Detailed information for compound 1295450

Basic information

Technical information
  • TDR Targets ID: 1295450
  • Name: T5589376
  • MW: 386.49 | Formula: C15H22N4O4S2
  • H donors: 2 H acceptors: 5 LogP: 1.56 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNC(=O)NC(=O)CSc1ccc(cn1)S(=O)(=O)N1CCCCC1
  • InChi: 1S/C15H22N4O4S2/c1-2-16-15(21)18-13(20)11-24-14-7-6-12(10-17-14)25(22,23)19-8-4-3-5-9-19/h6-7,10H,2-5,8-9,11H2,1H3,(H2,16,18,20,21)
  • InChiKey: HKJAXGOJHGZVIM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0032 0.003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0085 0.0083
Schistosoma mansoni cathepsin s 0.0883 0.3354 0.3352
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0032 0.0022
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0203 0.0201
Loa Loa (eye worm) hypothetical protein 0.0062 0.0197 0.0194
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.054 0.2036 0.2034
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.0533 0.0531
Schistosoma mansoni alpha-glucosidase 0.0137 0.0486 0.0484
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0928 0.0918
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0357 0.0355
Brugia malayi RNA, U transporter 1 0.0099 0.0341 0.0341
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.0703 0.0701
Schistosoma mansoni transient receptor potential channel 0.0098 0.0337 0.0334
Brugia malayi Cathepsin L-like precursor 0.0883 0.3354 0.3354
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0145 0.0143
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0061 0.0059
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.0703 0.0701
Loa Loa (eye worm) hypothetical protein 0.0034 0.0092 0.009
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0171 0.0168
Brugia malayi MH1 domain containing protein 0.0014 0.0012 0.0012
Schistosoma mansoni bromodomain containing protein 0.008 0.0268 0.0265
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0928 0.0918
Entamoeba histolytica cysteine protease, putative 0.1424 0.543 0.5425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.033 0.0327
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0032 0.0022
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0318 0.1181 0.1172
Entamoeba histolytica cysteine proteinase, putative 0.1424 0.543 0.5425
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2067 0.7902 0.79
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0136 0.0134
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0595 0.0585
Entamoeba histolytica hypothetical protein 0.0149 0.0534 0.0524
Schistosoma mansoni smad1 5 8 and 0.0024 0.0054 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0022
Echinococcus granulosus cathepsin l1 0.173 0.6606 0.6606
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.01 0.0098
Plasmodium falciparum serine repeat antigen 9 0.054 0.2036 0.2014
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.0056 0.0054
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0209 0.0207
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1424 0.543 0.5429
Loa Loa (eye worm) hypothetical protein 0.173 0.6606 0.6606
Brugia malayi Cathepsin L-like cysteine proteinase 0.173 0.6606 0.6606
Brugia malayi cathepsin L-like cysteine proteinase 0.054 0.2036 0.2036
Plasmodium vivax unspecified product 0.054 0.2036 0.2014
Giardia lamblia Cathepsin B precursor 0.1013 0.385 1
Schistosoma mansoni importin beta-1 0.0035 0.0094 0.0092
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.033 0.0327
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.0877 0.0875
Giardia lamblia Cathepsin B precursor 0.054 0.2036 0.5254
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0092 0.009
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0055 0.0027
Leishmania major importin beta-1 subunit, putative 0.0028 0.0069 0.0058
Brugia malayi intermediate filament protein 0.0027 0.0065 0.0065
Entamoeba histolytica cysteine proteinase, putative 0.1424 0.543 0.5425
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0032 0.003
Loa Loa (eye worm) acetyltransferase 0.0149 0.0533 0.0531
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0052 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.054 0.2036 0.2027
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0055 0.0044
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0161 0.0151
Brugia malayi hypothetical protein 0.0025 0.0055 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.054 0.2036 0.2027
Giardia lamblia Hypothetical protein 0.054 0.2036 0.5254
Brugia malayi MH2 domain containing protein 0.0024 0.0054 0.0054
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0354 0.0354
Echinococcus granulosus cathepsin L 0.054 0.2036 0.2034
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1013 0.385 0.3844
Echinococcus granulosus importin subunit beta 1 0.0035 0.0094 0.0092
Brugia malayi Importin beta-1 subunit 0.0035 0.0094 0.0094
Entamoeba histolytica cysteine protease, putative 0.054 0.2036 0.2027
Giardia lamblia Cathepsin B precursor 0.054 0.2036 0.5254
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0209 0.0207
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2067 0.7902 0.7902
Giardia lamblia DINP protein human, muc B family 0.0019 0.0032 0.0012
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0183 0.0181
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0039 0.0037
Echinococcus multilocularis pyruvate kinase 0.0034 0.0092 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0096 0.0085
Plasmodium falciparum serine repeat antigen 3 0.054 0.2036 0.2014
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.054 0.2036 0.2034
Schistosoma mansoni survival motor neuron protein 0.0049 0.0147 0.0145
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0145 0.0143
Brugia malayi Melibiase family protein 0.0069 0.0225 0.0225
Toxoplasma gondii exonuclease III APE 0.0018 0.0031 0.0014
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0054 0.0052
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0928 0.0918
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0032 0.0085 0.0083
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0059 0.0056
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0171 0.0168
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.033 0.0327
Loa Loa (eye worm) hypothetical protein 0.007 0.0229 0.0227
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.054 0.2036 0.2014
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0145 0.0143
Plasmodium vivax vivapain-3 0.1424 0.543 0.5417
Entamoeba histolytica cysteine protease, putative 0.1424 0.543 0.5425
Giardia lamblia Pyruvate kinase 0.0034 0.0092 0.0168
Brugia malayi cathepsin L precursor 0.054 0.2036 0.2036
Giardia lamblia Cathepsin L precursor 0.054 0.2036 0.5254
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.042 0.1572 0.157
Loa Loa (eye worm) hypothetical protein 0.173 0.6606 0.6606
Echinococcus granulosus GPCR family 2 0.0032 0.0085 0.0083
Brugia malayi cathepsin F-like cysteine proteinase 0.054 0.2036 0.2036
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0031 0.002
Leishmania major DNA polymerase kappa, putative 0.0019 0.0032 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.027 0.0268
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0031 0.0003
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.054 0.2036 0.2014
Schistosoma mansoni ap endonuclease 0.0018 0.0031 0.0028
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0032 0.0022
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0225 0.0223
Echinococcus multilocularis cathepsin L 0.1424 0.543 0.5429
Loa Loa (eye worm) papain family cysteine protease containing protein 0.054 0.2036 0.2034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.033 0.0327
Schistosoma mansoni cathepsin F (C01 family) 0.173 0.6606 0.6606
Plasmodium falciparum serine repeat antigen 6 0.054 0.2036 0.2014
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0161 0.0159
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0161 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1424 0.543 0.5425
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.054 0.2036 0.5254
Schistosoma mansoni intermediate filament proteins 0.0027 0.0065 0.0063
Brugia malayi Transient-receptor-potential like protein 0.0036 0.01 0.01
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0054 0.0052
Brugia malayi Papain family cysteine protease containing protein 0.1424 0.543 0.543
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0318 0.1181 0.1172
Loa Loa (eye worm) hypothetical protein 0.0103 0.0354 0.0352
Plasmodium falciparum serine repeat antigen 1 0.054 0.2036 0.2014
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0161 0.0159
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0136 0.012
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0161 0.0151
Brugia malayi Bromodomain containing protein 0.0094 0.0322 0.0322
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0096 0.0096
Schistosoma mansoni transcription factor LCR-F1 0.0149 0.0534 0.0532
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0883 0.3354 0.3354
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0059 0.0081
Trichomonas vaginalis ran, putative 0.0026 0.0059 0.0048
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.054 0.2036 0.2034
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0229 0.0229
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0092 0.009
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0096 0.0085
Echinococcus granulosus dna polymerase eta 0.0019 0.0032 0.003
Onchocerca volvulus 0.0477 0.1794 0.1793
Giardia lamblia Cathepsin L-like protease 0.054 0.2036 0.5254
Entamoeba histolytica cysteine proteinase 2 0.1424 0.543 0.5425
Echinococcus granulosus lamin 0.0027 0.0065 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.054 0.2036 0.2027
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0145 0.0143
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0092 0.0081
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0061 0.0059
Entamoeba histolytica papain family cysteine protease domain containing protein 0.054 0.2036 0.2027
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.054 0.2036 0.2027
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0136 0.012
Schistosoma mansoni hypothetical protein 0.007 0.0229 0.0227
Schistosoma mansoni cathepsin B (C01 family) 0.054 0.2036 0.2034
Plasmodium falciparum serine repeat antigen 7 0.054 0.2036 0.2014
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0092 0.0081
Plasmodium falciparum flap endonuclease 1 0.0026 0.0061 0.0033
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0008
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0094 0.0084
Brugia malayi Papain family cysteine protease containing protein 0.054 0.2036 0.2036
Schistosoma mansoni lamin 0.0027 0.0065 0.0063
Brugia malayi Cathepsin L-like precursor 0.173 0.6606 0.6606
Trypanosoma cruzi cysteine peptidase, putative 0.0883 0.3354 0.3347
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.054 0.2036 0.2027
Toxoplasma gondii cathepsin CPC2 0.054 0.2036 0.2023
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0081 0.027 0.0268
Giardia lamblia Cathepsin L precursor 0.054 0.2036 0.5254
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0171 0.0168
Loa Loa (eye worm) MBCTL1 0.0055 0.0171 0.0168
Schistosoma mansoni smad1 5 8 and 0.0024 0.0054 0.0052
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0065 0.0063
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0092 0.009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0032 0.0022
Onchocerca volvulus 0.173 0.6606 0.6606
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0032 0.0022
Brugia malayi Pre-SET motif family protein 0.042 0.1572 0.1572
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.054 0.2036 0.2034
Entamoeba histolytica cysteine proteinase, putative 0.1424 0.543 0.5425
Echinococcus multilocularis cathepsin L 0.054 0.2036 0.2034
Leishmania major pyruvate kinase 0.0034 0.0092 0.0081
Giardia lamblia Hypothetical protein 0.054 0.2036 0.5254
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0059 0.0059
Giardia lamblia Cathepsin L-like protease 0.054 0.2036 0.5254
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0538 0.0528
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0096 0.0085
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0083
Trypanosoma cruzi cysteine protease, putative 0.1424 0.543 0.5425
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0069 0.0058
Giardia lamblia Cathepsin B precursor 0.054 0.2036 0.5254
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.0533 0.0533
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0061 0.005
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0006
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0031 0.002
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0061 0.0033
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.005
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0318 0.1181 0.1172
Loa Loa (eye worm) hypothetical protein 0.0883 0.3354 0.3352
Trypanosoma brucei ISWI complex protein 0.0018 0.0031 0.0021
Echinococcus granulosus transient receptor potential gamma protein 0.0098 0.0337 0.0334
Brugia malayi cathepsin B-like cysteine proteinase 0.2067 0.7902 0.7902
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0112 0.0101
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0032 0.003
Onchocerca volvulus 0.0048 0.0145 0.0143
Brugia malayi hypothetical protein 0.0239 0.0877 0.0877
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0031 0.002
Brugia malayi Papain family cysteine protease containing protein 0.1424 0.543 0.543
Loa Loa (eye worm) hypothetical protein 0.0035 0.0094 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0022
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0149 0.0534 0.0532
Onchocerca volvulus 0.0027 0.0065 0.0063
Echinococcus multilocularis transient receptor potential ion channel A 0.0095 0.0324 0.0322
Brugia malayi PHD-finger family protein 0.0034 0.0089 0.0089
Schistosoma mansoni hypothetical protein 0.0049 0.0147 0.0145
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0136 0.0109
Toxoplasma gondii hypothetical protein 0.0051 0.0157 0.0141
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0061 0.0087
Loa Loa (eye worm) hypothetical protein 0.054 0.2036 0.2034
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0096 0.008
Loa Loa (eye worm) hypothetical protein 0.0178 0.0645 0.0643
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0595 0.0585
Echinococcus multilocularis GPCR, family 2 0.0032 0.0085 0.0083
Giardia lamblia Cathepsin L precursor 0.054 0.2036 0.5254
Entamoeba histolytica hypothetical protein 0.0028 0.0069 0.0058
Schistosoma mansoni flap endonuclease-1 0.0024 0.0051 0.0049
Entamoeba histolytica papain family cysteine protease domain containing protein 0.054 0.2036 0.2027
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0161 0.0151
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0103 0.0357 0.0355
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.054 0.2036 0.2034
Brugia malayi cathepsin Z-like cysteine proteinase 0.054 0.2036 0.2036
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0928 0.0918
Brugia malayi fibroinase precursor 0.054 0.2036 0.2036
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0032 0.003
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0092 0.0092
Echinococcus multilocularis zinc finger protein 0.0027 0.0065 0.0063
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0203 0.0201
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0161 0.0151
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0031 0.002
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0059 0.0031
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.0533 0.0531
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0006
Plasmodium falciparum cysteine proteinase falcipain 1 0.1424 0.543 0.5417
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.054 0.2036 0.2034
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0595 0.0585
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0225 0.0223
Loa Loa (eye worm) hypothetical protein 0.0085 0.0288 0.0286
Plasmodium vivax SET domain protein, putative 0.006 0.0191 0.0164
Onchocerca volvulus Cathepsin L homolog 0.054 0.2036 0.2034
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0055 0.0044
Plasmodium falciparum serine repeat antigen 2 0.054 0.2036 0.2014
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0161 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0629 0.0619
Toxoplasma gondii cathepsin B 0.1013 0.385 0.384
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0096 0.0094
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.0645 0.0643
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0145 0.0143
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0145 0.0143
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0092 0.0076
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0032 0.0022
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0065 0.0065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.033 0.0327
Toxoplasma gondii preprocathepsin c precursor, putative 0.054 0.2036 0.2023
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0161 0.0159
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.054 0.2036 0.2014
Echinococcus granulosus zinc finger protein 0.0027 0.0065 0.0063
Schistosoma mansoni hypothetical protein 0.0372 0.1388 0.1386
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0053
Echinococcus granulosus pyruvate kinase 0.0018 0.0028 0.0026
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0572 0.0569
Brugia malayi cathepsin F-like cysteine proteinase 0.0883 0.3354 0.3354
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0595 0.0585
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.054 0.2036 0.2027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0138 0.0136
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0203 0.3015
Leishmania major hypothetical protein, conserved 0.0025 0.0055 0.0044
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0069 0.0058
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0011 0.0001
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0032 0.0022
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0032 0.0022
Loa Loa (eye worm) hypothetical protein 0.0055 0.0171 0.0168
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.0603 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0096 0.0094
Loa Loa (eye worm) hypothetical protein 0.054 0.2036 0.2034
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0032 0.0022
Brugia malayi mbt repeat family protein 0.0048 0.0145 0.0145
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0085 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0022
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0094 0.0084
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0096 0.0085
Loa Loa (eye worm) transcription factor SMAD2 0.0359 0.1341 0.1339
Echinococcus multilocularis tumor protein p63 0.033 0.1226 0.1224
Schistosoma mansoni smad1 5 8 and 0.0024 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0081 0.027 0.0268
Echinococcus granulosus cathepsin L 0.1424 0.543 0.5429
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0032 0.0032
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0065 0.0063
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0054 0.0052
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.0928 0.0926
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0085 0.0083
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0061 0.0045
Brugia malayi MH1 domain containing protein 0.0014 0.0012 0.0012
Plasmodium vivax unspecified product 0.0883 0.3354 0.3335
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0031 0.0028
Leishmania major DNA polymerase eta, putative 0.0019 0.0032 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.027 0.0268
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0028 0.0011
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0136 0.0126
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.173 0.6606 0.6603
Echinococcus granulosus transient receptor potential ion channel A 0.0095 0.0324 0.0322
Giardia lamblia Cysteine protease 0.054 0.2036 0.5254
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0061
Echinococcus multilocularis lamin dm0 0.0027 0.0065 0.0063
Onchocerca volvulus 0.006 0.0191 0.0189
Toxoplasma gondii cathepsin CPC1 0.054 0.2036 0.2023
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0357 0.0355
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0145 0.0143
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0572 0.0569
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0092 0.0081
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0171 0.0171
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.054 0.2036 0.2027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1424 0.543 0.5425
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0061 0.005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.033 0.0327
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0096 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.054 0.2036 0.2027
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0011 0.0008
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2067 0.7902 0.7902
Echinococcus multilocularis smad 0.0024 0.0054 0.0052
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0354 0.0352
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0092 0.5
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0209 0.0207
Trypanosoma cruzi cysteine peptidase, putative 0.1424 0.543 0.5425
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0061 0.005
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0357 0.0355
Giardia lamblia Cysteine protease 0.054 0.2036 0.5254
Brugia malayi Cathepsin L-like precursor 0.173 0.6606 0.6606
Echinococcus granulosus cathepsin L cysteine protease 0.1424 0.543 0.5429
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.0877 0.0875
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0085 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.173 0.6606 0.6603
Schistosoma mansoni smad 0.0024 0.0054 0.0052
Toxoplasma gondii melibiase subfamily protein 0.0103 0.0357 0.0341
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0059 0.0056
Echinococcus granulosus lamin dm0 0.0027 0.0065 0.0063
Schistosoma mansoni hypothetical protein 0.0025 0.0056 0.0054
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0595 0.0593
Echinococcus multilocularis pyruvate kinase 0.0018 0.0028 0.0026
Loa Loa (eye worm) hypothetical protein 0.0098 0.0337 0.0334
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0022
Echinococcus granulosus tumor protein p63 0.033 0.1226 0.1224
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0059 0.0048
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0032 0.0022
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0059 0.0042
Entamoeba histolytica cysteine protease, putative 0.1424 0.543 0.5425
Trypanosoma cruzi lanosterol synthase, putative 0.0193 0.0703 0.0693
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0031 0.0031
Onchocerca volvulus 0.0149 0.0534 0.0532
Echinococcus multilocularis dna polymerase eta 0.0019 0.0032 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0022
Schistosoma mansoni alpha-glucosidase 0.0137 0.0486 0.0484
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0103 0.0357 0.0355
Entamoeba histolytica cysteine proteinase 1, putative 0.1424 0.543 0.5425
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0129 0.0454 0.7396
Trypanosoma brucei unspecified product 0.0019 0.0032 0.0022
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0132 0.0121
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0092 0.1069
Loa Loa (eye worm) cathepsin B 0.1013 0.385 0.3849
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0085 0.0083
Echinococcus multilocularis geminin 0.0171 0.0617 0.0615
Entamoeba histolytica cysteine protease, putative 0.054 0.2036 0.2027
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0103 0.0357 0.0355
Entamoeba histolytica Ran family GTPase 0.0026 0.0059 0.0048
Giardia lamblia Cathepsin L precursor 0.054 0.2036 0.5254
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0191 0.0189
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0092 0.0082
Plasmodium falciparum importin beta, putative 0.0035 0.0094 0.0066
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0209 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.054 0.2036 0.2027
Leishmania major mitochondrial DNA polymerase beta 0.0318 0.1181 0.1172
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0161 0.0151
Schistosoma mansoni zinc finger protein 0.0027 0.0065 0.0063
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0191 0.0189
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0096 0.0085
Echinococcus granulosus cathepsin b 0.2067 0.7902 0.7902
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0096 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0161 0.0159
Entamoeba histolytica cysteine protease, putative 0.054 0.2036 0.2027
Leishmania major lanosterol synthase, putative 0.0193 0.0703 0.0693
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0629 0.0619
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.003
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.054 0.2036 0.2034
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0032 0.0032
Onchocerca volvulus 0.054 0.2036 0.2034
Schistosoma mansoni transient receptor potential channel 4 0.0098 0.0337 0.0334
Loa Loa (eye worm) Smad1 0.0024 0.0054 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0022
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.054 0.2036 0.2034
Onchocerca volvulus 0.0048 0.0145 0.0143
Chlamydia trachomatis pyruvate kinase 0.0034 0.0092 0.5
Leishmania major hypothetical protein, conserved 0.0018 0.0031 0.002
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0032 0.0032
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0132 0.0121
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.054 0.2036 0.2014
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0059 0.0056
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0132 0.0122
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0147 0.0147
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1013 0.385 0.3849
Trichomonas vaginalis conserved hypothetical protein 0.054 0.2036 0.2027
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0052 0.0041
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.054 0.2036 0.2014
Brugia malayi MH2 domain containing protein 0.0359 0.1341 0.1341
Brugia malayi MAP kinase sur-1 0.0052 0.0161 0.0161
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0203 0.0193
Giardia lamblia Cathepsin L precursor 0.054 0.2036 0.5254
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0132 0.0121
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0069 0.0058
Onchocerca volvulus 0.0092 0.0314 0.0312
Echinococcus granulosus flap endonuclease 1 0.0026 0.0061 0.0059
Echinococcus granulosus intermediate filament protein 0.0027 0.0065 0.0063
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.0002 0.0002
Giardia lamblia Cathepsin B precursor 0.1013 0.385 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0069 0.0058
Echinococcus multilocularis pyruvate kinase 0.0018 0.0028 0.0026
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0055 0.0038
Trypanosoma cruzi lanosterol synthase, putative 0.0193 0.0703 0.0693
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0069 0.0225 0.0214
Entamoeba histolytica cysteine protease, putative 0.1424 0.543 0.5425
Plasmodium vivax serine-repeat antigen (SERA), putative 0.054 0.2036 0.2014
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0595 0.0585
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0096 0.0085
Plasmodium vivax serine-repeat antigen (SERA) 0.054 0.2036 0.2014
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0039 0.0037
Brugia malayi cahepsin L-like non-peptiedase homolog 0.054 0.2036 0.2036
Entamoeba histolytica cysteine protease, putative 0.054 0.2036 0.2027
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0055 0.0045
Entamoeba histolytica cysteine proteinase, putative 0.1424 0.543 0.5425
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0094 0.0092
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0016 0.0014
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.1424 0.543 0.5425
Giardia lamblia Cysteine protease 0.054 0.2036 0.5254
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0161 0.0145
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.054 0.2036 0.2034
Plasmodium vivax serine-repeat antigen (SERA) 0.054 0.2036 0.2014
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0506 0.0504
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0022
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0032 0.003
Loa Loa (eye worm) hypothetical protein 0.0883 0.3354 0.3352
Echinococcus granulosus dna polymerase kappa 0.0019 0.0032 0.003
Brugia malayi Pre-SET motif family protein 0.006 0.0191 0.0191
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0054 0.0052
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1424 0.543 0.5429
Plasmodium vivax serine-repeat antigen (SERA), putative 0.054 0.2036 0.2014
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0092 0.0082
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0055 0.0027
Echinococcus granulosus geminin 0.0171 0.0617 0.0615
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.054 0.2036 0.2014
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.033 0.0327
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0011 0.0008
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0171 0.0617 0.0615
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0032 0.0022
Trypanosoma cruzi cysteine proteinase, putative 0.1424 0.543 0.5425
Onchocerca volvulus 0.0027 0.0065 0.0063
Brugia malayi hypothetical protein 0.0016 0.0021 0.0021
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0094 0.0078
Brugia malayi MH2 domain containing protein 0.0011 0.0002 0.0002
Leishmania major GTP-binding protein, putative 0.0026 0.0059 0.0048
Trypanosoma cruzi cysteine proteinase, putative 0.1424 0.543 0.5425
Entamoeba histolytica cysteine protease, putative 0.1424 0.543 0.5425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.054 0.2036 0.2027
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0251 0.0249
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0357 0.0355
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.054 0.2036 0.2034
Brugia malayi Bromodomain containing protein 0.005 0.0152 0.0152
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.054 0.2036 0.2034
Plasmodium vivax importin-beta 2, putative 0.0035 0.0094 0.0066
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0161 0.0151
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0092 0.009
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1013 0.385 0.3844
Entamoeba histolytica hypothetical protein 0.054 0.2036 0.2027
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0161 0.0159
Echinococcus multilocularis musashi 0.0027 0.0065 0.0063
Loa Loa (eye worm) papain family cysteine protease containing protein 0.054 0.2036 0.2034
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0032 0.0022
Loa Loa (eye worm) hypothetical protein 0.0883 0.3354 0.3352
Plasmodium falciparum pyruvate kinase 0.0034 0.0092 0.0064
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0096 0.0085
Echinococcus multilocularis pyruvate kinase 0.0034 0.0092 0.009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.054 0.2036 0.2027
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0059 0.0048
Brugia malayi cathepsin L-like precursor 0.173 0.6606 0.6606
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1424 0.543 0.5429
Trypanosoma brucei protein kinase, putative 0.0052 0.0161 0.0151
Giardia lamblia Cathepsin B precursor 0.054 0.2036 0.5254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.054 0.2036 0.2027
Schistosoma mansoni hypothetical protein 0.0018 0.0031 0.0029
Entamoeba histolytica hypothetical protein 0.0149 0.0534 0.0524
Entamoeba histolytica cysteine protease, putative 0.1424 0.543 0.5425
Schistosoma mansoni hypothetical protein 0.0032 0.0085 0.0083
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0203 0.3015
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0092 0.0064
Giardia lamblia Encystation-specific protease 0.054 0.2036 0.5254
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0191 0.0189
Mycobacterium ulcerans hypothetical protein 0.0167 0.0603 1
Brugia malayi Papain family cysteine protease containing protein 0.054 0.2036 0.2036
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.054 0.2036 0.2027
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.054 0.2036 0.2027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.173 0.6606 0.6603
Entamoeba histolytica cysteine proteinase, putative 0.173 0.6606 0.6603
Giardia lamblia Dipeptidyl-peptidase I precursor 0.054 0.2036 0.5254
Schistosoma mansoni pyruvate kinase 0.0034 0.0092 0.009
Echinococcus granulosus Smad4 0.0024 0.0054 0.0052
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0031 0.0008
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0171 0.0168
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0191 0.0175
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0011 0.0008
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0161 0.0151
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0354 0.0354
Echinococcus multilocularis lamin 0.0027 0.0065 0.0063
Echinococcus granulosus histone lysine methyltransferase setb 0.0081 0.027 0.0268
Entamoeba histolytica hypothetical protein 0.0149 0.0534 0.0524
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0251 0.0249
Entamoeba histolytica cysteine protease, putative 0.1424 0.543 0.5425
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0538 0.0528
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.054 0.2036 0.2014
Trypanosoma cruzi cruzipain precursor, putative 0.0883 0.3354 0.3347
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0054 0.0052
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0092 0.0081
Schistosoma mansoni zinc finger protein 0.0018 0.0031 0.0029
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0096 0.0085
Entamoeba histolytica cysteine protease, putative 0.1424 0.543 0.5425
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.054 0.2036 0.2014
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0031 0.002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0085 0.0085
Brugia malayi MH1 domain containing protein 0.0024 0.0054 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0022
Giardia lamblia Dipeptidyl-peptidase I precursor 0.054 0.2036 0.5254
Entamoeba histolytica cysteine protease, putative 0.1424 0.543 0.5425
Loa Loa (eye worm) nuclear factor I 0.0014 0.0012 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0928 0.0918
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0595 0.0585
Schistosoma mansoni hypothetical protein 0.0171 0.0617 0.0615
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0136 0.0126
Giardia lamblia Cathepsin L precursor 0.054 0.2036 0.5254
Echinococcus multilocularis cathepsin b 0.2067 0.7902 0.7902
Trypanosoma cruzi ISWI complex protein 0.0018 0.0031 0.002
Brugia malayi MH1 domain containing protein 0.0024 0.0054 0.0054
Brugia malayi cathepsin Z-like cysteine proteinase 0.054 0.2036 0.2036
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1013 0.385 0.3844
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.0538 0.0529
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0928 0.0918
Echinococcus multilocularis snurportin 1 0.0372 0.1388 0.1386
Loa Loa (eye worm) hypothetical protein 0.2067 0.7902 0.7902
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.054 0.2036 0.2014
Schistosoma mansoni pyruvate kinase 0.0034 0.0092 0.009
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0032 0.003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0032 0.0032
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0065 0.0063
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0096 0.0085
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0112 0.0219
Trypanosoma cruzi ISWI complex protein 0.0018 0.0031 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0022
Entamoeba histolytica cysteine protease, putative 0.1424 0.543 0.5425
Loa Loa (eye worm) hypothetical protein 0.0048 0.0145 0.0143
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0054 0.0052
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0039 0.0037
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0059 0.0049
Entamoeba histolytica cysteine protease, putative 0.054 0.2036 0.2027
Echinococcus granulosus pyruvate kinase 0.0018 0.0028 0.0026
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0031 0.5
Echinococcus multilocularis Smad4 0.0024 0.0054 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.054 0.2036 0.2027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.054 0.2036 0.2027
Entamoeba histolytica cysteine protease, putative 0.1424 0.543 0.5425
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1424 0.543 0.5425
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0161 0.0151
Echinococcus multilocularis transient receptor potential gamma protein 0.0098 0.0337 0.0334
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0127 0.0125
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.054 0.2036 0.2014
Entamoeba histolytica cysteine protease, putative 0.054 0.2036 0.2027
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0092 0.009
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0161 0.0151
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0149 0.0534 0.0532
Schistosoma mansoni pyruvate kinase 0.0018 0.0028 0.0026
Schistosoma mansoni lamin 0.0027 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0008
Brugia malayi Smad1 0.0024 0.0054 0.0054
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0031 0.0021
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.033 0.033
Brugia malayi hypothetical protein 0.0149 0.0534 0.0534
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.054 0.2036 0.2014
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.01 0.0098
Echinococcus multilocularis pyruvate kinase 0.0018 0.0028 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.054 0.2036 0.2027
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0161 0.0159
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0145 0.0143
Loa Loa (eye worm) hypothetical protein 0.054 0.2036 0.2034
Giardia lamblia Cathepsin B precursor 0.054 0.2036 0.5254
Giardia lamblia Dipeptidyl-peptidase I precursor 0.054 0.2036 0.5254
Schistosoma mansoni hypothetical protein 0.0032 0.0085 0.0083
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0092 0.1069
Echinococcus granulosus pyruvate kinase 0.0018 0.0028 0.0026
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1388 0.1386
Schistosoma mansoni cathepsin C 0.054 0.2036 0.2034
Schistosoma mansoni ran 0.0026 0.0059 0.0056
Loa Loa (eye worm) hypothetical protein 0.0053 0.0163 0.0161
Echinococcus granulosus cathepsin b 0.2067 0.7902 0.7902
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0127 0.0125
Echinococcus granulosus snurportin 1 0.0372 0.1388 0.1386
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0059 0.0031
Plasmodium vivax unspecified product 0.1424 0.543 0.5417
Entamoeba histolytica cysteine protease, putative 0.1424 0.543 0.5425
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0096 0.0085
Loa Loa (eye worm) hypothetical protein 0.0033 0.0088 0.0085
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0883 0.3354 0.3352
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0145 0.0143
Brugia malayi Flap endonuclease-1 0.0026 0.0061 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0096 0.0085
Echinococcus granulosus pyruvate kinase 0.0034 0.0092 0.009
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0203 0.3015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1424 0.543 0.5425
Schistosoma mansoni DNA polymerase eta 0.0019 0.0032 0.003
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2413 0.9231 0.9231
Trypanosoma brucei cysteine peptidase C (CPC) 0.1013 0.385 0.3844
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0065 0.0063
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0572 0.0569
Loa Loa (eye worm) hypothetical protein 0.0036 0.01 0.0098
Loa Loa (eye worm) hypothetical protein 0.0239 0.0877 0.0875
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0065 0.0063
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0032 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0022
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0031 0.0028
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0096 0.0085
Brugia malayi MH2 domain containing protein 0.0024 0.0054 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.033 0.0327
Loa Loa (eye worm) hypothetical protein 0.0069 0.0225 0.0223
Brugia malayi mbt repeat family protein 0.0048 0.0145 0.0145
Schistosoma mansoni ap endonuclease 0.0018 0.0031 0.0028
Schistosoma mansoni hypothetical protein 0.0296 0.1099 0.1097
Plasmodium falciparum serine repeat antigen 8 0.054 0.2036 0.2014
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0031 0.0003
Schistosoma mansoni cathepsin S (C01 family) 0.054 0.2036 0.2034
Schistosoma mansoni Smad4 0.0024 0.0054 0.0052
Loa Loa (eye worm) MH2 domain-containing protein 0.0359 0.1341 0.1339
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0572 0.0569
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0161 0.0349
Echinococcus multilocularis pyruvate kinase 0.0027 0.0064 0.0062
Schistosoma mansoni hypothetical protein 0.0149 0.0534 0.0532
Plasmodium falciparum serine repeat antigen 4 0.054 0.2036 0.2014
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0112 0.0084
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0056 0.0054
Brugia malayi N-terminal motif family protein 0.0178 0.0645 0.0645
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0039 0.0037
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0203 0.0201
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0055 0.0027
Loa Loa (eye worm) hypothetical protein 0.0055 0.0172 0.017
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0171 0.0168
Giardia lamblia Cathepsin B precursor 0.1013 0.385 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0061 0.005
Trypanosoma cruzi major cysteine proteinase, putative 0.054 0.2036 0.2027
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0572 0.0572
Trichomonas vaginalis set domain proteins, putative 0.0477 0.1794 0.1786
Schistosoma mansoni ran 0.0026 0.0059 0.0056
Brugia malayi Papain family cysteine protease containing protein 0.054 0.2036 0.2036
Giardia lamblia Cysteine protease 0.054 0.2036 0.5254
Trypanosoma cruzi major cysteine proteinase, putative 0.054 0.2036 0.2027
Entamoeba histolytica hypothetical protein 0.0149 0.0534 0.0524
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0031 0.5
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0096 0.0094
Trypanosoma brucei lanosterol synthase 0.0193 0.0703 0.0694
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0032 0.0022
Loa Loa (eye worm) hypothetical protein 0.173 0.6606 0.6606
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0169 0.0159
Echinococcus granulosus pyruvate kinase 0.0034 0.0092 0.009
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.054 0.2036 0.2034
Schistosoma mansoni alpha glucosidase 0.0035 0.0096 0.0094
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0031 0.002
Echinococcus granulosus smad 0.0024 0.0054 0.0052
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0016 0.0014
Trypanosoma brucei glucosidase, putative 0.0035 0.0096 0.0086
Plasmodium falciparum serine repeat antigen 5 0.054 0.2036 0.2014
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0145 0.0143
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2067 0.7902 0.7902
Echinococcus granulosus cysteine protease 0.1424 0.543 0.5429
Schistosoma mansoni transient receptor potential channel 0.0065 0.0209 0.0207
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0595 0.0585
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0203 0.0187
Loa Loa (eye worm) hypothetical protein 0.0027 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0149 0.0534 0.0532
Leishmania major pyruvate kinase 0.0034 0.0092 0.0081
Loa Loa (eye worm) hypothetical protein 0.054 0.2036 0.2034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0203 0.3015
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0085 0.0083
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2067 0.7902 0.7902
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0203 0.0201
Echinococcus multilocularis cathepsin b 0.2067 0.7902 0.7902
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0092 0.009
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0061 0.0051
Schistosoma mansoni transient receptor potential channel 0.0065 0.0209 0.0207
Plasmodium vivax vivapain-1 0.1424 0.543 0.5417
Entamoeba histolytica cysteine protease, putative 0.1424 0.543 0.5425
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0048 0.0145 0.0143
Onchocerca volvulus 0.0049 0.0147 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.054 0.2036 0.2027
Brugia malayi hypothetical protein 0.0149 0.0534 0.0534
Schistosoma mansoni hypothetical protein 0.0032 0.0085 0.0083

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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