAA family protein 0.0031 0.0019 0.0423
Loa Loa (eye worm) hypothetical protein 0.0215 0.0824 0.0824
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0042 0.5489
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0605 0.2524 0.9603
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0172 0.0161
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0057
Onchocerca volvulus Peroxidase homolog 0.0156 0.0568 0.0558
Echinococcus multilocularis replication factor c subunit 1 0.0031 0.0019 0.0008
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Onchocerca volvulus 0.0095 0.0301 0.029
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Entamoeba histolytica hypothetical protein 0.0043 0.0076 0.0497
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0019 0.0168
Brugia malayi RNA binding protein 0.0076 0.022 0.022
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0076 0.0065
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0057 0.0046
Onchocerca volvulus 0.0156 0.0568 0.0558
Mycobacterium ulcerans hypothetical protein 0.0339 0.1362 0.5149
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0291 0.1153 1
Schistosoma mansoni tyrosine kinase 0.0179 0.0668 0.0658
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0076 0.1286
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0038 0.0052 0.0052
Echinococcus multilocularis insulin receptor 0.0394 0.1606 0.1596
Trypanosoma brucei aldo/keto reductase, putative 0.0038 0.0052 0.0454
Leishmania major hypothetical protein, conserved 0.0043 0.0076 0.0659
Trypanosoma cruzi FHA domain containing protein, putative 0.0031 0.0019 0.0168
Schistosoma mansoni lipoxygenase 0.0164 0.0599 0.0589
Loa Loa (eye worm) tyrosinase 1 0.0095 0.0301 0.0301
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.022 0.022
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0038 0.0052 0.0041
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0138 0.0126
Brugia malayi hypothetical protein 0.0039 0.0057 0.0057
Brugia malayi ShTK domain containing protein 0.0095 0.0301 0.0301
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0076 0.0076
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0306 0.2525
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0076 0.0659
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Loa Loa (eye worm) hypothetical protein 0.0276 0.1089 0.1089
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0076 0.1286
Echinococcus granulosus insulin receptor 0.0394 0.1606 0.1596
Schistosoma mansoni patched 1 0.0041 0.0066 0.0055
Brugia malayi hypothetical protein 0.0031 0.0019 0.0019
Onchocerca volvulus 0.0202 0.0766 0.0756
Loa Loa (eye worm) hypothetical protein 0.0031 0.0019 0.0019
Entamoeba histolytica alcohol dehydrogenase, putative 0.0038 0.0052 0.0291
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0475 0.1955 0.1946
Brugia malayi Muscleblind-like protein 0.0146 0.0523 0.0523
Mycobacterium ulcerans monoamine oxidase 0.0043 0.0072 0.0202
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.022 0.022
Onchocerca volvulus 0.0131 0.0459 0.0449
Schistosoma mansoni loxhd1 0.0039 0.0057 0.0046
Brugia malayi RE40412p 0.0029 0.0011 0.0011
Brugia malayi Common central domain of tyrosinase family protein 0.0095 0.0301 0.0301
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0342 0.1377 0.1368
Onchocerca volvulus 0.0039 0.0057 0.0046
Brugia malayi Peroxidasin 0.0156 0.0568 0.0568
Echinococcus granulosus tar DNA binding protein 0.0076 0.022 0.0209
Mycobacterium ulcerans oxidoreductase 0.0131 0.0459 0.1686
Schistosoma mansoni aldo-keto reductase 0.0131 0.0459 0.0449
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0475 0.1955 0.1946
Schistosoma mansoni tyrosine kinase 0.0176 0.0655 0.0644
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0072 0.9505
Brugia malayi DKFZp564C0469 protein 0.0031 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0042 0.5775
Echinococcus multilocularis muscleblind protein 0.0146 0.0523 0.0512
Echinococcus granulosus sodium:glucose cotransporter 2 0.0042 0.007 0.0059
Loa Loa (eye worm) MBCTL1 0.0066 0.0172 0.0172
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0057 0.0046
Echinococcus granulosus sodium:glucose cotransporter 0.0042 0.007 0.0059
Onchocerca volvulus Peroxidase homolog 0.0156 0.0568 0.0558
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Mycobacterium leprae Probable lipase LipE 0.0043 0.0076 0.1286
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Trichomonas vaginalis esterase, putative 0.0043 0.0076 0.1286
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0042
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0138 0.0126
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0011 0.1473
Schistosoma mansoni topbp1 0.0031 0.0019 0.0008
Echinococcus multilocularis expressed conserved protein 0.009 0.028 0.0269
Loa Loa (eye worm) hypothetical protein 0.0031 0.0019 0.0019
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0038 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0066
Echinococcus granulosus expressed conserved protein 0.009 0.028 0.0269
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0076 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0057 0.0046
Loa Loa (eye worm) hypothetical protein 0.0095 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Schistosoma mansoni lipoxygenase 0.0234 0.0906 0.0896
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0342 0.1377 0.1377
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0342 0.1377 0.1368
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0019 0.0168
Onchocerca volvulus 0.0043 0.0076 0.0065
Echinococcus granulosus replication factor c subunit 1 0.0031 0.0019 0.0008
Schistosoma mansoni amine oxidase 0.0043 0.0072 0.0061
Brugia malayi Doublecortin family protein 0.0039 0.0057 0.0057
Schistosoma mansoni peroxidasin 0.0156 0.0568 0.0558
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.0568 0.0568
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0342 0.1377 0.1377
Brugia malayi Pax transcription activation domain interacting protein 0.0031 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Brugia malayi topoisomerase 0.0031 0.0019 0.0019
Brugia malayi TAR-binding protein 0.0076 0.022 0.022
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0131 0.0459 0.0459
Toxoplasma gondii zinc finger cdgsh type protein 0.0029 0.0011 0.0244
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0019 0.0168
Schistosoma mansoni tar DNA-binding protein 0.0076 0.022 0.0209
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0131 0.0459 0.0459
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0094 0.0817
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0138 0.0126
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0094 0.1701
Onchocerca volvulus 0.0031 0.0019 0.0008
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Entamoeba histolytica hypothetical protein 0.0043 0.0076 0.0497
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0043 0.0072 0.015
Echinococcus granulosus muscleblind protein 0.0146 0.0523 0.0512
Onchocerca volvulus Peroxidasin homolog 0.0156 0.0568 0.0558
Echinococcus granulosus hypothetical protein 0.0131 0.0459 0.0449
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0076 0.0165
Schistosoma mansoni tyrosinase precursor 0.0095 0.0301 0.029
Brugia malayi Protein kinase domain containing protein 0.0291 0.1153 0.1153
Mycobacterium leprae Possible oxidoreductase 0.0038 0.0052 0.0749
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0127 0.0127
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0066 0.0055
Schistosoma mansoni topbp1 0.0031 0.0019 0.0008
Brugia malayi Protein kinase domain containing protein 0.0218 0.0837 0.0837
Schistosoma mansoni hypothetical protein 0.004 0.006 0.0049
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0043 0.0072 0.1572
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0076 0.0217
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0094 0.0287
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0031 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.004 0.006 0.0049
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0127 0.0116
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.0876 0.0866
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0486 0.0475
Echinococcus multilocularis aldo keto reductase 0.0131 0.0459 0.0449
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0066 0.0066
Mycobacterium tuberculosis Conserved protein 0.0043 0.0076 0.0165
Onchocerca volvulus 0.0131 0.0459 0.0449
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0076 0.0165
Loa Loa (eye worm) TK/INSR protein kinase 0.0394 0.1606 0.1606
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0072 0.0626
Toxoplasma gondii aldo-keto reductase 0.0038 0.0052 0.114
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0131 0.0459 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0094 0.0287
Echinococcus granulosus nibrin 0.0031 0.0019 0.0008
Loa Loa (eye worm) hypothetical protein 0.0276 0.1089 0.1089
Echinococcus multilocularis aldo keto reductase 0.0131 0.0459 0.0449
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0172 0.0161
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0312 0.0301
Echinococcus granulosus voltage gated potassium channel subunit 0.0038 0.0052 0.0041
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0394 0.1606 0.1596
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0057 0.7891
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0072 0.015
Loa Loa (eye worm) ShTK domain-containing protein 0.0095 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0381 0.1548 0.1548
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0149 0.0149
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0038 0.0052 0.0749
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0138 0.0126
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0076 0.0165
Toxoplasma gondii PfMNL-2 CISD1 family iron-sulfur protein, putative 0.0029 0.0011 0.0244
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0076 0.0217
Echinococcus granulosus aldo keto reductase 0.0131 0.0459 0.0449
Echinococcus multilocularis aldehyde reductase 0.0093 0.0293 0.0282
Schistosoma mansoni polycystin 1-related 0.0039 0.0057 0.0046
Mycobacterium tuberculosis Conserved protein 0.0043 0.0076 0.0165
Entamoeba histolytica hypothetical protein 0.0043 0.0076 0.0497
Schistosoma mansoni rab6-interacting 0.0039 0.0057 0.0046
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0011
Onchocerca volvulus 0.0131 0.0459 0.0449
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0172 0.0161
Echinococcus multilocularis voltage gated potassium channel subunit 0.0038 0.0052 0.0041
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0042 0.007 0.0059
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0057 0.0046
Entamoeba histolytica aldose reductase, putative 0.0131 0.0459 0.3879
Schistosoma mansoni aldo-keto reductase 0.0131 0.0459 0.0449
Onchocerca volvulus 0.0156 0.0568 0.0558
Toxoplasma gondii aldose reductase, putative 0.0131 0.0459 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0094 0.0287
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0057
Schistosoma mansoni rab6-interacting 0.0039 0.0057 0.0046
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0629 0.2627 1
Loa Loa (eye worm) hypothetical protein 0.0202 0.0766 0.0766
Schistosoma mansoni hypothetical protein 0.035 0.1413 0.1403
Echinococcus granulosus aldo keto reductase 0.0131 0.0459 0.0449
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0076 0.1286
Loa Loa (eye worm) hypothetical protein 0.0146 0.0523 0.0523
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0094 0.0235
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0131 0.0459 0.3982
Trichomonas vaginalis aldo/keto reductase, putative 0.0131 0.0459 1
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0202 0.0766 0.0766
Loa Loa (eye worm) hypothetical protein 0.0043 0.0076 0.0076
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0515 0.0515
Brugia malayi Animal haem peroxidase family protein 0.0156 0.0568 0.0568
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0172 0.0161
Schistosoma mansoni pol-related 0.0131 0.0459 0.0449
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.006 0.0149 0.0149
Toxoplasma gondii zinc finger CDGSH-type domain-containing protein 0.0029 0.0011 0.0244
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0076 0.0659
Loa Loa (eye worm) hypothetical protein 0.0095 0.0301 0.0301
Trichomonas vaginalis protein kinase inhibitor, putative 0.0063 0.0162 0.325
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0072 0.0626
Schistosoma mansoni hypothetical protein 0.004 0.006 0.0049
Echinococcus multilocularis protoporphyrinogen oxidase 0.0043 0.0072 0.0061
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Echinococcus granulosus dual specificity 0.0291 0.1153 0.1143
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0072 0.0061
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0076 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0066 0.1068
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0076 0.1286
Loa Loa (eye worm) ShTK domain-containing protein 0.0095 0.0301 0.0301
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0076 0.0165
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0043 0.0072 1
Brugia malayi hypothetical protein 0.0039 0.0057 0.0057
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0038 0.0052 0.114
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0629 0.2627 1
Schistosoma mansoni tyrosinase precursor 0.0095 0.0301 0.029
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0076 0.0076
Mycobacterium ulcerans dehydrogenase 0.0043 0.0072 0.0202
Echinococcus multilocularis protein patched 0.0041 0.0066 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0052 0.0749
Plasmodium falciparum protoporphyrinogen oxidase 0.0043 0.0072 1
Schistosoma mansoni potassium channel beta 0.0038 0.0052 0.0041
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0042 0.4221
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Loa Loa (eye worm) hypothetical protein 0.0131 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0096 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0043 0.0076 0.0076
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0076 0.0165
Onchocerca volvulus 0.0043 0.0076 0.0065
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0179 0.0668 0.0658
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0342 0.1377 0.1368
Brugia malayi hypothetical protein 0.0043 0.0072 0.0072
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0066 0.0055
Trypanosoma brucei aldo-keto reductase, putative 0.0131 0.0459 0.3982
Echinococcus multilocularis tar DNA binding protein 0.0076 0.022 0.0209
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0234 0.0906 0.0896
Brugia malayi Blistered cuticle protein 3 0.0156 0.0568 0.0568
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0131 0.0459 0.3982
Trypanosoma cruzi aldo-keto reductase 0.0131 0.0459 0.3982
Toxoplasma gondii histone lysine-specific demethylase 0.0043 0.0072 0.1572
Loa Loa (eye worm) oxidoreductase 0.0131 0.0459 0.0459
Leishmania major prostaglandin f synthase, putative 0.0131 0.0459 0.3982
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.0568
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.0459 0.1642
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0523 0.0512
Brugia malayi beta-lactamase 0.0043 0.0076 0.0076
Onchocerca volvulus 0.0095 0.0301 0.029
Brugia malayi RE40412p 0.0029 0.0011 0.0011
Trypanosoma brucei prostaglandin f synthase 0.0131 0.0459 0.3982
Echinococcus multilocularis geminin 0.0205 0.0778 0.0768
Entamoeba histolytica protein kinase, putative 0.0291 0.1153 1
Brugia malayi hypothetical protein 0.0156 0.0568 0.0568
Loa Loa (eye worm) blistered cuticle protein 3 0.0156 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Onchocerca volvulus 0.0043 0.0076 0.0065
Loa Loa (eye worm) oxidoreductase 0.0131 0.0459 0.0459
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0076 0.0065
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0076 0.0065
Brugia malayi Protein kinase domain containing protein 0.0394 0.1606 0.1606
Echinococcus multilocularis dual specificity 0.0291 0.1153 0.1143
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0459 0.0449
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0094 0.0817
Echinococcus granulosus solute carrier family 5 0.0042 0.007 0.0059
Schistosoma mansoni sodium/solute symporter 0.0042 0.007 0.0059
Schistosoma mansoni tar DNA-binding protein 0.0076 0.022 0.0209
Schistosoma mansoni tyrosine kinase 0.0179 0.0668 0.0658
Brugia malayi beta-lactamase family protein 0.0043 0.0076 0.0076
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.0301 0.0301
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0076 0.0065
Echinococcus granulosus dnaJ subfamily C 6 0.0063 0.0162 0.0151
Echinococcus multilocularis 0.0043 0.0072 0.0061
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0066
Loa Loa (eye worm) DnaJ domain-containing protein 0.0063 0.0162 0.0162
Echinococcus granulosus peroxidasin 0.0156 0.0568 0.0558
Brugia malayi NADH-dependent xylose reductase 0.0038 0.0052 0.0052
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0076 0.0165
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0131 0.0459 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0076 0.022 0.0209
Onchocerca volvulus 0.0156 0.0568 0.0558
Onchocerca volvulus 0.0058 0.0138 0.0126
Onchocerca volvulus 0.0048 0.0094 0.0083
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0127 0.0116
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0131 0.0459 1
Echinococcus multilocularis epidermal growth factor receptor 0.0179 0.0668 0.0658
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0563 0.2338 0.8885
Brugia malayi Furin-like cysteine rich region family protein 0.0179 0.0668 0.0668
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0043 0.0072 0.9505
Brugia malayi CHE-14 protein 0.0041 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0066 0.0172 0.0172
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0459 0.0449
Onchocerca volvulus 0.0038 0.0052 0.0041
Chlamydia trachomatis protoporphyrinogen oxidase 0.0043 0.0072 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0127 0.0127
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0066 0.0055
Schistosoma mansoni inositol transporter 0.0042 0.007 0.0059
Trypanosoma cruzi aldo/keto reductase, putative 0.0131 0.0459 0.3982
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0459 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 47.8 uM PUBCHEM_BIOASSAY: Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 69 uM PUBCHEM_BIOASSAY: Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: Dose Response validation of uHTS RPN11 inhibitor hits using a MMP-2 Fluorescence assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0046 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Saccharomyces cerevisiae ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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