Detailed information for compound 1292183

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 450.315 | Formula: C21H21Cl2N3O4
  • H donors: 1 H acceptors: 3 LogP: 3.5 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CNC(=O)c1ccc(cc1Cl)Cl)OCC(=O)N1CCN(CC1)c1ccccc1
  • InChi: 1S/C21H21Cl2N3O4/c22-15-6-7-17(18(23)12-15)21(29)24-13-20(28)30-14-19(27)26-10-8-25(9-11-26)16-4-2-1-3-5-16/h1-7,12H,8-11,13-14H2,(H,24,29)
  • InChiKey: OHQJFBGFIAIWGZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.02 0.1076 0.1076
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0327 0.1211
Brugia malayi cathepsin Z-like cysteine proteinase 0.02 0.1076 0.1076
Loa Loa (eye worm) hypothetical protein 0.02 0.1076 0.1076
Brugia malayi Cathepsin L-like precursor 0.0877 0.511 0.511
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0327 0.0606
Echinococcus granulosus flap endonuclease 1 0.0026 0.0043 0.0043
Giardia lamblia Cathepsin L-like protease 0.02 0.1076 0.2805
Entamoeba histolytica cysteine protease, putative 0.0877 0.511 1
Trypanosoma cruzi cysteine peptidase, putative 0.0877 0.511 0.511
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0327 0.1211
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1106 0.2164
Giardia lamblia Dipeptidyl-peptidase I precursor 0.02 0.1076 0.2805
Brugia malayi cahepsin L-like non-peptiedase homolog 0.02 0.1076 0.1076
Onchocerca volvulus 0.0877 0.511 1
Toxoplasma gondii ABC1 family protein 0.0074 0.0327 0.0606
Echinococcus multilocularis cathepsin L cysteine protease 0.0877 0.511 0.511
Entamoeba histolytica cysteine protease, putative 0.02 0.1076 0.2105
Onchocerca volvulus Cathepsin L homolog 0.02 0.1076 0.1566
Mycobacterium tuberculosis Conserved protein 0.0074 0.0327 0.1211
Trypanosoma cruzi cysteine peptidase, putative 0.0877 0.511 0.511
Onchocerca volvulus 0.0877 0.511 1
Toxoplasma gondii cathepsin CPC2 0.02 0.1076 0.2078
Giardia lamblia Dipeptidyl-peptidase I precursor 0.02 0.1076 0.2805
Onchocerca volvulus 0.0877 0.511 1
Entamoeba histolytica cysteine proteinase, putative 0.0474 0.2711 0.5306
Entamoeba histolytica cysteine protease, putative 0.02 0.1076 0.2105
Giardia lamblia Cysteine protease 0.02 0.1076 0.2805
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0043 0.0084
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0043 0.0049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0327 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0877 0.511 1
Brugia malayi Cathepsin L-like precursor 0.0877 0.511 0.511
Plasmodium falciparum serine repeat antigen 1 0.02 0.1076 0.2078
Brugia malayi cathepsin L precursor 0.02 0.1076 0.1076
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0327 0.0639
Toxoplasma gondii cathepsin B 0.0663 0.3836 0.7498
Schistosoma mansoni flap endonuclease-1 0.0024 0.0028 0.0028
Giardia lamblia Cathepsin L precursor 0.02 0.1076 0.2805
Echinococcus multilocularis cysteine protease 0.0877 0.511 0.511
Brugia malayi beta-lactamase family protein 0.0074 0.0327 0.0327
Giardia lamblia Cathepsin B precursor 0.02 0.1076 0.2805
Trypanosoma cruzi cysteine peptidase, putative 0.0877 0.511 0.511
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0663 0.3836 0.3836
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.099 0.099
Loa Loa (eye worm) cathepsin B 0.0663 0.3836 0.3836
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0877 0.511 1
Plasmodium vivax vivapain-2 0.0877 0.511 1
Entamoeba histolytica hypothetical protein 0.02 0.1076 0.2105
Brugia malayi Papain family cysteine protease containing protein 0.0474 0.2711 0.2711
Entamoeba histolytica cysteine protease, putative 0.02 0.1076 0.2105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0877 0.511 1
Plasmodium falciparum serine repeat antigen 4 0.02 0.1076 0.2078
Giardia lamblia Cathepsin B precursor 0.02 0.1076 0.2805
Brugia malayi Papain family cysteine protease containing protein 0.0877 0.511 0.511
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.099 0.099
Plasmodium falciparum serine repeat antigen 7 0.02 0.1076 0.2078
Giardia lamblia Dipeptidyl-peptidase I precursor 0.02 0.1076 0.2805
Giardia lamblia Encystation-specific protease 0.02 0.1076 0.2805
Loa Loa (eye worm) hypothetical protein 0.0074 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0074 0.0327 0.0327
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0327 0.0639
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.02 0.1076 0.2105
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1106 0.2164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.02 0.1076 0.2105
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.02 0.1076 0.2078
Trypanosoma cruzi cysteine peptidase, putative 0.0275 0.1522 0.1522
Loa Loa (eye worm) hypothetical protein 0.0152 0.0791 0.0791
Leishmania major cathepsin L-like protease 0.0877 0.511 1
Onchocerca volvulus 0.0877 0.511 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0327 0.0327
Brugia malayi cathepsin L-like precursor 0.0602 0.3475 0.3475
Entamoeba histolytica cysteine protease, putative 0.02 0.1076 0.2105
Entamoeba histolytica cysteine proteinase, putative 0.0474 0.2711 0.5306
Echinococcus granulosus cathepsin L 0.0474 0.2711 0.2711
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.099 0.099
Brugia malayi Cathepsin L-like precursor 0.0275 0.1522 0.1522
Leishmania major cathepsin L-like protease 0.0877 0.511 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0018 0.0018
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.1745 0.1745
Plasmodium falciparum serine repeat antigen 3 0.02 0.1076 0.2078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0877 0.511 1
Schistosoma mansoni cathepsin C 0.02 0.1076 0.1076
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.02 0.1076 0.1076
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.02 0.1076 0.2078
Leishmania major cathepsin L-like protease 0.0877 0.511 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0894 0.5213 0.5213
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.02 0.1076 0.2805
Echinococcus multilocularis geminin 0.0509 0.2918 0.2918
Brugia malayi Flap endonuclease-1 0.0026 0.0043 0.0043
Toxoplasma gondii preprocathepsin c precursor, putative 0.02 0.1076 0.2078
Mycobacterium ulcerans lipase LipD 0.0074 0.0327 1
Mycobacterium tuberculosis Conserved protein 0.0074 0.0327 0.1211
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0018 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1745 0.3414
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.02 0.1076 0.2078
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0327 0.0639
Entamoeba histolytica cysteine proteinase, putative 0.0474 0.2711 0.5306
Trypanosoma cruzi major cysteine proteinase, putative 0.02 0.1076 0.1076
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.02 0.1076 0.2078
Brugia malayi cathepsin L-like cysteine proteinase 0.02 0.1076 0.1076
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0327 0.0639
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0043 0.0111
Giardia lamblia Cathepsin B precursor 0.02 0.1076 0.2805
Brugia malayi cathepsin F-like cysteine proteinase 0.0275 0.1522 0.1522
Trypanosoma cruzi cysteine peptidase, putative 0.0877 0.511 0.511
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.02 0.1076 0.2078
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0327 0.0327
Leishmania major hypothetical protein, conserved 0.0074 0.0327 0.0639
Entamoeba histolytica cysteine protease, putative 0.0474 0.2711 0.5306
Giardia lamblia Cathepsin L precursor 0.02 0.1076 0.2805
Mycobacterium tuberculosis Conserved protein 0.0074 0.0327 0.1211
Schistosoma mansoni hypothetical protein 0.0509 0.2918 0.2918
Onchocerca volvulus Cathepsin L homolog 0.0877 0.511 1
Toxoplasma gondii cathepsin CPL 0.0877 0.511 1
Giardia lamblia Cysteine protease 0.02 0.1076 0.2805
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.099 0.099
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0327 0.1211
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0327 0.5
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.02 0.1076 0.1076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.02 0.1076 0.2105
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0474 0.2711 0.2711
Onchocerca volvulus Cathepsin F homolog 0.0877 0.511 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.02 0.1076 0.2105
Schistosoma mansoni ran 0.0022 0.0018 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0877 0.511 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.02 0.1076 0.2078
Leishmania major cathepsin L-like protease 0.0877 0.511 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0275 0.1522 0.1522
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0043 0.0084
Brugia malayi Papain family cysteine protease containing protein 0.0474 0.2711 0.2711
Loa Loa (eye worm) cysteine protease 0.0877 0.511 0.511
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0327 0.1211
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0065
Trypanosoma cruzi major cysteine proteinase, putative 0.02 0.1076 0.1076
Entamoeba histolytica Ran family GTPase 0.0022 0.0018 0.0035
Leishmania major importin beta-1 subunit, putative 0.0024 0.0031 0.0061
Brugia malayi Cathepsin L-like cysteine proteinase 0.0602 0.3475 0.3475
Loa Loa (eye worm) hypothetical protein 0.02 0.1076 0.1076
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0043 0.0043
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0065 0.0127
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0018 0.0018
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0043 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0877 0.511 1
Entamoeba histolytica cysteine protease, putative 0.0474 0.2711 0.5306
Loa Loa (eye worm) hypothetical protein 0.02 0.1076 0.1076
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0185 0.099 0.099
Entamoeba histolytica cysteine protease, putative 0.0474 0.2711 0.5306
Loa Loa (eye worm) hypothetical protein 0.0602 0.3475 0.3475
Loa Loa (eye worm) papain family cysteine protease containing protein 0.02 0.1076 0.1076
Plasmodium vivax vivapain-1 0.0474 0.2711 0.529
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.02 0.1076 0.2105
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.02 0.1076 0.1076
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.02 0.1076 0.2078
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0031 0.0061
Echinococcus granulosus cathepsin l1 0.0602 0.3475 0.3475
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0214 0.0214
Giardia lamblia Cathepsin B precursor 0.0663 0.3836 1
Giardia lamblia Cathepsin B precursor 0.02 0.1076 0.2805
Loa Loa (eye worm) hypothetical protein 0.0038 0.0111 0.0111
Echinococcus granulosus cathepsin L cysteine protease 0.0474 0.2711 0.2711
Loa Loa (eye worm) hypothetical protein 0.0275 0.1522 0.1522
Entamoeba histolytica papain family cysteine protease domain containing protein 0.02 0.1076 0.2105
Entamoeba histolytica cysteine proteinase, putative 0.0602 0.3475 0.6799
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1745 0.3414
Brugia malayi Papain family cysteine protease containing protein 0.02 0.1076 0.1076
Plasmodium vivax unspecified product 0.0474 0.2711 0.529
Schistosoma mansoni cathepsin F (C01 family) 0.0877 0.511 0.511
Onchocerca volvulus 0.0602 0.3475 0.6581
Brugia malayi cathepsin Z-like cysteine proteinase 0.02 0.1076 0.1076
Giardia lamblia Cathepsin L precursor 0.02 0.1076 0.2805
Echinococcus multilocularis cysteine protease 0.0877 0.511 0.511
Leishmania major cathepsin L-like protease 0.0877 0.511 1
Plasmodium vivax unspecified product 0.02 0.1076 0.2078
Onchocerca volvulus 0.0877 0.511 1
Plasmodium falciparum serine repeat antigen 5 0.02 0.1076 0.2078
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.1785 0.1785
Schistosoma mansoni ran 0.0022 0.0018 0.0018
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0031 0.0061
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0877 0.511 1
Brugia malayi Cathepsin L-like precursor 0.0877 0.511 0.511
Echinococcus multilocularis importin subunit beta 1 0.003 0.0065 0.0065
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.02 0.1076 0.1076
Onchocerca volvulus Cathepsin L homolog 0.0877 0.511 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0474 0.2711 0.2711
Entamoeba histolytica cysteine protease, putative 0.0474 0.2711 0.5306
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0877 0.511 0.511
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.02 0.1076 0.2078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0474 0.2711 0.5306
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0877 0.511 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0877 0.511 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0663 0.3836 0.7507
Trichomonas vaginalis esterase, putative 0.0074 0.0327 0.0639
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0018 0.0035
Loa Loa (eye worm) beta-lactamase 0.0074 0.0327 0.0327
Plasmodium vivax serine-repeat antigen (SERA), putative 0.02 0.1076 0.2078
Brugia malayi fibroinase precursor 0.02 0.1076 0.1076
Brugia malayi hypothetical protein 0.0152 0.0791 0.0791
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.02 0.1076 0.2105
Echinococcus granulosus geminin 0.0509 0.2918 0.2918
Loa Loa (eye worm) ctsf protein 0.0877 0.511 0.511
Loa Loa (eye worm) hypothetical protein 0.0602 0.3475 0.3475
Entamoeba histolytica cysteine proteinase, putative 0.0474 0.2711 0.5306
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.02 0.1076 0.2105
Leishmania major cathepsin L-like protease 0.0877 0.511 1
Trypanosoma cruzi cruzipain precursor, putative 0.0877 0.511 0.511
Entamoeba histolytica cysteine protease, putative 0.0474 0.2711 0.5306
Trypanosoma cruzi cysteine peptidase, putative 0.0474 0.2711 0.2711
Trichomonas vaginalis conserved hypothetical protein 0.02 0.1076 0.2105
Entamoeba histolytica cysteine protease, putative 0.0474 0.2711 0.5306
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0877 0.511 1
Loa Loa (eye worm) hypothetical protein 0.02 0.1076 0.1076
Giardia lamblia Cysteine protease 0.02 0.1076 0.2805
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.1171 0.2292
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0877 0.511 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0663 0.3836 0.7507
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0185 0.099 0.099
Entamoeba histolytica cysteine protease, putative 0.0474 0.2711 0.5306
Plasmodium vivax serine-repeat antigen (SERA) 0.02 0.1076 0.2078
Leishmania major cathepsin L-like protease 0.0877 0.511 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.02 0.1076 0.2078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.099 0.099
Brugia malayi Importin beta-1 subunit 0.003 0.0065 0.0065
Giardia lamblia Cathepsin L precursor 0.02 0.1076 0.2805
Giardia lamblia Cathepsin B precursor 0.0663 0.3836 1
Brugia malayi Papain family cysteine protease containing protein 0.02 0.1076 0.1076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0877 0.511 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0609 0.0609
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0609 0.0609
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0474 0.2711 0.2711
Plasmodium falciparum serine repeat antigen 6 0.02 0.1076 0.2078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0877 0.511 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0877 0.511 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1106 0.2164
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0327 1
Entamoeba histolytica cysteine protease, putative 0.0474 0.2711 0.5306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0474 0.2711 0.5306
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0018 0.0018
Schistosoma mansoni cathepsin s 0.0275 0.1522 0.1522
Onchocerca volvulus 0.0877 0.511 1
Echinococcus multilocularis cathepsin L 0.0474 0.2711 0.2711
Plasmodium falciparum flap endonuclease 1 0.0026 0.0043 0.0049
Entamoeba histolytica cysteine proteinase 2 0.0474 0.2711 0.5306
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0327 0.1211
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.02 0.1076 0.2078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0877 0.511 1
Entamoeba histolytica cysteine protease, putative 0.0474 0.2711 0.5306
Brugia malayi Cathepsin L-like precursor 0.0877 0.511 0.511
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1745 0.3414
Echinococcus granulosus importin subunit beta 1 0.003 0.0065 0.0065
Echinococcus granulosus cathepsin l1 0.0877 0.511 0.511
Loa Loa (eye worm) hypothetical protein 0.0275 0.1522 0.1522
Loa Loa (eye worm) hypothetical protein 0.02 0.1076 0.1076
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0327 0.0327
Plasmodium falciparum cysteine proteinase falcipain 1 0.0474 0.2711 0.529
Loa Loa (eye worm) hypothetical protein 0.0275 0.1522 0.1522
Giardia lamblia Cathepsin L precursor 0.02 0.1076 0.2805
Entamoeba histolytica cysteine protease, putative 0.0474 0.2711 0.5306
Echinococcus multilocularis cathepsin L cysteine protease 0.0877 0.511 0.511
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0877 0.511 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.02 0.1076 0.2105
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.1106 0.1629
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0877 0.511 1
Plasmodium falciparum importin beta, putative 0.003 0.0065 0.0092
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0018 0.0018
Brugia malayi beta-lactamase family protein 0.0074 0.0327 0.0327
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0327 0.0639
Loa Loa (eye worm) hypothetical protein 0.0055 0.0214 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0877 0.511 1
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.1171 0.2292
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0877 0.511 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.02 0.1076 0.2078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0474 0.2711 0.5306
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0327 0.0639
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.02 0.1076 0.2105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.02 0.1076 0.2105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.099 0.099
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1106 0.2164
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0065 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1745 0.3414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0877 0.511 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0327 0.0327
Onchocerca volvulus 0.0877 0.511 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.02 0.1076 0.2105
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0111 0.0111
Plasmodium falciparum serine repeat antigen 8 0.02 0.1076 0.2078
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.02 0.1076 0.2105
Echinococcus granulosus cathepsin L cysteine proteinase 0.0877 0.511 0.511
Plasmodium vivax vivapain-3 0.0474 0.2711 0.529
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0877 0.511 0.511
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0663 0.3836 0.3836
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0877 0.511 1
Schistosoma mansoni importin beta-1 0.003 0.0065 0.0065
Echinococcus multilocularis snurportin 1 0.0319 0.1785 0.1785
Loa Loa (eye worm) hypothetical protein 0.0074 0.0327 0.0327
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0877 0.511 0.511
Entamoeba histolytica cysteine proteinase, putative 0.0877 0.511 1
Plasmodium vivax serine-repeat antigen (SERA) 0.02 0.1076 0.2078
Loa Loa (eye worm) hypothetical protein 0.0074 0.0327 0.0327
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.2696 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1106 0.2164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0474 0.2711 0.5306
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.02 0.1076 0.2105
Brugia malayi Cathepsin L-like precursor 0.0877 0.511 0.511
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0327 0.0327
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0031 0.0061
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0043 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0877 0.511 1
Brugia malayi Cathepsin L-like precursor 0.0877 0.511 0.511
Plasmodium vivax vivapain-2 0.0877 0.511 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0877 0.511 1
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0043 0.0043
Brugia malayi RNA, U transporter 1 0.0085 0.0393 0.0393
Loa Loa (eye worm) hypothetical protein 0.0074 0.0327 0.0327
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0043 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0602 0.3475 0.6799
Giardia lamblia Cathepsin B precursor 0.02 0.1076 0.2805
Entamoeba histolytica cysteine protease, putative 0.0474 0.2711 0.5306
Giardia lamblia Hypothetical protein 0.02 0.1076 0.2805
Brugia malayi MH2 domain containing protein 0.0121 0.0609 0.0609
Entamoeba histolytica cysteine protease, putative 0.0474 0.2711 0.5306
Plasmodium vivax importin-beta 2, putative 0.003 0.0065 0.0092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0877 0.511 1
Loa Loa (eye worm) hypothetical protein 0.0877 0.511 0.511
Plasmodium falciparum cysteine proteinase falcipain 3 0.0877 0.511 1
Entamoeba histolytica cysteine protease, putative 0.02 0.1076 0.2105
Schistosoma mansoni hypothetical protein 0.0038 0.0111 0.0111
Schistosoma mansoni cathepsin F (C01 family) 0.0602 0.3475 0.3475
Echinococcus granulosus cysteine protease 0.0474 0.2711 0.2711
Mycobacterium ulcerans hypothetical protein 0.0074 0.0327 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0602 0.3475 0.6799
Leishmania major cathepsin L-like protease 0.0877 0.511 1
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1745 0.3414
Giardia lamblia Cathepsin B precursor 0.0663 0.3836 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.02 0.1076 0.2105
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0663 0.3836 0.7507
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0877 0.511 1
Brugia malayi cathepsin F-like cysteine proteinase 0.02 0.1076 0.1076
Trypanosoma cruzi cysteine proteinase, putative 0.0474 0.2711 0.2711
Brugia malayi Cathepsin L-like precursor 0.0602 0.3475 0.3475
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0877 0.511 0.511
Entamoeba histolytica cysteine protease, putative 0.02 0.1076 0.2105
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0327 0.1211
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0474 0.2711 0.2711
Giardia lamblia Cysteine protease 0.02 0.1076 0.2805
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0214 0.0214
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0602 0.3475 0.3475
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.1745 0.1745
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1106 0.2164
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0877 0.511 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0877 0.511 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0877 0.511 1
Entamoeba histolytica cysteine protease, putative 0.0474 0.2711 0.5306
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.099 0.099
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0018 0.0046
Onchocerca volvulus 0.02 0.1076 0.1566
Echinococcus granulosus cathepsin L 0.02 0.1076 0.1076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0877 0.511 1
Echinococcus granulosus snurportin 1 0.0319 0.1785 0.1785
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.02 0.1076 0.1076
Loa Loa (eye worm) hypothetical protein 0.0602 0.3475 0.3475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0877 0.511 1
Trichomonas vaginalis conserved hypothetical protein 0.02 0.1076 0.2105
Mycobacterium leprae Probable lipase LipE 0.0074 0.0327 0.5
Toxoplasma gondii cathepsin CPC1 0.02 0.1076 0.2078
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0877 0.511 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0877 0.511 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0275 0.1522 0.1522
Schistosoma mansoni hypothetical protein 0.0509 0.2918 0.2918
Schistosoma mansoni cathepsin B (C01 family) 0.02 0.1076 0.1076
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1106 0.2164
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.02 0.1076 0.1076
Loa Loa (eye worm) fibroinase 0.0877 0.511 0.511
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.02 0.1076 0.1076
Schistosoma mansoni hypothetical protein 0.0319 0.1785 0.1785
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.02 0.1076 0.1076
Loa Loa (eye worm) hypothetical protein 0.02 0.1076 0.1076
Trichomonas vaginalis ran, putative 0.0022 0.0018 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0877 0.511 1
Entamoeba histolytica hypothetical protein 0.0024 0.0031 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0877 0.511 1
Giardia lamblia Cathepsin L precursor 0.02 0.1076 0.2805
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.02 0.1076 0.2105
Plasmodium vivax unspecified product 0.0275 0.1522 0.2955
Trypanosoma cruzi cruzipain precursor, putative 0.0275 0.1522 0.1522
Echinococcus granulosus cathepsin l cysteine peptidase 0.0877 0.511 0.511
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0043 0.0043
Leishmania major GTP-binding protein, putative 0.0022 0.0018 0.0035
Brugia malayi Cathepsin L-like precursor 0.0602 0.3475 0.3475
Entamoeba histolytica cysteine proteinase, putative 0.0877 0.511 1
Schistosoma mansoni cathepsin F (C01 family) 0.0877 0.511 0.511
Loa Loa (eye worm) hypothetical protein 0.0074 0.0327 0.0327
Trypanosoma cruzi cysteine protease, putative 0.0474 0.2711 0.2711
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0327 0.1211
Mycobacterium ulcerans beta-lactamase 0.0074 0.0327 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0877 0.511 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0018 0.0018
Brugia malayi Papain family cysteine protease containing protein 0.02 0.1076 0.1076
Giardia lamblia Hypothetical protein 0.02 0.1076 0.2805
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.02 0.1076 0.2105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0877 0.511 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.02 0.1076 0.2078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0877 0.511 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.02 0.1076 0.2105
Echinococcus multilocularis cathepsin L 0.02 0.1076 0.1076
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0214 0.0214
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0031 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0327 0.0327
Giardia lamblia Cathepsin L-like protease 0.02 0.1076 0.2805
Entamoeba histolytica cysteine proteinase 1, putative 0.0474 0.2711 0.5306
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0327 1
Leishmania major cysteine peptidase A (CPA) 0.0877 0.511 1
Brugia malayi beta-lactamase 0.0074 0.0327 0.0327
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.02 0.1076 0.1076
Plasmodium falciparum serine repeat antigen 2 0.02 0.1076 0.2078
Trypanosoma cruzi cysteine proteinase, putative 0.0474 0.2711 0.2711
Schistosoma mansoni cathepsin S (C01 family) 0.02 0.1076 0.1076
Onchocerca volvulus 0.0152 0.0791 0.0971
Loa Loa (eye worm) papain family cysteine protease containing protein 0.02 0.1076 0.1076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.02 0.1076 0.2105
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0327 0.0327
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1745 0.3414
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0065 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0877 0.511 1
Plasmodium falciparum serine repeat antigen 9 0.02 0.1076 0.2078

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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