Detailed information for compound 1295128

Basic information

Technical information
  • TDR Targets ID: 1295128
  • Name: 2-[(4-hydroxy-6-oxo-1H-pyrimidin-2-yl)sulfany l]-N-(2-methoxyphenyl)acetamide
  • MW: 307.325 | Formula: C13H13N3O4S
  • H donors: 3 H acceptors: 5 LogP: 1.88 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1NC(=O)CSc1nc(O)cc(n1)O
  • InChi: 1S/C13H13N3O4S/c1-20-9-5-3-2-4-8(9)14-12(19)7-21-13-15-10(17)6-11(18)16-13/h2-6H,7H2,1H3,(H,14,19)(H2,15,16,17,18)
  • InChiKey: XRLNQPVPOBXXOY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(4-hydroxy-6-oxo-1H-pyrimidin-2-yl)thio]-N-(2-methoxyphenyl)acetamide
  • 2-[(4-hydroxy-6-keto-1H-pyrimidin-2-yl)thio]-N-(2-methoxyphenyl)acetamide
  • 2-[(4-hydroxy-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(2-methoxyphenyl)ethanamide
  • MLS000043124
  • ZINC04993330
  • 2-(4,6-Dihydroxy-pyrimidin-2-ylsulfanyl)-N-(2-methoxy-phenyl)-acetamide
  • MLS000032633
  • SMR000011502
  • BAS 02789997

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.008 0.016
Trypanosoma cruzi cysteine peptidase, putative 0.0991 0.3546 0.3532
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.0855 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0262 0.0246
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0991 0.3546 0.9668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0991 0.3546 0.9668
Echinococcus multilocularis peregrin 0.0198 0.0655 0.0639
Giardia lamblia Encystation-specific protease 0.0246 0.0832 0.2027
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0991 0.3546 0.9668
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0991 0.3546 0.9668
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0246 0.0832 0.2291
Brugia malayi cathepsin L precursor 0.0246 0.0832 0.0829
Trypanosoma brucei cysteine peptidase C (CPC) 0.1024 0.3667 1
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.008 0.0064
Giardia lamblia Cathepsin L precursor 0.0246 0.0832 0.2027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0991 0.3546 0.9668
Onchocerca volvulus 0.004 0.0078 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0246 0.0832 0.2232
Loa Loa (eye worm) MH2 domain-containing protein 0.0241 0.0813 0.0803
Onchocerca volvulus 0.0235 0.079 0.2135
Loa Loa (eye worm) hypothetical protein 0.0104 0.0312 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.0832 0.2232
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0033 0.0053 0.0036
Brugia malayi PHD-finger family protein 0.0048 0.0111 0.0108
Entamoeba histolytica cysteine protease, putative 0.0548 0.1932 0.5343
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0175 0.0158
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0208 0.0191
Echinococcus multilocularis 0.0024 0.0022 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0991 0.3546 0.9668
Giardia lamblia Cathepsin L precursor 0.0246 0.0832 0.2027
Brugia malayi cathepsin F-like cysteine proteinase 0.0246 0.0832 0.0829
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0246 0.0832 0.0832
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0246 0.0832 0.2291
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0689 0.2446 0.6653
Loa Loa (eye worm) glutaminase 0.0293 0.1003 0.0993
Echinococcus granulosus cathepsin l1 0.0991 0.3546 0.3535
Leishmania major cathepsin L-like protease 0.0991 0.3546 0.9668
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.008 0.0174
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0078 0.0168
Plasmodium falciparum serine repeat antigen 7 0.0246 0.0832 0.2291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0548 0.1932 0.524
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0109 0.0092
Entamoeba histolytica cysteine proteinase 1, putative 0.0548 0.1932 0.5343
Brugia malayi Cytochrome P450 family protein 0.0024 0.0022 0.0019
Plasmodium vivax serine-repeat antigen (SERA) 0.0246 0.0832 0.2291
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0017 0.0017
Loa Loa (eye worm) cysteine protease 0.0991 0.3546 0.3539
Trypanosoma cruzi cysteine peptidase, putative 0.0991 0.3546 0.3532
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.0832 0.2232
Echinococcus granulosus cathepsin L 0.0548 0.1932 0.1918
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0042 0.0042
Onchocerca volvulus Cathepsin L homolog 0.0991 0.3546 1
Loa Loa (eye worm) hypothetical protein 0.0302 0.1034 0.1024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0246 0.0832 0.2232
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.008 0.0174
Brugia malayi Bromodomain containing protein 0.0185 0.0609 0.0606
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0262 0.0262
Echinococcus multilocularis cysteine protease 0.0991 0.3546 0.3535
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0246 0.0832 0.2291
Brugia malayi Cathepsin L-like precursor 0.0991 0.3546 0.3544
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.0487 0.0484
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0109 0.0092
Loa Loa (eye worm) hypothetical protein 0.0246 0.0832 0.0821
Leishmania major cathepsin L-like protease 0.0991 0.3546 0.9668
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0246 0.0832 0.2232
Loa Loa (eye worm) hypothetical protein 0.0025 0.0025 0.0014
Echinococcus multilocularis cathepsin L 0.0246 0.0832 0.0816
Loa Loa (eye worm) hypothetical protein 0.0246 0.0832 0.0821
Plasmodium vivax vivapain-3 0.0548 0.1932 0.5416
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0991 0.3546 0.9668
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0108 0.0326 0.0847
Plasmodium falciparum serine repeat antigen 8 0.0246 0.0832 0.2291
Echinococcus multilocularis zinc finger protein 0.0025 0.0024 0.0008
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0084 0.0073
Leishmania major cathepsin L-like protease 0.0991 0.3546 0.9668
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0262 0.0246
Mycobacterium ulcerans beta-lactamase 0.004 0.0078 0.0571
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0067
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.0487 0.0484
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0262 0.0246
Brugia malayi Cathepsin L-like precursor 0.0689 0.2446 0.2444
Schistosoma mansoni hypothetical protein 0.0048 0.0111 0.0111
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0042 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0991 0.3546 0.9668
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0991 0.3546 0.9668
Loa Loa (eye worm) cathepsin B 0.1024 0.3667 0.366
Plasmodium falciparum phd finger protein, putative 0.0048 0.0111 0.0243
Trypanosoma cruzi cysteine peptidase, putative 0.0302 0.1034 0.1014
Brugia malayi Bromodomain containing protein 0.0082 0.0232 0.0229
Brugia malayi beta-lactamase family protein 0.004 0.0078 0.0075
Echinococcus granulosus enhancer of polycomb 0.003 0.0042 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0246 0.0832 0.2232
Entamoeba histolytica cysteine protease, putative 0.0991 0.3546 1
Loa Loa (eye worm) hypothetical protein 0.0246 0.0832 0.0821
Entamoeba histolytica cysteine proteinase 2 0.0548 0.1932 0.5343
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0262 0.0246
Entamoeba histolytica cysteine proteinase, putative 0.0548 0.1932 0.5343
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0246 0.0832 0.2232
Trypanosoma cruzi cysteine proteinase, putative 0.0548 0.1932 0.1914
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0078 0.0571
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0068 0.0052
Entamoeba histolytica cysteine protease, putative 0.0548 0.1932 0.5343
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0078 0.0672
Entamoeba histolytica cysteine protease, putative 0.0548 0.1932 0.5343
Toxoplasma gondii cathepsin CPC1 0.0246 0.0832 0.2221
Onchocerca volvulus Cathepsin L homolog 0.0991 0.3546 1
Brugia malayi Papain family cysteine protease containing protein 0.0548 0.1932 0.193
Mycobacterium leprae Probable lipase LipE 0.004 0.0078 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0115 0.0354 0.0337
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0078 0.0075
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0033 0.0055 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0298 0.077
Schistosoma mansoni cathepsin S (C01 family) 0.0246 0.0832 0.0832
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0246 0.0832 0.2027
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.0881 0.0866
Brugia malayi Bromodomain containing protein 0.0044 0.0095 0.0092
Mycobacterium tuberculosis Conserved protein 0.004 0.0078 0.0672
Schistosoma mansoni hypothetical protein 0.0048 0.0109 0.0109
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0078 0.0672
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0991 0.3546 0.9668
Plasmodium vivax unspecified product 0.0548 0.1932 0.5416
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0109 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0991 0.3546 0.9668
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.008 0.0595
Toxoplasma gondii cathepsin CPC2 0.0246 0.0832 0.2221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0246 0.0832 0.2232
Brugia malayi Cathepsin L-like precursor 0.0991 0.3546 0.3544
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0078 0.0168
Echinococcus granulosus cysteine protease 0.0548 0.1932 0.1918
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0017 0.0006
Plasmodium vivax serine-repeat antigen (SERA) 0.0246 0.0832 0.2291
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.008 0.0174
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0246 0.0832 0.0832
Schistosoma mansoni hypothetical protein 0.0024 0.0022 0.0022
Entamoeba histolytica cysteine proteinase, putative 0.0991 0.3546 1
Brugia malayi Pre-SET motif family protein 0.0206 0.0686 0.0683
Echinococcus granulosus cathepsin l cysteine peptidase 0.0991 0.3546 0.3535
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0078 0.0672
Toxoplasma gondii cathepsin B 0.1024 0.3667 1
Giardia lamblia Cysteine protease 0.0246 0.0832 0.2027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0991 0.3546 0.9668
Loa Loa (eye worm) hypothetical protein 0.0246 0.0832 0.0821
Entamoeba histolytica cysteine protease, putative 0.0548 0.1932 0.5343
Entamoeba histolytica cysteine protease, putative 0.0548 0.1932 0.5343
Leishmania major cathepsin L-like protease 0.0991 0.3546 0.9668
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0991 0.3546 0.9668
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0246 0.0832 0.2232
Schistosoma mansoni enhancer of polycomb 0.003 0.0042 0.0042
Onchocerca volvulus 0.0991 0.3546 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0991 0.3546 0.9668
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0991 0.3546 0.9668
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0017 0.0017
Entamoeba histolytica cysteine proteinase, putative 0.0548 0.1932 0.5343
Loa Loa (eye worm) hypothetical protein 0.0033 0.0055 0.0044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0078 0.0078
Plasmodium vivax SET domain protein, putative 0.003 0.0042 0.0048
Loa Loa (eye worm) hypothetical protein 0.0048 0.0109 0.0098
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0109 0.0106
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0312 0.0309
Trypanosoma cruzi cysteine protease, putative 0.0548 0.1932 0.1914
Schistosoma mansoni microtubule-associated protein tau 0.0758 0.2699 0.2699
Loa Loa (eye worm) beta-lactamase 0.004 0.0078 0.0067
Giardia lamblia Cysteine protease 0.0246 0.0832 0.2027
Onchocerca volvulus 0.0991 0.3546 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0246 0.0832 0.2232
Mycobacterium ulcerans glutaminase 0.0293 0.1003 1
Leishmania major cytochrome p450-like protein 0.0041 0.0084 0.017
Entamoeba histolytica cysteine protease, putative 0.0548 0.1932 0.5343
Loa Loa (eye worm) hypothetical protein 0.0047 0.0104 0.0093
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0033 0.0053 0.0036
Loa Loa (eye worm) hypothetical protein 0.0152 0.0487 0.0476
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0017 0.0017
Onchocerca volvulus 0.004 0.0078 0.0104
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0078 0.0672
Echinococcus multilocularis PHD finger protein rhinoceros 0.0048 0.0111 0.0094
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0246 0.0832 0.0832
Loa Loa (eye worm) hypothetical protein 0.0073 0.0199 0.0188
Onchocerca volvulus 0.0246 0.0832 0.2254
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0262 0.026
Schistosoma mansoni hypothetical protein 0.0048 0.0109 0.0109
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0115 0.0354 0.0351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0548 0.1932 0.5247
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0991 0.3546 0.3539
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0246 0.0832 0.0832
Loa Loa (eye worm) hypothetical protein 0.0689 0.2446 0.2437
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0109 0.0092
Plasmodium falciparum serine repeat antigen 4 0.0246 0.0832 0.2291
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0017 0.0017
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0065 0.7681
Giardia lamblia Cysteine protease 0.0246 0.0832 0.2027
Entamoeba histolytica cysteine proteinase, putative 0.0689 0.2446 0.6825
Brugia malayi glutaminase DH11.1 0.0293 0.1003 0.1
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0084 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0689 0.2446 0.6653
Brugia malayi Cyclic-nucleotide gated cation channel 0.0023 0.0017 0.0014
Schistosoma mansoni voltage-gated potassium channel 0.0126 0.0392 0.0392
Leishmania major hypothetical protein, conserved 0.004 0.0078 0.0154
Echinococcus granulosus voltage gated potassium channel 0.0033 0.0055 0.0039
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0041 0.0084 0.0631
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0018 0.0018
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0548 0.1932 0.1914
Brugia malayi Cathepsin L-like precursor 0.0302 0.1034 0.1032
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0246 0.0832 0.2027
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0067
Brugia malayi hypothetical protein 0.0025 0.0025 0.0022
Brugia malayi cathepsin Z-like cysteine proteinase 0.0246 0.0832 0.0829
Schistosoma mansoni hypothetical protein 0.0104 0.0312 0.0312
Onchocerca volvulus 0.0991 0.3546 1
Schistosoma mansoni hypothetical protein 0.0021 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0548 0.1932 0.524
Schistosoma mansoni voltage-gated potassium channel 0.0126 0.0392 0.0392
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0175 0.0158
Echinococcus granulosus cathepsin l1 0.0689 0.2446 0.2433
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0017 0.0017
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0078 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0991 0.3546 0.9668
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0108 0.0326 0.0847
Brugia malayi Cathepsin L-like precursor 0.0991 0.3546 0.3544
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0246 0.0832 0.2232
Schistosoma mansoni inositol monophosphatase 0.004 0.008 0.008
Giardia lamblia Cathepsin B precursor 0.0246 0.0832 0.2027
Giardia lamblia Cathepsin L-like protease 0.0246 0.0832 0.2027
Brugia malayi cytochrome P450 0.0024 0.0022 0.0019
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0246 0.0832 0.2291
Echinococcus granulosus PHD finger protein rhinoceros 0.0048 0.0111 0.0094
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0025 0.0008
Echinococcus granulosus inositol monophosphatase 1 0.004 0.008 0.0064
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0078 0.0168
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.008 0.5
Brugia malayi hypothetical protein 0.026 0.0881 0.0879
Leishmania major cathepsin L-like protease 0.0991 0.3546 0.9668
Brugia malayi cathepsin L-like cysteine proteinase 0.0246 0.0832 0.0829
Loa Loa (eye worm) glutaminase 2 0.0293 0.1003 0.0993
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0246 0.0832 0.0832
Onchocerca volvulus 0.0689 0.2446 0.686
Entamoeba histolytica cysteine protease, putative 0.0246 0.0832 0.2168
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0017 0.0017
Entamoeba histolytica hypothetical protein 0.0075 0.0208 0.0367
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0078 0.0571
Plasmodium falciparum serine repeat antigen 1 0.0246 0.0832 0.2291
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0991 0.3546 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0246 0.0832 0.2232
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0991 0.3546 0.9668
Plasmodium falciparum serine repeat antigen 3 0.0246 0.0832 0.2291
Toxoplasma gondii preprocathepsin c precursor, putative 0.0246 0.0832 0.2221
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0246 0.0832 0.0832
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0246 0.0832 0.0832
Trichomonas vaginalis set domain proteins, putative 0.0235 0.079 0.2118
Giardia lamblia Cathepsin L precursor 0.0246 0.0832 0.2027
Trypanosoma cruzi cysteine peptidase, putative 0.0991 0.3546 0.3532
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0991 0.3546 0.9668
Plasmodium falciparum serine repeat antigen 6 0.0246 0.0832 0.2291
Entamoeba histolytica cysteine protease, putative 0.0548 0.1932 0.5343
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0246 0.0832 0.2291
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0991 0.3546 0.9668
Leishmania major hypothetical protein, conserved 0.0025 0.0025 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0246 0.0832 0.2232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0991 0.3546 0.9668
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0033 0.0055 0.0039
Loa Loa (eye worm) hypothetical protein 0.0048 0.0111 0.01
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0991 0.3546 0.9668
Plasmodium falciparum serine repeat antigen 9 0.0246 0.0832 0.2291
Brugia malayi fibroinase precursor 0.0246 0.0832 0.0829
Onchocerca volvulus 0.004 0.0078 0.0104
Plasmodium falciparum serine repeat antigen 5 0.0246 0.0832 0.2291
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0991 0.3546 0.9668
Brugia malayi PHD-finger family protein 0.003 0.0044 0.0042
Brugia malayi Cytochrome P450 family protein 0.0081 0.0228 0.0226
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.0487 0.0476
Giardia lamblia Cathepsin B precursor 0.1024 0.3667 1
Echinococcus multilocularis microtubule associated protein 2 0.0758 0.2699 0.2686
Schistosoma mansoni inositol monophosphatase 0.004 0.008 0.008
Brugia malayi Cytochrome P450 family protein 0.0041 0.0084 0.0081
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0078 0.0672
Brugia malayi Cathepsin L-like cysteine proteinase 0.0689 0.2446 0.2444
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0078 0.0056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0246 0.0832 0.2232
Brugia malayi MH2 domain containing protein 0.0241 0.0813 0.081
Loa Loa (eye worm) hypothetical protein 0.0302 0.1034 0.1024
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.008 0.016
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0053 0.0042
Giardia lamblia Cathepsin L-like protease 0.0246 0.0832 0.2027
Loa Loa (eye worm) hypothetical protein 0.026 0.0881 0.0871
Brugia malayi Inositol-1 0.004 0.008 0.0078
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0055 0.0055
Echinococcus multilocularis GPCR, family 2 0.0048 0.0109 0.0092
Schistosoma mansoni survival motor neuron protein 0.0053 0.0127 0.0127
Entamoeba histolytica cysteine protease, putative 0.0548 0.1932 0.5343
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0246 0.0832 0.2232
Brugia malayi hypothetical protein 0.0075 0.0208 0.0205
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0548 0.1932 0.1932
Schistosoma mansoni hypothetical protein 0.0053 0.0127 0.0127
Entamoeba histolytica cysteine protease, putative 0.0246 0.0832 0.2168
Giardia lamblia Cathepsin L precursor 0.0246 0.0832 0.2027
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0067
Schistosoma mansoni hypothetical protein 0.0048 0.0109 0.0109
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1024 0.3667 0.3653
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0078 0.0168
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0302 0.1034 0.1024
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0042 0.0054
Mycobacterium ulcerans lipase LipD 0.004 0.0078 0.0571
Plasmodium vivax vivapain-2 0.0991 0.3546 1
Giardia lamblia Hypothetical protein 0.0246 0.0832 0.2027
Brugia malayi Papain family cysteine protease containing protein 0.0246 0.0832 0.0829
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0991 0.3546 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0025 0.0003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0111 0.01
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0991 0.3546 0.9668
Echinococcus granulosus peregrin 0.0198 0.0655 0.0639
Echinococcus multilocularis cathepsin L cysteine protease 0.0991 0.3546 0.3535
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0991 0.3546 0.9668
Schistosoma mansoni enhancer of polycomb 0.003 0.0042 0.0042
Giardia lamblia Cathepsin L precursor 0.0246 0.0832 0.2027
Loa Loa (eye worm) hypothetical protein 0.0689 0.2446 0.2437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0991 0.3546 0.9668
Trypanosoma cruzi cruzipain precursor, putative 0.0991 0.3546 0.3532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0548 0.1932 0.5247
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0106 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0991 0.3546 0.9668
Mycobacterium tuberculosis Conserved protein 0.004 0.0078 0.0672
Schistosoma mansoni cathepsin F (C01 family) 0.0689 0.2446 0.2446
Plasmodium vivax unspecified product 0.0246 0.0832 0.2291
Brugia malayi cathepsin L-like precursor 0.0689 0.2446 0.2444
Plasmodium vivax hypothetical protein, conserved 0.004 0.0078 0.0151
Trypanosoma cruzi major cysteine proteinase, putative 0.0246 0.0832 0.0811
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0262 0.0262
Leishmania major cysteine peptidase A (CPA) 0.0991 0.3546 0.9668
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0246 0.0832 0.2232
Loa Loa (eye worm) hypothetical protein 0.0246 0.0832 0.0821
Loa Loa (eye worm) hypothetical protein 0.0689 0.2446 0.2437
Echinococcus granulosus cathepsin L cysteine proteinase 0.0991 0.3546 0.3535
Giardia lamblia Cathepsin B precursor 0.0246 0.0832 0.2027
Toxoplasma gondii PHD-finger domain-containing protein 0.0048 0.0111 0.0243
Schistosoma mansoni hypothetical protein 0.0075 0.0208 0.0208
Plasmodium vivax vivapain-1 0.0548 0.1932 0.5416
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0689 0.2446 0.2429
Loa Loa (eye worm) hypothetical protein 0.0302 0.1034 0.1024
Onchocerca volvulus 0.0991 0.3546 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0115 0.0354 0.0343
Onchocerca volvulus 0.0991 0.3546 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0018 0.0001
Echinococcus granulosus cytochrome P450 2K1 0.0024 0.0022 0.0005
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0078 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0039 0.0078 0.0067
Leishmania major cathepsin L-like protease 0.0991 0.3546 0.9668
Echinococcus granulosus enhancer of polycomb 0.003 0.0042 0.0025
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0302 0.1034 0.1032
Entamoeba histolytica cysteine protease, putative 0.0548 0.1932 0.5343
Toxoplasma gondii cathepsin CPL 0.0991 0.3546 0.9668
Schistosoma mansoni cathepsin F (C01 family) 0.0991 0.3546 0.3546
Loa Loa (eye worm) CYP4Cod1 0.0041 0.0084 0.0073
Onchocerca volvulus 0.0991 0.3546 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0065 0.0516
Loa Loa (eye worm) inositol-1 0.004 0.008 0.0069
Onchocerca volvulus Cathepsin L homolog 0.0246 0.0832 0.2254
Onchocerca volvulus Alhambra homolog 0.0048 0.0111 0.0197
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0246 0.0832 0.0821
Trypanosoma cruzi cruzipain precursor, putative 0.0302 0.1034 0.1014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0106 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0991 0.3546 0.9668
Plasmodium falciparum cysteine proteinase falcipain 1 0.0548 0.1932 0.5416
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0991 0.3546 0.3539
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0084 0.0073
Brugia malayi Pre-SET motif family protein 0.003 0.0042 0.0039
Loa Loa (eye worm) hypothetical protein 0.01 0.0298 0.0287
Entamoeba histolytica cysteine protease, putative 0.0548 0.1932 0.5343
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0246 0.0832 0.2291
Plasmodium vivax vivapain-2 0.0991 0.3546 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0023 0.0017 0.0006
Giardia lamblia Cathepsin L precursor 0.0246 0.0832 0.2027
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0078 0.0061
Leishmania major cathepsin L-like protease 0.0991 0.3546 0.9668
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0068 0.0052
Toxoplasma gondii ABC1 family protein 0.004 0.0078 0.0154
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0246 0.0832 0.2168
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0991 0.3546 0.3535
Schistosoma mansoni phd finger protein 0.002 0.0006 0.0006
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0115 0.0354 0.0337
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0246 0.0832 0.0832
Plasmodium falciparum serine repeat antigen 2 0.0246 0.0832 0.2291
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0106 0.0089
Echinococcus multilocularis cysteine protease 0.0991 0.3546 0.3535
Brugia malayi Papain family cysteine protease containing protein 0.0246 0.0832 0.0829
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0991 0.3546 0.9668
Loa Loa (eye worm) hypothetical protein 0.01 0.0298 0.0287
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0033 0.0055 0.0039
Trypanosoma cruzi cysteine proteinase, putative 0.0548 0.1932 0.1914
Loa Loa (eye worm) hypothetical protein 0.0991 0.3546 0.3539
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0991 0.3546 0.9668
Entamoeba histolytica cysteine protease, putative 0.0246 0.0832 0.2168
Loa Loa (eye worm) ctsf protein 0.0991 0.3546 0.3539
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0127 0.0124
Echinococcus granulosus GPCR family 2 0.0048 0.0109 0.0092
Schistosoma mansoni zinc finger protein 0.0025 0.0024 0.0024
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0208 0.0191
Schistosoma mansoni cathepsin s 0.0302 0.1034 0.1034
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0246 0.0832 0.2291
Echinococcus multilocularis cathepsin L cysteine protease 0.0991 0.3546 0.3535
Schistosoma mansoni cathepsin C 0.0246 0.0832 0.0832
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0246 0.0832 0.2232
Onchocerca volvulus 0.0053 0.0127 0.0244
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0055 0.0055
Entamoeba histolytica cysteine proteinase, putative 0.0548 0.1932 0.5343
Plasmodium vivax unspecified product 0.0302 0.1034 0.2866
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0991 0.3546 0.9668
Entamoeba histolytica cysteine protease, putative 0.0548 0.1932 0.5343
Brugia malayi Cathepsin L-like precursor 0.0991 0.3546 0.3544
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0106 0.0106
Brugia malayi Cathepsin L-like precursor 0.0991 0.3546 0.3544
Brugia malayi cathepsin F-like cysteine proteinase 0.0302 0.1034 0.1032
Trypanosoma cruzi cysteine peptidase, putative 0.0991 0.3546 0.3532
Entamoeba histolytica cysteine protease, putative 0.0246 0.0832 0.2168
Echinococcus granulosus microtubule associated protein 2 0.0758 0.2699 0.2686
Schistosoma mansoni enhancer of polycomb 0.003 0.0042 0.0042
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.008 0.0058
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0006
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0067
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1024 0.3667 1
Entamoeba histolytica cysteine proteinase, putative 0.0548 0.1932 0.5343
Brugia malayi cathepsin Z-like cysteine proteinase 0.0246 0.0832 0.0829
Plasmodium falciparum cysteine proteinase falcipain 3 0.0991 0.3546 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0246 0.0832 0.2027
Entamoeba histolytica hypothetical protein 0.0246 0.0832 0.2168
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0025 0.0008
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0246 0.0832 0.0832
Giardia lamblia Cathepsin B precursor 0.0246 0.0832 0.2027
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0078 0.0154
Brugia malayi Papain family cysteine protease containing protein 0.0548 0.1932 0.193
Giardia lamblia Cysteine protease 0.0246 0.0832 0.2027
Brugia malayi Papain family cysteine protease containing protein 0.0991 0.3546 0.3544
Mycobacterium ulcerans hypothetical protein 0.004 0.0078 0.0571
Leishmania major cathepsin L-like protease 0.0991 0.3546 0.9668
Schistosoma mansoni enhancer of polycomb 0.003 0.0042 0.0042
Mycobacterium leprae conserved hypothetical protein 0.004 0.0078 1
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0208 0.0208
Schistosoma mansoni cathepsin F (C01 family) 0.0991 0.3546 0.3546
Schistosoma mansoni hypothetical protein 0.0048 0.0109 0.0109
Giardia lamblia Cathepsin B precursor 0.1024 0.3667 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0025 0.0003
Trypanosoma cruzi cysteine peptidase, putative 0.0548 0.1932 0.1914
Entamoeba histolytica cysteine protease, putative 0.0548 0.1932 0.5343
Brugia malayi jmjC domain containing protein 0.0033 0.0053 0.005
Loa Loa (eye worm) hypothetical protein 0.0246 0.0832 0.0821
Loa Loa (eye worm) fibroinase 0.0991 0.3546 0.3539
Echinococcus granulosus zinc finger protein 0.0025 0.0024 0.0008
Brugia malayi beta-lactamase family protein 0.004 0.0078 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0991 0.3546 0.9668
Mycobacterium tuberculosis Conserved protein 0.004 0.0078 0.0672
Entamoeba histolytica cysteine protease, putative 0.0246 0.0832 0.2168
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0078 0.0056
Toxoplasma gondii PHD-finger domain-containing protein 0.0048 0.0111 0.0243
Trichomonas vaginalis esterase, putative 0.004 0.0078 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0991 0.3546 0.9668
Echinococcus multilocularis cathepsin L 0.0548 0.1932 0.1918
Echinococcus granulosus survival motor neuron protein 1 0.026 0.0881 0.0866
Loa Loa (eye worm) hypothetical protein 0.0047 0.0106 0.0095
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0246 0.0832 0.2291
Entamoeba histolytica cysteine protease, putative 0.0548 0.1932 0.5343
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0078 0.0672
Loa Loa (eye worm) transcription factor SMAD2 0.0241 0.0813 0.0803
Echinococcus multilocularis voltage gated potassium channel 0.0033 0.0055 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0991 0.3546 0.9668
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0246 0.0832 0.2291
Brugia malayi Cathepsin L-like precursor 0.0689 0.2446 0.2444
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0178 0.0583 0.0583
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0246 0.0832 0.0821
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0246 0.0832 0.0829
Entamoeba histolytica cysteine protease, putative 0.0246 0.0832 0.2168
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0246 0.0832 0.2027
Onchocerca volvulus Cathepsin F homolog 0.0991 0.3546 1
Schistosoma mansoni cathepsin B (C01 family) 0.0246 0.0832 0.0832
Trichomonas vaginalis glutaminase, putative 0.0293 0.1003 0.2701
Echinococcus granulosus cathepsin L cysteine protease 0.0548 0.1932 0.1918
Giardia lamblia Hypothetical protein 0.0246 0.0832 0.2027
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0246 0.0832 0.0821
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0078 0.0672
Entamoeba histolytica hypothetical protein 0.0075 0.0208 0.0367
Loa Loa (eye worm) PHD-finger family protein 0.0048 0.0111 0.01
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0109 0.0106
Schistosoma mansoni glutaminase 0.0293 0.1003 0.1003
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0548 0.1932 0.1932
Giardia lamblia Cathepsin B precursor 0.0246 0.0832 0.2027
Brugia malayi Papain family cysteine protease containing protein 0.0246 0.0832 0.0829
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0109 0.0098
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0246 0.0832 0.2291
Giardia lamblia Cathepsin B precursor 0.0246 0.0832 0.2027
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0078 0.0168
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0246 0.0832 0.2291
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0246 0.0832 0.2232
Onchocerca volvulus 0.0991 0.3546 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0023 0.0017 0.0006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1024 0.3667 0.3667
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.008 0.0058
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0262 0.0251
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0686 0.0676
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0018 0.0001
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.008 0.016
Loa Loa (eye worm) cytochrome P450 family protein 0.0081 0.0228 0.0218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0991 0.3546 0.9668
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0991 0.3546 0.9668
Entamoeba histolytica hypothetical protein 0.0075 0.0208 0.0367
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0038 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0991 0.3546 0.9668
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0548 0.1932 0.1932
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0246 0.0832 0.2291
Schistosoma mansoni cytochrome P450 0.0024 0.0022 0.0022
Brugia malayi Cytochrome P450 family protein 0.0041 0.0084 0.0081
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0084 0.0062
Brugia malayi Cathepsin L-like precursor 0.0991 0.3546 0.3544
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0262 0.0262
Schistosoma mansoni bromodomain containing protein 0.007 0.0188 0.0188
Trypanosoma cruzi major cysteine proteinase, putative 0.0246 0.0832 0.0811
Brugia malayi beta-lactamase 0.004 0.0078 0.0075
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0246 0.0832 0.2168
Giardia lamblia Cathepsin B precursor 0.1024 0.3667 1
Trypanosoma brucei cytochrome P450, putative 0.0041 0.0084 0.017
Loa Loa (eye worm) cytochrome P450 0.0024 0.0022 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1024 0.3667 1
Echinococcus granulosus cathepsin L 0.0246 0.0832 0.0816
Entamoeba histolytica hypothetical protein 0.0075 0.0208 0.0367
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0246 0.0832 0.2291
Echinococcus multilocularis enhancer of polycomb 0.003 0.0042 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0246 0.0832 0.2232
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0111 0.0243
Echinococcus multilocularis enhancer of polycomb 0.003 0.0042 0.0025
Entamoeba histolytica cysteine proteinase, putative 0.0991 0.3546 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0067
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0991 0.3546 0.3535

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 74.74 um PUBCHEM_BIOASSAY: Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.6858 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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