Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Schistosoma mansoni | microtubule-associated protein tau | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma japonicum | ko:K04380 microtubule-associated protein tau, putative | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus granulosus | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0337 | 0.2503 | 0.3017 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0337 | 0.2503 | 0.3017 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0337 | 0.2503 | 0.3017 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.8296 | 0.8231 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0209 | 0.1002 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.8296 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.8296 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0337 | 0.2503 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0337 | 0.2503 | 0.2215 |
Echinococcus granulosus | hormone sensitive lipase | 0.0337 | 0.2503 | 0.2691 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5171 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (binding) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.